mutLBSgeneDB |
Gene summary for REG3A |
Gene summary |
Basic gene Info. | Gene symbol | REG3A |
Gene name | regenerating islet-derived 3 alpha | |
Synonyms | HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3 | |
Cytomap | UCSC genome browser: 2p12 | |
Type of gene | protein-coding | |
RefGenes | NM_002580.2, NM_138937.2,NM_138938.2, | |
Description | PAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation-inducing protein 34proliferation-inducing | |
Modification date | 20141222 | |
dbXrefs | MIM : 167805 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172016 | ||
HPRD : 01342 | ||
Vega : OTTHUMG00000130017 | ||
Protein | UniProt: Q06141 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_REG3A | |
BioGPS: 5068 | ||
Pathway | NCI Pathway Interaction Database: REG3A | |
KEGG: REG3A | ||
REACTOME: REG3A | ||
Pathway Commons: REG3A | ||
Context | iHOP: REG3A | |
ligand binding site mutation search in PubMed: REG3A | ||
UCL Cancer Institute: REG3A | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for REG3A |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E121 | S123R | LUAD | 1 | E121 | W120C | LUAD | 1 | H107 | P109R | LUAD | 1 | H107 | P109T | LUSC | 1 | H107 | P109S | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for REG3A |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H107 | P109S | -1.2812503 | H107 | P109T | -1.2258479 | H107 | P109R | -1.0285636 | E121 | W120C | -0.63396831 | E121 | S123R | -0.23512715 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for REG3A from PDB |
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Differential gene expression and gene-gene network for REG3A |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for REG3A |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for REG3A |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of REG3A go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4mth | A | H107 E121 |
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Conservation information for LBS of REG3A |
Multiple alignments for Q06141 in multiple species |
LBS | AA sequence | # species | Species | E121 | NGGGWEWSNND | 2 | Mus musculus, Rattus norvegicus | E121 | NGEGWEWSSSD | 1 | Homo sapiens | H107 | TWIGLHDPTLG | 2 | Mus musculus, Rattus norvegicus | H107 | VWIGLHDPTQG | 1 | Homo sapiens |
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