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mutLBSgeneDB |
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| Gene summary for GLRX5 |
 Gene summary |
| Basic gene Info. | Gene symbol | GLRX5 |
| Gene name | glutaredoxin 5 | |
| Synonyms | C14orf87|FLB4739|GRX5|PR01238|PRO1238|PRSA | |
| Cytomap | UCSC genome browser: 14q32.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016417.2, | |
| Description | glutaredoxin 5 homologglutaredoxin-related protein 5, mitochondrialmonothiol glutaredoxin-5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609588 | |
| HGNC : HGNC | ||
| HPRD : 12659 | ||
| Protein | UniProt: Q86SX6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GLRX5 | |
| BioGPS: 51218 | ||
| Pathway | NCI Pathway Interaction Database: GLRX5 | |
| KEGG: GLRX5 | ||
| REACTOME: GLRX5 | ||
| Pathway Commons: GLRX5 | ||
| Context | iHOP: GLRX5 | |
| ligand binding site mutation search in PubMed: GLRX5 | ||
| UCL Cancer Institute: GLRX5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for GLRX5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K101 | D102Y | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GLRX5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K101 | D102Y | -0.69976183 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GLRX5 from PDB |
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| Differential gene expression and gene-gene network for GLRX5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GLRX5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0002896 | Anemia, Sideroblastic | 3 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GLRX5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GLRX5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GSH | GLUTATHIONATE(1-) | 2wul | A | K101 | GSH | GLUTATHIONATE(1-) | 2wul | B | K101 | GSH | GLUTATHIONATE(1-) | 2wul | C | K101 | GSH | GLUTATHIONATE(1-) | 2wul | D | K101 |
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| Conservation information for LBS of GLRX5 |
| Multiple alignments for Q86SX6 in multiple species |
| LBS | AA sequence | # species | Species | C122 | EFVGGCDILLQ | 3 | Homo sapiens, Danio rerio, Mus musculus | C122 | EFVGGSDILAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C122 | EFIGGCDVITS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C67 | PEQPQCGFSNA | 2 | Homo sapiens, Mus musculus | C67 | PAQPMCGFSNA | 1 | Danio rerio | C67 | PTRPMCGFSLK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C67 | PEFPKCGFSRA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D123 | FVGGCDILLQM | 3 | Homo sapiens, Danio rerio, Mus musculus | D123 | FVGGSDILASM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D123 | FIGGCDVITSM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F69 | QPQCGFSNAVV | 2 | Homo sapiens, Mus musculus | F69 | QPMCGFSNAVV | 1 | Danio rerio | F69 | RPMCGFSLKAI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F69 | FPKCGFSRATI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G121 | GEFVGGCDILL | 3 | Homo sapiens, Danio rerio, Mus musculus | G121 | GEFVGGSDILA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G121 | KEFIGGCDVIT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I109 | SNWPTIPQVYL | 2 | Homo sapiens, Mus musculus | I109 | SNWPTIPQVFF | 1 | Danio rerio | I109 | SDWPTIPQLYI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I109 | SEWPTIPQLYV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K101 | LRQGIKDYSNW | 2 | Homo sapiens, Mus musculus | K101 | VRQGIKTFSNW | 1 | Danio rerio | K101 | LREGIKEFSDW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K101 | LREGIKEFSEW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K59 | VVVFLKGTPEQ | 2 | Homo sapiens, Mus musculus | K59 | VVVFMKGTPAQ | 1 | Danio rerio | K59 | IVLFMKGTPTR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K59 | VVLFMKGTPEF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R97 | DDPELRQGIKD | 2 | Homo sapiens, Mus musculus | R97 | DDQDVRQGIKT | 1 | Danio rerio | R97 | SNDELREGIKE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R97 | EDPELREGIKE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T108 | YSNWPTIPQVY | 2 | Homo sapiens, Mus musculus | T108 | FSNWPTIPQVF | 1 | Danio rerio | T108 | FSDWPTIPQLY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T108 | FSEWPTIPQLY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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