|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for ING4 |
 Gene summary |
| Basic gene Info. | Gene symbol | ING4 |
| Gene name | inhibitor of growth family, member 4 | |
| Synonyms | my036|p29ING4 | |
| Cytomap | UCSC genome browser: 12p13.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001127582.1, NM_001127583.1,NM_001127584.1,NM_001127585.1,NM_001127586.1, NM_016162.3,NM_198287.1, | |
| Description | brain my036 proteincandidate tumor suppressor p33 ING1 homologinhibitor of growth protein 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608524 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000111653 | ||
| HPRD : 09774 | ||
| Vega : OTTHUMG00000141274 | ||
| Protein | UniProt: Q9UNL4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ING4 | |
| BioGPS: 51147 | ||
| Pathway | NCI Pathway Interaction Database: ING4 | |
| KEGG: ING4 | ||
| REACTOME: ING4 | ||
| Pathway Commons: ING4 | ||
| Context | iHOP: ING4 | |
| ligand binding site mutation search in PubMed: ING4 | ||
| UCL Cancer Institute: ING4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006260 | DNA replication | 16387653 | GO:0006473 | protein acetylation | 12750254 | GO:0006915 | apoptotic process | 15251430 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 16387653 | GO:0007050 | cell cycle arrest | 15251430 | GO:0008285 | negative regulation of cell proliferation | 12750254 | GO:0043065 | positive regulation of apoptotic process | 16387653 | GO:0043966 | histone H3 acetylation | 16387653 | GO:0043981 | histone H4-K5 acetylation | 16387653 | GO:0043982 | histone H4-K8 acetylation | 16387653 | GO:0043983 | histone H4-K12 acetylation | 16387653 | GO:0043984 | histone H4-K16 acetylation | 16387653 | GO:0045892 | negative regulation of transcription, DNA-templated | 15029197 | GO:0045926 | negative regulation of growth | 12750254 |
| Top |
| Ligand binding site mutations for ING4 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | W221 | W221R | COAD | 1 | G235 | G235R | GBM | 1 | Y198 | T197N | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for ING4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y198 | T197N | -1.2474801 | W221 | W221R | -1.155592 | G235 | G235R | -0.72772323 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ING4 from PDB |
| Top |
| Differential gene expression and gene-gene network for ING4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for ING4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for ING4 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of ING4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG) | 2pnx | A | Y198 W221 G235 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR) | 2pnx | C | Y198 W221 G235 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR) | 2vnf | A | Y198 W221 G235 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER) | 2vnf | C | Y198 W221 G235 |
| Top |
| Conservation information for LBS of ING4 |
| Multiple alignments for Q9UNL4 in multiple species |
| LBS | AA sequence | # species | Species | C199 | NEPTYCLCHQV | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | C201 | PTYCLCHQVSY | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | C212 | GEMIGCDNPDC | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | C217 | CDNPDCSIEWF | 3 | Homo sapiens, Gallus gallus, Mus musculus | C217 | CDNPDCSIERF | 1 | Bos taurus | C226 | WFHFACVGLTT | 3 | Homo sapiens, Gallus gallus, Mus musculus | C226 | RFHFACVGLTT | 1 | Bos taurus | C239 | RGKWFCPRCSQ | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | C242 | WFCPRCSQERK | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | D213 | EMIGCDNPDCS | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | E195 | PVDPNEPTYCL | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | E208 | QVSYGEMIGCD | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | E220 | PDCSIEWFHFA | 3 | Homo sapiens, Gallus gallus, Mus musculus | E220 | PDCSIERFHFA | 1 | Bos taurus | F222 | CSIEWFHFACV | 3 | Homo sapiens, Gallus gallus, Mus musculus | F222 | CSIERFHFACV | 1 | Bos taurus | F224 | IEWFHFACVGL | 3 | Homo sapiens, Gallus gallus, Mus musculus | F224 | IERFHFACVGL | 1 | Bos taurus | G207 | HQVSYGEMIGC | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | G211 | YGEMIGCDNPD | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | G235 | TTKPRGKWFCP | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | H223 | SIEWFHFACVG | 3 | Homo sapiens, Gallus gallus, Mus musculus | H223 | SIERFHFACVG | 1 | Bos taurus | I210 | SYGEMIGCDNP | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | K232 | VGLTTKPRGKW | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | M209 | VSYGEMIGCDN | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | P233 | GLTTKPRGKWF | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | Q203 | YCLCHQVSYGE | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | S205 | LCHQVSYGEMI | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | W221 | DCSIEWFHFAC | 3 | Homo sapiens, Gallus gallus, Mus musculus | W221 | DCSIERFHFAC | 1 | Bos taurus | Y198 | PNEPTYCLCHQ | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus | Y206 | CHQVSYGEMIG | 4 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |