mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLAUR
Gene summary
Basic gene Info.Gene symbolPLAUR
Gene nameplasminogen activator, urokinase receptor
SynonymsCD87|U-PAR|UPAR|URKR
CytomapUCSC genome browser: 19q13
Type of geneprotein-coding
RefGenesNM_001005376.2,
NM_001005377.2,NM_001301037.1,NM_002659.3,
Descriptionmonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase plasminogen activator surface receptorurokinase-type plasminogen activator (uPA) receptor
Modification date20141222
dbXrefs MIM : 173391
HGNC : HGNC
Ensembl : ENSG00000011422
HPRD : 01421
Vega : OTTHUMG00000182778
ProteinUniProt: Q03405
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLAUR
BioGPS: 5329
PathwayNCI Pathway Interaction Database: PLAUR
KEGG: PLAUR
REACTOME: PLAUR
Pathway Commons: PLAUR
ContextiHOP: PLAUR
ligand binding site mutation search in PubMed: PLAUR
UCL Cancer Institute: PLAUR
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PLAUR

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K161R159CCOAD2
K72E71QBLCA1
E64E64QBLCA1
E64S66RBRCA1
E38A40SCOAD1
T149H150NKIRC1
S139R138HLUAD1
K161R159COV1
E38A40TUCEC1
R164R164HUCEC1
S139R138HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PLAUR
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K161R159C-1.3475264
K72E71Q-1.3463189
R164R164H-1.2818181
E38A40S-1.0251433
S139R138H-0.96549278
E64E64Q-0.92484848
E38A40T-0.88932754
T149H150N-0.65272178
E64S66R-0.50887556
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLAUR from PDB
PDB IDPDB titlePDB structure
1YWHcrystal structure of urokinase plasminogen activator receptor

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Differential gene expression and gene-gene network for PLAUR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLAUR and the right PPI network was created from samples without mutations in the LBS of PLAUR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PLAUR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027651Neoplasms16AlteredExpression, Biomarker
umls:C0027627Neoplasm Metastasis16AlteredExpression, Biomarker
umls:C0033578Prostatic Neoplasms4AlteredExpression, Biomarker
umls:C0007097Carcinoma4AlteredExpression, Biomarker
umls:C0027626Neoplasm Invasiveness2Biomarker
umls:C0021368Inflammation2Biomarker
umls:C0004352Autistic Disorder2Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PLAUR
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00009AlteplaseBiotech
Approved|investigational|withdrawnDB00013UrokinaseBiotech
ApprovedDB00015ReteplaseBiotech
ApprovedDB00029AnistreplaseBiotech
ApprovedDB00031TenecteplaseBiotech
InvestigationalDB05476WX-UK1Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLAUR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PLAUR
Multiple alignments for Q03405 in multiple species
LBSAA sequence# speciesSpecies
A277AHLGDAFSMN-2Homo sapiens, Pan troglodytes
A277LHVAEAFDLT-1Bos taurus
A277SHVADSFPTHL1Mus musculus
A277SHVADSFQTHV1Rattus norvegicus
D163GRPKDDRHLRG2Homo sapiens, Pan troglodytes
D163ENPGDERHIRG1Bos taurus
D163RSLKDEDYTRG1Mus musculus
D163RSVKDEPYTKG1Rattus norvegicus
D276HAHLGDAFSMN2Homo sapiens, Pan troglodytes
D276SLHVAEAFDLT1Bos taurus
D276GSHVADSFPTH1Mus musculus
D276GSHVADSFQTH1Rattus norvegicus
D96VVCGLDLCNQG2Homo sapiens, Pan troglodytes
D96TVCATNLCNRP2Mus musculus, Rattus norvegicus
D96TVCRSDLCNKP1Bos taurus
E141QCRYPTEHCIE2Mus musculus, Rattus norvegicus
E141QCRSPEEQCLD1Homo sapiens
E141QCLKSRDQCVD1Bos taurus
E141QCRNPEEQCLD1Pan troglodytes
E252ATGTHEPKNQS2Homo sapiens, Pan troglodytes
E252ATGLDVLGNRS2Mus musculus, Rattus norvegicus
E252ATGTKGLRNPS1Bos taurus
E38DCRVEECALGQ2Homo sapiens, Pan troglodytes
E38SCSVEECTPGQ1Bos taurus
E38SCLVEECALGQ1Mus musculus
E38DCLVEECALGQ1Rattus norvegicus
E64ELELVEKSCTH2Homo sapiens, Pan troglodytes
E64ELEVVTRGCAH2Mus musculus, Rattus norvegicus
E64EMNVVRKGCTH1Bos taurus
E90ITSLTEVVCGL2Homo sapiens, Pan troglodytes
E90IITLSETVCRS1Bos taurus
E90IISLTETVCAT1Mus musculus
E90IVSLTETVCAT1Rattus norvegicus
F278HLGDAFSMN-H2Homo sapiens, Pan troglodytes
F278HVAEAFDLT-H1Bos taurus
F278HVADSFPTHLN1Mus musculus
F278HVADSFQTHVN1Rattus norvegicus
G121ECASCTSLDQS2Mus musculus, Rattus norvegicus
G121ECISCGSSDMS1Homo sapiens
G121ECASCSSTDLS1Bos taurus
G121ECISCGSSNMS1Pan troglodytes
G249CLVATGTHEPK2Homo sapiens, Pan troglodytes
G249CLEATGTKGLR1Bos taurus
G249CLVATGLDVLG1Mus musculus
G249CLEATGLDVLG1Rattus norvegicus
H188NNDTFHFLKCC2Homo sapiens, Pan troglodytes
H188SNQTFHFLKCC2Mus musculus, Rattus norvegicus
H188NNHTFHFLRCC1Bos taurus
H273MCQHAHLGDAF2Homo sapiens, Pan troglodytes
H273WCQGSHVADSF2Mus musculus, Rattus norvegicus
H273WCQSLHVAEAF1Bos taurus
K161EEGRPKDDRHL2Homo sapiens, Pan troglodytes
K161LKENPGDERHI1Bos taurus
K161TERSLKDEDYT1Mus musculus
K161TERSVKDEPYT1Rattus norvegicus
K72CTHSEKTNRTL2Homo sapiens, Pan troglodytes
K72CTHPDKTNRSM1Bos taurus
K72CAHSEKTNRTM1Mus musculus
K72CAHKEKTNRTM1Rattus norvegicus
L145PEEQCLDVVTH2Homo sapiens, Pan troglodytes
L145PTEHCIEVVTL2Mus musculus, Rattus norvegicus
L145SRDQCVDVITH1Bos taurus
L166KDDRHLRGCGY2Homo sapiens, Pan troglodytes
L166GDERHIRGCGI1Bos taurus
L166KDEDYTRGCGS1Mus musculus
L166KDEPYTKGCGS1Rattus norvegicus
L172RGCGYLPGCPG2Homo sapiens, Pan troglodytes
L172RGCGILPGCPG1Bos taurus
L172RGCGSLPGCPG1Mus musculus
L172KGCGSLPGCPG1Rattus norvegicus
L190DTFHFLKCCNT2Homo sapiens, Pan troglodytes
L190HTFHFLRCCNT1Bos taurus
L190QTFHFLKCCNY1Mus musculus
L190QTFHFLKCCNF1Rattus norvegicus
L53TTIVRLWEEGE1Homo sapiens
L53TTVLSVWEGGN1Bos taurus
L53TTVLREWQDDR1Mus musculus
L53TTVLREWEDAE1Rattus norvegicus
L53TTIVRMWEEGE1Pan troglodytes
L62GEELELVEKSC2Homo sapiens, Pan troglodytes
L62GNEMNVVRKGC1Bos taurus
L62DRELEVVTRGC1Mus musculus
L62AEELEVVTRGC1Rattus norvegicus
L77KTNRTLSYRTG2Homo sapiens, Pan troglodytes
L77KTNRTMSYRMG2Mus musculus, Rattus norvegicus
L77KTNRSMSYRAA1Bos taurus
L88LKITSLTEVVC2Homo sapiens, Pan troglodytes
L88DQIITLSETVC1Bos taurus
L88SMIISLTETVC1Mus musculus
L88SVIVSLTETVC1Rattus norvegicus
L95EVVCGLDLCNQ2Homo sapiens, Pan troglodytes
L95ETVCATNLCNR2Mus musculus, Rattus norvegicus
L95ETVCRSDLCNK1Bos taurus
L97VCGLDLCNQGN2Homo sapiens, Pan troglodytes
L97VCATNLCNRPR2Mus musculus, Rattus norvegicus
L97VCRSDLCNKPN1Bos taurus
M26WGLRCMQCKTN2Homo sapiens, Pan troglodytes
M26WGLRCLQCENT1Bos taurus
M26QGLQCMQCESN1Mus musculus
M26QGLRCIQCESN1Rattus norvegicus
M280GDAFSMN-HID2Homo sapiens, Pan troglodytes
M280AEAFDLT-HVN1Bos taurus
M280ADSFPTHLNVS1Mus musculus
M280ADSFQTHVNLS1Rattus norvegicus
N255THEPKNQSYMV2Homo sapiens, Pan troglodytes
N255LDVLGNRSYTV2Mus musculus, Rattus norvegicus
N255TKGLRNPSYTI1Bos taurus
N281DAFSMN-HIDV2Homo sapiens, Pan troglodytes
N281EAFDLT-HVNV1Bos taurus
N281DSFPTHLNVSV1Mus musculus
N281DSFQTHVNLSI1Rattus norvegicus
P140LQCRYPTEHCI2Mus musculus, Rattus norvegicus
P140LQCRSPEEQCL1Homo sapiens
P140MQCLKSRDQCV1Bos taurus
P140LQCRNPEEQCL1Pan troglodytes
Q100LDLCNQGNSG-2Homo sapiens, Pan troglodytes
Q100TNLCNRPRPGA2Mus musculus, Rattus norvegicus
Q100SDLCNKPNPG-1Bos taurus
R164RPKDDRHLRGC2Homo sapiens, Pan troglodytes
R164NPGDERHIRGC1Bos taurus
R164SLKDEDYTRGC1Mus musculus
R164SVKDEPYTKGC1Rattus norvegicus
R24ASWGLRCMQCK2Homo sapiens, Pan troglodytes
R24GSWGLRCLQCE1Bos taurus
R24ASQGLQCMQCE1Mus musculus
R24ASQGLRCIQCE1Rattus norvegicus
R35TNGDCRVEECA2Homo sapiens, Pan troglodytes
R35NTTSCSVEECT1Bos taurus
R35SNQSCLVEECA1Mus musculus
R35SNQDCLVEECA1Rattus norvegicus
R75SEKTNRTLSYR2Homo sapiens, Pan troglodytes
R75PDKTNRSMSYR1Bos taurus
R75SEKTNRTMSYR1Mus musculus
R75KEKTNRTMSYR1Rattus norvegicus
S122CASCTSLDQSC2Mus musculus, Rattus norvegicus
S122CISCGSSDMSC1Homo sapiens
S122CASCSSTDLSC1Bos taurus
S122CISCGSSNMSC1Pan troglodytes
S123ASCTSLDQSCE2Mus musculus, Rattus norvegicus
S123ISCGSSDMSCE1Homo sapiens
S123ASCSSTDLSCE1Bos taurus
S123ISCGSSNMSCE1Pan troglodytes
S139SLQCRYPTEHC2Mus musculus, Rattus norvegicus
S139SLQCRSPEEQC1Homo sapiens
S139TMQCLKSRDQC1Bos taurus
S139SLQCRNPEEQC1Pan troglodytes
S279LGDAFSMN-HI2Homo sapiens, Pan troglodytes
S279VAEAFDLT-HV1Bos taurus
S279VADSFPTHLNV1Mus musculus
S279VADSFQTHVNL1Rattus norvegicus
T149CLDVVTHWIQE2Homo sapiens, Pan troglodytes
T149CIEVVTL---Q2Mus musculus, Rattus norvegicus
T149CVDVITH---R1Bos taurus
T248QCLVATGTHEP2Homo sapiens, Pan troglodytes
T248QCLEATGTKGL1Bos taurus
T248QCLVATGLDVL1Mus musculus
T248QCLEATGLDVL1Rattus norvegicus
T30CMQCKTNGDCR2Homo sapiens, Pan troglodytes
T30CLQCENTTSCS1Bos taurus
T30CMQCESNQSCL1Mus musculus
T30CIQCESNQDCL1Rattus norvegicus
T49DLCRTTVLREW2Mus musculus, Rattus norvegicus
T49DLCRTTIVRLW1Homo sapiens
T49DLCRTTVLSVW1Bos taurus
T49DLCRTTIVRMW1Pan troglodytes
T76EKTNRTLSYRT2Homo sapiens, Pan troglodytes
T76EKTNRTMSYRM2Mus musculus, Rattus norvegicus
T76DKTNRSMSYRA1Bos taurus
T89KITSLTEVVCG2Homo sapiens, Pan troglodytes
T89QIITLSETVCR1Bos taurus
T89MIISLTETVCA1Mus musculus
T89VIVSLTETVCA1Rattus norvegicus
V147EQCLDVVTHWI2Homo sapiens, Pan troglodytes
V147EHCIEVVTL--2Mus musculus, Rattus norvegicus
V147DQCVDVITH--1Bos taurus
V148QCLDVVTHWIQ2Homo sapiens, Pan troglodytes
V148HCIEVVTL---2Mus musculus, Rattus norvegicus
V148QCVDVITH---1Bos taurus
V36NGDCRVEECAL2Homo sapiens, Pan troglodytes
V36TTSCSVEECTP1Bos taurus
V36NQSCLVEECAL1Mus musculus
V36NQDCLVEECAL1Rattus norvegicus
V51CRTTIVRLWEE1Homo sapiens
V51CRTTVLSVWEG1Bos taurus
V51CRTTVLREWQD1Mus musculus
V51CRTTVLREWED1Rattus norvegicus
V51CRTTIVRMWEE1Pan troglodytes
V91TSLTEVVCGLD2Homo sapiens, Pan troglodytes
V91ITLSETVCRSD1Bos taurus
V91ISLTETVCATN1Mus musculus
V91VSLTETVCATN1Rattus norvegicus
Y79NRTLSYRTGLK2Homo sapiens, Pan troglodytes
Y79NRSMSYRAADQ1Bos taurus
Y79NRTMSYRMGSM1Mus musculus
Y79NRTMSYRMGSV1Rattus norvegicus


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