mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZMYND10
Gene summary
Basic gene Info.Gene symbolZMYND10
Gene namezinc finger, MYND-type containing 10
CytomapUCSC genome browser: 3p21.3
Type of geneprotein-coding
Descriptionprotein BLuzinc finger MYND domain-containing protein 10zinc finger, MYND domain containing 10
Modification date20141207
dbXrefs MIM : 607070
Ensembl : ENSG00000004838
HPRD : 06145
Vega : OTTHUMG00000156874
ProteinUniProt: O75800
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZMYND10
BioGPS: 51364
PathwayNCI Pathway Interaction Database: ZMYND10
Pathway Commons: ZMYND10
ContextiHOP: ZMYND10
ligand binding site mutation search in PubMed: ZMYND10
UCL Cancer Institute: ZMYND10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ZMYND10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ZMYND10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZMYND10 from PDB

Differential gene expression and gene-gene network for ZMYND10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZMYND10 and the right PPI network was created from samples without mutations in the LBS of ZMYND10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ZMYND10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3809543CILIARY DYSKINESIA, PRIMARY, 222GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ZMYND10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZMYND10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ZMYND10
Multiple alignments for O75800 in multiple species
LBSAA sequence# speciesSpecies
C394--RPRCAYCSA2Homo sapiens, Rattus norvegicus
C394DTDHTCATCQA1Drosophila melanogaster
C394--KPKCGACGR1Danio rerio
C394--RPRCGYCNA1Mus musculus
C397PRCAYCSAEAS2Homo sapiens, Rattus norvegicus
C397HTCATCQAKAK1Drosophila melanogaster
C397PKCGACGRTGV1Danio rerio
C397PRCGYCNAEAS1Mus musculus
C405EASKRCSRCQN2Homo sapiens, Mus musculus
C405KAKKKCACCKK1Drosophila melanogaster
C405TGVKRCSRCQG1Danio rerio
C405EASKRCSRCQK1Rattus norvegicus
C408KRCSRCQNEWY1Homo sapiens
C408KKCACCKKVHY1Drosophila melanogaster
C408KRCSRCQGEWY1Danio rerio
C408KRCSRCQNVWY1Mus musculus
C408KRCSRCQKVWY1Rattus norvegicus
C414QNEWYCCRECQ1Homo sapiens
C414KKVHYCSRDCQ1Drosophila melanogaster
C414QGEWYCNRECQ1Danio rerio
C414QNVWYCCRECQ1Mus musculus
C414QKVWYCCRECQ1Rattus norvegicus
C418YCCRECQVKHW3Homo sapiens, Mus musculus, Rattus norvegicus
C418YCSRDCQLKDW1Drosophila melanogaster
C418YCNRECQVKHW1Danio rerio
C430KHGKTCVLAAQ3Homo sapiens, Mus musculus, Rattus norvegicus
C430QHKLVCLKT--1Drosophila melanogaster
C430KHKPSCNLMAE1Danio rerio
H426KHWEKHGKTCV3Homo sapiens, Mus musculus, Rattus norvegicus
H426KDWPQHKLVCL1Drosophila melanogaster
H426KHWPKHKPSCN1Danio rerio

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas