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mutLBSgeneDB |
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| Gene summary for ADIPOR1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ADIPOR1 |
| Gene name | adiponectin receptor 1 | |
| Synonyms | ACDCR1|CGI45|PAQR1|TESBP1A | |
| Cytomap | UCSC genome browser: 1q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001290553.1, NM_001290557.1,NM_001290629.1,NM_015999.5,NR_046083.1, | |
| Description | adiponectin receptor protein 1progestin and adipoQ receptor family member I | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607945 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000159346 | ||
| HPRD : 06402 | ||
| Vega : OTTHUMG00000041391 | ||
| Protein | UniProt: Q96A54 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADIPOR1 | |
| BioGPS: 51094 | ||
| Pathway | NCI Pathway Interaction Database: ADIPOR1 | |
| KEGG: ADIPOR1 | ||
| REACTOME: ADIPOR1 | ||
| Pathway Commons: ADIPOR1 | ||
| Context | iHOP: ADIPOR1 | |
| ligand binding site mutation search in PubMed: ADIPOR1 | ||
| UCL Cancer Institute: ADIPOR1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0009755 | hormone-mediated signaling pathway | 12802337 | GO:0019395 | fatty acid oxidation | 12802337 |
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| Ligand binding site mutations for ADIPOR1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H191 | V193I | PRAD | 1 | H191 | L189I | SKCM | 1 | H191 | V193I | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ADIPOR1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H191 | V193I | -1.1304622 | H191 | L189I | -1.100092 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ADIPOR1 from PDB |
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| Differential gene expression and gene-gene network for ADIPOR1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ADIPOR1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0022661 | Kidney Failure, Chronic | 3 | Biomarker |
| umls:C0021361 | Infertility, Female | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ADIPOR1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ADIPOR1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 3wxv | A | H191 |
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| Conservation information for LBS of ADIPOR1 |
| Multiple alignments for Q96A54 in multiple species |
| LBS | AA sequence | # species | Species | H191 | FSWLFHTVYCH | 2 | Homo sapiens, Mus musculus | H191 | LSFAFHTLSCH | 1 | Caenorhabditis elegans | H191 | FSFAFHTLSCH | 1 | Drosophila melanogaster | H191 | LSSSFHCLKSH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H191 | CSTFYHTISNH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H337 | IWFQSHQIFHV | 2 | Homo sapiens, Mus musculus | H337 | IWFQSHQLFHT | 1 | Caenorhabditis elegans | H337 | IWGQSHQIFHI | 1 | Drosophila melanogaster | H337 | IWGHSHQLFHF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H337 | VFGSSHQWFHV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H341 | SHQIFHVLVVA | 2 | Homo sapiens, Mus musculus | H341 | SHQLFHTCVVI | 1 | Caenorhabditis elegans | H341 | SHQIFHILVIA | 1 | Drosophila melanogaster | H341 | SHQLFHFLVVI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H341 | SHQWFHVCVII | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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