mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL35
Gene summary
Basic gene Info.Gene symbolMRPL35
Gene namemitochondrial ribosomal protein L35
SynonymsL35mt|MRP-L35
CytomapUCSC genome browser: 2p11.2
Type of geneprotein-coding
RefGenesNM_016622.3,
NM_145644.2,
Description39S ribosomal protein L35, mitochondrial
Modification date20141207
dbXrefs MIM : 611841
HGNC : HGNC
Ensembl : ENSG00000132313
HPRD : 14755
Vega : OTTHUMG00000037385
ProteinUniProt: Q9NZE8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL35
BioGPS: 51318
PathwayNCI Pathway Interaction Database: MRPL35
KEGG: MRPL35
REACTOME: MRPL35
Pathway Commons: MRPL35
ContextiHOP: MRPL35
ligand binding site mutation search in PubMed: MRPL35
UCL Cancer Institute: MRPL35
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL35

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K126K126QBLCA1
K131K130NCOAD1
S164T163MSTAD1
R145E146KUCEC1
R124V123MUCEC1
R143R143QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL35
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R145E146K-1.0231207
R143R143Q-0.94211854
K126K126Q-0.91816938
S164T163M-0.82914349
K131K130N-0.55391552
R124V123M-0.54451399
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL35 from PDB

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Differential gene expression and gene-gene network for MRPL35
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL35 and the right PPI network was created from samples without mutations in the LBS of MRPL35. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL35
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL35
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL35 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7y3R124 K126 K131 R143 R145 S164


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Conservation information for LBS of MRPL35
Multiple alignments for Q9NZE8 in multiple species
LBSAA sequence# speciesSpecies
A109RKTVKAVIDRF1Homo sapiens
A109RKTVKSVVHRF1Mus musculus
A109RKTVKAVIYRF1Bos taurus
A127WLRRKAGYKKK2Mus musculus, Bos taurus
A127WVRRKAGYKKK1Homo sapiens
A99LTYFSARKGKR1Homo sapiens
A99LTYCSTRKGKR1Mus musculus
A99VTYCSSRKGKR1Bos taurus
D182YQKYHDRTNLK1Homo sapiens
D182YQMYHDRTNLR1Mus musculus
D182YQMYHDRTNLK1Bos taurus
F165KMTTSFWKRRN3Homo sapiens, Mus musculus, Bos taurus
F97RSLTYFSARKG1Homo sapiens
F97RALTYCSTRKG1Mus musculus
F97RTVTYCSSRKG1Bos taurus
G128LRRKAGYKKKL2Mus musculus, Bos taurus
G128VRRKAGYKKKL1Homo sapiens
H118RFLRLHSGLWL2Mus musculus, Bos taurus
H118RFLRLHCGLWV1Homo sapiens
K101YFSARKGKRKT1Homo sapiens
K101YCSTRKGKRKT1Mus musculus
K101YCSSRKGKRKT1Bos taurus
K103SARKGKRKTVK1Homo sapiens
K103STRKGKRKTVK1Mus musculus
K103SSRKGKRKTVK1Bos taurus
K105RKGKRKTVKAV2Homo sapiens, Bos taurus
K105RKGKRKTVKSV1Mus musculus
K108KRKTVKAVIDR1Homo sapiens
K108KRKTVKSVVHR1Mus musculus
K108KRKTVKAVIYR1Bos taurus
K126LWLRRKAGYKK2Mus musculus, Bos taurus
K126LWVRRKAGYKK1Homo sapiens
K131KAGYKKKLWKK3Homo sapiens, Mus musculus, Bos taurus
K132AGYKKKLWKKT2Homo sapiens, Bos taurus
K132AGYKKKLWKKS1Mus musculus
K135KKKLWKKTPAR1Homo sapiens
K135KKKLWKKSTAR1Mus musculus
K135KKKLWKKTVAR1Bos taurus
K136KKLWKKTPARK1Homo sapiens
K136KKLWKKSTARK1Mus musculus
K136KKLWKKTVARK1Bos taurus
K142TPARKKRLREF1Homo sapiens
K142STARKKRLREF1Mus musculus
K142TVARKRRLREF1Bos taurus
K152FVFCNKTQSKL2Homo sapiens, Bos taurus
K152FVFCSKTQSKL1Mus musculus
K156NKTQSKLLDKM2Homo sapiens, Bos taurus
K156SKTQSKLLDKM1Mus musculus
L133GYKKKLWKKTP1Homo sapiens
L133GYKKKLWKKST1Mus musculus
L133GYKKKLWKKTV1Bos taurus
L144ARKKRLREFVF2Homo sapiens, Mus musculus
L144ARKRRLREFVF1Bos taurus
L94LPVRSLTYFSA1Homo sapiens
L94PPVRALTYCST1Mus musculus
L94PPVRTVTYCSS1Bos taurus
Q154FCNKTQSKLLD2Homo sapiens, Bos taurus
Q154FCSKTQSKLLD1Mus musculus
R100TYFSARKGKRK1Homo sapiens
R100TYCSTRKGKRK1Mus musculus
R100TYCSSRKGKRK1Bos taurus
R104ARKGKRKTVKA1Homo sapiens
R104TRKGKRKTVKS1Mus musculus
R104SRKGKRKTVKA1Bos taurus
R113KAVIDRFLRLH1Homo sapiens
R113KSVVHRFLRLH1Mus musculus
R113KAVIYRFLRLH1Bos taurus
R124SGLWLRRKAGY2Mus musculus, Bos taurus
R124CGLWVRRKAGY1Homo sapiens
R140KKTPARKKRLR1Homo sapiens
R140KKSTARKKRLR1Mus musculus
R140KKTVARKRRLR1Bos taurus
R143PARKKRLREFV1Homo sapiens
R143TARKKRLREFV1Mus musculus
R143VARKRRLREFV1Bos taurus
R145RKKRLREFVFC2Homo sapiens, Mus musculus
R145RKRRLREFVFC1Bos taurus
R168TSFWKRRNWYA2Mus musculus, Bos taurus
R168TSFWKRRNWYV1Homo sapiens
R169SFWKRRNWYVD1Homo sapiens
R169SFWKRRNWYAG1Mus musculus
R169SFWKRRNWYAD1Bos taurus
S164DKMTTSFWKRR3Homo sapiens, Mus musculus, Bos taurus
S98SLTYFSARKGK1Homo sapiens
S98ALTYCSTRKGK1Mus musculus
S98TVTYCSSRKGK1Bos taurus
T106KGKRKTVKAVI2Homo sapiens, Bos taurus
T106KGKRKTVKSVV1Mus musculus
T153VFCNKTQSKLL2Homo sapiens, Bos taurus
T153VFCSKTQSKLL1Mus musculus
T95PVRSLTYFSAR1Homo sapiens
T95PVRALTYCSTR1Mus musculus
T95PVRTVTYCSSR1Bos taurus
V10AFAGAVRAASG1Homo sapiens
V10IFTGAVRAASG1Mus musculus
V10MFAGAVRAASG1Bos taurus
V107GKRKTVKAVID1Homo sapiens
V107GKRKTVKSVVH1Mus musculus
V107GKRKTVKAVIY1Bos taurus
W134YKKKLWKKTPA1Homo sapiens
W134YKKKLWKKSTA1Mus musculus
W134YKKKLWKKTVA1Bos taurus
W166MTTSFWKRRNW3Homo sapiens, Mus musculus, Bos taurus
W171WKRRNWYVDDP1Homo sapiens
W171WKRRNWYAGDP1Mus musculus
W171WKRRNWYADDP1Bos taurus


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