mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PGR

Gene summary

Basic gene Info.	Gene symbol	PGR
	Gene name	progesterone receptor
	Synonyms	NR3C3\|PR
	Cytomap	UCSC genome browser: 11q22-q23
	Type of gene	protein-coding
	RefGenes	NM_000926.4, NM_001202474.3,NM_001271161.2,NR_073141.2,NR_073142.2, NR_073143.2,NM_001271162.1,
	Description	nuclear receptor subfamily 3 group C member 3
	Modification date	20141207
dbXrefs	MIM : 607311
	HGNC : HGNC
	Ensembl : ENSG00000082175
	HPRD : 07077
	Vega : OTTHUMG00000167531
Protein	UniProt: P06401 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PGR
	BioGPS: 5241
Pathway	NCI Pathway Interaction Database: PGR
	KEGG: PGR
	REACTOME: PGR
	Pathway Commons: PGR
Context	iHOP: PGR
	ligand binding site mutation search in PubMed: PGR
	UCL Cancer Institute: PGR
Assigned class in mutLBSgeneDB	A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PGR.	1. Kubota, K., Cui, W., Dhakal, P., Wolfe, M. W., Rumi, M. K., Vivian, J. L., ... & Soares, M. J. (2016). Rethinking progesterone regulation of female reproductive cyclicity. Proceedings of the National Academy of Sciences,113(15), 4212-4217. 27035990

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	17785366

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Ligand binding site mutations for PGR

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E723	E723K	BRCA	1
L763	G762V	BRCA	1
Q747,D745	D746Y	COAD	1
M756	S757I	COAD	1
C584	L582F	GBM	1
E723	E723K	HNSC	1
G635	L634R	LUAD	1
K588	K588M	LUAD	1
M909	S910F	LUSC	1
I751	I751F	OV	1
M909,F905	E907K	SKCM	1
R637	R637L	SKCM	1
V912	E911D	STAD	1
R740	R740Q	STAD	1
C567	I566S	UCEC	1
K734	S733Y	UCEC	1
R623	R623H	UCEC	1
R740	R740Q	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PGR

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E723	E723K	-1.1997083
C567	I566S	-1.1449584
F905	E907K	-1.100191
M909	E907K	-1.100191
G635	L634R	-0.97735472
I751	I751F	-0.78755295
L763	G762V	-0.772838
D745	D746Y	-0.70773492
Q747	D746Y	-0.70773492
R637	R637L	-0.66149396
K734	S733Y	-0.65025483
K588	K588M	-0.59144382
R623	R623H	-0.57601158
V912	E911D	-0.5636496
C584	L582F	-0.55342392
M909	S910F	-0.38354356
M756	S757I	-0.24293248
R740	R740Q	-0.21716933

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PGR from PDB

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Differential gene expression and gene-gene network for PGR

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PGR and the right PPI network was created from samples without mutations in the LBS of PGR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PGR

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	89	AlteredExpression, Biomarker, GeneticVariation
umls:C0014175	Endometriosis	43	AlteredExpression, Biomarker, GeneticVariation
umls:C0007097	Carcinoma	30	AlteredExpression, Biomarker
umls:C0025286	Meningioma	16	AlteredExpression, Biomarker
umls:C0014170	Endometrial Neoplasms	14	AlteredExpression, Biomarker, GeneticVariation
umls:C0001418	Adenocarcinoma	11	Biomarker
umls:C0024667	Mammary Neoplasms, Animal	2	Biomarker, GeneticVariation
umls:C0024668	Mammary Neoplasms, Experimental	1	Biomarker
umls:C0025500	Mesothelioma	1	Biomarker
umls:C2825055	Recurrence	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PGR

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|investigational	DB00294	Etonogestrel	Small molecule
Approved	DB00304	Desogestrel	Small molecule
Approved\|vet_approved	DB00351	Megestrol acetate	Small molecule
Approved\|investigational	DB00367	Levonorgestrel	Small molecule
Approved\|withdrawn	DB00378	Dydrogesterone	Small molecule
Approved\|vet_approved	DB00396	Progesterone	Small molecule
Approved	DB00421	Spironolactone	Small molecule
Approved	DB00588	Fluticasone Propionate	Small molecule
Approved\|investigational	DB00603	Medroxyprogesterone acetate	Small molecule
Approved	DB00717	Norethisterone	Small molecule
Approved	DB00823	Ethynodiol diacetate	Small molecule
Approved\|investigational	DB00834	Mifepristone	Small molecule
Approved	DB00957	Norgestimate	Small molecule
Approved	DB01395	Drospirenone	Small molecule
Approved	DB01406	Danazol	Small molecule
Approved	DB01431	Allylestrenol	Small molecule
Experimental	DB02998	Methyltrienolone	Small molecule
Investigational	DB04787	Tanaproget	Small molecule
Investigational	DB05253	Proellex	Small molecule
Investigational	DB05366	CDB-2914	Small molecule
Approved	DB06713	Norelgestromin	Small molecule
Approved	DB06789	Hydroxyprogesterone caproate	Small molecule
Approved	DB08867	Ulipristal	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PGR go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ZN		ZINC(2+)	2c7a	A	C567 C584
ZN		ZINC(2+)	2c7a	B	C567 C584
2S0	ULIPRISTAL ACETATE	[(8S,11R,13S,14S,17R)-17-ACETYL-11-[4-(DIMETHYLAMINO) PHENYL]-13-METHYL-3-OXO-1,2,6,7,8,11,12,14,15,16- DECAHYDROCYCLOPENTA[A]PHENANTHREN-17-YL] ACETATE	4oar	A	E723
AS0		4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME	2ovm	A	E723 M756
AS0		4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME	4a2j	A	E723 M756 M909
AS0		4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME	4a2j	B	E723 M756 M909
486		MIFEPRISTONE	2w8y	A	E723 M756 M909 V912
T98		TANAPROGET	1zuc	A	F905
WOW		2-CHLORO-4-{(2-METHYLBENZYL)[(3S)-1-(METHYLSULFONYL)PYRROLIDIN-3-YL]AMINO}BENZONITRILE	3kba	B	F905
NUC		Nucleic Acids	2c7a	A	K588 G635 R637
NUC		Nucleic Acids	2c7a	B	K588 R637
III		Peptide ligand (GLY,LEU,GLU,ALA,ILE,ILE,ARG,LYS,ALA,LEU,MET)	4oar	A	K734 R740 D745 I751
III		Peptide ligand (GLY,LEU,GLU,ALA,ILE,ILE,ARG,LYS,ALA,LEU,MET,GLY,LYS)	2ovh	A	K734 R740 I751
III		Peptide ligand (LEU,GLU,ASP,ILE,ILE,ARG,LYS,ALA,LEU,MET,GLY)	2ovm	A	K734 R740 Q747 I751
WOW		2-CHLORO-4-{(2-METHYLBENZYL)[(3S)-1-(METHYLSULFONYL)PYRROLIDIN-3-YL]AMINO}BENZONITRILE	3kba	A	L763 F905
R18		17BETA-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE	1e3k	B	M756
NDR		(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE	1sqn	B	M756
AS0		4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME	2ovh	A	M756
NDR		(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE	2w8y	B	M756
NOG		NORGESTREL	3d90	A	M756
MOF		MOMETASONE FUROATE	1sr7	B	M756 F905
T98		TANAPROGET	1zuc	B	M756 F905
NOG		NORGESTREL	3d90	B	M756 F905
MOF		MOMETASONE FUROATE	1sr7	A	M756 F905 M909
OR8		2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE	3zr7	B	M756 F905 M909
ORB		N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE	3zra	B	M756 F905 M909
ORC		(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL) PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE	3zrb	B	M756 F905 M909
A2K		(8S,11R,13S,14S,16S,17S)-17-CYCLOPROPYLCARBONYL-16-ETHENYL-13-METHYL-11-(4-PYRIDINYLPHENYL)-2,6,7,8,11,12,14,15,16,17-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE	4apu	B	M756 F905 M909 V912
30X		N~2~-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-N,N-DIMETHYL-N~2~-(2,2,2-TRIFLUOROETHYL)-L-ALANINAMIDE	3g8o	A	M756 L763 F905 M909
30X		N~2~-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-N,N-DIMETHYL-N~2~-(2,2,2-TRIFLUOROETHYL)-L-ALANINAMIDE	3g8o	B	M756 L763 F905 M909
GKK		2-CHLORO-4-{[(3S)-1-METHYLPYRROLIDIN-3-YL][2-(TRIFLUOROMETHYL)BENZYL]AMINO}BENZONITRILE	3hq5	A	M756 L763 F905 M909
GKK		2-CHLORO-4-{[(3S)-1-METHYLPYRROLIDIN-3-YL][2-(TRIFLUOROMETHYL)BENZYL]AMINO}BENZONITRILE	3hq5	B	M756 L763 F905 M909
OR8		2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE	3zr7	A	M756 L763 F905 M909
ORB		N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE	3zra	A	M756 L763 F905 M909
STR		PROGESTERONE	1a28	A	M756 M909
STR		PROGESTERONE	1a28	B	M756 M909
R18		17BETA-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE	1e3k	A	M756 M909
NDR		(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE	1sqn	A	M756 M909
OR8		2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE	3zrb	A	M756 M909
OR8		2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE	4apu	A	M756 M909
NUC		Nucleic Acids	2c7a	A	R623
NUC		Nucleic Acids	2c7a	B	R623

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Conservation information for LBS of PGR

Multiple alignments for P06401 in multiple species

LBS	AA sequence	# species	Species
C567	LPQKICLICGD	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C570	KICLICGDEAS	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C577	DEASGCHYGVL	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C584	YGVLTCGSCKV	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C587	LTCGSCKVFFK	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C798	SFYSLCLTMWQ	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C798	SFYSLCLSMWQ	1	Gallus gallus
C891	QLHLYCLNTFI	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
C891	QLHLFCLNTFL	1	Gallus gallus
D745	RNLHIDDQITL	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
E723	LNQLGERQLLS	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
E723	LNHLCERQLLC	1	Gallus gallus
F778	GQMLYFAPDLI	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
F794	MKESSFYSLCL	4	Homo sapiens, Gallus gallus, Canis lupus familiaris, Pan troglodytes
F794	MKELSFYSLCL	1	Rattus norvegicus
F905	ALSVEFPEMMS	4	Homo sapiens, Gallus gallus, Canis lupus familiaris, Pan troglodytes
F905	ALAVEFPEMMS	1	Rattus norvegicus
G576	GDEASGCHYGV	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
G585	GVLTCGSCKVF	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
G635	AGMVLGGRKFK	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
G636	GMVLGGRKFKK	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
G722	SLNQLGERQLL	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
G722	SLNHLCERQLL	1	Gallus gallus
H578	EASGCHYGVLT	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
I744	FRNLHIDDQIT	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
I748	HIDDQITLIQY	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
I751	DQITLIQYSWM	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
I913	MMSEVIAAQLP	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K588	TCGSCKVFFKR	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K592	CKVFFKRAMEG	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K617	DKIRRKNCPAC	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K638	VLGGRKFKKFN	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K638	VLGGRKFKKLN	1	Gallus gallus
K734	VVKWSKSLPGF	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
K734	VVKWSKLLPGF	1	Gallus gallus
L715	TSSSLLTSLNQ	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L715	TPSSLLTSLNH	1	Gallus gallus
L718	SLLTSLNQLGE	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L718	SLLTSLNHLCE	1	Gallus gallus
L721	TSLNQLGERQL	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L721	TSLNHLCERQL	1	Gallus gallus
L726	LGERQLLSVVK	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L726	LCERQLLCVVK	1	Gallus gallus
L763	LMVFGLGWRSY	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L763	LMVFAMGWRSY	1	Gallus gallus
L797	SSFYSLCLTMW	3	Homo sapiens, Canis lupus familiaris, Pan troglodytes
L797	SSFYSLCLSMW	1	Gallus gallus
L797	LSFYSLCLTMW	1	Rattus norvegicus
L887	DLVKQLHLYCL	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
L887	DLVKQLHLFCL	1	Gallus gallus
M756	IQYSWMSLMVF	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
M759	SWMSLMVFGLG	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
M759	SWMSLMVFAMG	1	Gallus gallus
M801	SLCLTMWQIPQ	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
M801	SLCLSMWQLPQ	1	Gallus gallus
M909	EFPEMMSEVIA	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
N719	LLTSLNQLGER	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
N719	LLTSLNHLCER	1	Gallus gallus
Q725	QLGERQLLSVV	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
Q725	HLCERQLLCVV	1	Gallus gallus
Q747	LHIDDQITLIQ	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
Q752	QITLIQYSWMS	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R593	KVFFKRAMEGQ	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R616	VDKIRRKNCPA	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R623	NCPACRLRKCC	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R637	MVLGGRKFKKF	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R637	MVLGGRKFKKL	1	Gallus gallus
R740	SLPGFRNLHID	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R740	LLPGFRNLHID	1	Gallus gallus
R766	FGLGWRSYKHV	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
R766	FAMGWRSYKHV	1	Gallus gallus
S586	VLTCGSCKVFF	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
T894	LYCLNTFIQSR	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
T894	LFCLNTFLQSR	1	Gallus gallus
V589	CGSCKVFFKRA	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
V730	QLLSVVKWSKS	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
V730	QLLCVVKWSKL	1	Gallus gallus
V760	WMSLMVFGLGW	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
V760	WMSLMVFAMGW	1	Gallus gallus
V912	EMMSEVIAAQL	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
W755	LIQYSWMSLMV	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
Y579	ASGCHYGVLTC	5	Homo sapiens, Gallus gallus, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
Y890	KQLHLYCLNTF	4	Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Pan troglodytes
Y890	KQLHLFCLNTF	1	Gallus gallus