mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLA2G2A
Gene summary
Basic gene Info.Gene symbolPLA2G2A
Gene namephospholipase A2, group IIA (platelets, synovial fluid)
SynonymsMOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2
CytomapUCSC genome browser: 1p35
Type of geneprotein-coding
RefGenesNM_000300.3,
NM_001161727.1,NM_001161728.1,NM_001161729.1,
DescriptionGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, membrane associated
Modification date20141222
dbXrefs MIM : 172411
HGNC : HGNC
Ensembl : ENSG00000188257
HPRD : 01397
Vega : OTTHUMG00000002699
ProteinUniProt: P14555
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLA2G2A
BioGPS: 5320
PathwayNCI Pathway Interaction Database: PLA2G2A
KEGG: PLA2G2A
REACTOME: PLA2G2A
Pathway Commons: PLA2G2A
ContextiHOP: PLA2G2A
ligand binding site mutation search in PubMed: PLA2G2A
UCL Cancer Institute: PLA2G2A
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006644phospholipid metabolic process17069818
GO:0046473phosphatidic acid metabolic process9032461


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Ligand binding site mutations for PLA2G2A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C64C64RLUAD1
C64C63SLUAD1
I29K30NPRAD1
C64R62CSKCM1
Y41S40RSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PLA2G2A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C64C63S-1.6420774
I29K30N-1.2317216
C64R62C-1.2293213
C64C64R-0.77304145
Y41S40R-0.36039501
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLA2G2A from PDB

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Differential gene expression and gene-gene network for PLA2G2A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLA2G2A and the right PPI network was created from samples without mutations in the LBS of PLA2G2A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PLA2G2A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004153Atherosclerosis14AlteredExpression, Biomarker
umls:C1527249Colorectal Cancer6Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms2Biomarker
umls:C0151744Myocardial Ischemia1Biomarker
umls:C0035126Reperfusion Injury1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PLA2G2A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00328IndomethacinSmall molecule
Approved|vet_approvedDB00586DiclofenacSmall molecule
Approved|nutraceuticalDB01381Ginkgo bilobaSmall molecule
ExperimentalDB019551,4-ButanediolSmall molecule
ExperimentalDB020801-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)BenzeneSmall molecule
ApprovedDB02325Isopropyl AlcoholSmall molecule
ExperimentalDB02448N-Tridecanoic AcidSmall molecule
ExperimentalDB02504[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic AcidSmall molecule
ExperimentalDB029364-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric AcidSmall molecule
ExperimentalDB031211-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic AcidSmall molecule
ExperimentalDB034716-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic AcidSmall molecule
ExperimentalDB03784ElaidoylamideSmall molecule
ExperimentalDB041121-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl SulfideSmall molecule
ExperimentalDB04287(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic AcidSmall molecule
ApprovedDB04786SuraminSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLA2G2A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PLA2G2A
Multiple alignments for P14555 in multiple species
LBSAA sequence# speciesSpecies
A37TTGKEAALSYG1Homo sapiens
A37TTGKEPATRYS1Bos taurus
A37KTGKRADVSYG1Rattus norvegicus
A38TGKEAALSYGF1Homo sapiens
A38TGKEPATRYSF1Bos taurus
A38TGKRADVSYGF1Rattus norvegicus
C48FYGCHCGVGGR2Homo sapiens, Rattus norvegicus
C48FYGCYCGMSGR1Bos taurus
C64ATDRCCVTHDC1Homo sapiens
C64ATDWCCRAHDC1Bos taurus
C64ATDWCCVTHDC1Rattus norvegicus
D68CCVTHDCCYKR1Homo sapiens
D68CCRAHDCCYKN1Bos taurus
D68CCVTHDCCYNR1Rattus norvegicus
E75CYKRLEKRGCG1Homo sapiens
E75CYKNLESRGCR1Bos taurus
E75CYNRLEKRGCG1Rattus norvegicus
F118AAATCFARNKT1Homo sapiens
F118IAANCFAANLK1Bos taurus
F118AAAECFARNKK1Rattus norvegicus
F25GNLVNFHRMIK1Homo sapiens
F25GDLLNFRKMIK1Bos taurus
F25GSLLEFGQMIL1Rattus norvegicus
F43ALSYGFYGCHC1Homo sapiens
F43ATRYSFYGCYC1Bos taurus
F43DVSYGFYGCHC1Rattus norvegicus
G42AALSYGFYGCH1Homo sapiens
G42PATRYSFYGCY1Bos taurus
G42ADVSYGFYGCH1Rattus norvegicus
G45SYGFYGCHCGV2Homo sapiens, Rattus norvegicus
G45RYSFYGCYCGM1Bos taurus
G49YGCHCGVGGRG2Homo sapiens, Rattus norvegicus
G49YGCYCGMSGRG1Bos taurus
G51CHCGVGGRGSP2Homo sapiens, Rattus norvegicus
G51CYCGMSGRGTP1Bos taurus
H26NLVNFHRMIKL1Homo sapiens
H26DLLNFRKMIKL1Bos taurus
H26SLLEFGQMILF1Rattus norvegicus
H47GFYGCHCGVGG2Homo sapiens, Rattus norvegicus
H47SFYGCYCGMSG1Bos taurus
H67RCCVTHDCCYK1Homo sapiens
H67WCCRAHDCCYK1Bos taurus
H67WCCVTHDCCYN1Rattus norvegicus
I29NFHRMIKLTTG1Homo sapiens
I29NFRKMIKLTTG1Bos taurus
I29EFGQMILFKTG1Rattus norvegicus
K72HDCCYKRLEKR1Homo sapiens
K72HDCCYKNLESR1Bos taurus
K72HDCCYNRLEKR1Rattus norvegicus
K82RGCGTKFLSYK1Homo sapiens
K82RGCRTKFLKYN1Bos taurus
K82RGCGTKFLTYK1Rattus norvegicus
L22QAHGNLVNFHR1Homo sapiens
L22QVHGDLLNFRK1Bos taurus
L22QVQGSLLEFGQ1Rattus norvegicus
N134YQYYSNKHCRG1Homo sapiens
N134LRFYNKFRCRG1Bos taurus
N134YQFYPNKFCKG1Rattus norvegicus
V50GCHCGVGGRGS2Homo sapiens, Rattus norvegicus
V50GCYCGMSGRGT1Bos taurus
Y132KKYQYYSNKHC1Homo sapiens
Y132KKLRFYNKFRC1Bos taurus
Y132LKYQFYPNKFC1Rattus norvegicus
Y41EAALSYGFYGC1Homo sapiens
Y41EPATRYSFYGC1Bos taurus
Y41RADVSYGFYGC1Rattus norvegicus
Y44LSYGFYGCHCG1Homo sapiens
Y44TRYSFYGCYCG1Bos taurus
Y44VSYGFYGCHCG1Rattus norvegicus
Y71THDCCYKRLEK1Homo sapiens
Y71AHDCCYKNLES1Bos taurus
Y71THDCCYNRLEK1Rattus norvegicus


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