mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CLEC1B
Gene summary
Basic gene Info.Gene symbolCLEC1B
Gene nameC-type lectin domain family 1, member B
Synonyms1810061I13Rik|CLEC2|CLEC2B|PRO1384|QDED721
CytomapUCSC genome browser: 12p13.2
Type of geneprotein-coding
RefGenesNM_001099431.1,
NM_016509.3,
DescriptionC-type lectin domain family 1 member BC-type lectin-like receptor 2C-type lectin-like receptor-2CLEC-2
Modification date20141207
dbXrefs MIM : 606783
HGNC : HGNC
Ensembl : ENSG00000165682
HPRD : 09490
Vega : OTTHUMG00000168502
ProteinUniProt: Q9P126
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CLEC1B
BioGPS: 51266
PathwayNCI Pathway Interaction Database: CLEC1B
KEGG: CLEC1B
REACTOME: CLEC1B
Pathway Commons: CLEC1B
ContextiHOP: CLEC1B
ligand binding site mutation search in PubMed: CLEC1B
UCL Cancer Institute: CLEC1B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CLEC1B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R157R157CCOAD1
H119N120KLUAD1
G115C113SLUSC1
R157R157CPRAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CLEC1B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G115C113S-1.4750892
R157R157C-1.3845471
H119N120K-0.8478707
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CLEC1B from PDB

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Differential gene expression and gene-gene network for CLEC1B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CLEC1B and the right PPI network was created from samples without mutations in the LBS of CLEC1B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CLEC1B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CLEC1B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CLEC1B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SIAN-ACETYLNEURAMINIC ACID3wsrAG115 H119
SIAN-ACETYLNEURAMINIC ACID3wsrBH119
IIIPeptide ligand (ALA,GLU,ASP,ASP,VAL,VAL,THR,PRO,GLY,CYS)3wsrAR157
IIIPeptide ligand (GLY,ALA,GLU,ASP,ASP,VAL,VAL,THR,PRO,GLY,CYS)3wsrBR157


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Conservation information for LBS of CLEC1B
Multiple alignments for Q9P126 in multiple species
LBSAA sequence# speciesSpecies


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