mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GMPR2
Gene summary
Basic gene Info.Gene symbolGMPR2
Gene nameguanosine monophosphate reductase 2
CytomapUCSC genome browser: 14q12
Type of geneprotein-coding
DescriptionGMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isolog
Modification date20141207
dbXrefs MIM : 610781
Ensembl : ENSG00000100938
HPRD : 13590
Vega : OTTHUMG00000171912
ProteinUniProt: Q9P2T1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GMPR2
BioGPS: 51292
PathwayNCI Pathway Interaction Database: GMPR2
Pathway Commons: GMPR2
ContextiHOP: GMPR2
ligand binding site mutation search in PubMed: GMPR2
UCL Cancer Institute: GMPR2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0046037GMP metabolic process22037469

Ligand binding site mutations for GMPR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GMPR2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GMPR2 from PDB

Differential gene expression and gene-gene network for GMPR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GMPR2 and the right PPI network was created from samples without mutations in the LBS of GMPR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GMPR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GMPR2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GMPR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
5GPGMP RESIDUE2a7rAG242 A287 G290
IMPIMP2bznAG242 G290
IMPIMP2bznBG242 G290
IMPIMP2bznCG242 G290
IMPIMP2bznDG242 G290
IMPIMP2bznEG242 G290
IMPIMP2bznFG242 G290
IMPIMP2bznGG242 G290
IMPIMP2bznHG242 G290
IMPIMP2c6qAG242 G290
IMPIMP2c6qBG242 G290
IMPIMP2c6qCG242 G290
IMPIMP2c6qDG242 G290
IMPIMP2c6qEG242 G290
IMPIMP2c6qFG242 G290
IMPIMP2c6qGG242 G290
IMPIMP2c6qHG242 G290

Conservation information for LBS of GMPR2
Multiple alignments for Q9P2T1 in multiple species
LBSAA sequence# speciesSpecies
A131ICLDVANGYSE3Homo sapiens, Caenorhabditis elegans, Mus musculus
A131VCLDVANGYSE1Bos taurus
A287VAEYRASEGKT3Homo sapiens, Caenorhabditis elegans, Bos taurus
A287VAEYRASEGKI1Mus musculus
A53VPIIAANMDTV1Homo sapiens
A53VPVVASNMDTV1Caenorhabditis elegans
A53IPVIAANMDTV1Mus musculus
C186GPGSVCTTRKK4Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus
D129KYICLDVANGY3Homo sapiens, Caenorhabditis elegans, Mus musculus
D129KYVCLDVANGY1Bos taurus
D219GHIISDGGCSC3Homo sapiens, Bos taurus, Mus musculus
D219GHVMSDGGCSN1Caenorhabditis elegans
E289EYRASEGKTVE2Homo sapiens, Bos taurus
E289EYRASEGKTVT1Caenorhabditis elegans
E289EYRASEGKIVE1Mus musculus
G104LAASSGTGSSD2Homo sapiens, Bos taurus
G104LAISSGISDND1Caenorhabditis elegans
G104LAASSGSGSAD1Mus musculus
G179DIIKVGIGPGS3Homo sapiens, Bos taurus, Mus musculus
G179DIVKVGIGPGS1Caenorhabditis elegans
G181IKVGIGPGSVC3Homo sapiens, Bos taurus, Mus musculus
G181VKVGIGPGSVC1Caenorhabditis elegans
G183VGIGPGSVCTT4Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus
G220HIISDGGCSCP3Homo sapiens, Bos taurus, Mus musculus
G220HVMSDGGCSNP1Caenorhabditis elegans
G221IISDGGCSCPG3Homo sapiens, Bos taurus, Mus musculus
G221VMSDGGCSNPG1Caenorhabditis elegans
G242DFVMLGGMLAG3Homo sapiens, Bos taurus, Mus musculus
G242DFVMIGGLFAG1Caenorhabditis elegans
G243FVMLGGMLAGH3Homo sapiens, Bos taurus, Mus musculus
G243FVMIGGLFAGH1Caenorhabditis elegans
G268YKLFYGMSSEM3Homo sapiens, Bos taurus, Mus musculus
G268FKLFYGMSSDT1Caenorhabditis elegans
G290YRASEGKTVEV2Homo sapiens, Bos taurus
G290YRASEGKTVTI1Caenorhabditis elegans
G290YRASEGKIVEV1Mus musculus
I180IIKVGIGPGSV3Homo sapiens, Bos taurus, Mus musculus
I180IVKVGIGPGSV1Caenorhabditis elegans
K25KRSTLKSRSEV3Homo sapiens, Bos taurus, Mus musculus
K25KRSTLKSRADV1Caenorhabditis elegans
K78FTAVHKHYSLV1Homo sapiens
K78FTTIHKHYSVD1Caenorhabditis elegans
K78FTAIHKHYSIH1Mus musculus
M240GADFVMLGGML3Homo sapiens, Bos taurus, Mus musculus
M240GADFVMIGGLF1Caenorhabditis elegans
M269KLFYGMSSEMA3Homo sapiens, Bos taurus, Mus musculus
M269KLFYGMSSDTA1Caenorhabditis elegans
M275SSEMAMKKYAG2Homo sapiens, Bos taurus
M275SSDTAMKKHHG1Caenorhabditis elegans
M275SSEMAMKKYSG1Mus musculus
M55IIAANMDTVGT2Homo sapiens, Bos taurus
M55VVASNMDTVGT1Caenorhabditis elegans
M55VIAANMDTVGT1Mus musculus
N132CLDVANGYSEH3Homo sapiens, Bos taurus, Mus musculus
N132CLDVANGYSES1Caenorhabditis elegans
N158TIMAGNVVTGE4Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus
R27STLKSRSEVDL2Homo sapiens, Bos taurus
R27STLKSRADVEL1Caenorhabditis elegans
R27STLKSRSEVEL1Mus musculus
R286GVAEYRASEGK3Homo sapiens, Bos taurus, Mus musculus
R286SVAEYRASEGK1Caenorhabditis elegans
S184GIGPGSVCTTR4Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus
S26RSTLKSRSEVD2Homo sapiens, Bos taurus
S26RSTLKSRADVE1Caenorhabditis elegans
S26RSTLKSRSEVE1Mus musculus
S270LFYGMSSEMAM3Homo sapiens, Bos taurus, Mus musculus
S270LFYGMSSDTAM1Caenorhabditis elegans
S288AEYRASEGKTV3Homo sapiens, Caenorhabditis elegans, Bos taurus
S288AEYRASEGKIV1Mus musculus
S314LGGIRSTCTYV2Homo sapiens, Mus musculus
S314LGGIRSACTYT1Caenorhabditis elegans
S314IGGIRSTCTYV1Bos taurus
T105AASSGTGSSDF2Homo sapiens, Bos taurus
T105AISSGISDNDW1Caenorhabditis elegans
T105AASSGSGSADF1Mus musculus
T188GSVCTTRKKTG3Homo sapiens, Bos taurus, Mus musculus
T188GSVCTTRKKAG1Caenorhabditis elegans
T317IRSTCTYVGAA3Homo sapiens, Bos taurus, Mus musculus
T317IRSACTYTGAK1Caenorhabditis elegans
V130YICLDVANGYS3Homo sapiens, Caenorhabditis elegans, Mus musculus
V130YVCLDVANGYS1Bos taurus
Y285GGVAEYRASEG3Homo sapiens, Bos taurus, Mus musculus
Y285GSVAEYRASEG1Caenorhabditis elegans
Y318RSTCTYVGAAK3Homo sapiens, Bos taurus, Mus musculus
Y318RSACTYTGAKH1Caenorhabditis elegans

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