mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SERPINE2
Gene summary
Basic gene Info.Gene symbolSERPINE2
Gene nameserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SynonymsGDN|GDNPF|PI-7|PI7|PN-1|PN1|PNI
CytomapUCSC genome browser: 2q36.1
Type of geneprotein-coding
RefGenesNM_001136528.1,
NM_001136530.1,NM_006216.3,NR_073116.1,
Descriptionglia-derived nexinglial-derived neurite promoting factorpeptidase inhibitor 7protease nexin Iserpin E2
Modification date20141207
dbXrefs MIM : 177010
HGNC : HGNC
Ensembl : ENSG00000135919
HPRD : 01510
Vega : OTTHUMG00000133163
ProteinUniProt: P07093
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SERPINE2
BioGPS: 5270
PathwayNCI Pathway Interaction Database: SERPINE2
KEGG: SERPINE2
REACTOME: SERPINE2
Pathway Commons: SERPINE2
ContextiHOP: SERPINE2
ligand binding site mutation search in PubMed: SERPINE2
UCL Cancer Institute: SERPINE2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0030195negative regulation of blood coagulation17379830
GO:0045861negative regulation of proteolysis17379830
GO:0048711positive regulation of astrocyte differentiation1691280


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Ligand binding site mutations for SERPINE2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T328I327MBRCA1
E123P125HCOAD1
T328I327TLUAD1
G330G330EOV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SERPINE2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E123P125H-0.93567561
T328I327T-0.86266693
T328I327M-0.66430995
G330G330E-0.22411669
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SERPINE2 from PDB

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Differential gene expression and gene-gene network for SERPINE2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SERPINE2 and the right PPI network was created from samples without mutations in the LBS of SERPINE2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SERPINE2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SERPINE2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SERPINE2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of SERPINE2
Multiple alignments for P07093 in multiple species
LBSAA sequence# speciesSpecies
A325SKANFAKITTG1Homo sapiens
A325SKANFTKITR-1Mus musculus
A325SKANFAKITR-1Rattus norvegicus
E123NASEIEVPFVT1Homo sapiens
E123NGFKMEVPFAV1Mus musculus
E123NGFKVEVPFAA1Rattus norvegicus
G330AKITTGSENLH1Homo sapiens
G330TKITR-SESLH1Mus musculus
G330AKITR-SESLH1Rattus norvegicus
T328NFAKITTGSEN1Homo sapiens
T328NFTKITR-SES1Mus musculus
T328NFAKITR-SES1Rattus norvegicus
T329FAKITTGSENL1Homo sapiens
T329FTKITR-SESL1Mus musculus
T329FAKITR-SESL1Rattus norvegicus


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