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mutLBSgeneDB |
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| Gene summary for LARP7 |
 Gene summary |
| Basic gene Info. | Gene symbol | LARP7 |
| Gene name | La ribonucleoprotein domain family, member 7 | |
| Synonyms | ALAZS|PIP7S | |
| Cytomap | UCSC genome browser: 4q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001267039.1, NM_015454.2,NM_016648.3,NR_049768.1, | |
| Description | P-TEFb-interaction protein for 7SK stabilityla-related protein 7 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612026 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000174720 | ||
| HPRD : 17095 | ||
| Vega : OTTHUMG00000132909 | ||
| Protein | UniProt: Q4G0J3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LARP7 | |
| BioGPS: 51574 | ||
| Pathway | NCI Pathway Interaction Database: LARP7 | |
| KEGG: LARP7 | ||
| REACTOME: LARP7 | ||
| Pathway Commons: LARP7 | ||
| Context | iHOP: LARP7 | |
| ligand binding site mutation search in PubMed: LARP7 | ||
| UCL Cancer Institute: LARP7 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LARP7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F77 | S76Y | BRCA | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LARP7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F77 | S76Y | -0.74490199 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LARP7 from PDB |
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| Differential gene expression and gene-gene network for LARP7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LARP7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C3714756 | Intellectual Disability | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LARP7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LARP7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 4wkr | A | F77 | NUC | Nucleic Acids | 4wkr | B | F77 |
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| Conservation information for LBS of LARP7 |
| Multiple alignments for Q4G0J3 in multiple species |
| LBS | AA sequence | # species | Species | D54 | ANLHKDRFLRE | 2 | Homo sapiens, Rattus norvegicus | D54 | VNLHKDRFMKS | 1 | Danio rerio | D54 | VNLHKDRFLRE | 1 | Xenopus tropicalis | D54 | ANLHKDKFLRE | 1 | Mus musculus | F44 | AKQVDFWFGDA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F44 | KKQVEFWFGDV | 1 | Danio rerio | F44 | AKQVDFWFGDV | 1 | Xenopus tropicalis | F56 | LHKDRFLREQI | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | F56 | LHKDRFMKSII | 1 | Danio rerio | F56 | LHKDKFLREQI | 1 | Mus musculus | F77 | SLLVSFNKMKK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F77 | AVLTTFNRMKN | 1 | Danio rerio | F77 | SLLASFNKMKK | 1 | Xenopus tropicalis | H138 | PKNVTHSWIER | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | H138 | PKNVNHSWIER | 1 | Homo sapiens | H138 | PKTVTHIWLER | 1 | Danio rerio | I154 | GNVVYISIPHY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I154 | GHVVYISIPRY | 1 | Danio rerio | I154 | GMVVYVSIPRY | 1 | Xenopus tropicalis | K79 | LVSFNKMKKLT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K79 | LTTFNRMKNLT | 1 | Danio rerio | K79 | LASFNKMKKIT | 1 | Xenopus tropicalis | L57 | HKDRFLREQIE | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | L57 | HKDRFMKSIIE | 1 | Danio rerio | L57 | HKDKFLREQIE | 1 | Mus musculus | N78 | LLVSFNKMKKL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N78 | VLTTFNRMKNL | 1 | Danio rerio | N78 | LLASFNKMKKI | 1 | Xenopus tropicalis | Q41 | ADIAKQVDFWF | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | Q41 | SDVKKQVEFWF | 1 | Danio rerio | W45 | KQVDFWFGDAN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W45 | KQVEFWFGDVN | 1 | Danio rerio | W45 | KQVDFWFGDVN | 1 | Xenopus tropicalis | Y153 | CGNVVYISIPH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y153 | CGHVVYISIPR | 1 | Danio rerio | Y153 | YGMVVYVSIPR | 1 | Xenopus tropicalis |
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