mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL37
Gene summary
Basic gene Info.Gene symbolMRPL37
Gene namemitochondrial ribosomal protein L37
SynonymsL37mt|MRP-L2|MRP-L37|MRPL2|RPML2
CytomapUCSC genome browser: 1p32.1
Type of geneprotein-coding
RefGenesNM_016491.3,
Description39S ribosomal protein L2, mitochondrial39S ribosomal protein L37, mitochondrialL2mtribosomal protein, mitochondrial, L2
Modification date20141207
dbXrefs MIM : 611843
HGNC : HGNC
Ensembl : ENSG00000116221
HPRD : 14757
Vega : OTTHUMG00000008118
ProteinUniProt: Q9BZE1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL37
BioGPS: 51253
PathwayNCI Pathway Interaction Database: MRPL37
KEGG: MRPL37
REACTOME: MRPL37
Pathway Commons: MRPL37
ContextiHOP: MRPL37
ligand binding site mutation search in PubMed: MRPL37
UCL Cancer Institute: MRPL37
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL37

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L299N298ICOAD1
R350R350HHNSC1
H385H385RLUAD1
R350D348YLUSC1
Y82Y82CSKCM1
Y82G81SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL37
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R350D348Y0.20122741
R350R350H-1.6560438
Y82G81S-1.323586
Y82Y82C-1.1269219
H385H385R-0.75981617
L299N298I-0.3050712
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL37 from PDB

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Differential gene expression and gene-gene network for MRPL37
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL37 and the right PPI network was created from samples without mutations in the LBS of MRPL37. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL37
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL37
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL37 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7y5Y82 L299 R350 H385


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Conservation information for LBS of MRPL37
Multiple alignments for Q9BZE1 in multiple species
LBSAA sequence# speciesSpecies
C268IDLQECHVYEV2Mus musculus, Rattus norvegicus
C268IDLHECNIYDV1Homo sapiens
C268IDLQEVNVYQE1Gallus gallus
C268ISLQECHIYDV1Bos taurus
C388YQHFWCLPVIK2Homo sapiens, Bos taurus
C388YESAQCVPEVK1Gallus gallus
C388YRHFWCRPVIK1Mus musculus
C388YQHFWCRPVIK1Rattus norvegicus
D264ISPTIDLQECH2Mus musculus, Rattus norvegicus
D264ISPIIDLHECN1Homo sapiens
D264ISPTIDLQEVN1Gallus gallus
D264ISPTISLQECH1Bos taurus
E32-RGAYEWGVRS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E32PRGPLPRTPWT1Gallus gallus
F386LLYQHFWCLPV2Homo sapiens, Bos taurus
F386NLYESAQCVPE1Gallus gallus
F386LLYRHFWCRPV1Mus musculus
F386LLYQHFWCRPV1Rattus norvegicus
F66EGKKHFVPWLA2Mus musculus, Rattus norvegicus
F66AGKMHFVPWLA1Homo sapiens
F66AGRQYFVPGLA1Gallus gallus
F66AGKMHFMPGLA1Bos taurus
F87YKDPRFYRSPP1Homo sapiens
F87WREPWHSPGPR1Gallus gallus
F87WNDPRFHRAAP1Mus musculus
F87WIDPRFHRAAP1Rattus norvegicus
F87WTHPKFRRLPP1Bos taurus
G34GAYEWGVRSTR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G34GPLPRTPWTTR1Gallus gallus
H108PCYIFHQRCRL2Mus musculus, Rattus norvegicus
H108ACYIFHHRCRL1Homo sapiens
H108GCFICHQRVRM1Gallus gallus
H108VCYIFHQRCRL1Bos taurus
H266PTIDLQECHVY2Mus musculus, Rattus norvegicus
H266PIIDLHECNIY1Homo sapiens
H266PTIDLQEVNVY1Gallus gallus
H266PTISLQECHIY1Bos taurus
H302ANLRPQRFLPE2Mus musculus, Rattus norvegicus
H302ANLRPHRLQPD1Homo sapiens
H302ANKRPNRFRPE1Gallus gallus
H302ANLRAHRFQPD1Bos taurus
H385QLLYQHFWCLP2Homo sapiens, Bos taurus
H385QNLYESAQCVP1Gallus gallus
H385QLLYRHFWCRP1Mus musculus
H385QLLYQHFWCRP1Rattus norvegicus
H96PPLHEHPLYKD1Homo sapiens
H96PRYEDMPLRKE1Gallus gallus
H96APIHEQTLYKE1Mus musculus
H96APIHEQPLYKE1Rattus norvegicus
H96PPLQEHPLYKD1Bos taurus
I106DQACYIFHHRC1Homo sapiens
I106ERGCFICHQRV1Gallus gallus
I106EEPCYIFHQRC1Mus musculus
I106EQPCYIFHQRC1Rattus norvegicus
I106DEVCYIFHQRC1Bos taurus
I170HSTEDIPKRET3Mus musculus, Rattus norvegicus, Bos taurus
I170QTTEEIPKRET1Homo sapiens
I170ETTEVSPRREK1Gallus gallus
I270LHECNIYDVKN1Homo sapiens
I270LQEVNVYQELN1Gallus gallus
I270LQECHVYEVKD1Mus musculus
I270LQECHVYEVKE1Rattus norvegicus
I270LQECHIYDVND1Bos taurus
L299LEKANLRPQRF2Mus musculus, Rattus norvegicus
L299LDKANLRPHRL1Homo sapiens
L299LESANKRPNRF1Gallus gallus
L299LESANLRAHRF1Bos taurus
L93YRSPPLHEHPL1Homo sapiens
L93SPGPRYEDMPL1Gallus gallus
L93HRAAPIHEQTL1Mus musculus
L93HRAAPIHEQPL1Rattus norvegicus
L93RRLPPLQEHPL1Bos taurus
L98LHEHPLYKDQA1Homo sapiens
L98YEDMPLRKERG1Gallus gallus
L98IHEQTLYKEEP1Mus musculus
L98IHEQPLYKEQP1Rattus norvegicus
L98LQEHPLYKDEV1Bos taurus
P301KANLRPQRFLP2Mus musculus, Rattus norvegicus
P301KANLRPHRLQP1Homo sapiens
P301SANKRPNRFRP1Gallus gallus
P301SANLRAHRFQP1Bos taurus
P68KMHFVPWLARP1Homo sapiens
P68RQYFVPGLARP1Gallus gallus
P68KKHFVPWLARP1Mus musculus
P68KKHFVPWLAKP1Rattus norvegicus
P68KMHFMPGLARP1Bos taurus
P85RGYKDPRFYRS1Homo sapiens
P85RGWREPWHSPG1Gallus gallus
P85RGWNDPRFHRA1Mus musculus
P85RGWIDPRFHRA1Rattus norvegicus
P85PGWTHPKFRRL1Bos taurus
P91RFHRAAPIHEQ2Mus musculus, Rattus norvegicus
P91RFYRSPPLHEH1Homo sapiens
P91WHSPGPRYEDM1Gallus gallus
P91KFRRLPPLQEH1Bos taurus
P97PLHEHPLYKDQ1Homo sapiens
P97RYEDMPLRKER1Gallus gallus
P97PIHEQTLYKEE1Mus musculus
P97PIHEQPLYKEQ1Rattus norvegicus
P97PLQEHPLYKDE1Bos taurus
Q305RPQRFLPEQLR2Mus musculus, Rattus norvegicus
Q305RPHRLQPDQLR1Homo sapiens
Q305RPNRFRPEQLR1Gallus gallus
Q305RAHRFQPDQLR1Bos taurus
Q308RFLPEQLRAKM2Mus musculus, Rattus norvegicus
Q308RLQPDQLRAKM1Homo sapiens
Q308RFRPEQLRAKM1Gallus gallus
Q308RFQPDQLRAKM1Bos taurus
R110YIFHQRCRLLE3Mus musculus, Rattus norvegicus, Bos taurus
R110YIFHHRCRLLE1Homo sapiens
R110FICHQRVRMLE1Gallus gallus
R112FHQRCRLLEGM2Mus musculus, Rattus norvegicus
R112FHHRCRLLEGV1Homo sapiens
R112CHQRVRMLEGV1Gallus gallus
R112FHQRCRLLEGV1Bos taurus
R173EDIPKRETYCP3Mus musculus, Rattus norvegicus, Bos taurus
R173EEIPKRETYCP1Homo sapiens
R173EVSPRREKYCP1Gallus gallus
R223LLLQVRGTSST2Mus musculus, Rattus norvegicus
R223LLLQVRGSGGA1Homo sapiens
R223TLLQIRGLNGI1Gallus gallus
R223TLIQVHGSSGA1Bos taurus
R300EKANLRPQRFL2Mus musculus, Rattus norvegicus
R300DKANLRPHRLQ1Homo sapiens
R300ESANKRPNRFR1Gallus gallus
R300ESANLRAHRFQ1Bos taurus
R350VGTDGRVFQFL3Mus musculus, Rattus norvegicus, Bos taurus
R350VGTDGRVFHFL1Homo sapiens
R350VGTDGQLFQFL1Gallus gallus
R36YEWGVRSTRKP3Mus musculus, Rattus norvegicus, Bos taurus
R36YEWGVRSTRKS1Homo sapiens
R36LPRTPWTTRGP1Gallus gallus
R72VPWLARPIFPP2Homo sapiens, Mus musculus
R72VPGLARPRFPP1Gallus gallus
R72VPWLAKPIFPP1Rattus norvegicus
R72MPGLARPVFPP1Bos taurus
R86GYKDPRFYRSP1Homo sapiens
R86GWREPWHSPGP1Gallus gallus
R86GWNDPRFHRAA1Mus musculus
R86GWIDPRFHRAA1Rattus norvegicus
R86GWTHPKFRRLP1Bos taurus
R89DPRFHRAAPIH2Mus musculus, Rattus norvegicus
R89DPRFYRSPPLH1Homo sapiens
R89EPWHSPGPRYE1Gallus gallus
R89HPKFRRLPPLQ1Bos taurus
S37EWGVRSTRKPE3Mus musculus, Rattus norvegicus, Bos taurus
S37EWGVRSTRKSE1Homo sapiens
S37PRTPWTTRGPP1Gallus gallus
S90PRFHRAAPIHE2Mus musculus, Rattus norvegicus
S90PRFYRSPPLHE1Homo sapiens
S90PWHSPGPRYED1Gallus gallus
S90PKFRRLPPLQE1Bos taurus
V35AYEWGVRSTRK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V35PLPRTPWTTRG1Gallus gallus
W33RGAYEWGVRST4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W33RGPLPRTPWTT1Gallus gallus
W387LYQHFWCLPVI2Homo sapiens, Bos taurus
W387LYESAQCVPEV1Gallus gallus
W387LYRHFWCRPVI1Mus musculus
W387LYQHFWCRPVI1Rattus norvegicus
W69MHFVPWLARPI1Homo sapiens
W69QYFVPGLARPR1Gallus gallus
W69KHFVPWLARPI1Mus musculus
W69KHFVPWLAKPI1Rattus norvegicus
W69MHFMPGLARPV1Bos taurus
W78PIFPPWDRGYK1Homo sapiens
W78PRFPPWDRGWR1Gallus gallus
W78PIFPPWERGWN1Mus musculus
W78PIFPPWERGWI1Rattus norvegicus
W78PVFPPWDPGWT1Bos taurus
Y31R-RGAYEWGVR2Homo sapiens, Bos taurus
Y31K-RGAYEWGVR2Mus musculus, Rattus norvegicus
Y31RPRGPLPRTPW1Gallus gallus
Y82PWDRGYKDPRF1Homo sapiens
Y82PWDRGWREPWH1Gallus gallus
Y82PWERGWNDPRF1Mus musculus
Y82PWERGWIDPRF1Rattus norvegicus
Y82PWDPGWTHPKF1Bos taurus
Y88KDPRFYRSPPL1Homo sapiens
Y88REPWHSPGPRY1Gallus gallus
Y88NDPRFHRAAPI1Mus musculus
Y88IDPRFHRAAPI1Rattus norvegicus
Y88THPKFRRLPPL1Bos taurus


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