mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PIN1

Gene summary

Basic gene Info.	Gene symbol	PIN1
	Gene name	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
	Synonyms	DOD\|UBL5
	Cytomap	UCSC genome browser: 19p13
	Type of gene	protein-coding
	RefGenes	NM_006221.3, NR_038422.2,NR_038830.1,
	Description	PPIase Pin1peptidyl-prolyl cis-trans isomerase NIMA-interacting 1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1rotamase Pin1
	Modification date	20141207
dbXrefs	MIM : 601052
	HGNC : HGNC
	Ensembl : ENSG00000127445
	HPRD : 03031
	Vega : OTTHUMG00000180388
Protein	UniProt: Q13526 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PIN1
	BioGPS: 5300
Pathway	NCI Pathway Interaction Database: PIN1
	KEGG: PIN1
	REACTOME: PIN1
	Pathway Commons: PIN1
Context	iHOP: PIN1
	ligand binding site mutation search in PubMed: PIN1
	UCL Cancer Institute: PIN1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0000413	protein peptidyl-prolyl isomerization	19122240
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	19122240
GO:0051443	positive regulation of ubiquitin-protein transferase activity	19122240
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	19122240
GO:0070373	negative regulation of ERK1 and ERK2 cascade	20179103
GO:2000146	negative regulation of cell motility	20179103

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Ligand binding site mutations for PIN1

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E35	R36P	COAD	1
M146	E145K	HNSC	1
G148	G148R	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PIN1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E35	R36P	-1.2639761
M146	E145K	-1.1453837
G148	G148R	-0.49997469

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PIN1 from PDB

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Differential gene expression and gene-gene network for PIN1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PIN1 and the right PPI network was created from samples without mutations in the LBS of PIN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PIN1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	6	AlteredExpression, Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PIN1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB01766	Beta-(2-Naphthyl)-Alanine	Small molecule
Experimental	DB06867	3,6,9,12,15,18-HEXAOXAICOSANE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PIN1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (ARG,ILE,SER,PRO,PRO,LEU,PRO,PHE)	2n1o	A	E35
12P		DODECAETHYLENE GLYCOL	3kce	A	M146 G148

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Conservation information for LBS of PIN1

Multiple alignments for Q13526 in multiple species

LBS	AA sequence	# species	Species
A124	RGDLGAFSRGQ	2	Homo sapiens, Bos taurus
A124	GGDLGWFGRGE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A124	GGDLGSFGRGQ	1	Arabidopsis thaliana
A124	GGELGEFGRDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A124	RGDLGYFGRGD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A124	GGDLGKFGRGQ	1	Drosophila melanogaster
A124	RGDLGPFSRGQ	1	Mus musculus
A31	NHITNASQWER	3	Homo sapiens, Mus musculus, Bos taurus
A31	NPETKHSQWEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A31	-----------	1	Arabidopsis thaliana
A31	NTETHESLWEP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A31	NSATKTSRWEP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A31	NMYTKESQWDQ	1	Drosophila melanogaster
C113	SQFSDCSSAKA	3	Homo sapiens, Mus musculus, Bos taurus
C113	KERSDCSSYKR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C113	TRVSDCSSAKR	1	Arabidopsis thaliana
C113	MKESDCSSARR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C113	LTESDCSSARK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C113	RSYSDCSSAKR	1	Drosophila melanogaster
D112	ASQFSDCSSAK	3	Homo sapiens, Mus musculus, Bos taurus
D112	AKERSDCSSYK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D112	ATRVSDCSSAK	1	Arabidopsis thaliana
D112	AMKESDCSSAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D112	ALTESDCSSAR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D112	ARSYSDCSSAK	1	Drosophila melanogaster
D121	AKARGDLGAFS	2	Homo sapiens, Bos taurus
D121	YKRGGDLGWFG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D121	AKRGGDLGSFG	1	Arabidopsis thaliana
D121	ARRGGELGEFG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D121	ARKRGDLGYFG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D121	AKRGGDLGKFG	1	Drosophila melanogaster
D121	AKARGDLGPFS	1	Mus musculus
E12	LPPGWEKRMSR	3	Homo sapiens, Mus musculus, Bos taurus
E12	LPTPWTVRYSK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E12	-----------	1	Arabidopsis thaliana
E12	LPKPWIVKISR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E12	LPEDWEVRHSQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E12	LPDGWEKRTSR	1	Drosophila melanogaster
E35	NASQWERPSGN	2	Homo sapiens, Bos taurus
E35	KHSQWEEPEGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E35	-----------	1	Arabidopsis thaliana
E35	HESLWEPPAAT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E35	KTSRWEPPSGT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E35	KESQWDQPTEP	1	Drosophila melanogaster
E35	NASQWERPSGG	1	Mus musculus
F110	SLASQFSDCSS	3	Homo sapiens, Mus musculus, Bos taurus
F110	ALAKERSDCSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F110	EVATRVSDCSS	1	Arabidopsis thaliana
F110	DLAMKESDCSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F110	ELALTESDCSS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F110	ELARSYSDCSS	1	Drosophila melanogaster
F125	GDLGAFSRGQM	2	Homo sapiens, Bos taurus
F125	GDLGWFGRGEM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F125	GDLGSFGRGQM	1	Arabidopsis thaliana
F125	GELGEFGRDEM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F125	GDLGYFGRGDM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F125	GDLGKFGRGQM	1	Drosophila melanogaster
F125	GDLGPFSRGQM	1	Mus musculus
F134	QMQKPFEDASF	3	Homo sapiens, Mus musculus, Bos taurus
F134	EMQPSFEDAAF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F134	QMQKPFEEATY	1	Arabidopsis thaliana
F134	EMQKPFEDAAF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F134	DMQKEFEDAAF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F134	QMQAAFEDAAF	1	Drosophila melanogaster
F25	GRVYYFNHITN	3	Homo sapiens, Mus musculus, Bos taurus
F25	KREYFFNPETK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F25	-----------	1	Arabidopsis thaliana
F25	NRPYFFNTETH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F25	NLPYYFNSATK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F25	GMSYYLNMYTK	1	Drosophila melanogaster
G10	EKLPPGWEKRM	3	Homo sapiens, Mus musculus, Bos taurus
G10	TGLPTPWTVRY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G10	-----------	1	Arabidopsis thaliana
G10	TGLPKPWIVKI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G10	TGLPEDWEVRH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G10	EQLPDGWEKRT	1	Drosophila melanogaster
G148	TGEMSGPVFTD	3	Homo sapiens, Mus musculus, Bos taurus
G148	VGEVSDIVESG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G148	VGDISDIVDTD	1	Arabidopsis thaliana
G148	PGEISGVVETS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G148	PGEISGIVDTA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G148	VNQLSGIVDSD	1	Drosophila melanogaster
H157	TDSGIHIILRT	3	Homo sapiens, Mus musculus, Bos taurus
H157	SGSGVHVIKRV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H157	TDSGVHIIKRT	1	Arabidopsis thaliana
H157	TSSGFHIIQRH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H157	TASGLHLIERL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H157	SDSGLHIILRK	1	Drosophila melanogaster
H27	VYYFNHITNAS	3	Homo sapiens, Mus musculus, Bos taurus
H27	EYFFNPETKHS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H27	-----------	1	Arabidopsis thaliana
H27	PYFFNTETHES	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H27	PYYFNSATKTS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H27	SYYLNMYTKES	1	Drosophila melanogaster
H59	RVRCSHLLVKH	2	Homo sapiens, Bos taurus
H59	RVRCLHILIKH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H59	QVKASHILIKH	1	Arabidopsis thaliana
H59	KIRASHLLVKH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H59	KIRCAHLLVKH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H59	EVHCLHLLVKH	1	Drosophila melanogaster
H59	KVRCSHLLVKH	1	Mus musculus
I93	LINGYIQKI--	3	Homo sapiens, Mus musculus, Bos taurus
I93	ELKTLITRLDD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I93	QLKSIREDI--	1	Arabidopsis thaliana
I93	LAEHYEQLL--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I93	TLQGFEQRI--	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I93	LLEVYRNKI--	1	Drosophila melanogaster
K117	DCSSAKARGDL	3	Homo sapiens, Mus musculus, Bos taurus
K117	DCSSAKRGGDL	2	Arabidopsis thaliana, Drosophila melanogaster
K117	DCSSYKRGGDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K117	DCSSARRGGEL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K117	DCSSARKRGDL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K63	SHLLVKHSQSR	3	Homo sapiens, Mus musculus, Bos taurus
K63	LHILIKHKDSR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K63	SHILIKHQGSR	1	Arabidopsis thaliana
K63	SHLLVKHRESR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K63	AHLLVKHNQSR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K63	LHLLVKHKGSR	1	Drosophila melanogaster
K97	QKI--KSGEED	3	Homo sapiens, Mus musculus, Bos taurus
K97	TRLDDDSKTNS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K97	EDI--VSGKAN	1	Arabidopsis thaliana
K97	QLL--KSGSVS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K97	QRI--KSGSIS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K97	NKI--VQQEAT	1	Drosophila melanogaster
L122	KARGDLGAFSR	2	Homo sapiens, Bos taurus
L122	KRGGDLGWFGR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L122	KRGGDLGSFGR	1	Arabidopsis thaliana
L122	RRGGELGEFGR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L122	RKRGDLGYFGR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L122	KRGGDLGKFGR	1	Drosophila melanogaster
L122	KARGDLGPFSR	1	Mus musculus
L61	RCSHLLVKHSQ	3	Homo sapiens, Mus musculus, Bos taurus
L61	RCLHILIKHKD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L61	KASHILIKHQG	1	Arabidopsis thaliana
L61	RASHLLVKHRE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L61	RCAHLLVKHNQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L61	HCLHLLVKHKG	1	Drosophila melanogaster
L88	EEALELINGYI	3	Homo sapiens, Mus musculus, Bos taurus
L88	QDATDELKTLI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L88	EAAVEQLKSIR	1	Arabidopsis thaliana
L88	EEARKLAEHYE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L88	QEALTTLQGFE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L88	EEAQLLLEVYR	1	Drosophila melanogaster
M130	FSRGQMQKPFE	3	Homo sapiens, Mus musculus, Bos taurus
M130	FGRGEMQPSFE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M130	FGRGQMQKPFE	1	Arabidopsis thaliana
M130	FGRDEMQKPFE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M130	FGRGDMQKEFE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M130	FGRGQMQAAFE	1	Drosophila melanogaster
M146	LRTGEMSGPVF	3	Homo sapiens, Mus musculus, Bos taurus
M146	LKVGEVSDIVE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M146	LKVGDISDIVD	1	Arabidopsis thaliana
M146	LKPGEISGVVE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M146	LKPGEISGIVD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M146	LNVNQLSGIVD	1	Drosophila melanogaster
M15	GWEKRMSRSSG	3	Homo sapiens, Mus musculus, Bos taurus
M15	PWTVRYSKSKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M15	-----------	1	Arabidopsis thaliana
M15	PWIVKISRSRN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M15	DWEVRHSQSKN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M15	GWEKRTSRSTG	1	Drosophila melanogaster
N30	FNHITNASQWE	3	Homo sapiens, Mus musculus, Bos taurus
N30	FNPETKHSQWE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N30	-----------	1	Arabidopsis thaliana
N30	FNTETHESLWE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N30	FNSATKTSRWE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N30	LNMYTKESQWD	1	Drosophila melanogaster
P149	GEMSGPVFTDS	3	Homo sapiens, Mus musculus, Bos taurus
P149	GEVSDIVESGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P149	GDISDIVDTDS	1	Arabidopsis thaliana
P149	GEISGVVETSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P149	GEISGIVDTAS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P149	NQLSGIVDSDS	1	Drosophila melanogaster
P9	EEKLPPGWEKR	3	Homo sapiens, Mus musculus, Bos taurus
P9	RTGLPTPWTVR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P9	-----------	1	Arabidopsis thaliana
P9	-TGLPKPWIVK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P9	ETGLPEDWEVR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P9	AEQLPDGWEKR	1	Drosophila melanogaster
Q129	AFSRGQMQKPF	2	Homo sapiens, Bos taurus
Q129	WFGRGEMQPSF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q129	SFGRGQMQKPF	1	Arabidopsis thaliana
Q129	EFGRDEMQKPF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q129	YFGRGDMQKEF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q129	KFGRGQMQAAF	1	Drosophila melanogaster
Q129	PFSRGQMQKPF	1	Mus musculus
Q131	SRGQMQKPFED	3	Homo sapiens, Mus musculus, Bos taurus
Q131	GRGEMQPSFED	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q131	GRGQMQKPFEE	1	Arabidopsis thaliana
Q131	GRDEMQKPFED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q131	GRGDMQKEFED	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q131	GRGQMQAAFED	1	Drosophila melanogaster
Q33	ITNASQWERPS	3	Homo sapiens, Mus musculus, Bos taurus
Q33	ETKHSQWEEPE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q33	-----------	1	Arabidopsis thaliana
Q33	ETHESLWEPPA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q33	ATKTSRWEPPS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q33	YTKESQWDQPT	1	Drosophila melanogaster
R14	PGWEKRMSRSS	3	Homo sapiens, Mus musculus, Bos taurus
R14	TPWTVRYSKSK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R14	-----------	1	Arabidopsis thaliana
R14	KPWIVKISRSR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R14	EDWEVRHSQSK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R14	DGWEKRTSRST	1	Drosophila melanogaster
R17	EKRMSRSSGRV	3	Homo sapiens, Mus musculus, Bos taurus
R17	TVRYSKSKKRE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R17	-----------	1	Arabidopsis thaliana
R17	IVKISRSRNRP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R17	EVRHSQSKNLP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R17	EKRTSRSTGMS	1	Drosophila melanogaster
R21	SRSSGRVYYFN	3	Homo sapiens, Mus musculus, Bos taurus
R21	SKSKKREYFFN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R21	-----------	1	Arabidopsis thaliana
R21	SRSRNRPYFFN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R21	SQSKNLPYYFN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R21	SRSTGMSYYLN	1	Drosophila melanogaster
R68	KHSQSRRPSSW	3	Homo sapiens, Mus musculus, Bos taurus
R68	KHKDSRRPASH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R68	KHQGSRRKASW	1	Arabidopsis thaliana
R68	KHRESRRPSSW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R68	KHNQSRRPSSW	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R68	KHKGSRRPSSW	1	Drosophila melanogaster
R69	HSQSRRPSSWR	3	Homo sapiens, Mus musculus, Bos taurus
R69	HKDSRRPASHR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R69	HQGSRRKASWK	1	Arabidopsis thaliana
R69	HRESRRPSSWK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R69	HNQSRRPSSWR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R69	HKGSRRPSSWR	1	Drosophila melanogaster
S114	QFSDCSSAKAR	3	Homo sapiens, Mus musculus, Bos taurus
S114	ERSDCSSYKRG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S114	RVSDCSSAKRG	1	Arabidopsis thaliana
S114	KESDCSSARRG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S114	TESDCSSARKR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S114	SYSDCSSAKRG	1	Drosophila melanogaster
S115	FSDCSSAKARG	3	Homo sapiens, Mus musculus, Bos taurus
S115	RSDCSSYKRGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S115	VSDCSSAKRGG	1	Arabidopsis thaliana
S115	ESDCSSARRGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S115	ESDCSSARKRG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S115	YSDCSSAKRGG	1	Drosophila melanogaster
S147	RTGEMSGPVFT	3	Homo sapiens, Mus musculus, Bos taurus
S147	KVGEVSDIVES	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147	KVGDISDIVDT	1	Arabidopsis thaliana
S147	KPGEISGVVET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147	KPGEISGIVDT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S147	NVNQLSGIVDS	1	Drosophila melanogaster
S154	PVFTDSGIHII	3	Homo sapiens, Mus musculus, Bos taurus
S154	IVESGSGVHVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S154	IVDTDSGVHII	1	Arabidopsis thaliana
S154	VVETSSGFHII	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S154	IVDTASGLHLI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S154	IVDSDSGLHII	1	Drosophila melanogaster
S16	WEKRMSRSSGR	3	Homo sapiens, Mus musculus, Bos taurus
S16	WTVRYSKSKKR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S16	-----------	1	Arabidopsis thaliana
S16	WIVKISRSRNR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S16	WEVRHSQSKNL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S16	WEKRTSRSTGM	1	Drosophila melanogaster
S18	KRMSRSSGRVY	3	Homo sapiens, Mus musculus, Bos taurus
S18	VRYSKSKKREY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S18	-----------	1	Arabidopsis thaliana
S18	VKISRSRNRPY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S18	VRHSQSKNLPY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S18	KRTSRSTGMSY	1	Drosophila melanogaster
S32	HITNASQWERP	3	Homo sapiens, Mus musculus, Bos taurus
S32	PETKHSQWEEP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S32	-----------	1	Arabidopsis thaliana
S32	TETHESLWEPP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S32	SATKTSRWEPP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S32	MYTKESQWDQP	1	Drosophila melanogaster
S71	QSRRPSSWRQE	3	Homo sapiens, Mus musculus, Bos taurus
S71	DSRRPASHRSE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S71	GSRRKASWKDP	1	Arabidopsis thaliana
S71	ESRRPSSWKEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S71	QSRRPSSWRES	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S71	GSRRPSSWREA	1	Drosophila melanogaster
S72	SRRPSSWRQEK	3	Homo sapiens, Mus musculus, Bos taurus
S72	SRRPASHRSEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S72	SRRKASWKDPE	1	Arabidopsis thaliana
S72	SRRPSSWKEEH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S72	SRRPSSWRESE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S72	SRRPSSWREAN	1	Drosophila melanogaster
V22	RSSGRVYYFNH	3	Homo sapiens, Mus musculus, Bos taurus
V22	KSKKREYFFNP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V22	-----------	1	Arabidopsis thaliana
V22	RSRNRPYFFNT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V22	QSKNLPYYFNS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V22	RSTGMSYYLNM	1	Drosophila melanogaster
W34	TNASQWERPSG	3	Homo sapiens, Mus musculus, Bos taurus
W34	TKHSQWEEPEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W34	-----------	1	Arabidopsis thaliana
W34	THESLWEPPAA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W34	TKTSRWEPPSG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W34	TKESQWDQPTE	1	Drosophila melanogaster
W73	RRPSSWRQEK-	3	Homo sapiens, Mus musculus, Bos taurus
W73	RRPASHRSEN-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W73	RRKASWKDPEG	1	Arabidopsis thaliana
W73	RRPSSWKEEH-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W73	RRPSSWRESE-	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W73	RRPSSWREAN-	1	Drosophila melanogaster
Y23	SSGRVYYFNHI	3	Homo sapiens, Mus musculus, Bos taurus
Y23	SKKREYFFNPE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y23	-----------	1	Arabidopsis thaliana
Y23	SRNRPYFFNTE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y23	SKNLPYYFNSA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y23	STGMSYYLNMY	1	Drosophila melanogaster