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mutLBSgeneDB |
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| Gene summary for PCBP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | PCBP2 |
| Gene name | poly(rC) binding protein 2 | |
| Synonyms | HNRNPE2|HNRPE2|hnRNP-E2 | |
| Cytomap | UCSC genome browser: 12q13.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001098620.2, NM_001128911.1,NM_001128912.1,NM_001128913.1,NM_001128914.1, NM_005016.5,NM_031989.4, | |
| Description | alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2poly(rC)-binding protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601210 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197111 | ||
| HPRD : 03129 | ||
| Vega : OTTHUMG00000169439 | ||
| Protein | UniProt: Q15366 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PCBP2 | |
| BioGPS: 5094 | ||
| Pathway | NCI Pathway Interaction Database: PCBP2 | |
| KEGG: PCBP2 | ||
| REACTOME: PCBP2 | ||
| Pathway Commons: PCBP2 | ||
| Context | iHOP: PCBP2 | |
| ligand binding site mutation search in PubMed: PCBP2 | ||
| UCL Cancer Institute: PCBP2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PCBP2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G22 | M20V | BRCA | 1 | G52 | G52W | COAD | 1 | R40 | R40C | HNSC | 1 | R314 | R314H | KIRC | 1 | R57 | E56Q | LUAD | 1 | R314 | R314C | SKCM | 1 | R333 | V335F | UCEC | 1 | R46 | R46H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PCBP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R46 | R46H | -1.1968636 | G22 | M20V | -1.133753 | R314 | R314H | -1.0681425 | R57 | E56Q | -1.029728 | G52 | G52W | -0.98998394 | R333 | V335F | -0.92825906 | R314 | R314C | -0.77510064 | R40 | R40C | -0.71399305 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PCBP2 from PDB |
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| Differential gene expression and gene-gene network for PCBP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PCBP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PCBP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PCBP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2axy | B | G22 R40 R46 R57 | NUC | Nucleic Acids | 2axy | D | G22 R40 R46 R57 | NUC | Nucleic Acids | 2pqu | B | G22 R40 R57 | NUC | Nucleic Acids | 2py9 | B | G22 R40 R57 | NUC | Nucleic Acids | 2p2r | A | R314 R333 | NUC | Nucleic Acids | 2pqu | C | R40 R46 G52 R57 | NUC | Nucleic Acids | 2py9 | C | R40 R46 R57 | NUC | Nucleic Acids | 2axy | A | R40 R57 | NUC | Nucleic Acids | 2axy | C | R40 R57 |
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| Conservation information for LBS of PCBP2 |
| Multiple alignments for Q15366 in multiple species |
| LBS | AA sequence | # species | Species |
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