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mutLBSgeneDB |
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| Gene summary for LACTB2 |
 Gene summary |
| Basic gene Info. | Gene symbol | LACTB2 |
| Gene name | lactamase, beta 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 8q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016027.2, | |
| Description | beta-lactamase-like protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000147592 | ||
| HPRD : 13955 | ||
| Vega : OTTHUMG00000164430 | ||
| Protein | UniProt: Q53H82 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LACTB2 | |
| BioGPS: 51110 | ||
| Pathway | NCI Pathway Interaction Database: LACTB2 | |
| KEGG: LACTB2 | ||
| REACTOME: LACTB2 | ||
| Pathway Commons: LACTB2 | ||
| Context | iHOP: LACTB2 | |
| ligand binding site mutation search in PubMed: LACTB2 | ||
| UCL Cancer Institute: LACTB2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LACTB2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H145 | D147N | LUAD | 1 | D164 | S162F | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LACTB2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H145 | D147N | -0.78041229 | D164 | S162F | -0.11500824 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LACTB2 from PDB |
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| Differential gene expression and gene-gene network for LACTB2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LACTB2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LACTB2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LACTB2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4ad9 | A | D164 | ZN | ZINC(2+) | 4ad9 | B | D164 | ZN | ZINC(2+) | 4ad9 | C | D164 | ZN | ZINC(2+) | 4ad9 | D | D164 | ZN | ZINC(2+) | 4ad9 | E | D164 | ZN | ZINC(2+) | 4ad9 | F | D164 | ZN | ZINC(2+) | 4ad9 | A | H145 D164 | ZN | ZINC(2+) | 4ad9 | B | H145 D164 | ZN | ZINC(2+) | 4ad9 | C | H145 D164 | ZN | ZINC(2+) | 4ad9 | D | H145 D164 | ZN | ZINC(2+) | 4ad9 | E | H145 D164 | ZN | ZINC(2+) | 4ad9 | F | H145 D164 |
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| Conservation information for LBS of LACTB2 |
| Multiple alignments for Q53H82 in multiple species |
| LBS | AA sequence | # species | Species | D164 | AIFSGDCILGE | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | D164 | ALFSGDCILGE | 2 | Caenorhabditis elegans, Bos taurus | D164 | TLFSGDCILGE | 1 | Drosophila melanogaster | D164 | AVFSGDCILGE | 1 | Danio rerio | D81 | THWHRDHSGGI | 2 | Homo sapiens, Rattus norvegicus | D81 | THWHGDHVGGI | 1 | Caenorhabditis elegans | D81 | THWHHDHVGGV | 1 | Drosophila melanogaster | D81 | THWHHDHTGGV | 1 | Danio rerio | D81 | THWHVDHVGGI | 1 | Xenopus tropicalis | D81 | THWHRDHTGGI | 1 | Bos taurus | D81 | THWHSDHSGGI | 1 | Mus musculus | H145 | LYTPGHTDDHM | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | H145 | IATPGHTADHF | 1 | Caenorhabditis elegans | H145 | VHTPGHTTDHV | 1 | Drosophila melanogaster | H145 | LFTPGHTDDHM | 1 | Danio rerio | H145 | VYTPGHTDDHM | 1 | Bos taurus | H199 | IIYPGHGPVIH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H199 | RIYPGHGPVID | 1 | Caenorhabditis elegans | H199 | RIFPGHGNVIE | 1 | Drosophila melanogaster | H199 | LIYPGHGPVVH | 1 | Danio rerio | H199 | KIYPGHGPVVL | 1 | Xenopus tropicalis | H199 | VIYPGHGPVIH | 1 | Bos taurus | H77 | EIVVTHWHRDH | 1 | Homo sapiens | H77 | YIVITHWHGDH | 1 | Caenorhabditis elegans | H77 | TILLTHWHHDH | 1 | Drosophila melanogaster | H77 | HIIVTHWHHDH | 1 | Danio rerio | H77 | EIIVTHWHVDH | 1 | Xenopus tropicalis | H77 | EIIVTHWHRDH | 1 | Bos taurus | H77 | EILVTHWHSDH | 1 | Mus musculus | H77 | EILVTHWHRDH | 1 | Rattus norvegicus | H79 | VVTHWHRDHSG | 1 | Homo sapiens | H79 | VITHWHGDHVG | 1 | Caenorhabditis elegans | H79 | LLTHWHHDHVG | 1 | Drosophila melanogaster | H79 | IVTHWHHDHTG | 1 | Danio rerio | H79 | IVTHWHVDHVG | 1 | Xenopus tropicalis | H79 | IVTHWHRDHTG | 1 | Bos taurus | H79 | LVTHWHSDHSG | 1 | Mus musculus | H79 | LVTHWHRDHSG | 1 | Rattus norvegicus | H82 | HWHRDHSGGIG | 1 | Homo sapiens | H82 | HWHGDHVGGID | 1 | Caenorhabditis elegans | H82 | HWHHDHVGGVK | 1 | Drosophila melanogaster | H82 | HWHHDHTGGVQ | 1 | Danio rerio | H82 | HWHVDHVGGIA | 1 | Xenopus tropicalis | H82 | HWHRDHTGGIG | 1 | Bos taurus | H82 | HWHSDHSGGIV | 1 | Mus musculus | H82 | HWHRDHSGGIV | 1 | Rattus norvegicus |
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