mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PIN1
Gene summary
Basic gene Info.Gene symbolPIN1
Gene namepeptidylprolyl cis/trans isomerase, NIMA-interacting 1
SynonymsDOD|UBL5
CytomapUCSC genome browser: 19p13
Type of geneprotein-coding
RefGenesNM_006221.3,
NR_038422.2,NR_038830.1,
DescriptionPPIase Pin1peptidyl-prolyl cis-trans isomerase NIMA-interacting 1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1rotamase Pin1
Modification date20141207
dbXrefs MIM : 601052
HGNC : HGNC
Ensembl : ENSG00000127445
HPRD : 03031
Vega : OTTHUMG00000180388
ProteinUniProt: Q13526
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PIN1
BioGPS: 5300
PathwayNCI Pathway Interaction Database: PIN1
KEGG: PIN1
REACTOME: PIN1
Pathway Commons: PIN1
ContextiHOP: PIN1
ligand binding site mutation search in PubMed: PIN1
UCL Cancer Institute: PIN1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000413protein peptidyl-prolyl isomerization19122240
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway19122240
GO:0051443positive regulation of ubiquitin-protein transferase activity19122240
GO:0060393regulation of pathway-restricted SMAD protein phosphorylation19122240
GO:0070373negative regulation of ERK1 and ERK2 cascade20179103
GO:2000146negative regulation of cell motility20179103


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Ligand binding site mutations for PIN1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E35R36PCOAD1
M146E145KHNSC1
G148G148RSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PIN1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E35R36P-1.2639761
M146E145K-1.1453837
G148G148R-0.49997469
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PIN1 from PDB

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Differential gene expression and gene-gene network for PIN1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PIN1 and the right PPI network was created from samples without mutations in the LBS of PIN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PIN1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms6AlteredExpression, Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PIN1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01766Beta-(2-Naphthyl)-AlanineSmall molecule
ExperimentalDB068673,6,9,12,15,18-HEXAOXAICOSANESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PIN1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ARG,ILE,SER,PRO,PRO,LEU,PRO,PHE)2n1oAE35
12PDODECAETHYLENE GLYCOL3kceAM146 G148


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Conservation information for LBS of PIN1
Multiple alignments for Q13526 in multiple species
LBSAA sequence# speciesSpecies
A124RGDLGAFSRGQ2Homo sapiens, Bos taurus
A124GGDLGWFGRGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A124GGDLGSFGRGQ1Arabidopsis thaliana
A124GGELGEFGRDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A124RGDLGYFGRGD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A124GGDLGKFGRGQ1Drosophila melanogaster
A124RGDLGPFSRGQ1Mus musculus
A31NHITNASQWER3Homo sapiens, Mus musculus, Bos taurus
A31NPETKHSQWEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A31-----------1Arabidopsis thaliana
A31NTETHESLWEP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A31NSATKTSRWEP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A31NMYTKESQWDQ1Drosophila melanogaster
C113SQFSDCSSAKA3Homo sapiens, Mus musculus, Bos taurus
C113KERSDCSSYKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C113TRVSDCSSAKR1Arabidopsis thaliana
C113MKESDCSSARR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C113LTESDCSSARK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C113RSYSDCSSAKR1Drosophila melanogaster
D112ASQFSDCSSAK3Homo sapiens, Mus musculus, Bos taurus
D112AKERSDCSSYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D112ATRVSDCSSAK1Arabidopsis thaliana
D112AMKESDCSSAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D112ALTESDCSSAR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D112ARSYSDCSSAK1Drosophila melanogaster
D121AKARGDLGAFS2Homo sapiens, Bos taurus
D121YKRGGDLGWFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D121AKRGGDLGSFG1Arabidopsis thaliana
D121ARRGGELGEFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D121ARKRGDLGYFG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D121AKRGGDLGKFG1Drosophila melanogaster
D121AKARGDLGPFS1Mus musculus
E12LPPGWEKRMSR3Homo sapiens, Mus musculus, Bos taurus
E12LPTPWTVRYSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E12-----------1Arabidopsis thaliana
E12LPKPWIVKISR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E12LPEDWEVRHSQ1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E12LPDGWEKRTSR1Drosophila melanogaster
E35NASQWERPSGN2Homo sapiens, Bos taurus
E35KHSQWEEPEGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E35-----------1Arabidopsis thaliana
E35HESLWEPPAAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E35KTSRWEPPSGT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E35KESQWDQPTEP1Drosophila melanogaster
E35NASQWERPSGG1Mus musculus
F110SLASQFSDCSS3Homo sapiens, Mus musculus, Bos taurus
F110ALAKERSDCSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F110EVATRVSDCSS1Arabidopsis thaliana
F110DLAMKESDCSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F110ELALTESDCSS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F110ELARSYSDCSS1Drosophila melanogaster
F125GDLGAFSRGQM2Homo sapiens, Bos taurus
F125GDLGWFGRGEM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F125GDLGSFGRGQM1Arabidopsis thaliana
F125GELGEFGRDEM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F125GDLGYFGRGDM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F125GDLGKFGRGQM1Drosophila melanogaster
F125GDLGPFSRGQM1Mus musculus
F134QMQKPFEDASF3Homo sapiens, Mus musculus, Bos taurus
F134EMQPSFEDAAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F134QMQKPFEEATY1Arabidopsis thaliana
F134EMQKPFEDAAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F134DMQKEFEDAAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F134QMQAAFEDAAF1Drosophila melanogaster
F25GRVYYFNHITN3Homo sapiens, Mus musculus, Bos taurus
F25KREYFFNPETK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F25-----------1Arabidopsis thaliana
F25NRPYFFNTETH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F25NLPYYFNSATK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F25GMSYYLNMYTK1Drosophila melanogaster
G10EKLPPGWEKRM3Homo sapiens, Mus musculus, Bos taurus
G10TGLPTPWTVRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G10-----------1Arabidopsis thaliana
G10TGLPKPWIVKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G10TGLPEDWEVRH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G10EQLPDGWEKRT1Drosophila melanogaster
G148TGEMSGPVFTD3Homo sapiens, Mus musculus, Bos taurus
G148VGEVSDIVESG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G148VGDISDIVDTD1Arabidopsis thaliana
G148PGEISGVVETS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G148PGEISGIVDTA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G148VNQLSGIVDSD1Drosophila melanogaster
H157TDSGIHIILRT3Homo sapiens, Mus musculus, Bos taurus
H157SGSGVHVIKRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H157TDSGVHIIKRT1Arabidopsis thaliana
H157TSSGFHIIQRH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H157TASGLHLIERL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H157SDSGLHIILRK1Drosophila melanogaster
H27VYYFNHITNAS3Homo sapiens, Mus musculus, Bos taurus
H27EYFFNPETKHS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H27-----------1Arabidopsis thaliana
H27PYFFNTETHES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H27PYYFNSATKTS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H27SYYLNMYTKES1Drosophila melanogaster
H59RVRCSHLLVKH2Homo sapiens, Bos taurus
H59RVRCLHILIKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H59QVKASHILIKH1Arabidopsis thaliana
H59KIRASHLLVKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H59KIRCAHLLVKH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H59EVHCLHLLVKH1Drosophila melanogaster
H59KVRCSHLLVKH1Mus musculus
I93LINGYIQKI--3Homo sapiens, Mus musculus, Bos taurus
I93ELKTLITRLDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I93QLKSIREDI--1Arabidopsis thaliana
I93LAEHYEQLL--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I93TLQGFEQRI--1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I93LLEVYRNKI--1Drosophila melanogaster
K117DCSSAKARGDL3Homo sapiens, Mus musculus, Bos taurus
K117DCSSAKRGGDL2Arabidopsis thaliana, Drosophila melanogaster
K117DCSSYKRGGDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K117DCSSARRGGEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K117DCSSARKRGDL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K63SHLLVKHSQSR3Homo sapiens, Mus musculus, Bos taurus
K63LHILIKHKDSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K63SHILIKHQGSR1Arabidopsis thaliana
K63SHLLVKHRESR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K63AHLLVKHNQSR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K63LHLLVKHKGSR1Drosophila melanogaster
K97QKI--KSGEED3Homo sapiens, Mus musculus, Bos taurus
K97TRLDDDSKTNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K97EDI--VSGKAN1Arabidopsis thaliana
K97QLL--KSGSVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K97QRI--KSGSIS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K97NKI--VQQEAT1Drosophila melanogaster
L122KARGDLGAFSR2Homo sapiens, Bos taurus
L122KRGGDLGWFGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L122KRGGDLGSFGR1Arabidopsis thaliana
L122RRGGELGEFGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L122RKRGDLGYFGR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L122KRGGDLGKFGR1Drosophila melanogaster
L122KARGDLGPFSR1Mus musculus
L61RCSHLLVKHSQ3Homo sapiens, Mus musculus, Bos taurus
L61RCLHILIKHKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L61KASHILIKHQG1Arabidopsis thaliana
L61RASHLLVKHRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L61RCAHLLVKHNQ1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L61HCLHLLVKHKG1Drosophila melanogaster
L88EEALELINGYI3Homo sapiens, Mus musculus, Bos taurus
L88QDATDELKTLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L88EAAVEQLKSIR1Arabidopsis thaliana
L88EEARKLAEHYE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L88QEALTTLQGFE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L88EEAQLLLEVYR1Drosophila melanogaster
M130FSRGQMQKPFE3Homo sapiens, Mus musculus, Bos taurus
M130FGRGEMQPSFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M130FGRGQMQKPFE1Arabidopsis thaliana
M130FGRDEMQKPFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M130FGRGDMQKEFE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M130FGRGQMQAAFE1Drosophila melanogaster
M146LRTGEMSGPVF3Homo sapiens, Mus musculus, Bos taurus
M146LKVGEVSDIVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M146LKVGDISDIVD1Arabidopsis thaliana
M146LKPGEISGVVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M146LKPGEISGIVD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M146LNVNQLSGIVD1Drosophila melanogaster
M15GWEKRMSRSSG3Homo sapiens, Mus musculus, Bos taurus
M15PWTVRYSKSKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M15-----------1Arabidopsis thaliana
M15PWIVKISRSRN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M15DWEVRHSQSKN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M15GWEKRTSRSTG1Drosophila melanogaster
N30FNHITNASQWE3Homo sapiens, Mus musculus, Bos taurus
N30FNPETKHSQWE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N30-----------1Arabidopsis thaliana
N30FNTETHESLWE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N30FNSATKTSRWE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N30LNMYTKESQWD1Drosophila melanogaster
P149GEMSGPVFTDS3Homo sapiens, Mus musculus, Bos taurus
P149GEVSDIVESGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P149GDISDIVDTDS1Arabidopsis thaliana
P149GEISGVVETSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P149GEISGIVDTAS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P149NQLSGIVDSDS1Drosophila melanogaster
P9EEKLPPGWEKR3Homo sapiens, Mus musculus, Bos taurus
P9RTGLPTPWTVR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P9-----------1Arabidopsis thaliana
P9-TGLPKPWIVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P9ETGLPEDWEVR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P9AEQLPDGWEKR1Drosophila melanogaster
Q129AFSRGQMQKPF2Homo sapiens, Bos taurus
Q129WFGRGEMQPSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q129SFGRGQMQKPF1Arabidopsis thaliana
Q129EFGRDEMQKPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q129YFGRGDMQKEF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q129KFGRGQMQAAF1Drosophila melanogaster
Q129PFSRGQMQKPF1Mus musculus
Q131SRGQMQKPFED3Homo sapiens, Mus musculus, Bos taurus
Q131GRGEMQPSFED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q131GRGQMQKPFEE1Arabidopsis thaliana
Q131GRDEMQKPFED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q131GRGDMQKEFED1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q131GRGQMQAAFED1Drosophila melanogaster
Q33ITNASQWERPS3Homo sapiens, Mus musculus, Bos taurus
Q33ETKHSQWEEPE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q33-----------1Arabidopsis thaliana
Q33ETHESLWEPPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q33ATKTSRWEPPS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q33YTKESQWDQPT1Drosophila melanogaster
R14PGWEKRMSRSS3Homo sapiens, Mus musculus, Bos taurus
R14TPWTVRYSKSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R14-----------1Arabidopsis thaliana
R14KPWIVKISRSR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R14EDWEVRHSQSK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R14DGWEKRTSRST1Drosophila melanogaster
R17EKRMSRSSGRV3Homo sapiens, Mus musculus, Bos taurus
R17TVRYSKSKKRE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R17-----------1Arabidopsis thaliana
R17IVKISRSRNRP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R17EVRHSQSKNLP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R17EKRTSRSTGMS1Drosophila melanogaster
R21SRSSGRVYYFN3Homo sapiens, Mus musculus, Bos taurus
R21SKSKKREYFFN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R21-----------1Arabidopsis thaliana
R21SRSRNRPYFFN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R21SQSKNLPYYFN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R21SRSTGMSYYLN1Drosophila melanogaster
R68KHSQSRRPSSW3Homo sapiens, Mus musculus, Bos taurus
R68KHKDSRRPASH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R68KHQGSRRKASW1Arabidopsis thaliana
R68KHRESRRPSSW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R68KHNQSRRPSSW1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R68KHKGSRRPSSW1Drosophila melanogaster
R69HSQSRRPSSWR3Homo sapiens, Mus musculus, Bos taurus
R69HKDSRRPASHR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R69HQGSRRKASWK1Arabidopsis thaliana
R69HRESRRPSSWK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R69HNQSRRPSSWR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R69HKGSRRPSSWR1Drosophila melanogaster
S114QFSDCSSAKAR3Homo sapiens, Mus musculus, Bos taurus
S114ERSDCSSYKRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S114RVSDCSSAKRG1Arabidopsis thaliana
S114KESDCSSARRG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S114TESDCSSARKR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S114SYSDCSSAKRG1Drosophila melanogaster
S115FSDCSSAKARG3Homo sapiens, Mus musculus, Bos taurus
S115RSDCSSYKRGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S115VSDCSSAKRGG1Arabidopsis thaliana
S115ESDCSSARRGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S115ESDCSSARKRG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S115YSDCSSAKRGG1Drosophila melanogaster
S147RTGEMSGPVFT3Homo sapiens, Mus musculus, Bos taurus
S147KVGEVSDIVES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147KVGDISDIVDT1Arabidopsis thaliana
S147KPGEISGVVET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147KPGEISGIVDT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S147NVNQLSGIVDS1Drosophila melanogaster
S154PVFTDSGIHII3Homo sapiens, Mus musculus, Bos taurus
S154IVESGSGVHVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S154IVDTDSGVHII1Arabidopsis thaliana
S154VVETSSGFHII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S154IVDTASGLHLI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S154IVDSDSGLHII1Drosophila melanogaster
S16WEKRMSRSSGR3Homo sapiens, Mus musculus, Bos taurus
S16WTVRYSKSKKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S16-----------1Arabidopsis thaliana
S16WIVKISRSRNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S16WEVRHSQSKNL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S16WEKRTSRSTGM1Drosophila melanogaster
S18KRMSRSSGRVY3Homo sapiens, Mus musculus, Bos taurus
S18VRYSKSKKREY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S18-----------1Arabidopsis thaliana
S18VKISRSRNRPY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S18VRHSQSKNLPY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S18KRTSRSTGMSY1Drosophila melanogaster
S32HITNASQWERP3Homo sapiens, Mus musculus, Bos taurus
S32PETKHSQWEEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S32-----------1Arabidopsis thaliana
S32TETHESLWEPP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S32SATKTSRWEPP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S32MYTKESQWDQP1Drosophila melanogaster
S71QSRRPSSWRQE3Homo sapiens, Mus musculus, Bos taurus
S71DSRRPASHRSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S71GSRRKASWKDP1Arabidopsis thaliana
S71ESRRPSSWKEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S71QSRRPSSWRES1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S71GSRRPSSWREA1Drosophila melanogaster
S72SRRPSSWRQEK3Homo sapiens, Mus musculus, Bos taurus
S72SRRPASHRSEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S72SRRKASWKDPE1Arabidopsis thaliana
S72SRRPSSWKEEH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S72SRRPSSWRESE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S72SRRPSSWREAN1Drosophila melanogaster
V22RSSGRVYYFNH3Homo sapiens, Mus musculus, Bos taurus
V22KSKKREYFFNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V22-----------1Arabidopsis thaliana
V22RSRNRPYFFNT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V22QSKNLPYYFNS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V22RSTGMSYYLNM1Drosophila melanogaster
W34TNASQWERPSG3Homo sapiens, Mus musculus, Bos taurus
W34TKHSQWEEPEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W34-----------1Arabidopsis thaliana
W34THESLWEPPAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W34TKTSRWEPPSG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W34TKESQWDQPTE1Drosophila melanogaster
W73RRPSSWRQEK-3Homo sapiens, Mus musculus, Bos taurus
W73RRPASHRSEN-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W73RRKASWKDPEG1Arabidopsis thaliana
W73RRPSSWKEEH-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W73RRPSSWRESE-1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W73RRPSSWREAN-1Drosophila melanogaster
Y23SSGRVYYFNHI3Homo sapiens, Mus musculus, Bos taurus
Y23SKKREYFFNPE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y23-----------1Arabidopsis thaliana
Y23SRNRPYFFNTE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y23SKNLPYYFNSA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y23STGMSYYLNMY1Drosophila melanogaster


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