mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PAK1

Gene summary

Basic gene Info.	Gene symbol	PAK1
	Gene name	p21 protein (Cdc42/Rac)-activated kinase 1
	Synonyms	PAKalpha
	Cytomap	UCSC genome browser: 11q13-q14
	Type of gene	protein-coding
	RefGenes	NM_001128620.1, NM_002576.4,
	Description	STE20 homolog, yeastalpha-PAKp21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)p65-PAKserine/threonine-protein kinase PAK 1
	Modification date	20141207
dbXrefs	MIM : 602590
	HGNC : HGNC
	Ensembl : ENSG00000149269
	HPRD : 03995
	Vega : OTTHUMG00000165138
Protein	UniProt: Q13153 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PAK1
	BioGPS: 5058
Pathway	NCI Pathway Interaction Database: PAK1
	KEGG: PAK1
	REACTOME: PAK1
	Pathway Commons: PAK1
Context	iHOP: PAK1
	ligand binding site mutation search in PubMed: PAK1
	UCL Cancer Institute: PAK1
Assigned class in mutLBSgeneDB	A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PAK1.	1. Akinmade, D., Talukder, A. H., Zhang, Y., Luo, W. M., Kumar, R., & Hamburger, A. W. (2008). Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells. British journal of cancer,98(6), 1132-1140. 18283314

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0000165	MAPK cascade	8805275
GO:0006468	protein phosphorylation	9852149
GO:0031532	actin cytoskeleton reorganization	9395435
GO:0033138	positive regulation of peptidyl-serine phosphorylation	19667065
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16278681
GO:0046777	protein autophosphorylation	8805275

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Ligand binding site mutations for PAK1

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
I312	I312S	COAD	1
V318,I316	L317Q	COAD	1
V318,I316	L317M	COAD	1
V318,I316	L317P	COAD	1
D354	V356L	LUAD	1
I327	N326H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PAK1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
I316	L317Q	-1.3684023
V318	L317Q	-1.3684023
I312	I312S	-1.2129591
I316	L317P	-1.1848415
V318	L317P	-1.1848415
I327	N326H	-1.1706708
V318	L317M	-1.0814045
I316	L317M	-1.0814045
D354	V356L	-0.61652158

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PAK1 from PDB

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Differential gene expression and gene-gene network for PAK1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PAK1 and the right PPI network was created from samples without mutations in the LBS of PAK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PAK1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	10	AlteredExpression, Biomarker, PostTranslationalModification
umls:C0007134	Carcinoma, Renal Cell	1	Biomarker
umls:C0033687	Proteinuria	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PAK1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PAK1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
4OR		(S)-N-(TERT-BUTYL)-3-((2-CHLORO-5-ETHYL-8-FLUORO- DIBENZODIAZEPIN-11-YL)AMINO)PYRROLIDINE-1-CARBOXAMIDE	4zjj	B	I312 I327
4OR		(S)-N-(TERT-BUTYL)-3-((2-CHLORO-5-ETHYL-8-FLUORO- DIBENZODIAZEPIN-11-YL)AMINO)PYRROLIDINE-1-CARBOXAMIDE	4zjj	A	I312 V318 I327
XR1		6-[2-CHLORO-4-(1,3-THIAZOL-5-YL)PHENYL]-8-ETHYL-2-{[4- (4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}PYRIDO[2,3- D]PYRIMIDIN-7(8H)-ONE	4eqc	A	I316 D354
4OQ		2-CHLORO-5-ETHYL-8-FLUORO-11-(4-METHYLPIPERAZIN-1-YL)- DIBENZODIAZEPINE	4zji	A	V318 I327
4OQ		2-CHLORO-5-ETHYL-8-FLUORO-11-(4-METHYLPIPERAZIN-1-YL)- DIBENZODIAZEPINE	4zji	B	V318 I327
4OQ		2-CHLORO-5-ETHYL-8-FLUORO-11-(4-METHYLPIPERAZIN-1-YL)- DIBENZODIAZEPINE	4zji	C	V318 I327
4OQ		2-CHLORO-5-ETHYL-8-FLUORO-11-(4-METHYLPIPERAZIN-1-YL)- DIBENZODIAZEPINE	4zji	D	V318 I327
4OR		(S)-N-(TERT-BUTYL)-3-((2-CHLORO-5-ETHYL-8-FLUORO- DIBENZODIAZEPIN-11-YL)AMINO)PYRROLIDINE-1-CARBOXAMIDE	4zjj	C	V318 I327
4OR		(S)-N-(TERT-BUTYL)-3-((2-CHLORO-5-ETHYL-8-FLUORO- DIBENZODIAZEPIN-11-YL)AMINO)PYRROLIDINE-1-CARBOXAMIDE	4zjj	D	V318 I327
4PV		2,8-DIFLUORO-11-(4-METHYLPIPERAZIN-1-YL)-5H-DIBENZO[B, E][1,4]DIAZEPINE	4zlo	A	V318 I327

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Conservation information for LBS of PAK1

Multiple alignments for Q13153 in multiple species

LBS	AA sequence	# species	Species
A280	KIGQGASGTVY	3	Homo sapiens, Rattus norvegicus, Bos taurus
A280	KIGQGASGDVY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A280	KIGQGASGGVY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A280	KIGSGASGSVY	1	Caenorhabditis elegans
A297	TGQEVAIKQMN	3	Homo sapiens, Rattus norvegicus, Bos taurus
A297	TNLSVAIKKMN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A297	TNVSVAIKQMN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A297	TEAEVAIKQMN	1	Caenorhabditis elegans
A348	VMEYLAGGSLT	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
A348	VMEYMRGGSLT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A348	IMEYMEGGSLT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A412	DFGFCAQITPE	3	Homo sapiens, Rattus norvegicus, Bos taurus
A412	DFGFCAQIDSN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A412	DFGFCAQINEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A412	DFGFCAQLSPE	1	Caenorhabditis elegans
D354	GGSLTDVVTET	3	Homo sapiens, Rattus norvegicus, Bos taurus
D354	GGSLTEVVTNN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D354	GGSLTDVVTHC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D354	GGSLTDVVTEC	1	Caenorhabditis elegans
D393	RDIKSDNILLG	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
D393	RDIKSDNILLS	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D407	SVKLTDFGFCA	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
D407	DIKLTDFGFCA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E315	ELIINEILVMR	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
E315	EFIVNEILVMK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E315	ELIINEILVMK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E345	LWVVMEYLAGG	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
E345	LWMVMEYMRGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E345	LWVIMEYMEGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E461	EMIEGEPPYLN	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Bos taurus
E461	EMVEGEPPYLN	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
F379	LQALEFLHSNQ	3	Homo sapiens, Rattus norvegicus, Bos taurus
F379	LEGLQHLHENG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F379	LSGLEFLHSKG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F379	LQALEFLHSRH	1	Caenorhabditis elegans
F408	VKLTDFGFCAQ	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
F408	IKLTDFGFCAQ	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G277	RFEKIGQGASG	3	Homo sapiens, Rattus norvegicus, Bos taurus
G277	NFVKIGQGASG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G277	NLVKIGQGASG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G277	KVDKIGSGASG	1	Caenorhabditis elegans
G279	EKIGQGASGTV	3	Homo sapiens, Rattus norvegicus, Bos taurus
G279	VKIGQGASGDV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G279	VKIGQGASGGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G279	DKIGSGASGSV	1	Caenorhabditis elegans
G282	GQGASGTVYTA	3	Homo sapiens, Rattus norvegicus, Bos taurus
G282	GQGASGDVYSA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G282	GQGASGGVYTA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G282	GSGASGSVYTA	1	Caenorhabditis elegans
G350	EYLAGGSLTDV	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
G350	EYMRGGSLTEV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G350	EYMEGGSLTDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H387	SNQVIHRDIKS	3	Homo sapiens, Rattus norvegicus, Bos taurus
H387	ENGIVHRDIKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H387	SKGVLHRDIKS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H387	SRHVIHRDIKS	1	Caenorhabditis elegans
I276	TRFEKIGQGAS	3	Homo sapiens, Rattus norvegicus, Bos taurus
I276	RNFVKIGQGAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I276	ANLVKIGQGAS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I276	RKVDKIGSGAS	1	Caenorhabditis elegans
I312	PKKELIINEIL	5	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Rattus norvegicus, Bos taurus
I312	PKKEFIVNEIL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I316	LIINEILVMRE	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
I316	FIVNEILVMKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I316	LIINEILVMKG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I327	NKNPNIVNYLD	3	Homo sapiens, Rattus norvegicus, Bos taurus
I327	HHHKNIVNFID	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I327	SKHPNIVNFID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I327	NKHANIVNYLD	1	Caenorhabditis elegans
K299	QEVAIKQMNLQ	3	Homo sapiens, Rattus norvegicus, Bos taurus
K299	LSVAIKKMNIN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K299	VSVAIKQMNLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K299	AEVAIKQMNLK	1	Caenorhabditis elegans
K391	IHRDIKSDNIL	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
K391	VHRDIKSDNIL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K391	LHRDIKSDNIL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K538	-----KE--AT	3	Homo sapiens, Rattus norvegicus, Bos taurus
K538	-----KS--IH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K538	DDNDNEH--IN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K538	-----KKSIAE	1	Caenorhabditis elegans
L347	VVMEYLAGGSL	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
L347	MVMEYMRGGSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L347	VIMEYMEGGSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L380	QALEFLHSNQV	3	Homo sapiens, Rattus norvegicus, Bos taurus
L380	EGLQHLHENGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L380	SGLEFLHSKGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L380	QALEFLHSRHV	1	Caenorhabditis elegans
L396	KSDNILLGMDG	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
L396	KSDNILLSLQG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L396	KSDNILLSMEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L405	DGSVKLTDFGF	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
L405	QGDIKLTDFGF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L405	EGDIKLTDFGF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M319	NEILVMRENKN	3	Homo sapiens, Rattus norvegicus, Bos taurus
M319	NEILVMKSHHH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M319	NEILVMKGSKH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M319	NEILVMRENKH	1	Caenorhabditis elegans
M344	ELWVVMEYLAG	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
M344	ELWMVMEYMRG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M344	DLWVIMEYMEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N322	LVMRENKNPNI	3	Homo sapiens, Rattus norvegicus, Bos taurus
N322	LVMKSHHHKNI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N322	LVMKGSKHPNI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N322	LVMRENKHANI	1	Caenorhabditis elegans
N383	EFLHSNQVIHR	3	Homo sapiens, Rattus norvegicus, Bos taurus
N383	QHLHENGIVHR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N383	EFLHSKGVLHR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N383	EFLHSRHVIHR	1	Caenorhabditis elegans
N394	DIKSDNILLGM	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
N394	DIKSDNILLSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N394	DIKSDNILLSM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P462	MIEGEPPYLNE	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Bos taurus
P462	MVEGEPPYLNE	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
Q278	FEKIGQGASGT	3	Homo sapiens, Rattus norvegicus, Bos taurus
Q278	FVKIGQGASGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q278	LVKIGQGASGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q278	VDKIGSGASGS	1	Caenorhabditis elegans
S281	IGQGASGTVYT	3	Homo sapiens, Rattus norvegicus, Bos taurus
S281	IGQGASGDVYS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S281	IGQGASGGVYT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S281	IGSGASGSVYT	1	Caenorhabditis elegans
S351	YLAGGSLTDVV	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
S351	YMRGGSLTEVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S351	YMEGGSLTDVV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T20	PPMRNTSTMIG	3	Homo sapiens, Rattus norvegicus, Bos taurus
T20	EPVRYEVEDDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T20	QFTRVSSSSVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T20	PPIRFSSSA--	1	Caenorhabditis elegans
T406	GSVKLTDFGFC	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
T406	GDIKLTDFGFC	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V284	GASGTVYTAMD	3	Homo sapiens, Rattus norvegicus, Bos taurus
V284	GASGDVYSARQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V284	GASGGVYTAYE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V284	GASGSVYTAIE	1	Caenorhabditis elegans
V318	INEILVMRENK	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
V318	VNEILVMKSHH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V318	INEILVMKGSK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V328	KNPNIVNYLDS	3	Homo sapiens, Rattus norvegicus, Bos taurus
V328	HHKNIVNFIDT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V328	KHPNIVNFIDS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V328	KHANIVNYLDS	1	Caenorhabditis elegans
V342	GDELWVVMEYL	3	Homo sapiens, Rattus norvegicus, Bos taurus
V342	KSELWMVMEYM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V342	KGDLWVIMEYM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V342	CDELWVVMEYL	1	Caenorhabditis elegans
V385	LHSNQVIHRDI	3	Homo sapiens, Rattus norvegicus, Bos taurus
V385	LHENGIVHRDI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V385	LHSKGVLHRDI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V385	LHSRHVIHRDI	1	Caenorhabditis elegans
Y346	WVVMEYLAGGS	4	Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus
Y346	WMVMEYMRGGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y346	WVIMEYMEGGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)