mutLBSgeneDB |
Gene summary for IL21R |
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Basic gene Info. | Gene symbol | IL21R |
Gene name | interleukin 21 receptor | |
Synonyms | CD360|NILR | |
Cytomap | UCSC genome browser: 16p11 | |
Type of gene | protein-coding | |
RefGenes | NM_021798.3, NM_181078.2,NM_181079.4, | |
Description | IL-21 receptorinterleukin-21 receptornovel interleukin receptor | |
Modification date | 20141207 | |
dbXrefs | MIM : 605383 | |
HGNC : HGNC | ||
Ensembl : ENSG00000103522 | ||
HPRD : 05649 | ||
Vega : OTTHUMG00000131675 | ||
Protein | UniProt: Q9HBE5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL21R | |
BioGPS: 50615 | ||
Pathway | NCI Pathway Interaction Database: IL21R | |
KEGG: IL21R | ||
REACTOME: IL21R | ||
Pathway Commons: IL21R | ||
Context | iHOP: IL21R | |
ligand binding site mutation search in PubMed: IL21R | ||
UCL Cancer Institute: IL21R | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for IL21R |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | T213 | Q211R | KIRC | 1 | I36 | C35F | LUAD | 1 | R201 | R201W | PRAD | 1 | R201 | R201W | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL21R |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R201 | R201W | -0.66034497 | T213 | Q211R | -0.64721644 | I36 | C35F | -0.4853489 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for IL21R |
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Phenotype information for IL21R |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0024141 | Lupus Erythematosus, Systemic | 6 | Biomarker, GeneticVariation, Therapeutic |
umls:C3554687 | IL21R IMMUNODEFICIENCY | 1 | GeneticVariation |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL21R |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of IL21R |
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LBS | AA sequence | # species | Species |
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