mutLBSgeneDB |
Gene summary for ANAPC11 |
Gene summary |
Basic gene Info. | Gene symbol | ANAPC11 |
Gene name | anaphase promoting complex subunit 11 | |
Synonyms | APC11|Apc11p | |
Cytomap | UCSC genome browser: 17q25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001002244.2, NM_001002245.2,NM_001002246.2,NM_001002247.2,NM_001002248.2, NM_001002249.2,NM_001289414.1,NM_001289415.1,NM_001289416.1, NM_001289417.1,NM_001289418.1,NM_001289419.1,NM_001289420.1, NM_016476.11, | |
Description | APC11 anaphase promoting complex subunit 11 homologanaphase promoting complex subunit 11 (yeast APC11 homolog)anaphase-promoting complex subunit 11cyclosome subunit 11hepatocellular carcinoma-associated RING finger protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 614534 | |
HGNC : HGNC | ||
Ensembl : ENSG00000141552 | ||
HPRD : 12452 | ||
Vega : OTTHUMG00000177982 | ||
Protein | UniProt: Q9NYG5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ANAPC11 | |
BioGPS: 51529 | ||
Pathway | NCI Pathway Interaction Database: ANAPC11 | |
KEGG: ANAPC11 | ||
REACTOME: ANAPC11 | ||
Pathway Commons: ANAPC11 | ||
Context | iHOP: ANAPC11 | |
ligand binding site mutation search in PubMed: ANAPC11 | ||
UCL Cancer Institute: ANAPC11 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0016567 | protein ubiquitination | 11739784 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
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Ligand binding site mutations for ANAPC11 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C44 | D43Y | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ANAPC11 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C44 | D43Y | -0.1183779 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ANAPC11 from PDB |
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Differential gene expression and gene-gene network for ANAPC11 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ANAPC11 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ANAPC11 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ANAPC11 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4r2y | A | C44 | ZN | ZINC(2+) | 4r2y | B | C44 | ZN | ZINC(2+) | 4r2y | C | C44 | ZN | ZINC(2+) | 4r2y | D | C44 | ZN | ZINC(2+) | 4ui9 | B | C44 | ZN | ZINC(2+) | 5a31 | B | C44 |
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Conservation information for LBS of ANAPC11 |
Multiple alignments for Q9NYG5 in multiple species |
LBS | AA sequence | # species | Species | C23 | EN---CGICRM | 3 | Homo sapiens, Bos taurus, Mus musculus | C23 | EDEDVCGICRA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C23 | DV---CGICRV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C23 | ET---CGICRM | 1 | Arabidopsis thaliana | C26 | --CGICRMAFN | 3 | Homo sapiens, Bos taurus, Mus musculus | C26 | DVCGICRASYN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C26 | --CGICRVPFD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C26 | --CGICRMAFD | 1 | Arabidopsis thaliana | C34 | AFNGCCPDCKV | 3 | Homo sapiens, Bos taurus, Mus musculus | C34 | SYNGTCPSCKF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C34 | PFDGCCPQCTS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C34 | AFDGCCPDCKL | 1 | Arabidopsis thaliana | C37 | GCCPDCKVPGD | 3 | Homo sapiens, Bos taurus, Mus musculus | C37 | GTCPSCKFPGD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C37 | GCCPQCTSPGD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C37 | GCCPDCKLPGD | 1 | Arabidopsis thaliana | C44 | VPGDDCPLVWG | 3 | Homo sapiens, Bos taurus, Mus musculus | C44 | FPGDQCPLVIG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C44 | SPGDNCPIVWG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C44 | LPGDDCPLIWG | 1 | Arabidopsis thaliana | C51 | LVWGQCSHCFH | 3 | Homo sapiens, Bos taurus, Mus musculus | C51 | LVIGLCHHNFH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C51 | IVWGKCKHIFH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C51 | LIWGACNHAFH | 1 | Arabidopsis thaliana | C59 | CFHMHCILKWL | 3 | Homo sapiens, Bos taurus, Mus musculus | C59 | NFHDHCIYRWL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C59 | IFHAHCIQNWL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C59 | AFHLHCILKWV | 1 | Arabidopsis thaliana | C73 | QVQQHCPMCRQ | 3 | Homo sapiens, Bos taurus, Mus musculus | C73 | TSKGLCPMCRQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C73 | GSQGQCPMDRQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C73 | TSQAHCPMCRR | 1 | Arabidopsis thaliana | C76 | QHCPMCRQEWK | 3 | Homo sapiens, Bos taurus, Mus musculus | C76 | GLCPMCRQTFQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C76 | GQCPMDRQTFV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C76 | AHCPMCRREWQ | 1 | Arabidopsis thaliana | H53 | WGQCSHCFHMH | 3 | Homo sapiens, Bos taurus, Mus musculus | H53 | IGLCHHNFHDH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H53 | WGKCKHIFHAH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H53 | WGACNHAFHLH | 1 | Arabidopsis thaliana | H56 | CSHCFHMHCIL | 3 | Homo sapiens, Bos taurus, Mus musculus | H56 | CHHNFHDHCIY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H56 | CKHIFHAHCIQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H56 | CNHAFHLHCIL | 1 | Arabidopsis thaliana | H58 | HCFHMHCILKW | 3 | Homo sapiens, Bos taurus, Mus musculus | H58 | HNFHDHCIYRW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H58 | HIFHAHCIQNW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H58 | HAFHLHCILKW | 1 | Arabidopsis thaliana | I25 | ---CGICRMAF | 4 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus | I25 | EDVCGICRASY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I25 | ---CGICRVPF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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