mutLBSgeneDB |
Gene summary for YTHDF2 |
Gene summary |
Basic gene Info. | Gene symbol | YTHDF2 |
Gene name | YTH N(6)-methyladenosine RNA binding protein 2 | |
Synonyms | CAHL|HGRG8|NY-REN-2 | |
Cytomap | UCSC genome browser: 1p35 | |
Type of gene | protein-coding | |
RefGenes | NM_001172828.1, NM_001173128.1,NM_016258.2, | |
Description | 9430020E02RikCLL-associated antigen KW-14YTH domain family, member 2YTH domain-containing family protein 2high-glucose-regulated protein 8renal carcinoma antigen NY-REN-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610640 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198492 | ||
HPRD : 06587 | ||
Vega : OTTHUMG00000003648 | ||
Protein | UniProt: Q9Y5A9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_YTHDF2 | |
BioGPS: 51441 | ||
Pathway | NCI Pathway Interaction Database: YTHDF2 | |
KEGG: YTHDF2 | ||
REACTOME: YTHDF2 | ||
Pathway Commons: YTHDF2 | ||
Context | iHOP: YTHDF2 | |
ligand binding site mutation search in PubMed: YTHDF2 | ||
UCL Cancer Institute: YTHDF2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for YTHDF2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | W491 | W491L | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for YTHDF2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | W491 | W491L | -1.3944338 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for YTHDF2 from PDB |
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Differential gene expression and gene-gene network for YTHDF2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for YTHDF2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for YTHDF2 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of YTHDF2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 6MD | N-METHYLADENOSINE | 4rdn | A | W491 | 6MD | N-METHYLADENOSINE | 4rdn | B | W491 |
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Conservation information for LBS of YTHDF2 |
Multiple alignments for Q9Y5A9 in multiple species |
LBS | AA sequence | # species | Species | C433 | KYNIWCSTEHG | 3 | Homo sapiens, Bos taurus, Mus musculus | D422 | SYSEDDIHRSI | 3 | Homo sapiens, Bos taurus, Mus musculus | D528 | VTNSRDTQEVP | 3 | Homo sapiens, Bos taurus, Mus musculus | K416 | RVFIIKSYSED | 3 | Homo sapiens, Bos taurus, Mus musculus | K490 | VWSQDKWKGRF | 3 | Homo sapiens, Bos taurus, Mus musculus | N462 | LLFSVNGSGHF | 3 | Homo sapiens, Bos taurus, Mus musculus | S417 | VFIIKSYSEDD | 3 | Homo sapiens, Bos taurus, Mus musculus | T435 | NIWCSTEHGNK | 3 | Homo sapiens, Bos taurus, Mus musculus | W432 | IKYNIWCSTEH | 3 | Homo sapiens, Bos taurus, Mus musculus | W486 | TCAGVWSQDKW | 3 | Homo sapiens, Bos taurus, Mus musculus | W491 | WSQDKWKGRFD | 3 | Homo sapiens, Bos taurus, Mus musculus | Y418 | FIIKSYSEDDI | 3 | Homo sapiens, Bos taurus, Mus musculus |
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