mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PCNA

Gene summary

Basic gene Info.	Gene symbol	PCNA
	Gene name	proliferating cell nuclear antigen
	Synonyms	ATLD2
	Cytomap	UCSC genome browser: 20pter-p12
	Type of gene	protein-coding
	RefGenes	NM_002592.2, NM_182649.1,
	Description	DNA polymerase delta auxiliary proteincyclin
	Modification date	20141222
dbXrefs	MIM : 176740
	HGNC : HGNC
	Ensembl : ENSG00000132646
	HPRD : 01456
	Vega : OTTHUMG00000031798
Protein	UniProt: P12004 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PCNA
	BioGPS: 5111
Pathway	NCI Pathway Interaction Database: PCNA
	KEGG: PCNA
	REACTOME: PCNA
	Pathway Commons: PCNA
Context	iHOP: PCNA
	ligand binding site mutation search in PubMed: PCNA
	UCL Cancer Institute: PCNA
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006298	mismatch repair	11005803
GO:0019985	translesion synthesis	20129063
GO:0032077	positive regulation of deoxyribonuclease activity	19443450

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Ligand binding site mutations for PCNA

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E85	D86Y	COAD	1
E85	E85Q	KICH	1
D120	D120N	KIRC	1
A105	E104K	SKCM	1
Y211	Y211H	STAD	1
K77	S76P	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PCNA

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
Y211	Y211H	-1.1259049
A105	E104K	-1.0635491
D120	D120N	-1.0404915
E85	D86Y	-0.8376356
K77	S76P	-0.70352928
E85	E85Q	-0.64954132

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PCNA from PDB

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Differential gene expression and gene-gene network for PCNA

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PCNA and the right PPI network was created from samples without mutations in the LBS of PCNA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PCNA

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0001418	Adenocarcinoma	25	Biomarker, GeneticVariation
umls:C0006118	Brain Neoplasms	6	Biomarker, GeneticVariation
umls:C0024121	Lung Neoplasms	4	AlteredExpression, Biomarker
umls:C0206624	Hepatoblastoma	4	Biomarker
umls:C0022116	Ischemia	3	Biomarker
umls:C0017661	Glomerulonephritis, IGA	2	Biomarker
umls:C0033860	Psoriasis	2	Biomarker
umls:C0009375	Colonic Neoplasms	2	Biomarker
umls:C0017668	Glomerulosclerosis, Focal Segmental	1	Biomarker
umls:C0027659	Neoplasms, Experimental	1	Biomarker
umls:C0034531	Radiation Injuries, Experimental	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PCNA

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PCNA go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (ARG,GLN,THR,SER,MET,THR,ASP,PHE,TYR,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	1axc	A	D120
III		Peptide ligand (ARG,GLN,THR,SER,MET,THR,ASP,PHE,TYR,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	1axc	C	D120
III		Peptide ligand (ARG,GLN,THR,SER,MET,THR,ASP,PHE,TYR,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	1axc	E	D120
III		Peptide ligand (LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	A	D120
III		Peptide ligand (ASP,LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	B	D120
III		Peptide ligand (ASP,LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	C	D120
III		Peptide ligand (LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	D	D120
III		Peptide ligand (LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	E	D120
III		Peptide ligand (ASP,LYS,SER,GLY,MET,LYS,SER,ILE,ASP,THR,PHE,PHE)	3p87	F	D120
III		Peptide ligand (LYS,ARG,ARG,GLN,THR,SER,MET,THR,ASP,PHE,PHE,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	4rjf	A	D120
III		Peptide ligand (ARG,ARG,GLN,THR,SER,MET,THR,ASP,PHE,PHE,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	4rjf	C	D120
III		Peptide ligand (ARG,GLN,THR,SER,MET,THR,ASP,PHE,PHE,HIS,SER,LYS,ARG,ARG,LEU,ILE,PHE,SER)	4rjf	E	D120
III		Peptide ligand (CYS,LYS,ARG,PRO,ARG,PRO,GLU,GLY,MET,GLN,THR,LEU,GLU,SER,PHE,PHE,LYS,PRO,LEU,THR)	2zvk	A	Y211
III		Peptide ligand (ALA,PRO,VAL,CYS,VAL,ARG,PRO,THR,PRO,LYS,TRP,GLN,LYS,GLY,ILE,GLY,GLU,PHE,PHE,ALA,ALA)	4d2g	B	Y211
III		Peptide ligand (ALA,PRO,VAL,CYS,VAL,ARG,PRO,THR,PRO,LYS,TRP,GLN,LYS,GLY,ILE,GLY,GLU,PHE,PHE,ALA,ALA)	4d2g	C	Y211

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Conservation information for LBS of PCNA

Multiple alignments for P12004 in multiple species

LBS	AA sequence	# species	Species
A105	ALVFEAPNQEK	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
A105	TFMFESPTQDK	2	Arabidopsis thaliana, Arabidopsis thaliana
A105	ILLFEDTKKDR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A105	IFTFADPKRDK	1	Caenorhabditis elegans
A105	NLVFESEKNDR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A105	TFMFESPNQDK	1	Oryza sativa subsp. japonica
A105	TIMFESANQEK	1	Drosophila melanogaster
A208	VQLTFALRYLN	4	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus
A208	VSLSFALRYMN	2	Arabidopsis thaliana, Arabidopsis thaliana
A208	VDLTFGAKYLL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A208	VNVNFSIKYMN	1	Caenorhabditis elegans
A208	VTLTFSLKYLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A208	VSLTFALRYMN	1	Oryza sativa subsp. japonica
A208	VTLTFACRYLN	1	Drosophila melanogaster
A208	VHLTFALRYLN	1	Mus musculus
A252	LKYYLAPKIED	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
A252	IRYYLAPKIEE	2	Arabidopsis thaliana, Arabidopsis thaliana
A252	LQFFLAPKFND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A252	LRFYLAPKIDD	1	Caenorhabditis elegans
A252	LRFYLAPKIGE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A252	IRFYLAPKIEE	1	Oryza sativa subsp. japonica
A252	IRYYLAPKIED	1	Drosophila melanogaster
A67	CDRNLAMGVNL	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
A67	CDRNLSMGMNL	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
A67	CDHPVTLGMDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A67	CDRTINLGLSL	1	Caenorhabditis elegans
A67	CDRNIALGINL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A67	CDRNIAMGVNL	1	Gallus gallus
C27	LINEACWDISS	3	Homo sapiens, Bos taurus, Rattus norvegicus
C27	CVQLVNFQCKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C27	LVTDAPFDCSE	1	Caenorhabditis elegans
C27	LVTDANFDCND	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C27	LVTDANFDCSG	1	Oryza sativa subsp. japonica
C27	LVNDANFDCST	1	Arabidopsis thaliana
C27	LVNDANFDCSS	1	Arabidopsis thaliana
C27	LLNEATFDCSD	1	Drosophila melanogaster
C27	LITEACWDLGS	1	Gallus gallus
C27	LINEACWDVSS	1	Mus musculus
D120	EMKLMDLDVEQ	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
D120	EMKLMDIDSEH	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D120	SLKLMDIDADF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D120	TVKMMDIDSEH	1	Caenorhabditis elegans
D120	DVKLMDIDQEH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D120	EMKLMNLDQEH	1	Drosophila melanogaster
D122	KLMDLDVEQLG	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
D122	KLMDIDSEHLG	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D122	KLMDIDADFLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D122	KMMDIDSEHLG	1	Caenorhabditis elegans
D122	KLMDIDQEHLG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D122	KLMNLDQEHLG	1	Drosophila melanogaster
D156	LSHIGDAVVIS	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
D156	LSSIGDTVVIS	2	Arabidopsis thaliana, Arabidopsis thaliana
D156	LSQLSDSINIM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D156	LSTFSDSLNIT	1	Caenorhabditis elegans
D156	LLTLSDSVTIN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D156	LSSIGDTVIIS	1	Oryza sativa subsp. japonica
D156	LAQFSESVVIC	1	Drosophila melanogaster
D21	LEALKDLINEA	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
D21	IDGFKDCVQLV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D21	VESIKDLVTDA	1	Caenorhabditis elegans
D21	LDAIKELVTDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D21	LEAIRELVTDA	1	Oryza sativa subsp. japonica
D21	LEAVKDLVNDA	1	Arabidopsis thaliana
D21	LESIKDLVNDA	1	Arabidopsis thaliana
D21	LDAIKDLLNEA	1	Drosophila melanogaster
D21	LEALKDLITEA	1	Gallus gallus
D232	LSMSADVPLVV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
D232	ISLSSELPVVV	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D232	IRLSSEAPALF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D232	LSLCNDVPVVV	1	Caenorhabditis elegans
D232	LSMSNDVPLLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D232	LSMCADVPLVV	1	Drosophila melanogaster
D257	APKIEDEEGS-	3	Homo sapiens, Bos taurus, Rattus norvegicus
D257	APKFNDEE---	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D257	APKIDDDENMD	1	Caenorhabditis elegans
D257	APKIGEEDEE-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D257	APKIEEDEEMK	1	Oryza sativa subsp. japonica
D257	APKIEEEEDTK	1	Arabidopsis thaliana
D257	APKIEEEEDTN	1	Arabidopsis thaliana
D257	APKIEDNET--	1	Drosophila melanogaster
D257	APKIEDQQEGS	1	Gallus gallus
D257	APKIEDEEAS-	1	Mus musculus
D29	NEACWDISSSG	2	Homo sapiens, Bos taurus
D29	QLVNFQCKEDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D29	TDAPFDCSETA	1	Caenorhabditis elegans
D29	TDANFDCNDNG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D29	TDANFDCSGTG	1	Oryza sativa subsp. japonica
D29	NDANFDCSTTG	1	Arabidopsis thaliana
D29	NDANFDCSSTG	1	Arabidopsis thaliana
D29	NEATFDCSDSG	1	Drosophila melanogaster
D29	TEACWDLGSGG	1	Gallus gallus
D29	NEACWDISSGG	1	Rattus norvegicus
D29	NEACWDVSSGG	1	Mus musculus
D97	EDN-ADTLALV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
D97	DDG-SDTVTFM	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
D97	DNT-PDSIILL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D97	EENEGDSIIFT	1	Caenorhabditis elegans
D97	EDT-PEVLNLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D97	DDG-GDTVTFM	1	Arabidopsis thaliana
D97	QDN-ADTVTIM	1	Drosophila melanogaster
E124	MDLDVEQLGIP	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
E124	MDIDSEHLGIP	4	Caenorhabditis elegans, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E124	MDIDADFLKIE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E124	MDIDQEHLGIP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E124	MNLDQEHLGIP	1	Drosophila melanogaster
E25	KDLINEACWDI	3	Homo sapiens, Bos taurus, Rattus norvegicus
E25	KDLVNDANFDC	2	Arabidopsis thaliana, Arabidopsis thaliana
E25	KDCVQLVNFQC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E25	KDLVTDAPFDC	1	Caenorhabditis elegans
E25	KELVTDANFDC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E25	RELVTDANFDC	1	Oryza sativa subsp. japonica
E25	KDLLNEATFDC	1	Drosophila melanogaster
E25	KDLITEACWDL	1	Gallus gallus
E25	KDLINEACWDV	1	Mus musculus
E256	LAPKIEDEEGS	3	Homo sapiens, Bos taurus, Rattus norvegicus
E256	LAPKIEEEEDT	2	Arabidopsis thaliana, Arabidopsis thaliana
E256	LAPKFNDEE--	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E256	LAPKIDDDENM	1	Caenorhabditis elegans
E256	LAPKIGEEDEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E256	LAPKIEEDEEM	1	Oryza sativa subsp. japonica
E256	LAPKIEDNET-	1	Drosophila melanogaster
E256	LAPKIEDQQEG	1	Gallus gallus
E256	LAPKIEDEEAS	1	Mus musculus
E3		12	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gal
E85	KCAGNEDIITL	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
E85	KCAGNDDIITI	2	Arabidopsis thaliana, Arabidopsis thaliana
E85	RCGNNTDTLTL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E85	KCANNDDTCML	1	Caenorhabditis elegans
E85	RCAQNEDLVTL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E85	RCAGNDDIITI	1	Oryza sativa subsp. japonica
E85	KCANNEDNVTM	1	Drosophila melanogaster
F207	PVQLTFALRYL	4	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus
F207	PVSLSFALRYM	2	Arabidopsis thaliana, Arabidopsis thaliana
F207	PVDLTFGAKYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F207	PVNVNFSIKYM	1	Caenorhabditis elegans
F207	AVTLTFSLKYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F207	PVSLTFALRYM	1	Oryza sativa subsp. japonica
F207	PVTLTFACRYL	1	Drosophila melanogaster
F207	PVHLTFALRYL	1	Mus musculus
G127	DVEQLGIPEQE	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
G127	DSEHLGIPDAE	2	Arabidopsis thaliana, Arabidopsis thaliana
G127	DADFLKIEELQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G127	DSEHLGIPDQD	1	Caenorhabditis elegans
G127	DQEHLGIPDIE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G127	DSEHLGIPDSE	1	Oryza sativa subsp. japonica
G127	DQEHLGIPETD	1	Drosophila melanogaster
G155	DLSHIGDAVVI	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
G155	DLSSIGDTVVI	2	Arabidopsis thaliana, Arabidopsis thaliana
G155	DLSQLSDSINI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G155	DLSTFSDSLNI	1	Caenorhabditis elegans
G155	DLLTLSDSVTI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G155	DLSSIGDTVII	1	Oryza sativa subsp. japonica
G155	DLAQFSESVVI	1	Drosophila melanogaster
G69	RNLAMGVNLTS	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
G69	RNLSMGMNLGN	2	Arabidopsis thaliana, Arabidopsis thaliana
G69	HPVTLGMDLTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G69	RTINLGLSLAN	1	Caenorhabditis elegans
G69	RNIALGINLNA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G69	RNLSMGMNLNN	1	Oryza sativa subsp. japonica
G69	RNLSMGMNLGS	1	Drosophila melanogaster
G69	RNIAMGVNLNS	1	Gallus gallus
H153	CRDLSHIGDAV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
H153	CKDLSSIGDTV	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
H153	VRDLSQLSDSI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H153	CKDLSTFSDSL	1	Caenorhabditis elegans
H153	TRDLLTLSDSV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H153	CRDLAQFSESV	1	Drosophila melanogaster
H44	SMDSSHVSLVQ	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
H44	AMDSSHVALVS	4	Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Arabidopsis thaliana
H44	AVDDSRVLLVS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H44	AMDSSHVALVA	1	Oryza sativa subsp. japonica
H44	AMDNSHVSLVS	1	Drosophila melanogaster
I11	LVQGSLLKKVL	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
I11	LVQGSILKKVL	2	Homo sapiens, Bos taurus
I11	LIQGSILKKVL	2	Rattus norvegicus, Mus musculus
I11	FEEASLFKRII	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I11	LANAGLLKKIV	1	Caenorhabditis elegans
I11	FQQAALLKKLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I11	LGQATILKKIL	1	Drosophila melanogaster
I11	LVQGSVLKRVL	1	Gallus gallus
I128	VEQLGIPEQEY	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
I128	SEHLGIPDAEY	2	Arabidopsis thaliana, Arabidopsis thaliana
I128	ADFLKIEELQY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I128	SEHLGIPDQDY	1	Caenorhabditis elegans
I128	QEHLGIPDIEY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I128	SEHLGIPDSEY	1	Oryza sativa subsp. japonica
I128	QEHLGIPETDF	1	Drosophila melanogaster
I197	EEAVTIEMNEP	3	Homo sapiens, Gallus gallus, Mus musculus
I197	ETSIKLEMDQP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I197	TEAVTLEVKDP	1	Caenorhabditis elegans
I197	DQSIEISLTQA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I197	EDATIIEMQEP	1	Oryza sativa subsp. japonica
I197	EDAIVIEMNEP	1	Arabidopsis thaliana
I197	EDAIVIEMKEP	1	Arabidopsis thaliana
I197	EEAVIIEMQEP	1	Drosophila melanogaster
I197	EEAVAIEMNEP	1	Bos taurus
I197	EEAVSIEMNEP	1	Rattus norvegicus
I255	YLAPKIEDEEG	3	Homo sapiens, Bos taurus, Rattus norvegicus
I255	YLAPKIEEEED	2	Arabidopsis thaliana, Arabidopsis thaliana
I255	FLAPKFNDEE-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I255	YLAPKIDDDEN	1	Caenorhabditis elegans
I255	YLAPKIGEEDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I255	YLAPKIEEDEE	1	Oryza sativa subsp. japonica
I255	YLAPKIEDNET	1	Drosophila melanogaster
I255	YLAPKIEDQQE	1	Gallus gallus
I255	YLAPKIEDEEA	1	Mus musculus
K13	QGSILKKVLEA	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K13	QGSLLKKVLEA	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
K13	EASLFKRIIDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K13	NAGLLKKIVES	1	Caenorhabditis elegans
K13	QAALLKKLLDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K13	QGSLLKKVLES	1	Arabidopsis thaliana
K13	QATILKKILDA	1	Drosophila melanogaster
K13	QGSVLKRVLEA	1	Gallus gallus
K254	YYLAPKIEDEE	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K254	YYLAPKIEEEE	2	Arabidopsis thaliana, Arabidopsis thaliana
K254	FFLAPKFNDEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K254	FYLAPKIDDDE	1	Caenorhabditis elegans
K254	FYLAPKIGEED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K254	FYLAPKIEEDE	1	Oryza sativa subsp. japonica
K254	YYLAPKIEDNE	1	Drosophila melanogaster
K254	YYLAPKIEDQQ	1	Gallus gallus
K77	LTSMSKILKCA	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K77	LGNMSKMLKCA	2	Arabidopsis thaliana, Arabidopsis thaliana
K77	LTSLSKILRCG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K77	LANMSKALKCA	1	Caenorhabditis elegans
K77	LNALSKVLRCA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K77	LNNMAKMLRCA	1	Oryza sativa subsp. japonica
K77	LGSMAKILKCA	1	Drosophila melanogaster
K77	LNSMSKILKCA	1	Gallus gallus
L118	DYEMKLMDLDV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
L118	DFEMKLMDIDS	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
L118	EYSLKLMDIDA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L118	DVTVKMMDIDS	1	Caenorhabditis elegans
L118	DYDVKLMDIDQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L118	DYEMKLMNLDQ	1	Drosophila melanogaster
L121	MKLMDLDVEQL	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
L121	MKLMDIDSEHL	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
L121	LKLMDIDADFL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L121	VKMMDIDSEHL	1	Caenorhabditis elegans
L121	VKLMDIDQEHL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L121	MKLMNLDQEHL	1	Drosophila melanogaster
L126	LDVEQLGIPEQ	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
L126	IDSEHLGIPDA	2	Arabidopsis thaliana, Arabidopsis thaliana
L126	IDADFLKIEEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L126	IDSEHLGIPDQ	1	Caenorhabditis elegans
L126	IDQEHLGIPDI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L126	IDSEHLGIPDS	1	Oryza sativa subsp. japonica
L126	LDQEHLGIPET	1	Drosophila melanogaster
L47	SSHVSLVQLTL	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
L47	SSHVALVSLLL	2	Arabidopsis thaliana, Arabidopsis thaliana
L47	DSRVLLVSLEI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L47	SSHVALVSLKL	1	Caenorhabditis elegans
L47	SSHVALVSMLI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L47	SSHVALVALLL	1	Oryza sativa subsp. japonica
L47	NSHVSLVSLTL	1	Drosophila melanogaster
M119	YEMKLMDLDVE	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
M119	FEMKLMDIDSE	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
M119	YSLKLMDIDAD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M119	VTVKMMDIDSE	1	Caenorhabditis elegans
M119	YDVKLMDIDQE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M119	YEMKLMNLDQE	1	Drosophila melanogaster
M40	VNLQSMDSSHV	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
M40	FSLQAMDSSHV	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
M40	IIAQAVDDSRV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M40	MSLQAMDSSHV	1	Caenorhabditis elegans
M40	ISLQAMDSSHV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M40	IQLQAMDNSHV	1	Drosophila melanogaster
M40	ISLQSMDSSHV	1	Gallus gallus
M68	DRNLAMGVNLT	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
M68	DRNLSMGMNLG	3	Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
M68	DHPVTLGMDLT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M68	DRTINLGLSLA	1	Caenorhabditis elegans
M68	DRNIALGINLN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M68	DRNLSMGMNLN	1	Oryza sativa subsp. japonica
M68	DRNIAMGVNLN	1	Gallus gallus
N213	ALRYLNFFTKA	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
N213	ALRYMNSFTKA	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
N213	GAKYLLDIIKG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N213	SIKYMNQFTKA	1	Caenorhabditis elegans
N213	SLKYLAQFTKA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N213	ACRYLNAFTKA	1	Drosophila melanogaster
P129	EQLGIPEQEYS	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
P129	EHLGIPDAEYH	2	Arabidopsis thaliana, Arabidopsis thaliana
P129	DFLKIEELQYD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P129	EHLGIPDQDYA	1	Caenorhabditis elegans
P129	EHLGIPDIEYD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P129	EHLGIPDSEYQ	1	Oryza sativa subsp. japonica
P129	EHLGIPETDFS	1	Drosophila melanogaster
P234	MSADVPLVVEY	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
P234	LSSELPVVVEY	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
P234	LSSEAPALFQF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P234	LCNDVPVVVEY	1	Caenorhabditis elegans
P234	MSNDVPLLVEY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P234	MCADVPLVVEY	1	Drosophila melanogaster
P253	KYYLAPKIEDE	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
P253	RYYLAPKIEEE	2	Arabidopsis thaliana, Arabidopsis thaliana
P253	QFFLAPKFNDE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P253	RFYLAPKIDDD	1	Caenorhabditis elegans
P253	RFYLAPKIGEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P253	RFYLAPKIEED	1	Oryza sativa subsp. japonica
P253	RYYLAPKIEDN	1	Drosophila melanogaster
P253	KYYLAPKIEDQ	1	Gallus gallus
Q125	DLDVEQLGIPE	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
Q125	DIDSEHLGIPD	4	Caenorhabditis elegans, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
Q125	DIDADFLKIEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q125	DIDQEHLGIPD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q125	NLDQEHLGIPE	1	Drosophila melanogaster
Q131	LGIPEQEYSCV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
Q131	LGIPDAEYHSI	2	Arabidopsis thaliana, Arabidopsis thaliana
Q131	LKIEELQYDST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q131	LGIPDQDYAVV	1	Caenorhabditis elegans
Q131	LGIPDIEYDAT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q131	LGIPDSEYQAI	1	Oryza sativa subsp. japonica
Q131	LGIPETDFSCV	1	Drosophila melanogaster
R149	FARICRDLSHI	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
R149	FSRICKDLSSI	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
R149	FSKIVRDLSQL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R149	FQKTCKDLSTF	1	Caenorhabditis elegans
R149	FQRITRDLLTL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R149	FARICRDLAQF	1	Drosophila melanogaster
R210	LTFALRYLNFF	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
R210	LSFALRYMNSF	2	Arabidopsis thaliana, Arabidopsis thaliana
R210	LTFGAKYLLDI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R210	VNFSIKYMNQF	1	Caenorhabditis elegans
R210	LTFSLKYLAQF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R210	LTFALRYMNSF	1	Oryza sativa subsp. japonica
R210	LTFACRYLNAF	1	Drosophila melanogaster
S152	ICRDLSHIGDA	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
S152	ICKDLSSIGDT	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
S152	IVRDLSQLSDS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S152	TCKDLSTFSDS	1	Caenorhabditis elegans
S152	ITRDLLTLSDS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S152	ICRDLAQFSES	1	Drosophila melanogaster
S43	QSMDSSHVSLV	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
S43	QAMDSSHVALV	5	Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
S43	QAVDDSRVLLV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S43	QAMDNSHVSLV	1	Drosophila melanogaster
S46	DSSHVSLVQLT	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
S46	DSSHVALVSLL	2	Arabidopsis thaliana, Arabidopsis thaliana
S46	DDSRVLLVSLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S46	DSSHVALVSLK	1	Caenorhabditis elegans
S46	DSSHVALVSML	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S46	DSSHVALVALL	1	Oryza sativa subsp. japonica
S46	DNSHVSLVSLT	1	Drosophila melanogaster
T206	EPVQLTFALRY	4	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus
T206	EPVSLSFALRY	2	Arabidopsis thaliana, Arabidopsis thaliana
T206	QPVDLTFGAKY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T206	DPVNVNFSIKY	1	Caenorhabditis elegans
T206	QAVTLTFSLKY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T206	EPVSLTFALRY	1	Oryza sativa subsp. japonica
T206	EPVTLTFACRY	1	Drosophila melanogaster
T206	EPVHLTFALRY	1	Mus musculus
V123	LMDLDVEQLGI	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
V123	LMDIDSEHLGI	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
V123	LMDIDADFLKI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V123	MMDIDSEHLGI	1	Caenorhabditis elegans
V123	LMDIDQEHLGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V123	LMNLDQEHLGI	1	Drosophila melanogaster
V233	SMSADVPLVVE	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
V233	SLSSELPVVVE	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
V233	RLSSEAPALFQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V233	SLCNDVPVVVE	1	Caenorhabditis elegans
V233	SMSNDVPLLVE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V233	SMCADVPLVVE	1	Drosophila melanogaster
V45	MDSSHVSLVQL	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
V45	MDSSHVALVSL	3	Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana
V45	VDDSRVLLVSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V45	MDSSHVALVSM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V45	MDSSHVALVAL	1	Oryza sativa subsp. japonica
V45	MDNSHVSLVSL	1	Drosophila melanogaster
Y211	TFALRYLNFFT	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
Y211	SFALRYMNSFT	2	Arabidopsis thaliana, Arabidopsis thaliana
Y211	TFGAKYLLDII	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y211	NFSIKYMNQFT	1	Caenorhabditis elegans
Y211	TFSLKYLAQFT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y211	TFALRYMNSFT	1	Oryza sativa subsp. japonica
Y211	TFACRYLNAFT	1	Drosophila melanogaster
Y250	GHLKYYLAPKI	5	Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus, Mus musculus
Y250	GYIRYYLAPKI	2	Arabidopsis thaliana, Arabidopsis thaliana
Y250	GFLQFFLAPKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y250	GYLRFYLAPKI	1	Caenorhabditis elegans
Y250	GFLRFYLAPKI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y250	GYIRFYLAPKI	1	Oryza sativa subsp. japonica
Y250	GHIRYYLAPKI	1	Drosophila melanogaster