mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GLRX5
Gene summary
Basic gene Info.Gene symbolGLRX5
Gene nameglutaredoxin 5
CytomapUCSC genome browser: 14q32.13
Type of geneprotein-coding
Descriptionglutaredoxin 5 homologglutaredoxin-related protein 5, mitochondrialmonothiol glutaredoxin-5
Modification date20141207
dbXrefs MIM : 609588
HPRD : 12659
ProteinUniProt: Q86SX6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GLRX5
BioGPS: 51218
PathwayNCI Pathway Interaction Database: GLRX5
Pathway Commons: GLRX5
ContextiHOP: GLRX5
ligand binding site mutation search in PubMed: GLRX5
UCL Cancer Institute: GLRX5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for GLRX5
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GLRX5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GLRX5 from PDB

Differential gene expression and gene-gene network for GLRX5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GLRX5 and the right PPI network was created from samples without mutations in the LBS of GLRX5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GLRX5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0002896Anemia, Sideroblastic3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GLRX5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GLRX5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of GLRX5
Multiple alignments for Q86SX6 in multiple species
LBSAA sequence# speciesSpecies
C122EFVGGCDILLQ3Homo sapiens, Danio rerio, Mus musculus
C122EFVGGSDILAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C122EFIGGCDVITS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C67PEQPQCGFSNA2Homo sapiens, Mus musculus
C67PAQPMCGFSNA1Danio rerio
C67PTRPMCGFSLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C67PEFPKCGFSRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D123FVGGCDILLQM3Homo sapiens, Danio rerio, Mus musculus
D123FVGGSDILASM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D123FIGGCDVITSM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F69QPQCGFSNAVV2Homo sapiens, Mus musculus
F69QPMCGFSNAVV1Danio rerio
F69RPMCGFSLKAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F69FPKCGFSRATI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G121GEFVGGCDILL3Homo sapiens, Danio rerio, Mus musculus
G121GEFVGGSDILA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G121KEFIGGCDVIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I109SNWPTIPQVYL2Homo sapiens, Mus musculus
I109SNWPTIPQVFF1Danio rerio
I109SDWPTIPQLYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I109SEWPTIPQLYV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K101LRQGIKDYSNW2Homo sapiens, Mus musculus
K101VRQGIKTFSNW1Danio rerio
K101LREGIKEFSDW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K101LREGIKEFSEW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K59VVVFLKGTPEQ2Homo sapiens, Mus musculus
K59VVVFMKGTPAQ1Danio rerio
K59IVLFMKGTPTR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K59VVLFMKGTPEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R97DDPELRQGIKD2Homo sapiens, Mus musculus
R97DDQDVRQGIKT1Danio rerio
R97SNDELREGIKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97EDPELREGIKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T108YSNWPTIPQVY2Homo sapiens, Mus musculus
T108FSNWPTIPQVF1Danio rerio
T108FSDWPTIPQLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T108FSEWPTIPQLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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