mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DCXR
Gene summary
Basic gene Info.Gene symbolDCXR
Gene namedicarbonyl/L-xylulose reductase
SynonymsDCR|HCR2|HCRII|KIDCR|P34H|PNTSU|SDR20C1|XR
CytomapUCSC genome browser: 17q25.3
Type of geneprotein-coding
RefGenesNM_001195218.1,
NM_016286.3,
DescriptionL-xylulose reductasecarbonyl reductase 2carbonyl reductase IIkidney dicarbonyl reductaseshort chain dehydrogenase/reductase family 20C, member 1sperm surface protein P34H
Modification date20141207
dbXrefs MIM : 608347
HGNC : HGNC
Ensembl : ENSG00000169738
HPRD : 16320
Vega : OTTHUMG00000178483
ProteinUniProt: Q7Z4W1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DCXR
BioGPS: 51181
PathwayNCI Pathway Interaction Database: DCXR
KEGG: DCXR
REACTOME: DCXR
Pathway Commons: DCXR
ContextiHOP: DCXR
ligand binding site mutation search in PubMed: DCXR
UCL Cancer Institute: DCXR
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0005997xylulose metabolic process11882650
GO:0006006glucose metabolic process11882650
GO:0051289protein homotetramerization11882650
GO:0055114oxidation-reduction process19442656


Top
Ligand binding site mutations for DCXR
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G62E63QBLCA1
G187,W191W189CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for DCXR
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DCXR from PDB

Top
Differential gene expression and gene-gene network for DCXR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DCXR and the right PPI network was created from samples without mutations in the LBS of DCXR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for DCXR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms2AlteredExpression, Biomarker
umls:C0028754Obesity1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for DCXR
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB02325Isopropyl AlcoholSmall molecule
ExperimentalDB02831Dihydrogenphosphate IonSmall molecule
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DCXR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION1pr9BG187
NAPNADP ZWITTERION1wntAG187
NAPNADP ZWITTERION1wntCG187
NAPNADP ZWITTERION1wntDG187
NAPNADP ZWITTERION3d3wAG187
NAPNADP ZWITTERION3d3wBG187
NAPNADP ZWITTERION1wntBG62 G187
2HPDIHYDROGENPHOSPHATE1pr9AW191
2HPDIHYDROGENPHOSPHATE1pr9BW191


Top
Conservation information for LBS of DCXR
Multiple alignments for Q7Z4W1 in multiple species
LBSAA sequence# speciesSpecies
A84LLVNNAAVALL2Homo sapiens, Mus musculus
A84GLVNNAGIATN1Caenorhabditis elegans
A84LLVNNAAVAML1Gallus gallus
A84LLVNNAAVAFL1Bos taurus
A84LLVNNAAVATL1Rattus norvegicus
A85LVNNAAVALLQ2Homo sapiens, Mus musculus
A85LVNNAGIATNH1Caenorhabditis elegans
A85LVNNAAVAMLQ1Gallus gallus
A85LVNNAAVAFLQ1Bos taurus
A85LVNNAAVATLQ1Rattus norvegicus
C138NVSSQASQRAL3Gallus gallus, Mus musculus, Rattus norvegicus
C138NVSSQCSQRAV1Homo sapiens
C138NISSQAAIRPL1Caenorhabditis elegans
C138NVSSQASQRGL1Bos taurus
D43SRTQADLDSLV2Homo sapiens, Bos taurus
D43ARNEANLLSLV1Caenorhabditis elegans
D43SRTAADLESLV1Gallus gallus
D43SRTREDLDDLV1Mus musculus
D43SRTREDLDSLV1Rattus norvegicus
D60EPVCVDL-ADW2Mus musculus, Rattus norvegicus
D60EPVCVDL-GDW1Homo sapiens
D60RYTIIPIVGDV1Caenorhabditis elegans
D60EPLCLDL-ADW1Gallus gallus
D60ETVCVDL-ADW1Bos taurus
G14RALVTGAGKGI4Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G14RVLVTGAGKGI1Homo sapiens
G14RILVTGASQGI1Caenorhabditis elegans
G16LVTGAGKGIGR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G16LVTGASQGIGK1Caenorhabditis elegans
G18TGAGKGIGRST2Mus musculus, Rattus norvegicus
G18TGAGKGIGRGT1Homo sapiens
G18TGASQGIGKEI1Caenorhabditis elegans
G18TGAGKGIGRAV1Gallus gallus
G18TGAGKGIGRSI1Bos taurus
G187VMTSMGQATWS1Homo sapiens
G187VMTDMGRDNWS1Caenorhabditis elegans
G187VMTDMGRINWS1Gallus gallus
G187VMTPMGQAAWS1Bos taurus
G187VMTPMGRTNWS1Mus musculus
G187VMTPMGRANWS1Rattus norvegicus
G62CVDL-ADWEAT3Bos taurus, Mus musculus, Rattus norvegicus
G62CVDL-GDWEAT1Homo sapiens
G62IIPIVGDVSAN1Caenorhabditis elegans
G62CLDL-ADWDAT1Gallus gallus
H146RALTNHTVYCS2Mus musculus, Rattus norvegicus
H146RAVTNHSVYCS1Homo sapiens
H146RPLDNHTVYCA1Caenorhabditis elegans
H146RALRDHAVYCS1Gallus gallus
H146RGLTNHSVYCS1Bos taurus
I19GAGKGIGRSTV2Mus musculus, Rattus norvegicus
I19GAGKGIGRGTV1Homo sapiens
I19GASQGIGKEIC1Caenorhabditis elegans
I19GAGKGIGRAVA1Gallus gallus
I19GAGKGIGRSIV1Bos taurus
K153VYCSTKGALDM3Homo sapiens, Mus musculus, Rattus norvegicus
K153VYCASKAALDM1Caenorhabditis elegans
K153VYCSTKSALDM1Gallus gallus
K153VYCSTKGALDT1Bos taurus
K17VTGAGKGIGRS3Bos taurus, Mus musculus, Rattus norvegicus
K17VTGAGKGIGRG1Homo sapiens
K17VTGASQGIGKE1Caenorhabditis elegans
K17VTGAGKGIGRA1Gallus gallus
L61PVCVDL-ADWE2Mus musculus, Rattus norvegicus
L61PVCVDL-GDWE1Homo sapiens
L61YTIIPIVGDVS1Caenorhabditis elegans
L61PLCLDL-ADWD1Gallus gallus
L61TVCVDL-ADWE1Bos taurus
M186VVMTSMGQATW1Homo sapiens
M186VVMTDMGRDNW1Caenorhabditis elegans
M186VVMTDMGRINW1Gallus gallus
M186VVMTPMGQAAW1Bos taurus
M186VVMTPMGRTNW1Mus musculus
M186VVMTPMGRANW1Rattus norvegicus
M200HKAKTMLNRIP1Homo sapiens
M200DKKKKMLDRMP1Caenorhabditis elegans
M200QKSAAMINRIP1Gallus gallus
M200QKAKAMLDRIP1Bos taurus
M200HKAKAMLDRIP1Mus musculus
M200HKAKVMLDRIP1Rattus norvegicus
N83DLLVNNAAVAL2Homo sapiens, Mus musculus
N83HGLVNNAGIAT1Caenorhabditis elegans
N83ELLVNNAAVAM1Gallus gallus
N83DLLVNNAAVAF1Bos taurus
N83DLLVNNAAVAT1Rattus norvegicus
P179VNAVNPTVVMT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P179VNSVNPTVVMT1Caenorhabditis elegans
P179VNTVNPTVVMT1Gallus gallus
R102KEACDTSFNVN2Mus musculus, Rattus norvegicus
R102KEAFDRSFEVN1Homo sapiens
R102QQSIDRTFAVN1Caenorhabditis elegans
R102REAVERSFDVN1Gallus gallus
R102KEAYDMSFSVN1Bos taurus
R39VVAVSRTQADL2Homo sapiens, Bos taurus
R39VVAVSRTREDL2Mus musculus, Rattus norvegicus
R39VIAFARNEANL1Caenorhabditis elegans
R39VTALSRTAADL1Gallus gallus
S135AIVNVSSQASQ3Gallus gallus, Mus musculus, Rattus norvegicus
S135AIVNVSSQCSQ1Homo sapiens
S135SIVNISSQAAI1Caenorhabditis elegans
S135VIVNVSSQASQ1Bos taurus
S136IVNVSSQASQR4Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S136IVNVSSQCSQR1Homo sapiens
S136IVNISSQAAIR1Caenorhabditis elegans
S185TVVMTSMGQAT1Homo sapiens
S185TVVMTDMGRDN1Caenorhabditis elegans
S185TVVMTDMGRIN1Gallus gallus
S185TVVMTPMGQAA1Bos taurus
S185TVVMTPMGRTN1Mus musculus
S185TVVMTPMGRAN1Rattus norvegicus
S38RVVAVSRTQAD2Homo sapiens, Bos taurus
S38QVVAVSRTRED2Mus musculus, Rattus norvegicus
S38QVIAFARNEAN1Caenorhabditis elegans
S38RVTALSRTAAD1Gallus gallus
T180NAVNPTVVMTP3Bos taurus, Mus musculus, Rattus norvegicus
T180NAVNPTVVMTS1Homo sapiens
T180NSVNPTVVMTD1Caenorhabditis elegans
T180NTVNPTVVMTD1Gallus gallus
T184PTVVMTSMGQA1Homo sapiens
T184PTVVMTDMGRD1Caenorhabditis elegans
T184PTVVMTDMGRI1Gallus gallus
T184PTVVMTPMGQA1Bos taurus
T184PTVVMTPMGRT1Mus musculus
T184PTVVMTPMGRA1Rattus norvegicus
T40VAVSRTQADLD2Homo sapiens, Bos taurus
T40VAVSRTREDLD2Mus musculus, Rattus norvegicus
T40IAFARNEANLL1Caenorhabditis elegans
T40TALSRTAADLE1Gallus gallus
V106DRSFEVNLRAV1Homo sapiens
V106DRTFAVNVRGP1Caenorhabditis elegans
V106ERSFDVNFRAV1Gallus gallus
V106DMSFSVNLRAV1Bos taurus
V106DTSFNVNLRAV1Mus musculus
V106DTSFNVNFRAV1Rattus norvegicus
V134GAIVNVSSQAS3Gallus gallus, Mus musculus, Rattus norvegicus
V134GAIVNVSSQCS1Homo sapiens
V134GSIVNISSQAA1Caenorhabditis elegans
V134GVIVNVSSQAS1Bos taurus
V143ASQRALTNHTV2Mus musculus, Rattus norvegicus
V143CSQRAVTNHSV1Homo sapiens
V143AAIRPLDNHTV1Caenorhabditis elegans
V143ASQRALRDHAV1Gallus gallus
V143ASQRGLTNHSV1Bos taurus
V181AVNPTVVMTPM3Bos taurus, Mus musculus, Rattus norvegicus
V181AVNPTVVMTSM1Homo sapiens
V181SVNPTVVMTDM1Caenorhabditis elegans
V181TVNPTVVMTDM1Gallus gallus
V182VNPTVVMTPMG3Bos taurus, Mus musculus, Rattus norvegicus
V182VNPTVVMTDMG2Caenorhabditis elegans, Gallus gallus
V182VNPTVVMTSMG1Homo sapiens
V59VEPVCVDL-AD2Mus musculus, Rattus norvegicus
V59IEPVCVDL-GD1Homo sapiens
V59LRYTIIPIVGD1Caenorhabditis elegans
V59IEPLCLDL-AD1Gallus gallus
V59VETVCVDL-AD1Bos taurus
V86VNNAAVALLQP2Homo sapiens, Mus musculus
V86VNNAGIATNHA1Caenorhabditis elegans
V86VNNAAVAMLQP1Gallus gallus
V86VNNAAVAFLQP1Bos taurus
V86VNNAAVATLQP1Rattus norvegicus
W191MGQATWSDPHK1Homo sapiens
W191MGRDNWSDPDK1Caenorhabditis elegans
W191MGRINWSDPQK1Gallus gallus
W191MGQAAWSDPQK1Bos taurus
W191MGRTNWSDPHK1Mus musculus
W191MGRANWSDPHK1Rattus norvegicus
Y149TNHSVYCSTKG2Homo sapiens, Bos taurus
Y149TNHTVYCSTKG2Mus musculus, Rattus norvegicus
Y149DNHTVYCASKA1Caenorhabditis elegans
Y149RDHAVYCSTKS1Gallus gallus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas