mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PCK1
Gene summary
Basic gene Info.Gene symbolPCK1
Gene namephosphoenolpyruvate carboxykinase 1 (soluble)
SynonymsPEPCK-C|PEPCK1|PEPCKC
CytomapUCSC genome browser: 20q13.31
Type of geneprotein-coding
RefGenesNM_002591.3,
DescriptionPEP carboxykinasephosphoenolpyruvate carboxykinase, cytosolicphosphoenolpyruvate carboxykinase, cytosolic [GTP]phosphoenolpyruvate carboxylasephosphopyruvate carboxylase
Modification date20141207
dbXrefs MIM : 614168
HGNC : HGNC
HPRD : 02028
ProteinUniProt: P35558
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PCK1
BioGPS: 5105
PathwayNCI Pathway Interaction Database: PCK1
KEGG: PCK1
REACTOME: PCK1
Pathway Commons: PCK1
ContextiHOP: PCK1
ligand binding site mutation search in PubMed: PCK1
UCL Cancer Institute: PCK1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006475internal protein amino acid acetylation20167786
GO:0032868response to insulin14764811


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Ligand binding site mutations for PCK1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G529G529VCOAD1
G289G289WLUAD1
D311D311NLUAD1
N403,R405S404LLUAD1
A287A287SLUAD1
G289G289WLUSC1
F333F333LLUSC1
F333G334CLUSC1
G289G289RSKCM1
R87E89KSKCM1
K342S340LSKCM1
N403P402SSKCM1
A287A287TSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PCK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K342S340L0.038908506
R87E89K-1.1283789
A287A287S-0.99200931
D311D311N-0.97375788
A287A287T-0.86393882
N403P402S-0.70377062
G529G529V-0.61018472
G289G289R-0.41469418
F333G334C-0.40625695
G289G289W-0.35787702
R405S404L-0.25454209
N403S404L-0.25454209
F333F333L-0.15759556
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PCK1 from PDB

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Differential gene expression and gene-gene network for PCK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PCK1 and the right PPI network was created from samples without mutations in the LBS of PCK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PCK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0028754Obesity3Biomarker
umls:C0011853Diabetes Mellitus, Experimental2Biomarker
umls:C2239176Carcinoma, Hepatocellular1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PCK1
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01819PhosphoenolpyruvateSmall molecule
ExperimentalDB020081-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineSmall molecule
ExperimentalDB032671-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineSmall molecule
ExperimentalDB03725Phosphomethylphosphonic Acid-Guanylate EsterSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PCK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FTB1-(2-FLUOROBENZYL)-3-BUTYL-8-(N-ACETYL-4-AMINOBENZYL)-XANTHINE1nhxAA287 G289 G529
UN8N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE2gmvAA287 G289 K342
MNMANGANESE(2+)1khbAD311
MNMANGANESE(2+)1kheAD311
MNMANGANESE(2+)1khfAD311
MNMANGANESE(2+)1khgAD311
MNMANGANESE(2+)1m51AD311
MNMANGANESE(2+)1nhxAD311
MNMANGANESE(2+)2gmvAD311
MNMANGANESE(2+)2gmvBD311
TSX1-ALLYL-3-BUTYL-8-(N-ACETYL-4-AMINOBENZYL)-XANTHINE1m51AG289 G529
PEPPHOSPHOENOLPYRUVATE2gmvAR87 F333 N403 R405
PEPPHOSPHOENOLPYRUVATE1khfAR87 N403 R405
PEPPHOSPHOENOLPYRUVATE1nhxAR87 N403 R405
PEPPHOSPHOENOLPYRUVATE2gmvBR87 N403 R405


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Conservation information for LBS of PCK1
Multiple alignments for P35558 in multiple species
LBSAA sequence# speciesSpecies
A287AAFPSACGKTN5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A86DPRDVARIESK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A86NPRDVARIESK1Gallus gallus
C288AFPSACGKTNL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
D310VECVGDDIAWM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D310IECVGDDIAWM1Gallus gallus
D311ECVGDDIAWMK5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F333PENGFFGVAPG5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F485FAMRPFFGYNF4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F485FAMGPFFGYNF1Bos taurus
F517FHVNWFRKDKE1Homo sapiens
F517FHVNWFRKDSQ1Gallus gallus
F517FHVNWFRKDKA1Bos taurus
F517FHVNWFRKDKD1Mus musculus
F517FHVNWFRKDKN1Rattus norvegicus
F525DKEGKFLWPGF1Homo sapiens
F525DSQGKFLWPGY1Gallus gallus
F525DKAGRFLWPGF1Bos taurus
F525DKDGKFLWPGF1Mus musculus
F525DKNGKFLWPGF1Rattus norvegicus
F530FLWPGFGENSR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F530FLWPGYGENSR1Gallus gallus
G236FGSGYGGNSLL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G237GSGYGGNSLLG5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G289FPSACGKTNLA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G529KFLWPGFGENS3Homo sapiens, Mus musculus, Rattus norvegicus
G529KFLWPGYGENS1Gallus gallus
G529RFLWPGFGENS1Bos taurus
K244SLLGKKCFALR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K290PSACGKTNLAM5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K342PGTSVKTNPNA3Homo sapiens, Mus musculus, Rattus norvegicus
K342PGTSIKTNPNA1Gallus gallus
K342PGTSVRTNPNA1Bos taurus
L293CGKTNLAMMNP5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M296TNLAMMNPSLP2Homo sapiens, Mus musculus
M296TNLAMMNPTLP2Bos taurus, Rattus norvegicus
M296TNLAMMNPSRP1Gallus gallus
N292ACGKTNLAMMN5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N403PCAHPNSRFCT5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N533PGFGENSRVLE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N533PGYGENSRVLE1Gallus gallus
P528GKFLWPGFGEN3Homo sapiens, Mus musculus, Rattus norvegicus
P528GKFLWPGYGEN1Gallus gallus
P528GRFLWPGFGEN1Bos taurus
R405AHPNSRFCTPA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
R436IIFGGRRPAGV3Homo sapiens, Gallus gallus, Rattus norvegicus
R436IIFGGRRPVGV1Bos taurus
R436IIFGGRRPEGV1Mus musculus
R87PRDVARIESKT5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T291SACGKTNLAMM5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T343GTSVKTNPNAI3Homo sapiens, Mus musculus, Rattus norvegicus
T343GTSIKTNPNAI1Gallus gallus
T343GTSVRTNPNAI1Bos taurus
W516IFHVNWFRKDK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W516IFHVNWFRKDS1Gallus gallus
W527EGKFLWPGFGE1Homo sapiens
W527QGKFLWPGYGE1Gallus gallus
W527AGRFLWPGFGE1Bos taurus
W527DGKFLWPGFGE1Mus musculus
W527NGKFLWPGFGE1Rattus norvegicus
Y235SFGSGYGGNSL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus


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