mutLBSgeneDB |
Gene summary for PANK1 |
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Basic gene Info. | Gene symbol | PANK1 |
Gene name | pantothenate kinase 1 | |
Synonyms | PANK | |
Cytomap | UCSC genome browser: 10q23.31 | |
Type of gene | protein-coding | |
RefGenes | NM_138316.3, NM_148977.2,NM_148978.2, | |
Description | pantothenic acid kinase 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606160 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152782 | ||
HPRD : 07549 | ||
Protein | UniProt: Q8TE04 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PANK1 | |
BioGPS: 53354 | ||
Pathway | NCI Pathway Interaction Database: PANK1 | |
KEGG: PANK1 | ||
REACTOME: PANK1 | ||
Pathway Commons: PANK1 | ||
Context | iHOP: PANK1 | |
ligand binding site mutation search in PubMed: PANK1 | ||
UCL Cancer Institute: PANK1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for PANK1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | A492 | G490R | BLCA | 1 | Y479,Y483 | G481E | BLCA | 1 | M501 | M501I | BRCA | 1 | N547 | L549I | COAD | 1 | R432 | V433L | LUAD | 1 | Y483 | D482N | LUSC | 1 | M501 | M501T | STAD | 1 | N547 | N547H | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PANK1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | M501 | M501T | -1.2683993 | N547 | L549I | -1.1346436 | Y483 | D482N | -0.913865 | M501 | M501I | -0.84204754 | A492 | G490R | -0.62173958 | R432 | V433L | -0.58450003 | Y479 | G481E | -0.47731086 | Y483 | G481E | -0.47731086 | N547 | N547H | -0.28271987 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for PANK1 |
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Phenotype information for PANK1 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PANK1 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ACO | ACETYL COENZYME *A | 2i7n | A | A492 | ACO | ACETYL COENZYME *A | 2i7n | A | R432 | ACO | ACETYL COENZYME *A | 2i7n | B | R432 | ACO | ACETYL COENZYME *A | 3smp | A | R432 | ACO | ACETYL COENZYME *A | 3smp | B | R432 N547 | ACO | ACETYL COENZYME *A | 2i7n | B | Y479 A492 | ACO | ACETYL COENZYME *A | 3smp | A | Y479 A492 M501 | ACO | ACETYL COENZYME *A | 3smp | B | Y479 Y483 A492 |
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Conservation information for LBS of PANK1 |
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LBS | AA sequence | # species | Species |
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