mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ADIPOR1
Gene summary
Basic gene Info.Gene symbolADIPOR1
Gene nameadiponectin receptor 1
CytomapUCSC genome browser: 1q32.1
Type of geneprotein-coding
Descriptionadiponectin receptor protein 1progestin and adipoQ receptor family member I
Modification date20141207
dbXrefs MIM : 607945
Ensembl : ENSG00000159346
HPRD : 06402
Vega : OTTHUMG00000041391
ProteinUniProt: Q96A54
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADIPOR1
BioGPS: 51094
PathwayNCI Pathway Interaction Database: ADIPOR1
Pathway Commons: ADIPOR1
ContextiHOP: ADIPOR1
ligand binding site mutation search in PubMed: ADIPOR1
UCL Cancer Institute: ADIPOR1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0009755hormone-mediated signaling pathway12802337
GO:0019395fatty acid oxidation12802337

Ligand binding site mutations for ADIPOR1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ADIPOR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ADIPOR1 from PDB

Differential gene expression and gene-gene network for ADIPOR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ADIPOR1 and the right PPI network was created from samples without mutations in the LBS of ADIPOR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ADIPOR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0022661Kidney Failure, Chronic3Biomarker
umls:C0021361Infertility, Female1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ADIPOR1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ADIPOR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ADIPOR1
Multiple alignments for Q96A54 in multiple species
LBSAA sequence# speciesSpecies
H191FSWLFHTVYCH2Homo sapiens, Mus musculus
H191LSFAFHTLSCH1Caenorhabditis elegans
H191FSFAFHTLSCH1Drosophila melanogaster
H191LSSSFHCLKSH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H191CSTFYHTISNH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H337IWFQSHQIFHV2Homo sapiens, Mus musculus
H337IWFQSHQLFHT1Caenorhabditis elegans
H337IWGQSHQIFHI1Drosophila melanogaster
H337IWGHSHQLFHF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H337VFGSSHQWFHV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H341SHQIFHVLVVA2Homo sapiens, Mus musculus
H341SHQLFHTCVVI1Caenorhabditis elegans
H341SHQIFHILVIA1Drosophila melanogaster
H341SHQLFHFLVVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H341SHQWFHVCVII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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