mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IL22
Gene summary
Basic gene Info.Gene symbolIL22
Gene nameinterleukin 22
SynonymsIL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18
CytomapUCSC genome browser: 12q15
Type of geneprotein-coding
RefGenesNM_020525.4,
DescriptionIL-10-related T-cell-derived inducible factorIL-10-related T-cell-derived-inducible factorcytokine Zcyto18interleukin-22
Modification date20141222
dbXrefs MIM : 605330
HGNC : HGNC
Ensembl : ENSG00000127318
HPRD : 05621
Vega : OTTHUMG00000169119
ProteinUniProt: Q9GZX6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL22
BioGPS: 50616
PathwayNCI Pathway Interaction Database: IL22
KEGG: IL22
REACTOME: IL22
Pathway Commons: IL22
ContextiHOP: IL22
ligand binding site mutation search in PubMed: IL22
UCL Cancer Institute: IL22
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for IL22
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R55F57SLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for IL22
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R55F57S-0.90715398
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IL22 from PDB

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Differential gene expression and gene-gene network for IL22
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IL22 and the right PPI network was created from samples without mutations in the LBS of IL22. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IL22
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0860207Drug-Induced Liver Injury3Therapeutic
umls:C0241910Hepatitis, Autoimmune1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IL22
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IL22 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FUCALPHA-L-FUCOPYRANOSE1ykbAR55
FUCALPHA-L-FUCOPYRANOSE1ykbDR55
MANALPHA-D-MANNOSE3dgcMR55


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Conservation information for LBS of IL22
Multiple alignments for Q9GZX6 in multiple species
LBSAA sequence# speciesSpecies
R55PYIVNRTFMLA2Mus musculus, Mus musculus
R55PYITNRTFMLA1Homo sapiens
Y114DRFQPYMQEVV3Homo sapiens, Mus musculus, Mus musculus
Y51NFQQPYIVNRT2Mus musculus, Mus musculus
Y51NFQQPYITNRT1Homo sapiens


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