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mutLBSgeneDB |
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| Gene summary for ADAM22 |
 Gene summary |
| Basic gene Info. | Gene symbol | ADAM22 |
| Gene name | ADAM metallopeptidase domain 22 | |
| Synonyms | ADAM 22|MDC2 | |
| Cytomap | UCSC genome browser: 7q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004194.3, NM_016351.4,NM_021721.3,NM_021722.4,NM_021723.3, | |
| Description | a disintegrin and metalloproteinase domain 22disintegrin and metalloproteinase domain-containing protein 22metalloproteinase-disintegrin ADAM22-3metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603709 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000008277 | ||
| HPRD : 04751 | ||
| Vega : OTTHUMG00000137417 | ||
| Protein | UniProt: Q9P0K1 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADAM22 | |
| BioGPS: 53616 | ||
| Pathway | NCI Pathway Interaction Database: ADAM22 | |
| KEGG: ADAM22 | ||
| REACTOME: ADAM22 | ||
| Pathway Commons: ADAM22 | ||
| Context | iHOP: ADAM22 | |
| ligand binding site mutation search in PubMed: ADAM22 | ||
| UCL Cancer Institute: ADAM22 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ADAM22 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I512,E514 | R513C | BLCA | 1 | G448 | G448S | GBM | 1 | I527 | H528R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ADAM22 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E514 | R513C | -1.1896344 | I512 | R513C | -1.1896344 | I527 | H528R | -1.1396766 | G448 | G448S | -0.72013904 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ADAM22 from PDB |
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| Differential gene expression and gene-gene network for ADAM22 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ADAM22 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ADAM22 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ADAM22 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 3g5c | A | G448 | CA | CALCIUM(2+) | 3g5c | B | G448 | CA | CALCIUM(2+) | 3g5c | A | I512 E514 I527 | CA | CALCIUM(2+) | 3g5c | B | I512 E514 I527 |
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| Conservation information for LBS of ADAM22 |
| Multiple alignments for Q9P0K1 in multiple species |
| LBS | AA sequence | # species | Species |
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