mutLBSgeneDB |
Gene summary for IL22 |
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Basic gene Info. | Gene symbol | IL22 |
Gene name | interleukin 22 | |
Synonyms | IL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18 | |
Cytomap | UCSC genome browser: 12q15 | |
Type of gene | protein-coding | |
RefGenes | NM_020525.4, | |
Description | IL-10-related T-cell-derived inducible factorIL-10-related T-cell-derived-inducible factorcytokine Zcyto18interleukin-22 | |
Modification date | 20141222 | |
dbXrefs | MIM : 605330 | |
HGNC : HGNC | ||
Ensembl : ENSG00000127318 | ||
HPRD : 05621 | ||
Vega : OTTHUMG00000169119 | ||
Protein | UniProt: Q9GZX6 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL22 | |
BioGPS: 50616 | ||
Pathway | NCI Pathway Interaction Database: IL22 | |
KEGG: IL22 | ||
REACTOME: IL22 | ||
Pathway Commons: IL22 | ||
Context | iHOP: IL22 | |
ligand binding site mutation search in PubMed: IL22 | ||
UCL Cancer Institute: IL22 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for IL22 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | R55 | F57S | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL22 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R55 | F57S | -0.90715398 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for IL22 |
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Phenotype information for IL22 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0860207 | Drug-Induced Liver Injury | 3 | Therapeutic |
umls:C0241910 | Hepatitis, Autoimmune | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL22 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FUC | ALPHA-L-FUCOPYRANOSE | 1ykb | A | R55 | FUC | ALPHA-L-FUCOPYRANOSE | 1ykb | D | R55 | MAN | ALPHA-D-MANNOSE | 3dgc | M | R55 |
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Conservation information for LBS of IL22 |
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LBS | AA sequence | # species | Species | R55 | PYIVNRTFMLA | 2 | Mus musculus, Mus musculus | R55 | PYITNRTFMLA | 1 | Homo sapiens | Y114 | DRFQPYMQEVV | 3 | Homo sapiens, Mus musculus, Mus musculus | Y51 | NFQQPYIVNRT | 2 | Mus musculus, Mus musculus | Y51 | NFQQPYITNRT | 1 | Homo sapiens |
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