|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for PLG |
 Gene summary |
| Basic gene Info. | Gene symbol | PLG |
| Gene name | plasminogen | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 6q26 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000301.3, NM_001168338.1, | |
| Description | plasmin | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 173350 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000122194 | ||
| HPRD : 01417 | ||
| Vega : OTTHUMG00000015957 | ||
| Protein | UniProt: P00747 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLG | |
| BioGPS: 5340 | ||
| Pathway | NCI Pathway Interaction Database: PLG | |
| KEGG: PLG | ||
| REACTOME: PLG | ||
| Pathway Commons: PLG | ||
| Context | iHOP: PLG | |
| ligand binding site mutation search in PubMed: PLG | ||
| UCL Cancer Institute: PLG | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010812 | negative regulation of cell-substrate adhesion | 14699093 | GO:0022617 | extracellular matrix disassembly | 14699093 | GO:0051918 | negative regulation of fibrinolysis | 14726399 | GO:0051919 | positive regulation of fibrinolysis | 6438154 |
| Top |
| Ligand binding site mutations for PLG |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | W334,H336 | C335R | COAD | 2 | N251 | D249E | BRCA | 1 | W254 | W254L | COAD | 1 | W244,E240 | R242W | COAD | 1 | W244,E240 | R242Q | COAD | 1 | D158 | D158N | COAD | 1 | Q212 | S213G | COAD | 1 | N251 | D249N | COAD | 1 | R172 | E170V | COAD | 1 | W446 | V444I | COAD | 1 | R239 | R239K | COAD | 1 | Y165 | T166S | KIRC | 1 | H215 | H215Q | LUAD | 1 | D210 | W209R | LUAD | 1 | D210 | D210Y | LUAD | 1 | D210 | W209L | LUAD | 1 | W163 | G161W | LUAD | 1 | D158 | Q160H | LUAD | 1 | K330 | D328E | OV | 1 | F224 | P225S | SKCM | 1 | D432 | D432H | SKCM | 1 | D432 | D432N | SKCM | 1 | K330 | G329E | SKCM | 1 | D158 | P159S | SKCM | 1 | W446 | E447K | SKCM | 1 | A216 | A216S | STAD | 1 | R172 | E170A | THCA | 1 | D210,Q212 | S211F | UCEC | 1 | W244,E240 | R242Q | UCEC | 1 | D158 | D158N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for PLG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W254 | W254L | 0.018108665 | W446 | E447K | -1.7595611 | D432 | D432N | -1.6548488 | D432 | D432H | -1.6119451 | F224 | P225S | -1.5423757 | D158 | P159S | -1.3780083 | A216 | A216S | -1.2497692 | R172 | E170A | -1.2478122 | W334 | C335R | -1.0498788 | H336 | C335R | -1.0498788 | D158 | D158N | -1.0166645 | D158 | Q160H | -0.96108995 | W244 | R242Q | -0.95726195 | E240 | R242Q | -0.95726195 | Q212 | S213G | -0.95314444 | D210 | W209R | -0.89353664 | R172 | E170V | -0.88589484 | N251 | D249N | -0.86518328 | H215 | H215Q | -0.77663115 | R239 | R239K | -0.76870875 | K330 | G329E | -0.74583357 | E240 | R242W | -0.69985904 | W244 | R242W | -0.69985904 | W163 | G161W | -0.67657607 | D210 | W209L | -0.56114833 | W446 | V444I | -0.53898952 | K330 | D328E | -0.47912213 | N251 | D249E | -0.42274317 | Y165 | T166S | -0.42029001 | D210 | D210Y | -0.35143121 | Q212 | S211F | -0.088561168 | D210 | S211F | -0.088561168 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PLG from PDB |
| PDB ID | PDB title | PDB structure | 1DDJ | CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN |  |
| Top |
| Differential gene expression and gene-gene network for PLG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for PLG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1968804 | Plasminogen Deficiency, Type I | 14 | Biomarker, GeneticVariation |
| umls:C0020538 | Hypertension | 6 | Biomarker |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | Biomarker |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Therapeutic |
| umls:C0042487 | Venous Thrombosis | 1 | Therapeutic |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for PLG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00009 | Alteplase | Biotech |  |
| Approved|investigational|withdrawn | DB00013 | Urokinase | Biotech |  |
| Approved | DB00015 | Reteplase | Biotech |  |
| Approved | DB00029 | Anistreplase | Biotech |  |
| Approved | DB00031 | Tenecteplase | Biotech |  |
| Approved | DB00086 | Streptokinase | Biotech |  |
| Approved | DB00302 | Tranexamic Acid | Small molecule |  |
| Approved|investigational | DB00513 | Aminocaproic Acid | Small molecule |  |
| Experimental | DB03709 | Bicine | Small molecule |  |
| Investigational | DB04925 | Desmoteplase | Biotech |  |
| Approved|withdrawn | DB06692 | Aprotinin | Biotech |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of PLG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of PLG |
| Multiple alignments for P00747 in multiple species |
| LBS | AA sequence | # species | Species | A216 | SQSPHAHGYIP | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | C756 | GGTDSCQGDSG | 3 | Homo sapiens, Bos taurus, Macaca mulatta | C756 | GGVDSCQGDSG | 1 | Mus musculus | C756 | GGIDSCQGDSG | 1 | Rattus norvegicus | D156 | YCRNPDNDEQG | 2 | Mus musculus, Rattus norvegicus | D156 | YCRNPDNDPQG | 1 | Homo sapiens | D156 | YCRNPDNDENG | 1 | Bos taurus | D156 | YCRNPDNDGQG | 1 | Macaca mulatta | D158 | RNPDNDEQGPW | 2 | Mus musculus, Rattus norvegicus | D158 | RNPDNDPQGPW | 1 | Homo sapiens | D158 | RNPDNDENGPW | 1 | Bos taurus | D158 | RNPDNDGQGPW | 1 | Macaca mulatta | D210 | ECQAWDSQSPH | 2 | Homo sapiens, Macaca mulatta | D210 | DCQAWDSQSPH | 2 | Bos taurus, Mus musculus | D210 | DCQSWDSQSPH | 1 | Rattus norvegicus | D238 | YCRNPDGEPRP | 4 | Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | D238 | YCRNPDRELRP | 1 | Homo sapiens | D430 | YCRNPDAD-KG | 2 | Homo sapiens, Macaca mulatta | D430 | YCRNPDAD-KS | 1 | Bos taurus | D430 | YCRNPDGD-KG | 1 | Mus musculus | D430 | YCRNPDNDQRG | 1 | Rattus norvegicus | D432 | RNPDAD-KGPW | 2 | Homo sapiens, Macaca mulatta | D432 | RNPDAD-KSPW | 1 | Bos taurus | D432 | RNPDGD-KGPW | 1 | Mus musculus | D432 | RNPDNDQRGPW | 1 | Rattus norvegicus | D754 | LAGGTDSCQGD | 2 | Homo sapiens, Macaca mulatta | D754 | LIGGTDSCQGD | 1 | Bos taurus | D754 | LAGGVDSCQGD | 1 | Mus musculus | D754 | LAGGIDSCQGD | 1 | Rattus norvegicus | E240 | RNPDGEPRPWC | 4 | Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | E240 | RNPDRELRPWC | 1 | Homo sapiens | F137 | PHRPRFSPATH | 1 | Homo sapiens | F137 | PHVPKFSPEKF | 1 | Bos taurus | F137 | PHRPTFSPATH | 1 | Macaca mulatta | F137 | PHVPNYSPSTH | 1 | Mus musculus | F137 | PHVPKYSPSTH | 1 | Rattus norvegicus | F224 | YIPSKFPNKNL | 3 | Homo sapiens, Bos taurus, Macaca mulatta | F224 | YIPAKFPSKNL | 2 | Mus musculus, Rattus norvegicus | F246 | PRPWCFTTDPN | 2 | Macaca mulatta, Rattus norvegicus | F246 | LRPWCFTTDPN | 1 | Homo sapiens | F246 | PRPWCFTTDPQ | 1 | Bos taurus | F246 | PRPWCFTTDPT | 1 | Mus musculus | G218 | SPHAHGYIPSK | 3 | Homo sapiens, Bos taurus, Macaca mulatta | G218 | SPHAHGYIPAK | 2 | Mus musculus, Rattus norvegicus | G758 | TDSCQGDSGGP | 3 | Homo sapiens, Bos taurus, Macaca mulatta | G758 | VDSCQGDSGGP | 1 | Mus musculus | G758 | IDSCQGDSGGP | 1 | Rattus norvegicus | G781 | GVTSWGLGCAR | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | G783 | TSWGLGCARPN | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | H133 | SSTSPHRPRFS | 1 | Homo sapiens | H133 | SATSPHVPKFS | 1 | Bos taurus | H133 | SSTSPHRPTFS | 1 | Macaca mulatta | H133 | GATFPHVPNYS | 1 | Mus musculus | H133 | SDTSPHVPKYS | 1 | Rattus norvegicus | H215 | DSQSPHAHGYI | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | H217 | QSPHAHGYIPS | 3 | Homo sapiens, Bos taurus, Macaca mulatta | H217 | QSPHAHGYIPA | 2 | Mus musculus, Rattus norvegicus | H336 | TAPWCYTTDSQ | 2 | Mus musculus, Rattus norvegicus | H336 | RAPWCHTTNSQ | 1 | Homo sapiens | H336 | KAPWCYTTNSE | 1 | Bos taurus | H336 | KAPWCYTTNSQ | 1 | Macaca mulatta | H622 | VLTAAHCLEKS | 4 | Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus | H622 | VLTAAHCLDNI | 1 | Bos taurus | I220 | HAHGYIPSKFP | 3 | Homo sapiens, Bos taurus, Macaca mulatta | I220 | HAHGYIPAKFP | 2 | Mus musculus, Rattus norvegicus | I701 | RTECFITGWGE | 2 | Homo sapiens, Macaca mulatta | I701 | RTECYITGWGE | 1 | Bos taurus | I701 | RTICYITGWGE | 1 | Mus musculus | I701 | RTLCYITGWGE | 1 | Rattus norvegicus | K223 | GYIPSKFPNKN | 3 | Homo sapiens, Bos taurus, Macaca mulatta | K223 | GYIPAKFPSKN | 2 | Mus musculus, Rattus norvegicus | K330 | RNPDGETAPWC | 2 | Mus musculus, Rattus norvegicus | K330 | RNPDGKRAPWC | 1 | Homo sapiens | K330 | RNPNGEKAPWC | 1 | Bos taurus | K330 | RNPDGEKAPWC | 1 | Macaca mulatta | K411 | PHRHQKTPENY | 1 | Homo sapiens | K411 | PHRHLKTPENY | 1 | Bos taurus | K411 | PHWHEKTPENF | 1 | Macaca mulatta | K411 | PHRHSKTPENF | 1 | Mus musculus | K411 | PHSHSKTPANF | 1 | Rattus norvegicus | N157 | CRNPDNDEQGP | 2 | Mus musculus, Rattus norvegicus | N157 | CRNPDNDPQGP | 1 | Homo sapiens | N157 | CRNPDNDENGP | 1 | Bos taurus | N157 | CRNPDNDGQGP | 1 | Macaca mulatta | N251 | FTTDPNKRWEL | 2 | Homo sapiens, Macaca mulatta | N251 | FTTDPQKRWEF | 1 | Bos taurus | N251 | FTTDPTKRWEY | 1 | Mus musculus | N251 | FTTDPNKRWEY | 1 | Rattus norvegicus | P135 | TSPHRPRFSPA | 1 | Homo sapiens | P135 | TSPHVPKFSPE | 1 | Bos taurus | P135 | TSPHRPTFSPA | 1 | Macaca mulatta | P135 | TFPHVPNYSPS | 1 | Mus musculus | P135 | TSPHVPKYSPS | 1 | Rattus norvegicus | P237 | NYCRNPDGEPR | 4 | Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | P237 | NYCRNPDRELR | 1 | Homo sapiens | Q212 | QAWDSQSPHAH | 4 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus | Q212 | QSWDSQSPHAH | 1 | Rattus norvegicus | Q757 | GTDSCQGDSGG | 3 | Homo sapiens, Bos taurus, Macaca mulatta | Q757 | GVDSCQGDSGG | 1 | Mus musculus | Q757 | GIDSCQGDSGG | 1 | Rattus norvegicus | R134 | STSPHRPRFSP | 1 | Homo sapiens | R134 | ATSPHVPKFSP | 1 | Bos taurus | R134 | STSPHRPTFSP | 1 | Macaca mulatta | R134 | ATFPHVPNYSP | 1 | Mus musculus | R134 | DTSPHVPKYSP | 1 | Rattus norvegicus | R136 | SPHRPRFSPAT | 1 | Homo sapiens | R136 | SPHVPKFSPEK | 1 | Bos taurus | R136 | SPHRPTFSPAT | 1 | Macaca mulatta | R136 | FPHVPNYSPST | 1 | Mus musculus | R136 | SPHVPKYSPST | 1 | Rattus norvegicus | R172 | TDPEKRYDYCD | 1 | Homo sapiens | R172 | TDPDKRYDYCD | 1 | Bos taurus | R172 | TDPEERFDYCD | 1 | Macaca mulatta | R172 | TDPDKRYDYCN | 1 | Mus musculus | R172 | TDPDQRYEYCN | 1 | Rattus norvegicus | R239 | CRNPDGEPRPW | 4 | Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | R239 | CRNPDRELRPW | 1 | Homo sapiens | R253 | TDPNKRWELCD | 2 | Homo sapiens, Macaca mulatta | R253 | TDPQKRWEFCD | 1 | Bos taurus | R253 | TDPTKRWEYCD | 1 | Mus musculus | R253 | TDPNKRWEYCD | 1 | Rattus norvegicus | R309 | PHTHNRTPENF | 2 | Homo sapiens, Macaca mulatta | R309 | PHRHNRTPENF | 2 | Mus musculus, Rattus norvegicus | R309 | PHKHNRTPENF | 1 | Bos taurus | R343 | TNSQVRWEYCK | 2 | Homo sapiens, Macaca mulatta | R343 | TDSQLRWEYCE | 2 | Mus musculus, Rattus norvegicus | R343 | TNSEVRWEYCT | 1 | Bos taurus | S222 | HGYIPSKFPNK | 3 | Homo sapiens, Bos taurus, Macaca mulatta | S222 | HGYIPAKFPSK | 2 | Mus musculus, Rattus norvegicus | S755 | AGGTDSCQGDS | 2 | Homo sapiens, Macaca mulatta | S755 | IGGTDSCQGDS | 1 | Bos taurus | S755 | AGGVDSCQGDS | 1 | Mus musculus | S755 | AGGIDSCQGDS | 1 | Rattus norvegicus | S760 | SCQGDSGGPLV | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | S779 | LQGVTSWGLGC | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | W163 | DEQGPWCYTTD | 2 | Mus musculus, Rattus norvegicus | W163 | DPQGPWCYTTD | 1 | Homo sapiens | W163 | DENGPWCYTTD | 1 | Bos taurus | W163 | DGQGPWCYTTD | 1 | Macaca mulatta | W244 | GEPRPWCFTTD | 4 | Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | W244 | RELRPWCFTTD | 1 | Homo sapiens | W254 | DPNKRWELCDI | 2 | Homo sapiens, Macaca mulatta | W254 | DPQKRWEFCDI | 1 | Bos taurus | W254 | DPTKRWEYCDI | 1 | Mus musculus | W254 | DPNKRWEYCDI | 1 | Rattus norvegicus | W334 | GEKAPWCYTTN | 2 | Bos taurus, Macaca mulatta | W334 | GETAPWCYTTD | 2 | Mus musculus, Rattus norvegicus | W334 | GKRAPWCHTTN | 1 | Homo sapiens | W344 | NSQVRWEYCKI | 2 | Homo sapiens, Macaca mulatta | W344 | DSQLRWEYCEI | 2 | Mus musculus, Rattus norvegicus | W344 | NSEVRWEYCTI | 1 | Bos taurus | W446 | DPSVRWEYCNL | 4 | Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus | W446 | DPRVRWEFCNL | 1 | Bos taurus | W780 | QGVTSWGLGCA | 5 | Homo sapiens, Bos taurus, Macaca mulatta, Mus musculus, Rattus norvegicus | Y165 | QGPWCYTTDPE | 2 | Homo sapiens, Macaca mulatta | Y165 | QGPWCYTTDPD | 2 | Mus musculus, Rattus norvegicus | Y165 | NGPWCYTTDPD | 1 | Bos taurus | Y173 | DPEKRYDYCDI | 1 | Homo sapiens | Y173 | DPDKRYDYCDI | 1 | Bos taurus | Y173 | DPEERFDYCDI | 1 | Macaca mulatta | Y173 | DPDKRYDYCNI | 1 | Mus musculus | Y173 | DPDQRYEYCNI | 1 | Rattus norvegicus | Y219 | PHAHGYIPSKF | 3 | Homo sapiens, Bos taurus, Macaca mulatta | Y219 | PHAHGYIPAKF | 2 | Mus musculus, Rattus norvegicus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |