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mutLBSgeneDB |
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| Gene summary for PCBP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | PCBP1 |
| Gene name | poly(rC) binding protein 1 | |
| Synonyms | HEL-S-85|HNRPE1|HNRPX|hnRNP-E1|hnRNP-X | |
| Cytomap | UCSC genome browser: 2p13-p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006196.3, | |
| Description | alpha-CP1epididymis secretory protein Li 85heterogeneous nuclear ribonucleoprotein E1heterogenous nuclear ribonucleoprotein E1heterogenous nuclear ribonucleoprotein Xnucleic acid-binding protein SUB2.3poly(rC)-binding protein 1 | |
| Modification date | 20141215 | |
| dbXrefs | MIM : 601209 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169564 | ||
| HPRD : 03128 | ||
| Vega : OTTHUMG00000129645 | ||
| Protein | UniProt: Q15365 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PCBP1 | |
| BioGPS: 5093 | ||
| Pathway | NCI Pathway Interaction Database: PCBP1 | |
| KEGG: PCBP1 | ||
| REACTOME: PCBP1 | ||
| Pathway Commons: PCBP1 | ||
| Context | iHOP: PCBP1 | |
| ligand binding site mutation search in PubMed: PCBP1 | ||
| UCL Cancer Institute: PCBP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PCBP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K78 | D77Y | KIRC | 1 | D82 | I83F | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PCBP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D82 | I83F | -1.1595824 | K78 | D77Y | -0.32537442 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PCBP1 from PDB |
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| Differential gene expression and gene-gene network for PCBP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PCBP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PCBP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PCBP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3vke | A | D82 | NUC | Nucleic Acids | 3vke | B | D82 | NUC | Nucleic Acids | 1ztg | C | K78 | NUC | Nucleic Acids | 1ztg | B | K78 D82 |
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| Conservation information for LBS of PCBP1 |
| Multiple alignments for Q15365 in multiple species |
| LBS | AA sequence | # species | Species | D82 | DKLEEDINSSM | 3 | Homo sapiens, Bos taurus, Mus musculus | E51 | RINISEGNCPE | 3 | Homo sapiens, Bos taurus, Mus musculus | G22 | RLLMHGKEVGS | 3 | Homo sapiens, Bos taurus, Mus musculus | G26 | HGKEVGSIIGK | 3 | Homo sapiens, Bos taurus, Mus musculus | G30 | VGSIIGKKGES | 3 | Homo sapiens, Bos taurus, Mus musculus | G33 | IIGKKGESVKR | 3 | Homo sapiens, Bos taurus, Mus musculus | I29 | EVGSIIGKKGE | 3 | Homo sapiens, Bos taurus, Mus musculus | I49 | GARINISEGNC | 3 | Homo sapiens, Bos taurus, Mus musculus | K23 | LLMHGKEVGSI | 3 | Homo sapiens, Bos taurus, Mus musculus | K31 | GSIIGKKGESV | 3 | Homo sapiens, Bos taurus, Mus musculus | K32 | SIIGKKGESVK | 3 | Homo sapiens, Bos taurus, Mus musculus | K37 | KGESVKRIREE | 3 | Homo sapiens, Bos taurus, Mus musculus | K78 | AMIIDKLEEDI | 3 | Homo sapiens, Bos taurus, Mus musculus | N48 | SGARINISEGN | 3 | Homo sapiens, Bos taurus, Mus musculus | R40 | SVKRIREESGA | 3 | Homo sapiens, Bos taurus, Mus musculus | R57 | GNCPERIITLT | 3 | Homo sapiens, Bos taurus, Mus musculus | S27 | GKEVGSIIGKK | 3 | Homo sapiens, Bos taurus, Mus musculus | V36 | KKGESVKRIRE | 3 | Homo sapiens, Bos taurus, Mus musculus |
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