mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLAT
Gene summary
Basic gene Info.Gene symbolPLAT
Gene nameplasminogen activator, tissue
SynonymsT-PA|TPA
CytomapUCSC genome browser: 8p12
Type of geneprotein-coding
RefGenesNM_000930.3,
NM_033011.2,NM_000931.2,
Descriptionalteplaseplasminogen activator, tissue typereteplaset-plasminogen activatortissue plasminogen activator (t-PA)tissue-type plasminogen activator
Modification date20141207
dbXrefs MIM : 173370
HGNC : HGNC
Ensembl : ENSG00000104368
HPRD : 01419
Vega : OTTHUMG00000164072
ProteinUniProt: P00750
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLAT
BioGPS: 5327
PathwayNCI Pathway Interaction Database: PLAT
KEGG: PLAT
REACTOME: PLAT
Pathway Commons: PLAT
ContextiHOP: PLAT
ligand binding site mutation search in PubMed: PLAT
UCL Cancer Institute: PLAT
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0031639plasminogen activation12694198
GO:0045861negative regulation of proteolysis1695900


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Ligand binding site mutations for PLAT

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E422E422DCOAD1
H322H322YLUAD1
H357A356TSTAD1
S513S513LSTAD1
A508A508SSTAD1
R484R484IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PLAT
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H322H322Y0.16717597
H357A356T-1.525274
A508A508S-1.2240217
E422E422D-0.86583609
R484R484I-0.80116432
S513S513L-0.028344303
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLAT from PDB

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Differential gene expression and gene-gene network for PLAT
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLAT and the right PPI network was created from samples without mutations in the LBS of PLAT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PLAT
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038454Stroke79AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0027051Myocardial Infarction45Biomarker, GeneticVariation, Therapeutic
umls:C0007786Brain Ischemia30Biomarker, GeneticVariation, Therapeutic
umls:C2937358Cerebral Hemorrhage21Biomarker
umls:C0151699Intracranial Hemorrhages14Biomarker
umls:C0034065Pulmonary Embolism10Biomarker, Therapeutic
umls:C0007785Cerebral Infarction8Biomarker, Therapeutic
umls:C0019080Hemorrhage8Biomarker
umls:C0040053Thrombosis7AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0020538Hypertension7Biomarker, GeneticVariation
umls:C0004153Atherosclerosis7Biomarker, GeneticVariation, Therapeutic
umls:C0010072Coronary Thrombosis5Biomarker, Therapeutic
umls:C1861172Venous Thromboembolism4Biomarker, GeneticVariation
umls:C0740392Infarction, Middle Cerebral Artery4Therapeutic
umls:C0040038Thromboembolism3Biomarker, Therapeutic
umls:C0002994Angioedema3Biomarker
umls:C0042487Venous Thrombosis3Therapeutic
umls:C0035126Reperfusion Injury2Biomarker, Therapeutic
umls:C0877172Hematoma, Epidural, Spinal2Biomarker
umls:C0007781Intracranial Embolism and Thrombosis2Therapeutic
umls:C0236733Amphetamine-Related Disorders1Biomarker
umls:C0003537Aphasia1Therapeutic
umls:C0003838Arterial Occlusive Diseases1Therapeutic
umls:C0004604Back Pain1Biomarker
umls:C0004610Bacteremia1Therapeutic
umls:C0751955Brain Infarction1Therapeutic
umls:C0007177Cardiac Tamponade1Biomarker
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0860207Drug-Induced Liver Injury1Biomarker
umls:C0013922Embolism1Therapeutic
umls:C0085307Embolism and Thrombosis1Therapeutic
umls:C0149649Embolism, Cholesterol1Biomarker
umls:C0018801Heart Failure1Biomarker
umls:C0018946Hematoma, Subdural1Biomarker
umls:C0020649Hypotension1Biomarker
umls:C0752143Intracranial Thrombosis1Therapeutic
umls:C0024031Low Back Pain1Therapeutic
umls:C0025309Meningoencephalitis1Therapeutic
umls:C0027746Nerve Degeneration1Biomarker
umls:C0235032Neurotoxicity Syndromes1Biomarker
umls:C0030552Paresis1Therapeutic
umls:C0031039Pericardial Effusion1Biomarker
umls:C0036980Shock, Cardiogenic1Therapeutic
umls:C0037926Spinal Cord Compression1Biomarker
umls:C0751895Vasospasm, Intracranial1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PLAT
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigational|withdrawnDB00013UrokinaseBiotech
Approved|investigationalDB00513Aminocaproic AcidSmall molecule
ApprovedDB01050IbuprofenSmall molecule
Approved|investigationalDB01088IloprostSmall molecule
ExperimentalDB076845-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLAT go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PLAT
Multiple alignments for P00750 in multiple species
LBSAA sequence# speciesSpecies
A320LFADIASHPWQ1Homo sapiens
A320LYTDITSHPWQ1Mus musculus
A320LFTDITSHPWQ1Rattus norvegicus
A320LFADITSHPWQ1Bos taurus
A508ANLHDACQGDS1Homo sapiens
A508-DLHDACQGDS1Mus musculus
A508-DVHDACQGDS1Rattus norvegicus
A508TNLHDACQGDS1Bos taurus
C430VVRTVCLPPAD1Homo sapiens
C430SVGTACLPDPN1Mus musculus
C430SVGTACLPDPD1Rattus norvegicus
C430SVRTICLPDAS1Bos taurus
C509NLHDACQGDSG2Homo sapiens, Bos taurus
C509DLHDACQGDSG1Mus musculus
C509DVHDACQGDSG1Rattus norvegicus
C537SWGLGCGQKDV3Homo sapiens, Mus musculus, Rattus norvegicus
C537SWGLGCGRKDV1Bos taurus
D271YCRNPDGDAKP2Homo sapiens, Rattus norvegicus
D271YCRNPDGDARP1Mus musculus
D271HCRNPDGDAQP1Bos taurus
D273RNPDGDAKPWC2Homo sapiens, Rattus norvegicus
D273RNPDGDARPWC1Mus musculus
D273RNPDGDAQPWC1Bos taurus
D401KEFDDDTYDND3Homo sapiens, Rattus norvegicus, Bos taurus
D401EEFDDDTYDND1Mus musculus
D507QANLHDACQGD1Homo sapiens
D507Q-DLHDACQGD1Mus musculus
D507Q-DVHDACQGD1Rattus norvegicus
D507HTNLHDACQGD1Bos taurus
E422SRCAQESSVVR1Homo sapiens
E422KQCAQESSSVG1Mus musculus
E422SQCAQESSSVG1Rattus norvegicus
E422LTCARESASVR1Bos taurus
E445DWTECELSGYG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E465SERLKEAHVRL2Homo sapiens, Bos taurus
E465SDRLKEAHVRL2Mus musculus, Rattus norvegicus
G511HDACQGDSGGP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G534GIISWGLGCGQ3Homo sapiens, Mus musculus, Rattus norvegicus
G534GIISWGLGCGR1Bos taurus
G536ISWGLGCGQKD3Homo sapiens, Mus musculus, Rattus norvegicus
G536ISWGLGCGRKD1Bos taurus
G544QKDVPGVYTKV2Homo sapiens, Mus musculus
G544QKDVPGIYTKV1Rattus norvegicus
G544RKDVPGVYTKV1Bos taurus
H279AKPWCHVLKNR1Homo sapiens
H279ARPWCHVMKDR1Mus musculus
H279AKPWCHVMKDR1Rattus norvegicus
H279AQPWCHVWKDR1Bos taurus
H322TDITSHPWQAA2Mus musculus, Rattus norvegicus
H322ADIASHPWQAA1Homo sapiens
H322ADITSHPWQAA1Bos taurus
H357ILSAAHCFQER1Homo sapiens
H357VLSAAHCFLER1Mus musculus
H357VLSAAHCFVER1Rattus norvegicus
H357VLSAAHCFQER1Bos taurus
I531TLVGIISWGLG2Homo sapiens, Bos taurus
I531TLTGIISWGLG1Mus musculus
I531TLLGIISWGLG1Rattus norvegicus
K247MILIGKVYTAQ1Homo sapiens
K247IVLMGKSYTAW1Mus musculus
K247MILIGKTYTAW1Rattus norvegicus
K247VFLTSKIYTAW1Bos taurus
L286MKDRKLTWEYC2Mus musculus, Rattus norvegicus
L286LKNRRLTWEYC1Homo sapiens
L286WKDRQLTWEYC1Bos taurus
L535IISWGLGCGQK3Homo sapiens, Mus musculus, Rattus norvegicus
L535IISWGLGCGRK1Bos taurus
M525LNDGRMTLVGI1Homo sapiens
M525MINKQMTLTGI1Mus musculus
M525MIDKRMTLLGI1Rattus norvegicus
M525MKDNHMTLVGI1Bos taurus
P323DITSHPWQAAI3Mus musculus, Rattus norvegicus, Bos taurus
P323DIASHPWQAAI1Homo sapiens
Q510LHDACQGDSGG3Homo sapiens, Mus musculus, Bos taurus
Q510VHDACQGDSGG1Rattus norvegicus
R427ESSSVGTACLP2Mus musculus, Rattus norvegicus
R427ESSVVRTVCLP1Homo sapiens
R427ESASVRTICLP1Bos taurus
R484QHLLNRTVTDN1Homo sapiens
R484QHLFNKTVTNN1Mus musculus
R484QHLFNKTITSN1Rattus norvegicus
R484QHLFNRTVTNN1Bos taurus
R524CLNDGRMTLVG1Homo sapiens
R524CMINKQMTLTG1Mus musculus
R524CMIDKRMTLLG1Rattus norvegicus
R524CMKDNHMTLVG1Bos taurus
S321FADIASHPWQA1Homo sapiens
S321YTDITSHPWQA1Mus musculus
S321FTDITSHPWQA1Rattus norvegicus
S321FADITSHPWQA1Bos taurus
S424CAQESSSVGTA2Mus musculus, Rattus norvegicus
S424CAQESSVVRTV1Homo sapiens
S424CARESASVRTI1Bos taurus
S513ACQGDSGGPLV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S532LVGIISWGLGC2Homo sapiens, Bos taurus
S532LTGIISWGLGC1Mus musculus
S532LLGIISWGLGC1Rattus norvegicus
T287KDRKLTWEYCD2Mus musculus, Rattus norvegicus
T287KNRRLTWEYCD1Homo sapiens
T287KDRQLTWEYCD1Bos taurus
T402EFDDDTYDNDI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T428SSSVGTACLPD2Mus musculus, Rattus norvegicus
T428SSVVRTVCLPP1Homo sapiens
T428SASVRTICLPD1Bos taurus
V248ILIGKVYTAQN1Homo sapiens
V248VLMGKSYTAWR1Mus musculus
V248ILIGKTYTAWR1Rattus norvegicus
V248FLTSKIYTAWK1Bos taurus
V429SSVGTACLPDP2Mus musculus, Rattus norvegicus
V429SVVRTVCLPPA1Homo sapiens
V429ASVRTICLPDA1Bos taurus
W277GDAKPWCHVLK1Homo sapiens
W277GDARPWCHVMK1Mus musculus
W277GDAKPWCHVMK1Rattus norvegicus
W277GDAQPWCHVWK1Bos taurus
W288DRKLTWEYCDM2Mus musculus, Rattus norvegicus
W288NRRLTWEYCDV1Homo sapiens
W288DRQLTWEYCDV1Bos taurus
W324ITSHPWQAAIF3Mus musculus, Rattus norvegicus, Bos taurus
W324IASHPWQAAIF1Homo sapiens
W533VGIISWGLGCG2Homo sapiens, Bos taurus
W533TGIISWGLGCG1Mus musculus
W533LGIISWGLGCG1Rattus norvegicus
Y249LIGKVYTAQNP1Homo sapiens
Y249LMGKSYTAWRT1Mus musculus
Y249LIGKTYTAWRA1Rattus norvegicus
Y249LTSKIYTAWKS1Bos taurus
Y403FDDDTYDNDIA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus


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