mutLBSgeneDB |
Gene summary for CDK16 |
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Basic gene Info. | Gene symbol | CDK16 |
Gene name | cyclin-dependent kinase 16 | |
Synonyms | PCTAIRE|PCTAIRE1|PCTGAIRE|PCTK1 | |
Cytomap | UCSC genome browser: Xp11 | |
Type of gene | protein-coding | |
RefGenes | NM_001170460.1, NM_006201.4,NM_033018.3, | |
Description | PCTAIRE-motif protein kinase 1cell division protein kinase 16serine/threonine-protein kinase PCTAIRE-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 311550 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102225 | ||
HPRD : 02409 | ||
Vega : OTTHUMG00000021438 | ||
Protein | UniProt: Q00536 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDK16 | |
BioGPS: 5127 | ||
Pathway | NCI Pathway Interaction Database: CDK16 | |
KEGG: CDK16 | ||
REACTOME: CDK16 | ||
Pathway Commons: CDK16 | ||
Context | iHOP: CDK16 | |
ligand binding site mutation search in PubMed: CDK16 | ||
UCL Cancer Institute: CDK16 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CDK16 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | Q290 | K288T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CDK16 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Q290 | K288T | -1.1134678 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CDK16 |
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Phenotype information for CDK16 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CDK16 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB07766 | (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FEF | INDIRUBIN DERIVATIVE E804 | 3mtl | A | Q290 |
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Conservation information for LBS of CDK16 |
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LBS | AA sequence | # species | Species |
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