mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for THAP4
Gene summary
Basic gene Info.Gene symbolTHAP4
Gene nameTHAP domain containing 4
CytomapUCSC genome browser: 2q37.3
Type of geneprotein-coding
DescriptionTHAP domain-containing protein 4
Modification date20141207
dbXrefs MIM : 612533
Ensembl : ENSG00000176946
HPRD : 11630
Vega : OTTHUMG00000133410
ProteinUniProt: Q8WY91
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_THAP4
BioGPS: 51078
PathwayNCI Pathway Interaction Database: THAP4
Pathway Commons: THAP4
ContextiHOP: THAP4
ligand binding site mutation search in PubMed: THAP4
UCL Cancer Institute: THAP4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for THAP4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for THAP4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for THAP4 from PDB

Differential gene expression and gene-gene network for THAP4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of THAP4 and the right PPI network was created from samples without mutations in the LBS of THAP4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for THAP4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for THAP4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of THAP4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of THAP4
Multiple alignments for Q8WY91 in multiple species
LBSAA sequence# speciesSpecies
F448PTLQPFQYLEE3Homo sapiens, Mus musculus, Rattus norvegicus
F448PTIPSFRYGEE1Arabidopsis thaliana
F448PTLQPFRYLEE1Bos taurus
H480THKPMHRECGF3Bos taurus, Mus musculus, Rattus norvegicus
H480TRKPMHRECGF1Homo sapiens
H480SGAPMHAESGY1Arabidopsis thaliana
H567QPMTQHLHITY2Mus musculus, Rattus norvegicus
H567QPMTQHLHVTY1Homo sapiens
H567NPLQPHLKAIL1Arabidopsis thaliana
H567QPLTQHLHVTY1Bos taurus
I539PHVEQITRKFR3Homo sapiens, Bos taurus, Mus musculus
I539-KVKEISREFE1Arabidopsis thaliana
I539PHVQQITRKFR1Rattus norvegicus
L445GTFPTLQPFQY2Mus musculus, Rattus norvegicus
L445GTYPTLQPFQY1Homo sapiens
L445GEYPTIPSFRY1Arabidopsis thaliana
L445GTFPTLQPFRY1Bos taurus
L568PMTQHLHITYK2Mus musculus, Rattus norvegicus
L568PMTQHLHVTYK1Homo sapiens
L568PLQPHLKAILD1Arabidopsis thaliana
L568PLTQHLHVTYK1Bos taurus
M479ETHKPMHRECG2Mus musculus, Rattus norvegicus
M479DTRKPMHRECG1Homo sapiens
M479ESGAPMHAESG1Arabidopsis thaliana
M479DTHKPMHRECG1Bos taurus
M557EQTVSMATTTQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M557SYVVRMSTTTN1Arabidopsis thaliana
P534SFAKEPHVEQI3Homo sapiens, Bos taurus, Mus musculus
P534S-----KVKEI1Arabidopsis thaliana
P534SFAKEPHVQQI1Rattus norvegicus
R541VEQITRKFRLN3Homo sapiens, Bos taurus, Mus musculus
R541VKEISREFEL-1Arabidopsis thaliana
R541VQQITRKFRLN1Rattus norvegicus
S470NFSFNSFHPET2Mus musculus, Rattus norvegicus
S470NFSFNSFHPDT1Homo sapiens
S470AYTQKTWKLES1Arabidopsis thaliana
S470NFSFNAFHPDT1Bos taurus
T444VGTFPTLQPFQ2Mus musculus, Rattus norvegicus
T444AGTYPTLQPFQ1Homo sapiens
T444EGEYPTIPSFR1Arabidopsis thaliana
T444AGTFPTLQPFR1Bos taurus
T559TVSMATTTQPM3Homo sapiens, Mus musculus, Rattus norvegicus
T559VVRMSTTTNPL1Arabidopsis thaliana
T559TVSMATTTQPL1Bos taurus
V555KLEQTVSMATT3Homo sapiens, Mus musculus, Rattus norvegicus
V555KLSYVVRMSTT1Arabidopsis thaliana
V555NLEQTVSMATT1Bos taurus
Y450LQPFQYLEEVH3Homo sapiens, Mus musculus, Rattus norvegicus
Y450IPSFRYGEEIR1Arabidopsis thaliana
Y450LQPFRYLEEAH1Bos taurus

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