mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HSPB11
Gene summary
Basic gene Info.Gene symbolHSPB11
Gene nameheat shock protein family B (small), member 11
SynonymsC1orf41|HSPCO34|IFT25|PP25
CytomapUCSC genome browser: 1p32
Type of geneprotein-coding
RefGenesNM_016126.2,
Descriptionheat shock protein beta-11intraflagellar transport 25 homologintraflagellar transport protein 25 homologplacental protein 25
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000081870
Vega : OTTHUMG00000008408
ProteinUniProt: Q9Y547
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSPB11
BioGPS: 51668
PathwayNCI Pathway Interaction Database: HSPB11
KEGG: HSPB11
REACTOME: HSPB11
Pathway Commons: HSPB11
ContextiHOP: HSPB11
ligand binding site mutation search in PubMed: HSPB11
UCL Cancer Institute: HSPB11
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for HSPB11

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T37T37MBLCA1
H130V132ICOAD1
T37F38VSTAD1
H130V132IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HSPB11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T37T37M-1.3066917
T37F38V-0.87675339
H130V132I-0.76739626
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HSPB11 from PDB

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Differential gene expression and gene-gene network for HSPB11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HSPB11 and the right PPI network was created from samples without mutations in the LBS of HSPB11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HSPB11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HSPB11
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HSPB11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1tvgAT37 H130


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Conservation information for LBS of HSPB11
Multiple alignments for Q9Y547 in multiple species
LBSAA sequence# speciesSpecies


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