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mutLBSgeneDB |
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| Gene summary for ANAPC5 |
 Gene summary |
| Basic gene Info. | Gene symbol | ANAPC5 |
| Gene name | anaphase promoting complex subunit 5 | |
| Synonyms | APC5 | |
| Cytomap | UCSC genome browser: 12q24.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001137559.1, NM_016237.4, | |
| Description | anaphase-promoting complex subunit 5cyclosome subunit 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606948 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000089053 | ||
| HPRD : 10453 | ||
| Vega : OTTHUMG00000169157 | ||
| Protein | UniProt: Q9UJX4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANAPC5 | |
| BioGPS: 51433 | ||
| Pathway | NCI Pathway Interaction Database: ANAPC5 | |
| KEGG: ANAPC5 | ||
| REACTOME: ANAPC5 | ||
| Pathway Commons: ANAPC5 | ||
| Context | iHOP: ANAPC5 | |
| ligand binding site mutation search in PubMed: ANAPC5 | ||
| UCL Cancer Institute: ANAPC5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
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| Ligand binding site mutations for ANAPC5 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A734 | A734V | COAD | 1 | A734 | A734V | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ANAPC5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A734 | A734V | -0.35356096 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ANAPC5 from PDB |
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| Differential gene expression and gene-gene network for ANAPC5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ANAPC5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ANAPC5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ANAPC5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (MET,SER,ARG,ARG,PRO,CYS,SER,CYS,ALA,LEU,ARG,PRO,PRO,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA) | 4ui9 | O | A734 | III | Peptide ligand (UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK,UNK) | 5a31 | O | A734 |
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| Conservation information for LBS of ANAPC5 |
| Multiple alignments for Q9UJX4 in multiple species |
| LBS | AA sequence | # species | Species | A734 | ERNRCAMLFRQ | 1 | Homo sapiens | A734 | EREEAASLFKK | 1 | Arabidopsis thaliana | A734 | ERNKCAMLFRQ | 1 | Gallus gallus | A734 | ERNHCAMIFRQ | 1 | Mus musculus | A734 | ERNHCAMVFRQ | 1 | Rattus norvegicus | F737 | RCAMLFRQLHQ | 1 | Homo sapiens | F737 | EAASLFKK-HI | 1 | Arabidopsis thaliana | F737 | KCAMLFRQLHQ | 1 | Gallus gallus | F737 | HCAMIFRQLHQ | 1 | Mus musculus | F737 | HCAMVFRQLHQ | 1 | Rattus norvegicus | H741 | LFRQLHQELPS | 1 | Homo sapiens | H741 | LFKK-HIIALE | 1 | Arabidopsis thaliana | H741 | LFRQLHQELPA | 1 | Gallus gallus | H741 | IFRQLHQELPA | 1 | Mus musculus | H741 | VFRQLHQELPS | 1 | Rattus norvegicus | N731 | KTQERNRCAML | 1 | Homo sapiens | N731 | RLDEREEAASL | 1 | Arabidopsis thaliana | N731 | KTQERNKCAML | 1 | Gallus gallus | N731 | KTQERNHCAMI | 1 | Mus musculus | N731 | KTQERNHCAMV | 1 | Rattus norvegicus | R730 | GKTQERNHCAM | 2 | Mus musculus, Rattus norvegicus | R730 | GKTQERNRCAM | 1 | Homo sapiens | R730 | GRLDEREEAAS | 1 | Arabidopsis thaliana | R730 | GKTQERNKCAM | 1 | Gallus gallus | R738 | CAMLFRQLHQE | 2 | Homo sapiens, Gallus gallus | R738 | AASLFKK-HII | 1 | Arabidopsis thaliana | R738 | CAMIFRQLHQE | 1 | Mus musculus | R738 | CAMVFRQLHQE | 1 | Rattus norvegicus | Y715 | IRDVVYFQARL | 1 | Homo sapiens | Y715 | AAEASYLMAMV | 1 | Arabidopsis thaliana | Y715 | LRDVLYFQARL | 1 | Gallus gallus | Y715 | IRDVAYFQARL | 1 | Mus musculus | Y715 | IRDVSYFQARL | 1 | Rattus norvegicus |
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