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mutLBSgeneDB |
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| Gene summary for GLTP |
 Gene summary |
| Basic gene Info. | Gene symbol | GLTP |
| Gene name | glycolipid transfer protein | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12q24.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016433.3, | |
| Description | truncated glycolipid transfer protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608949 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000139433 | ||
| HPRD : 16409 | ||
| Vega : OTTHUMG00000169278 | ||
| Protein | UniProt: Q9NZD2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GLTP | |
| BioGPS: 51228 | ||
| Pathway | NCI Pathway Interaction Database: GLTP | |
| KEGG: GLTP | ||
| REACTOME: GLTP | ||
| Pathway Commons: GLTP | ||
| Context | iHOP: GLTP | |
| ligand binding site mutation search in PubMed: GLTP | ||
| UCL Cancer Institute: GLTP | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046836 | glycolipid transport | 15901739 |
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| Ligand binding site mutations for GLTP |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F161 | D160N | GBM | 1 | V27 | E25K | KIRC | 1 | L9 | H7N | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GLTP |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V27 | E25K | -0.77597655 | L9 | H7N | -0.60315308 | F161 | D160N | -0.36772445 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GLTP from PDB |
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| Differential gene expression and gene-gene network for GLTP |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GLTP |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GLTP |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03203 | Sphingosine | Small molecule |  |
| Experimental | DB03600 | Decanoic Acid | Small molecule |  |
| Approved|vet_approved | DB04224 | Oleic Acid | Small molecule |  |
| Approved | DB04465 | Lactose | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GLTP go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 03F | N-(9Z-OCTADECENOYL)-1--GLUCOSYL-SPHING-4-ENINE | 3s0k | A | F161 | CIS | CIS-TETRACOSENOYL SULFATIDE | 3s0i | A | L9 |
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| Conservation information for LBS of GLTP |
| Multiple alignments for Q9NZD2 in multiple species |
| LBS | AA sequence | # species | Species | A128 | LIRVNATKAYE | 3 | Homo sapiens, Pan troglodytes, Bos taurus | A128 | LIRVNANKAYE | 2 | Mus musculus, Rattus norvegicus | A128 | LIKVNVTKAYE | 1 | Danio rerio | A151 | KIFQAALYAAP | 3 | Homo sapiens, Pan troglodytes, Bos taurus | A151 | KIFKAALYAAP | 2 | Mus musculus, Rattus norvegicus | A151 | KLFQAALYAAP | 1 | Danio rerio | A155 | AALYAAPYKSD | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | A155 | AALYAAPYRSD | 1 | Danio rerio | A93 | VGATLALMWLK | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | A93 | VGATLALLWLK | 2 | Mus musculus, Rattus norvegicus | D48 | TPIKADISGNI | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | D48 | SPIKADIAGNI | 1 | Danio rerio | F103 | KRGLRFIQVFL | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | F103 | KRGLRFIQVLL | 1 | Danio rerio | F107 | RFIQVFLQSIC | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | F107 | RFIQVLLQSLV | 1 | Danio rerio | F148 | IVQKIFQAALY | 3 | Homo sapiens, Pan troglodytes, Bos taurus | F148 | LVQKIFKAALY | 2 | Mus musculus, Rattus norvegicus | F148 | IVQKLFQAALY | 1 | Danio rerio | F161 | PYKSDFLKALS | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | F161 | PYRSDFLRALS | 1 | Danio rerio | F183 | EKIRLFLVNYT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | F183 | DKVRQFLVNFT | 1 | Danio rerio | F183 | EKVRLFLVNYT | 1 | Bos taurus | F33 | SHLPPFFDCLG | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | F33 | AHLPPFFDCLG | 2 | Mus musculus, Rattus norvegicus | F34 | HLPPFFDCLGS | 6 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | F42 | LGSPVFTPIKA | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | F42 | LGSAVFSPIKA | 1 | Danio rerio | G100 | MWLKRGLRFIQ | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | G100 | LWLKRGLRFIQ | 2 | Mus musculus, Rattus norvegicus | H140 | ALKKYHGWIVQ | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | H140 | ALKKYHGWLVQ | 2 | Mus musculus, Rattus norvegicus | I104 | RGLRFIQVFLQ | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | I104 | RGLRFIQVLLQ | 1 | Danio rerio | I124 | NHPNLIRVNAT | 3 | Homo sapiens, Pan troglodytes, Bos taurus | I124 | NHPNLIRVNAN | 2 | Mus musculus, Rattus norvegicus | I124 | NNPNLIKVNVT | 1 | Danio rerio | I147 | WIVQKIFQAAL | 3 | Homo sapiens, Pan troglodytes, Bos taurus | I147 | WLVQKIFKAAL | 2 | Mus musculus, Rattus norvegicus | I147 | WIVQKLFQAAL | 1 | Danio rerio | I45 | PVFTPIKADIS | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | I45 | AVFSPIKADIA | 1 | Danio rerio | I49 | PIKADISGNIT | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | I49 | PIKADIAGNIT | 1 | Danio rerio | K55 | SGNITKIKAVY | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | K55 | AGNITKIKAVY | 1 | Danio rerio | K87 | GAEWPKVGATL | 6 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | L108 | FIQVFLQSICD | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | L108 | FIQVLLQSLVD | 1 | Danio rerio | L136 | AYEMALKKYHG | 6 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | L152 | IFQAALYAAPY | 3 | Homo sapiens, Pan troglodytes, Bos taurus | L152 | IFKAALYAAPY | 2 | Mus musculus, Rattus norvegicus | L152 | LFQAALYAAPY | 1 | Danio rerio | L165 | DFLKALSKGQN | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | L165 | DFLRALSKGRE | 1 | Danio rerio | L30 | EAVSHLPPFFD | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | L30 | EAVAHLPPFFD | 2 | Mus musculus, Rattus norvegicus | L37 | PFFDCLGSPVF | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | L37 | PFFDCLGSAVF | 1 | Danio rerio | L9 | LAEHLLKPLPA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | L9 | LMEHQFRQLPA | 1 | Danio rerio | L9 | LAEHLLRPLPA | 1 | Bos taurus | L92 | KVGATLALMWL | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | L92 | KVGATLALLWL | 2 | Mus musculus, Rattus norvegicus | N52 | ADISGNITKIK | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | N52 | ADIAGNITKIK | 1 | Danio rerio | P40 | DCLGSPVFTPI | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | P40 | DCLGSAVFSPI | 1 | Danio rerio | P44 | SPVFTPIKADI | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | P44 | SAVFSPIKADI | 1 | Danio rerio | V144 | YHGWIVQKIFQ | 3 | Homo sapiens, Pan troglodytes, Bos taurus | V144 | YHGWLVQKIFK | 2 | Mus musculus, Rattus norvegicus | V144 | YHGWIVQKLFQ | 1 | Danio rerio | V27 | PFLEAVSHLPP | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | V27 | PFLEAVAHLPP | 2 | Mus musculus, Rattus norvegicus | V41 | CLGSPVFTPIK | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | V41 | CLGSAVFSPIK | 1 | Danio rerio | W96 | TLALMWLKRGL | 4 | Homo sapiens, Danio rerio, Pan troglodytes, Bos taurus | W96 | TLALLWLKRGL | 2 | Mus musculus, Rattus norvegicus | Y132 | NATKAYEMALK | 3 | Homo sapiens, Pan troglodytes, Bos taurus | Y132 | NANKAYEMALK | 2 | Mus musculus, Rattus norvegicus | Y132 | NVTKAYEMALK | 1 | Danio rerio | Y187 | LFLVNYTATID | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | Y187 | QFLVNFTATND | 1 | Danio rerio | Y207 | NAELNYKV | 3 | Homo sapiens, Pan troglodytes, Bos taurus | Y207 | NAELDYTV | 2 | Mus musculus, Rattus norvegicus | Y207 | NADLDYKV | 1 | Danio rerio |
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