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mutLBSgeneDB |
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| Gene summary for CDK12 |
 Gene summary |
| Basic gene Info. | Gene symbol | CDK12 |
| Gene name | cyclin-dependent kinase 12 | |
| Synonyms | CRK7|CRKR|CRKRS | |
| Cytomap | UCSC genome browser: 17q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015083.2, NM_016507.3, | |
| Description | CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615514 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167258 | ||
| HPRD : 10849 | ||
| Vega : OTTHUMG00000133214 | ||
| Protein | UniProt: Q9NYV4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDK12 | |
| BioGPS: 51755 | ||
| Pathway | NCI Pathway Interaction Database: CDK12 | |
| KEGG: CDK12 | ||
| REACTOME: CDK12 | ||
| Pathway Commons: CDK12 | ||
| Context | iHOP: CDK12 | |
| ligand binding site mutation search in PubMed: CDK12 | ||
| UCL Cancer Institute: CDK12 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046777 | protein autophosphorylation | 11683387 |
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| Ligand binding site mutations for CDK12 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K756 | V758L | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CDK12 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K756 | V758L | -0.74041335 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CDK12 from PDB |
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| Differential gene expression and gene-gene network for CDK12 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CDK12 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CDK12 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CDK12 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 4nst | A | K756 | ADP | ADP | 4nst | C | K756 | ANP | AMP-PNP | 4cxa | A | K756 |
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| Conservation information for LBS of CDK12 |
| Multiple alignments for Q9NYV4 in multiple species |
| LBS | AA sequence | # species | Species | A754 | TGELVALKKVR | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | D819 | EYMDHDLMGLL | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | D859 | NFLHRDIKCSN | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | D877 | QIKLADFGLAR | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | E735 | IGIIGEGTYGQ | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | E814 | FYLVFEYMDHD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | F813 | AFYLVFEYMDH | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | G736 | GIIGEGTYGQV | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | H1040 | HWQDCHELWSK | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | H999 | LDLLDHMLTLD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | I733 | DIIGIIGEGTY | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | K756 | ELVALKKVRLD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | K861 | LHRDIKCSNIL | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | L866 | KCSNILLNNSG | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | M816 | LVFEYMDHDLM | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | N864 | DIKCSNILLNN | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | S1017 | EQTLQSDFLKD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | S863 | RDIKCSNILLN | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T737 | IIGEGTYGQVY | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | Y815 | YLVFEYMDHDL | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus |
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