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mutLBSgeneDB |
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| Gene summary for PARN |
 Gene summary |
| Basic gene Info. | Gene symbol | PARN |
| Gene name | poly(A)-specific ribonuclease | |
| Synonyms | DAN | |
| Cytomap | UCSC genome browser: 16p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001134477.2, NM_001242992.1,NM_002582.3, | |
| Description | deadenylating nucleasedeadenylation nucleasepoly(A)-specific ribonuclease (deadenylation nuclease)poly(A)-specific ribonuclease PARNpolyadenylate-specific ribonuclease | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604212 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140694 | ||
| HPRD : 07250 | ||
| Vega : OTTHUMG00000173199 | ||
| Protein | UniProt: O95453 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PARN | |
| BioGPS: 5073 | ||
| Pathway | NCI Pathway Interaction Database: PARN | |
| KEGG: PARN | ||
| REACTOME: PARN | ||
| Pathway Commons: PARN | ||
| Context | iHOP: PARN | |
| ligand binding site mutation search in PubMed: PARN | ||
| UCL Cancer Institute: PARN | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PARN |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S112 | I113V | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PARN |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S112 | I113V | -1.1806337 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PARN from PDB |
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| Differential gene expression and gene-gene network for PARN |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PARN |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PARN |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PARN go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2a1r | A | S112 | NUC | Nucleic Acids | 2a1r | B | S112 |
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| Conservation information for LBS of PARN |
| Multiple alignments for O95453 in multiple species |
| LBS | AA sequence | # species | Species | D28 | DFFAIDGEFSG | 3 | Homo sapiens, Mus musculus, Bos taurus | D28 | DFVAIDLEMTG | 1 | Arabidopsis thaliana | D28 | HYVSIDCEFSG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D28 | DFISIDGEFTG | 1 | Danio rerio | D477 | ---WIDDTSAF | 3 | Homo sapiens, Mus musculus, Bos taurus | D477 | SVYHVDDSAVF | 1 | Arabidopsis thaliana | D477 | ------TALLF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D477 | ---WVDDTSAF | 1 | Danio rerio | D478 | --WIDDTSAFV | 3 | Homo sapiens, Mus musculus, Bos taurus | D478 | VYHVDDSAVFV | 1 | Arabidopsis thaliana | D478 | -----TALLFV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D478 | --WVDDTSAFV | 1 | Danio rerio | E30 | FAIDGEFSGIS | 3 | Homo sapiens, Mus musculus, Bos taurus | E30 | VAIDLEMTGVT | 1 | Arabidopsis thaliana | E30 | VSIDCEFSGLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E30 | ISIDGEFTGIS | 1 | Danio rerio | F115 | SSSIDFLASQG | 4 | Homo sapiens, Danio rerio, Mus musculus, Bos taurus | F115 | TTSMDFLAKYQ | 1 | Arabidopsis thaliana | F115 | ASSIKFLIQQG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F31 | AIDGEFSGISD | 3 | Homo sapiens, Mus musculus, Bos taurus | F31 | AIDLEMTGVTS | 1 | Arabidopsis thaliana | F31 | SIDCEFSGLLR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F31 | SIDGEFTGISD | 1 | Danio rerio | G29 | FFAIDGEFSGI | 3 | Homo sapiens, Mus musculus, Bos taurus | G29 | FVAIDLEMTGV | 1 | Arabidopsis thaliana | G29 | YVSIDCEFSGL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G29 | FISIDGEFTGI | 1 | Danio rerio | H287 | KLVIGHNMLLD | 2 | Homo sapiens, Bos taurus | H287 | KLVVGHNMLLD | 2 | Danio rerio, Mus musculus | H287 | KLIVGHNCFLD | 1 | Arabidopsis thaliana | H287 | KSVVCHNGMAD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H377 | ASEQLHEAGYD | 3 | Homo sapiens, Mus musculus, Bos taurus | H377 | NAGGKHEAGYD | 1 | Arabidopsis thaliana | H377 | ----------- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H377 | STEQLHEAGYD | 1 | Danio rerio | I34 | GEFSGISDGPS | 3 | Homo sapiens, Mus musculus, Bos taurus | I34 | LEMTGVTSAPW | 1 | Arabidopsis thaliana | I34 | CEFSGLLRDFN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I34 | GEFTGISDGPS | 1 | Danio rerio | K326 | RLLDTKLMAST | 4 | Homo sapiens, Danio rerio, Mus musculus, Bos taurus | K326 | YIVDTKILLNV | 1 | Arabidopsis thaliana | K326 | SIYDTKLL--- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K454 | HVTFPKEWKTS | 3 | Homo sapiens, Mus musculus, Bos taurus | K454 | IWNFPRKLKAR | 1 | Arabidopsis thaliana | K454 | ----PHE-AGK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K454 | YVTFPKEWKTS | 1 | Danio rerio | K457 | FPKEWKTSDLY | 4 | Homo sapiens, Danio rerio, Mus musculus, Bos taurus | K457 | FPRKLKARGIK | 1 | Arabidopsis thaliana | K457 | -PHE-AGKDSY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L343 | INNTSLAELEK | 3 | Homo sapiens, Mus musculus, Bos taurus | L343 | KSSTSLSSAFS | 1 | Arabidopsis thaliana | L343 | LKSDDLQHV-- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L343 | IHNTSLAELHK | 1 | Danio rerio | N288 | LVIGHNMLLDV | 2 | Homo sapiens, Bos taurus | N288 | LVVGHNMLLDV | 2 | Danio rerio, Mus musculus | N288 | LIVGHNCFLDI | 1 | Arabidopsis thaliana | N288 | SVVCHNGMADL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S112 | VCQSSSIDFLA | 3 | Homo sapiens, Mus musculus, Bos taurus | S112 | LCQTTSMDFLA | 1 | Arabidopsis thaliana | S112 | CSEASSIKFLI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S112 | ICQSSSIDFLA | 1 | Danio rerio | S342 | IINNTSLAELE | 3 | Homo sapiens, Mus musculus, Bos taurus | S342 | KKSSTSLSSAF | 1 | Arabidopsis thaliana | S342 | YLKSDDLQHV- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S342 | IIHNTSLAELH | 1 | Danio rerio | W456 | TFPKEWKTSDL | 4 | Homo sapiens, Danio rerio, Mus musculus, Bos taurus | W456 | NFPRKLKARGI | 1 | Arabidopsis thaliana | W456 | --PHE-AGKDS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W475 | IS---WIDDTS | 3 | Homo sapiens, Mus musculus, Bos taurus | W475 | VTSVYHVDDSA | 1 | Arabidopsis thaliana | W475 | --------TAL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W475 | VS---WVDDTS | 1 | Danio rerio |
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