mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ANAPC11
Gene summary
Basic gene Info.Gene symbolANAPC11
Gene nameanaphase promoting complex subunit 11
CytomapUCSC genome browser: 17q25.3
Type of geneprotein-coding
DescriptionAPC11 anaphase promoting complex subunit 11 homologanaphase promoting complex subunit 11 (yeast APC11 homolog)anaphase-promoting complex subunit 11cyclosome subunit 11hepatocellular carcinoma-associated RING finger protein
Modification date20141207
dbXrefs MIM : 614534
Ensembl : ENSG00000141552
HPRD : 12452
Vega : OTTHUMG00000177982
ProteinUniProt: Q9NYG5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ANAPC11
BioGPS: 51529
PathwayNCI Pathway Interaction Database: ANAPC11
Pathway Commons: ANAPC11
ContextiHOP: ANAPC11
ligand binding site mutation search in PubMed: ANAPC11
UCL Cancer Institute: ANAPC11
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0016567protein ubiquitination11739784
GO:0070979protein K11-linked ubiquitination18485873

Ligand binding site mutations for ANAPC11

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ANAPC11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ANAPC11 from PDB

Differential gene expression and gene-gene network for ANAPC11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ANAPC11 and the right PPI network was created from samples without mutations in the LBS of ANAPC11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ANAPC11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ANAPC11
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ANAPC11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ANAPC11
Multiple alignments for Q9NYG5 in multiple species
LBSAA sequence# speciesSpecies
C23EN---CGICRM3Homo sapiens, Bos taurus, Mus musculus
C23EDEDVCGICRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C23DV---CGICRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C23ET---CGICRM1Arabidopsis thaliana
C26--CGICRMAFN3Homo sapiens, Bos taurus, Mus musculus
C26DVCGICRASYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C26--CGICRVPFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C26--CGICRMAFD1Arabidopsis thaliana
C34AFNGCCPDCKV3Homo sapiens, Bos taurus, Mus musculus
C34SYNGTCPSCKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C34PFDGCCPQCTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C34AFDGCCPDCKL1Arabidopsis thaliana
C37GCCPDCKVPGD3Homo sapiens, Bos taurus, Mus musculus
C37GTCPSCKFPGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C37GCCPQCTSPGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C37GCCPDCKLPGD1Arabidopsis thaliana
C44VPGDDCPLVWG3Homo sapiens, Bos taurus, Mus musculus
C44FPGDQCPLVIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C44SPGDNCPIVWG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C44LPGDDCPLIWG1Arabidopsis thaliana
C51LVWGQCSHCFH3Homo sapiens, Bos taurus, Mus musculus
C51LVIGLCHHNFH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C51IVWGKCKHIFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C51LIWGACNHAFH1Arabidopsis thaliana
C59CFHMHCILKWL3Homo sapiens, Bos taurus, Mus musculus
C59NFHDHCIYRWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C59IFHAHCIQNWL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C59AFHLHCILKWV1Arabidopsis thaliana
C73QVQQHCPMCRQ3Homo sapiens, Bos taurus, Mus musculus
C73TSKGLCPMCRQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C73GSQGQCPMDRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C73TSQAHCPMCRR1Arabidopsis thaliana
C76QHCPMCRQEWK3Homo sapiens, Bos taurus, Mus musculus
C76GLCPMCRQTFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C76GQCPMDRQTFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C76AHCPMCRREWQ1Arabidopsis thaliana
H53WGQCSHCFHMH3Homo sapiens, Bos taurus, Mus musculus
H53IGLCHHNFHDH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H53WGKCKHIFHAH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H53WGACNHAFHLH1Arabidopsis thaliana
H56CSHCFHMHCIL3Homo sapiens, Bos taurus, Mus musculus
H56CHHNFHDHCIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H56CKHIFHAHCIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H56CNHAFHLHCIL1Arabidopsis thaliana
H58HCFHMHCILKW3Homo sapiens, Bos taurus, Mus musculus
H58HNFHDHCIYRW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H58HIFHAHCIQNW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H58HAFHLHCILKW1Arabidopsis thaliana
I25---CGICRMAF4Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus
I25EDVCGICRASY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I25---CGICRVPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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