mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PIK3CG
Gene summary
Basic gene Info.Gene symbolPIK3CG
Gene namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
SynonymsPI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K
CytomapUCSC genome browser: 7q22.3
Type of geneprotein-coding
RefGenesNM_001282426.1,
NM_001282427.1,NM_002649.3,
Description1-phosphatidylinositol 3-kinasePI3-kinase subunit gammaphosphatidylinositol 3 kinase gamma, p110 gammaphosphatidylinositol 3-kinase catalytic 110-kD gammaphosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformphosphatidylinosit
Modification date20141207
dbXrefs MIM : 601232
HGNC : HGNC
Ensembl : ENSG00000105851
HPRD : 03135
Vega : OTTHUMG00000157641
ProteinUniProt: P48736
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PIK3CG
BioGPS: 5294
PathwayNCI Pathway Interaction Database: PIK3CG
KEGG: PIK3CG
REACTOME: PIK3CG
Pathway Commons: PIK3CG
ContextiHOP: PIK3CG
ligand binding site mutation search in PubMed: PIK3CG
UCL Cancer Institute: PIK3CG
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007186G-protein coupled receptor signaling pathway12507995
GO:0014065phosphatidylinositol 3-kinase signaling12507995
GO:0043406positive regulation of MAP kinase activity12507995
GO:0051897positive regulation of protein kinase B signaling12507995


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Ligand binding site mutations for PIK3CG

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F965G966WCOAD1
A885A885TGBM1
L838,Q840R839CHNSC1
Y867Y867CLUAD1
A885A885TSKCM1
Y867G868DSKCM1
A885A885TSTAD1
P810P810TSTAD1
E880E880KUCEC1
V803V803LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PIK3CG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A885A885T-1.3322495
Y867Y867C-1.2250856
Y867G868D-1.008528
E880E880K-0.9946936
P810P810T-0.97267425
V803V803L-0.8770461
L838R839C-0.76750021
Q840R839C-0.76750021
F965G966W-0.60605503
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PIK3CG from PDB

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Differential gene expression and gene-gene network for PIK3CG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PIK3CG and the right PPI network was created from samples without mutations in the LBS of PIK3CG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PIK3CG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0079744Lymphoma, Large B-Cell, Diffuse9Biomarker
umls:C0025149Medulloblastoma6Biomarker
umls:C0018801Heart Failure4Biomarker
umls:C0016059Fibrosis2Biomarker
umls:C0004352Autistic Disorder2Biomarker
umls:C0018800Cardiomegaly1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PIK3CG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02010StaurosporineSmall molecule
ExperimentalDB02375MyricetinSmall molecule
ExperimentalDB026562-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-OneSmall molecule
ExperimentalDB04216QuercetinSmall molecule
ExperimentalDB047695-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONESmall molecule
InvestigationalDB05241XL765Small molecule
ExperimentalDB068312-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONESmall molecule
ExperimentalDB06836N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDESmall molecule
ExperimentalDB070735,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-oneSmall molecule
ExperimentalDB073353-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLSmall molecule
ExperimentalDB07503(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONESmall molecule
ExperimentalDB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall molecule
ExperimentalDB083001-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PIK3CG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
DW2RU-PYRIDOCARBAZOLE-23csfAA885
MMY5-(2-MORPHOLIN-4-YL-7-PYRIDIN-3-YL-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PYRIMIDIN-2-YLAMINE3apdAE880
0SE2-(1-{[2-(2-AMINOPYRIMIDIN-5-YL)-4-(MORPHOLIN-4-YL) PYRIDO[3,2-D]PYRIMIDIN-6-YL]METHYL}PIPERIDIN-4-YL) PROPAN-2-OL4ezlAE880
ZW3N-{6-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]IMIDAZO[1,2-A]PYRIDIN-2-YL}ACETAMIDE3zw3AE880 A885
MMD5-(7-METHANESULFONYL-2-MORPHOLIN-4-YL-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PYRIMIDIN-2-YLAMINE3apcAL838 E880
NPZ1-METHYL-3-NAPHTHALEN-2-YL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE3eneAL838 E880
JZX5-(6-{[4-(METHYLSULFONYL)PIPERAZIN-1-YL]METHYL}-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL)PYRIDIN-2-AMINE3l16AL838 E880
JZY4-METHYL-5-(6-{[4-(METHYLSULFONYL)PIPERAZIN-1-YL]METHYL}-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL)PYRIMIDIN-2-AMINE3l17AL838 E880
13KN~6~-(3,4-DIMETHOXYPHENYL)-2-(MORPHOLIN-4-YL)-4,5'- BIPYRIMIDINE-2',6-DIAMINE3tjpAL838 E880
980(2S)-1-(4-{[2-(2-AMINOPYRIMIDIN-5-YL)-7-METHYL-4-(MORPHOLIN-4-YL)THIENO[3,2-D]PYRIMIDIN-6-YL]METHYL}PIPERAZIN-1-YL)-2-HYDROXYPROPAN-1-ONE3tl5AL838 E880
L641-(4-{4-MORPHOLIN-4-YL-1-[1-(PYRIDIN-3-YLCARBONYL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL}PHENYL)-3-PYRIDIN-4-YLUREA3ibeAL838 Q840 E880
JZW[3-(6-{[4-(METHYLSULFONYL)PIPERAZIN-1-YL]METHYL}-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL)PHENYL]METHANOL3l13AL838 Y867 E880
3PS4-AMINO-N-(6-METHOXYPYRIDIN-3-YL)-2-METHYLQUINAZOLINE-8-CARBOXAMIDE3ps6AL838 Y867 E880
0KO4-(2-[(6-METHOXYPYRIDIN-3-YL)AMINO]-5-{[4-(METHYLSULFONYL)PIPERAZIN-1-YL]METHYL}PYRIDIN-3-YL)-6-METHYL-1,3,5-TRIAZIN-2-AMINE4dk5AL838 Y867 E880
14K4-(2-[(5-FLUORO-6-METHOXYPYRIDIN-3-YL)AMINO]-5-{(1R)-1- [4-(METHYLSULFONYL)PIPERAZIN-1-YL]ETHYL}PYRIDIN-3-YL)- 6-METHYL-1,3,5-TRIAZIN-2-AMINE4flhAL838 Y867 E880
2WKN-[6-(5,6-DIMETHOXYPYRIDIN-3-YL)-1,3-BENZOTHIAZOL-2- YL]ACETAMIDE4ps8AL838 Y867 E880 A885
QYT5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE2a5uAP810 E880
17V2-[1-(PROPAN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]-4,5- DIHYDROTHIENO[3,2-D][1]BENZOXEPINE-8-CARBOXAMIDE4hleAP810 E880 A885
ZIG2,4-DIFLUORO-N-[2-METHOXY-5-(4-PYRIDAZIN-4-YLQUINOLIN-6-YL)PYRIDIN-3-YL]BENZENESULFONAMIDE3l08AP810 L838 Y867 E880
SD5BKM-120|3sd5AP810 L838 Y867 E880
41A5,5-DIMETHYL-2-MORPHOLIN-4-YL-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE3dpdAP810 Y867 E880
NZS6-(1,1-DIOXIDOTHIOMORPHOLIN-4-YL)-N-(3-METHOXYPHENYL)-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE3nzsAP810 Y867 E880
2NQN-{2-CHLORO-5-[4-(MORPHOLIN-4-YL)QUINOLIN-6-YL]PYRIDIN-3-YL}-4-FLUOROBENZENESULFONAMIDE3s2aAP810 Y867 E880
7512-{4-[(4'-METHOXYBIPHENYL-3-YL)SULFONYL]PIPERAZIN-1-YL}-3-(4-METHOXYPHENYL)PYRAZINE4anvAP810 Y867 E880
O923-AMINO-6-{4-CHLORO-3-[(2,3-DIFLUOROPHENYL)SULFAMOYL]PHENYL}-N-METHYLPYRAZINE-2-CARBOXAMIDE4anwAP810 Y867 E880
F1SN-(5-{[3-(4-AMINO-6-METHYL-1,3,5-TRIAZIN-2-YL)-5- (TETRAHYDRO-2H-PYRAN-4-YL)PYRIDIN-2-YL]AMINO}-2- CHLOROPYRIDIN-3-YL)METHANESULFONAMIDE4f1sAP810 Y867 E880
0W72-[4-(MORPHOLIN-4-YL)-6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL]- N-PHENYLACETAMIDE4g11AP810 Y867 E880
0WR2-[1-({2-[2-(DIMETHYLAMINO)-1H-BENZIMIDAZOL-1-YL]-9- METHYL-6-(MORPHOLIN-4-YL)-9H-PURIN-8-YL}METHYL) PIPERIDIN-4-YL]PROPAN-2-OL4gb9AP810 Y867 E880
3VEN-{(1S)-1-[8-CHLORO-2-(2-METHYLPYRIDIN-3-YL)QUINOLIN-3- YL]ETHYL}-9H-PURIN-6-AMINE4wwpAP810 Y867 E880
STUSTAUROSPORINE1e8zAP810 Y867 E880 A885
BYM(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE2a4zAP810 Y867 E880 A885
QJZN-{6-[2-(METHYLSULFANYL)PYRIMIDIN-4-YL]-1,3-BENZOTHIAZOL-2-YL}ACETAMIDE3qjzAP810 Y867 E880 A885
QK0N-[6-(6-CHLORO-5-{[(4-FLUOROPHENYL)SULFONYL]AMINO}PYRIDIN-3-YL)-1,3-BENZOTHIAZOL-2-YL]ACETAMIDE3qk0AP810 Y867 E880 A885
7L0N-[6-(5-METHYLSULFONYLPYRIDIN-3-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL]ETHANAMIDE4aofAP810 Y867 E880 A885
FJY4-[3,3-DIMETHYL-6-(MORPHOLIN-4-YL)-2,3-DIHYDRO-1H- INDOL-1-YL]-7-FLUORO-3-METHYL-2-(PYRIDIN-3-YL) QUINOLINE4fjyAP810 Y867 E880 A885
0VU4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2- YL}AMINO)BENZENESULFONAMIDE4fulAP810 Y867 E880 A885
2WH1-[6-(5-METHOXYPYRIDIN-3-YL)-1,3-BENZOTHIAZOL-2-YL]-3- [2-(1-PROPYL-1H-IMIDAZOL-4-YL)ETHYL]UREA4ps3AP810 Y867 E880 A885
3VDN-{(1S)-1-[8-CHLORO-2-(3-FLUOROPHENYL)QUINOLIN-3- YL]ETHYL}-9H-PURIN-6-AMINE4wwoAP810 Y867 E880 A885
4FJ1'-[7-FLUORO-3-METHYL-2-(PYRIDIN-2-YL)QUINOLIN-4-YL]- 6'-(MORPHOLIN-4-YL)-1',2,2',3,5,6- HEXAHYDROSPIRO[PYRAN-4,3'-PYRROLO[3,2-B]PYRIDINE]4fjzAV803 P810 E880
039PIK-392chwAV803 P810 E880 A885
3VCN-{(1S)-1-[7-FLUORO-2-(PYRIDIN-2-YL)QUINOLIN-3- YL]ETHYL}-9H-PURIN-6-AMINE4wwnAV803 P810 Y867 E880 A885
5MT4-AZANYL-6-[[(1~{S})-1-[6-FLUORANYL-1-(3- METHYLSULFONYLPHENYL)BENZIMIDAZOL-2- YL]ETHYL]AMINO]PYRIMIDINE-5-CARBONITRILE5edsAV803 P810 Y867 E880 A885
ABJ3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL2v4lAY867 E880
BMW3-[7-(1H-BENZIMIDAZOL-5-YL)-2-(MORPHOLIN-4-YL)-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]PHENOL3apfAY867 E880
GD92-(1H-INDAZOL-4-YL)-6-{[4-(METHYLSULFONYL)PIPERAZIN-1-YL]METHYL}-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE3dbsAY867 E880
LXX6-(1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)-4-PYRIDIN-4-YLQUINOLINE3l54AY867 E880
WYE(2Z)-4,6-DIHYDROXY-2-{[1-METHYL-4-(4-METHYLPIPERAZIN-1-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]METHYLIDENE}-1-BENZOFURAN-3(2H)-ONE3lj3AY867 E880
WYF(2Z)-4,6-DIHYDROXY-2-[(8-METHOXY-1,2,3,4-TETRAHYDROPYRAZINO[1,2-A]INDOL-10-YL)METHYLIDENE]-1-BENZOFURAN-3(2H)-ONE3mjwAY867 E880
NZU6-(2H-INDAZOL-4-YL)-1-METHYL-N-[3-(METHYLSULFONYL)PROPYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE3nzuAY867 E880
OAW2-AMINO-4-METHYL-8-(1-METHYLETHYL)-6-(1H-PYRAZOL-4-YL)PTERIDIN-7(8H)-ONE3oawAY867 E880
P2B3-[2-MORPHOLIN-4-YL-6-(PYRIDIN-3-YLAMINO)PYRIMIDIN-4-YL]PHENOL3p2bAY867 E880
3RE2-AMINO-8-(TRANS-4-METHOXYCYCLOHEXYL)-4-METHYL-6-(1H-PYRAZOL-3-YL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE3preAY867 E880
3RZ4-AMINO-2-METHYL-N-(1H-PYRAZOL-3-YL)QUINAZOLINE-8-CARBOXAMIDE3przAY867 E880
QAR1-(4-AMINO-6-METHYL-1,3,5-TRIAZIN-2-YL)-N-(1H-PYRAZOL-3-YL)-1H-BENZO[D]IMIDAZOL-2-AMINE3qarAY867 E880
FAVN-(2-CHLOROPHENYL)-N-METHYL-4H-THIENO[3,2-C]CHROMENE-2-CARBOXAMIDE3r7qAY867 E880
XAZ5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-AMINE3zvvAY867 E880
EM73-AMINO-N-METHYL-6-[3-(1H-TETRAZOL-5-YL)PHENYL]PYRAZINE-2-CARBOXAMIDE4anuAY867 E880
5345-{3-[(4-{3-[4-(1-METHYLETHYL)PHENYL]PYRAZIN-2-YL}PIPERAZIN-1-YL)SULFONYL]PHENYL}PYRIMIDIN-2-AMINE4anxAY867 E880
0TZ3-(4-AMINO-6-METHYL-1,3,5-TRIAZIN-2-YL)-N-(1H-PYRAZOL- 5-YL)IMIDAZO[1,2-A]PYRIDIN-2-AMINE4fhjAY867 E880
0TA2-AMINO-8-CYCLOPENTYL-4-METHYL-6-(1H-PYRAZOL-4-YL) PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE4fa6AY867 E880
0TB2-AMINO-6-(5-FLUORO-6-METHOXYPYRIDIN-3-YL)-4-METHYL-8- (PYRROLIDIN-1-YL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE4fadAY867 E880
0SC2-(1-{[2-(5-FLUORO-1H-INDOL-4-YL)-4-(MORPHOLIN-4-YL) PYRIDO[3,2-D]PYRIMIDIN-6-YL]METHYL}PIPERIDIN-4-YL) PROPAN-2-OL4ezjAY867 E880
0SD2-(1-{[2-(2H-INDAZOL-4-YL)-4-(MORPHOLIN-4-YL)PYRIDO[3, 2-D]PYRIMIDIN-6-YL]METHYL}PIPERIDIN-4-YL)PROPAN-2-OL4ezkAY867 E880
19P1-{1-[(2S)-2-HYDROXYPROPANOYL]PIPERIDIN-4-YL}-3-METHYL- 8-(6-METHYLPYRIDIN-3-YL)-1,3-DIHYDRO-2H-IMIDAZO[4,5- C][1,5]NAPHTHYRIDIN-2-ONE4hvbAY867 E880
A822-[[(1R)-1-(7-METHYL-2-MORPHOLIN-4-YL-4- OXIDANYLIDENE-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYL] AMINO]BENZOIC ACID4urkAY867 E880
090S1187_SELLECK2chxAY867 E880 A885
093PIK-932chzAY867 E880 A885
E52METHYLATED RUTHENIUM PYRIDOCARBAZOLE3cstAY867 E880 A885
ML92-AMINO-8-[TRANS-4-(2-HYDROXYETHOXY)CYCLOHEXYL]-6-(6-METHOXYPYRIDIN-3-YL)-4-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE3ml9AY867 E880 A885
QAQ2-(4-(2-(3-HYDROXYPHENYLAMINO)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YLAMINO)ACETONITRILE3qaqAY867 E880 A885
FAZ8-(ACETYLAMINO)-N-(2-CHLOROPHENYL)-N-METHYL-4,5-DIHYDROTHIENO[3,2-D][1]BENZOXEPINE-2-CARBOXAMIDE3r7rAY867 E880 A885
3T8N~2~-{2-CHLORO-4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}-N~2~,N~8~-DIMETHYL-4,5-DIHYDROTHIENO[3,2-D][1]BENZOXEPINE-2,8-DICARBOXAMIDE3t8mAY867 E880 A885
0U03-[2-METHYL-6-(PYRAZIN-2-YLAMINO)PYRIMIDIN-4-YL]-N-(1H- PYRAZOL-3-YL)IMIDAZO[1,2-B]PYRIDAZIN-2-AMINE4fhkAY867 E880 A885
1UJMETHYL 2-(ACETYLAMINO)-1,3-BENZOTHIAZOLE-6-CARBOXYLATE4kz0AY867 E880 A885
1UKN-{6-[6-AMINO-5-(TRIFLUOROMETHYL)PYRIDIN-3- YL]IMIDAZO[1,2-A]PYRIDIN-2-YL}ACETAMIDE4kzcAY867 E880 A885
1JV2-METHYL-1-(4-{2-[1-(2,2,2-TRIFLUOROETHYL)-1H-1,2,4- TRIAZOL-5-YL]-4,5-DIHYDRO[1]BENZOXEPINO[5,4-D][1, 3]THIAZOL-8-YL}-1H-PYRAZOL-1-YL)PROPAN-2-OL4j6iAY867 E880 A885
2WJN-[6-(PYRIDIN-3-YL)-1,3-BENZOTHIAZOL-2-YL]ACETAMIDE4ps7AY867 E880 A885
43RN-[5-(5-METHOXYPYRIDIN-3-YL)-4,5,6,7-TETRAHYDRO[1, 3]THIAZOLO[5,4-C]PYRIDIN-2-YL]ACETAMIDE4xx5AY867 E880 A885
ML88-CYCLOPENTYL-6-[3-(HYDROXYMETHYL)PHENYL]-4-METHYL-2-(METHYLAMINO)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE3ml8AY867 E880 A885 F965


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Conservation information for LBS of PIK3CG
Multiple alignments for P48736 in multiple species
LBSAA sequence# speciesSpecies


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