mutLBSgeneDB |
Gene summary for HSPB11 |
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Basic gene Info. | Gene symbol | HSPB11 |
Gene name | heat shock protein family B (small), member 11 | |
Synonyms | C1orf41|HSPCO34|IFT25|PP25 | |
Cytomap | UCSC genome browser: 1p32 | |
Type of gene | protein-coding | |
RefGenes | NM_016126.2, | |
Description | heat shock protein beta-11intraflagellar transport 25 homologintraflagellar transport protein 25 homologplacental protein 25 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000081870 | ||
Vega : OTTHUMG00000008408 | ||
Protein | UniProt: Q9Y547 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HSPB11 | |
BioGPS: 51668 | ||
Pathway | NCI Pathway Interaction Database: HSPB11 | |
KEGG: HSPB11 | ||
REACTOME: HSPB11 | ||
Pathway Commons: HSPB11 | ||
Context | iHOP: HSPB11 | |
ligand binding site mutation search in PubMed: HSPB11 | ||
UCL Cancer Institute: HSPB11 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for HSPB11 |
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LBS | AAchange of nsSNV | Cancer type | # samples | T37 | T37M | BLCA | 1 | H130 | V132I | COAD | 1 | T37 | F38V | STAD | 1 | H130 | V132I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for HSPB11 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T37 | T37M | -1.3066917 | T37 | F38V | -0.87675339 | H130 | V132I | -0.76739626 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for HSPB11 |
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Phenotype information for HSPB11 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for HSPB11 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1tvg | A | T37 H130 |
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Conservation information for LBS of HSPB11 |
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LBS | AA sequence | # species | Species |
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