mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL51
Gene summary
Basic gene Info.Gene symbolMRPL51
Gene namemitochondrial ribosomal protein L51
SynonymsHSPC241|MRP64|bMRP64
CytomapUCSC genome browser: 12p13.3-p13.1
Type of geneprotein-coding
RefGenesNM_016497.3,
Description39S ribosomal protein L51, mitochondrialL51mtMRP-L51bMRP-64mitochondrial ribosomal protein 64mitochondrial ribosomal protein bMRP64
Modification date20141207
dbXrefs MIM : 611855
HGNC : HGNC
HPRD : 14769
ProteinUniProt: Q4U2R6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL51
BioGPS: 51258
PathwayNCI Pathway Interaction Database: MRPL51
KEGG: MRPL51
REACTOME: MRPL51
Pathway Commons: MRPL51
ContextiHOP: MRPL51
ligand binding site mutation search in PubMed: MRPL51
UCL Cancer Institute: MRPL51
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL51

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P70P70LBRCA1
R51E49DLUAD1
P70P70LSKCM1
I32G33CSTAD1
W79L80IUCEC1
R113R113HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL51
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
W79L80I-1.332606
R113R113H-1.3262031
R51E49D-0.61973446
P70P70L-0.30244178
I32G33C-0.27796502
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL51 from PDB

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Differential gene expression and gene-gene network for MRPL51
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL51 and the right PPI network was created from samples without mutations in the LBS of MRPL51. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL51
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL51
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL51 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yiI32 R51 P70 W79 R113


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Conservation information for LBS of MRPL51
Multiple alignments for Q4U2R6 in multiple species
LBSAA sequence# speciesSpecies
E87GWKGNELQRCI3Homo sapiens, Xenopus tropicalis, Bos taurus
E87GFRGNELQRLL1Danio rerio
E87GWRGNELQRCI1Gallus gallus
E87GWRGNELQRCV1Mus musculus
F121YLYKHFNRHGK2Homo sapiens, Mus musculus
F121HLYRRFNRHGK1Danio rerio
F121FLYKRFNRYGK1Xenopus tropicalis
F121FLYKRFNRTGK1Gallus gallus
F121FLYKRFNRHGK1Bos taurus
F24--CRSFSLGVP2Homo sapiens, Mus musculus
F24QSSRLFSTGSC1Danio rerio
F24QGCRSFSLGSR1Xenopus tropicalis
F24--ITSPLAGLP1Gallus gallus
F24--CRSFFLGVP1Bos taurus
F66GILGNFEKHPK3Homo sapiens, Bos taurus, Mus musculus
F66GILGDFKAHPK1Danio rerio
F66GILGDFKAHPR1Xenopus tropicalis
F66GILGGFQIHPK1Gallus gallus
G125RFNRHGKHR2Danio rerio, Bos taurus
G125HFNRHGKFR1Homo sapiens
G125RFNRYGKHR1Xenopus tropicalis
G125RFNRTGKHR1Gallus gallus
G125HFNRHGKYR1Mus musculus
G61VYDNIGILGNF3Homo sapiens, Bos taurus, Mus musculus
G61VYDNIGILGDF2Danio rerio, Xenopus tropicalis
G61VYDNVGILGGF1Gallus gallus
H108FADDLHNLNKR1Homo sapiens
H108MTEDRHNLQKR1Danio rerio
H108FYEDRENLNKR1Xenopus tropicalis
H108FMDDYHNLKKR1Gallus gallus
H108FIDDLHNLNKR1Bos taurus
H108FIEDLHNLNKR1Mus musculus
H120RYLYKHFNRHG1Homo sapiens
H120SHLYRRFNRHG1Danio rerio
H120RFLYKRFNRYG1Xenopus tropicalis
H120RFLYKRFNRTG1Gallus gallus
H120SFLYKRFNRHG1Bos taurus
H120SYLYKHFNRHG1Mus musculus
H124KHFNRHGKFR1Homo sapiens
H124RRFNRHGKHR1Danio rerio
H124KRFNRYGKHR1Xenopus tropicalis
H124KRFNRTGKHR1Gallus gallus
H124KRFNRHGKHR1Bos taurus
H124KHFNRHGKYR1Mus musculus
H69GNFEKHPKELI3Homo sapiens, Bos taurus, Mus musculus
H69GDFKAHPKDMI1Danio rerio
H69GDFKAHPRDLI1Xenopus tropicalis
H69GGFQIHPKHLI1Gallus gallus
I32GVPRLIGIRLT1Homo sapiens
I32GSCARIRMH-A1Danio rerio
I32GSRDLRKMN-F1Xenopus tropicalis
I32GLPRNFRVR-E1Gallus gallus
I32GVPRLFHVRVT1Bos taurus
I32GVPRLAFVRLT1Mus musculus
K112LHNLNKRIRYL1Homo sapiens
K112RHNLQKRISHL1Danio rerio
K112RENLNKRIRFL1Xenopus tropicalis
K112YHNLKKRIRFL1Gallus gallus
K112LHNLNKRISFL1Bos taurus
K112LHNLNKRISYL1Mus musculus
K119IRYLYKHFNRH1Homo sapiens
K119ISHLYRRFNRH1Danio rerio
K119IRFLYKRFNRY1Xenopus tropicalis
K119IRFLYKRFNRT1Gallus gallus
K119ISFLYKRFNRH1Bos taurus
K119ISYLYKHFNRH1Mus musculus
K126FNRHGKHR2Danio rerio, Bos taurus
K126FNRHGKFR1Homo sapiens
K126FNRYGKHR1Xenopus tropicalis
K126FNRTGKHR1Gallus gallus
K126FNRHGKYR1Mus musculus
K68LGNFEKHPKEL3Homo sapiens, Bos taurus, Mus musculus
K68LGDFKAHPKDM1Danio rerio
K68LGDFKAHPRDL1Xenopus tropicalis
K68LGGFQIHPKHL1Gallus gallus
K96CIRKRKMVGSR1Homo sapiens
K96LLRKRNMVGDR1Danio rerio
K96CIRKRQMVGPR1Xenopus tropicalis
K96CIRKKQMVGDR1Gallus gallus
K96CIRKKRMVGNR1Bos taurus
K96CVRKKKFVGNR1Mus musculus
L117KRIRFLYKRFN2Xenopus tropicalis, Gallus gallus
L117KRIRYLYKHFN1Homo sapiens
L117KRISHLYRRFN1Danio rerio
L117KRISFLYKRFN1Bos taurus
L117KRISYLYKHFN1Mus musculus
L36LIGIRLTLPPP1Homo sapiens
L36RIRMH-AIPKL1Danio rerio
L36LRKMN-FMPQP1Xenopus tropicalis
L36NFRVR-EPPKP1Gallus gallus
L36LFHVRVTLPPP1Bos taurus
L36LAFVRLTLPPP1Mus musculus
M97IRKRKMVGSRM1Homo sapiens
M97LRKRNMVGDRM1Danio rerio
M97IRKRQMVGPRM1Xenopus tropicalis
M97IRKKQMVGDRM1Gallus gallus
M97IRKKRMVGNRM1Bos taurus
M97VRKKKFVGNRM1Mus musculus
N86RGWKGNELQRC3Homo sapiens, Xenopus tropicalis, Bos taurus
N86RGWRGNELQRC2Gallus gallus, Mus musculus
N86RGFRGNELQRL1Danio rerio
P70NFEKHPKELIK2Bos taurus, Mus musculus
P70NFEKHPKELIR1Homo sapiens
P70DFKAHPKDMIR1Danio rerio
P70DFKAHPRDLII1Xenopus tropicalis
P70GFQIHPKHLIM1Gallus gallus
P77ELIKGPVWLRG2Bos taurus, Mus musculus
P77ELIRGPIWLRG1Homo sapiens
P77DMIRGPVWVRG1Danio rerio
P77DLIIGPSWLRG1Xenopus tropicalis
P77HLIMGPKWLRG1Gallus gallus
R113HNLNKRIRYLY1Homo sapiens
R113HNLQKRISHLY1Danio rerio
R113ENLNKRIRFLY1Xenopus tropicalis
R113HNLKKRIRFLY1Gallus gallus
R113HNLNKRISFLY1Bos taurus
R113HNLNKRISYLY1Mus musculus
R115LNKRIRYLYKH1Homo sapiens
R115LQKRISHLYRR1Danio rerio
R115LNKRIRFLYKR1Xenopus tropicalis
R115LKKRIRFLYKR1Gallus gallus
R115LNKRISFLYKR1Bos taurus
R115LNKRISYLYKH1Mus musculus
R123YKHFNRHGKFR1Homo sapiens
R123YRRFNRHGKHR1Danio rerio
R123YKRFNRYGKHR1Xenopus tropicalis
R123YKRFNRTGKHR1Gallus gallus
R123YKRFNRHGKHR1Bos taurus
R123YKHFNRHGKYR1Mus musculus
R35RLIGIRLTLPP1Homo sapiens
R35ARIRMH-AIPK1Danio rerio
R35DLRKMN-FMPQ1Xenopus tropicalis
R35RNFRVR-EPPK1Gallus gallus
R35RLFHVRVTLPP1Bos taurus
R35RLAFVRLTLPP1Mus musculus
R46PKVVDRWNEKR2Homo sapiens, Mus musculus
R46LKEVDRWTEKR1Danio rerio
R46PKNTDRWDHKR1Xenopus tropicalis
R46PQKVDRWTEKR1Gallus gallus
R46PKVIDRWNQKR1Bos taurus
R51RWNEKRAMFGV1Homo sapiens
R51RWTEKRSMFGV1Danio rerio
R51RWDHKRALYGV1Xenopus tropicalis
R51RWTEKRALFGV1Gallus gallus
R51RWNQKRAMFGV1Bos taurus
R51RWNEKRALFGV1Mus musculus
R75PKELIKGPVWL2Bos taurus, Mus musculus
R75PKELIRGPIWL1Homo sapiens
R75PKDMIRGPVWV1Danio rerio
R75PRDLIIGPSWL1Xenopus tropicalis
R75PKHLIMGPKWL1Gallus gallus
R93LQRCIRKRKMV1Homo sapiens
R93LQRLLRKRNMV1Danio rerio
R93LQRCIRKRQMV1Xenopus tropicalis
R93LQRCIRKKQMV1Gallus gallus
R93LQRCIRKKRMV1Bos taurus
R93LQRCVRKKKFV1Mus musculus
W79IRGPIWLRGWK1Homo sapiens
W79IRGPVWVRGFR1Danio rerio
W79IIGPSWLRGWK1Xenopus tropicalis
W79IMGPKWLRGWR1Gallus gallus
W79IKGPVWLRGWK1Bos taurus
W79IKGPVWLRGWR1Mus musculus
Y116NKRIRYLYKHF1Homo sapiens
Y116QKRISHLYRRF1Danio rerio
Y116NKRIRFLYKRF1Xenopus tropicalis
Y116KKRIRFLYKRF1Gallus gallus
Y116NKRISFLYKRF1Bos taurus
Y116NKRISYLYKHF1Mus musculus
Y118RIRFLYKRFNR2Xenopus tropicalis, Gallus gallus
Y118RIRYLYKHFNR1Homo sapiens
Y118RISHLYRRFNR1Danio rerio
Y118RISFLYKRFNR1Bos taurus
Y118RISYLYKHFNR1Mus musculus


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