|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for ZMYND10 |
 Gene summary |
| Basic gene Info. | Gene symbol | ZMYND10 |
| Gene name | zinc finger, MYND-type containing 10 | |
| Synonyms | BLU|CILD22|FLU | |
| Cytomap | UCSC genome browser: 3p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015896.2, | |
| Description | protein BLuzinc finger MYND domain-containing protein 10zinc finger, MYND domain containing 10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607070 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000004838 | ||
| HPRD : 06145 | ||
| Vega : OTTHUMG00000156874 | ||
| Protein | UniProt: O75800 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZMYND10 | |
| BioGPS: 51364 | ||
| Pathway | NCI Pathway Interaction Database: ZMYND10 | |
| KEGG: ZMYND10 | ||
| REACTOME: ZMYND10 | ||
| Pathway Commons: ZMYND10 | ||
| Context | iHOP: ZMYND10 | |
| ligand binding site mutation search in PubMed: ZMYND10 | ||
| UCL Cancer Institute: ZMYND10 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for ZMYND10 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C397 | S398T | BRCA | 1 | C430 | L432Q | COAD | 1 | C405 | R404C | UCEC | 1 | C397 | A399T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for ZMYND10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C405 | R404C | -0.85252548 | C430 | L432Q | -0.83704566 | C397 | A399T | -0.14082572 | C397 | S398T | -0.14074782 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZMYND10 from PDB |
| Top |
| Differential gene expression and gene-gene network for ZMYND10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for ZMYND10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C3809543 | CILIARY DYSKINESIA, PRIMARY, 22 | 2 | GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for ZMYND10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of ZMYND10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of ZMYND10 |
| Multiple alignments for O75800 in multiple species |
| LBS | AA sequence | # species | Species | C394 | --RPRCAYCSA | 2 | Homo sapiens, Rattus norvegicus | C394 | DTDHTCATCQA | 1 | Drosophila melanogaster | C394 | --KPKCGACGR | 1 | Danio rerio | C394 | --RPRCGYCNA | 1 | Mus musculus | C397 | PRCAYCSAEAS | 2 | Homo sapiens, Rattus norvegicus | C397 | HTCATCQAKAK | 1 | Drosophila melanogaster | C397 | PKCGACGRTGV | 1 | Danio rerio | C397 | PRCGYCNAEAS | 1 | Mus musculus | C405 | EASKRCSRCQN | 2 | Homo sapiens, Mus musculus | C405 | KAKKKCACCKK | 1 | Drosophila melanogaster | C405 | TGVKRCSRCQG | 1 | Danio rerio | C405 | EASKRCSRCQK | 1 | Rattus norvegicus | C408 | KRCSRCQNEWY | 1 | Homo sapiens | C408 | KKCACCKKVHY | 1 | Drosophila melanogaster | C408 | KRCSRCQGEWY | 1 | Danio rerio | C408 | KRCSRCQNVWY | 1 | Mus musculus | C408 | KRCSRCQKVWY | 1 | Rattus norvegicus | C414 | QNEWYCCRECQ | 1 | Homo sapiens | C414 | KKVHYCSRDCQ | 1 | Drosophila melanogaster | C414 | QGEWYCNRECQ | 1 | Danio rerio | C414 | QNVWYCCRECQ | 1 | Mus musculus | C414 | QKVWYCCRECQ | 1 | Rattus norvegicus | C418 | YCCRECQVKHW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C418 | YCSRDCQLKDW | 1 | Drosophila melanogaster | C418 | YCNRECQVKHW | 1 | Danio rerio | C430 | KHGKTCVLAAQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C430 | QHKLVCLKT-- | 1 | Drosophila melanogaster | C430 | KHKPSCNLMAE | 1 | Danio rerio | H426 | KHWEKHGKTCV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H426 | KDWPQHKLVCL | 1 | Drosophila melanogaster | H426 | KHWPKHKPSCN | 1 | Danio rerio |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |