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mutLBSgeneDB |
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| Gene summary for PPIL3 |
 Gene summary |
| Basic gene Info. | Gene symbol | PPIL3 |
| Gene name | peptidylprolyl isomerase (cyclophilin)-like 3 | |
| Synonyms | CYPJ | |
| Cytomap | UCSC genome browser: 2q33.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032472.3, NM_130906.2,NM_131916.1, | |
| Description | PPIasePPIase-like protein 3cyclophilin Jcyclophilin-like protein 3cyclophilin-like protein PPIL3peptidyl-prolyl cis-trans isomerase-like 3peptidylprolyl cis-trans isomerase-like protein 3rotamase PPIL3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615811 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000240344 | ||
| HPRD : 15163 | ||
| Vega : OTTHUMG00000132782 | ||
| Protein | UniProt: Q9H2H8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PPIL3 | |
| BioGPS: 53938 | ||
| Pathway | NCI Pathway Interaction Database: PPIL3 | |
| KEGG: PPIL3 | ||
| REACTOME: PPIL3 | ||
| Pathway Commons: PPIL3 | ||
| Context | iHOP: PPIL3 | |
| ligand binding site mutation search in PubMed: PPIL3 | ||
| UCL Cancer Institute: PPIL3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PPIL3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M50 | M50I | LUAD | 1 | F102 | F102L | LUAD | 1 | Q100 | S99A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PPIL3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Q100 | S99A | -1.1371697 | M50 | M50I | -0.62182233 | F102 | F102L | -0.48491926 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PPIL3 from PDB |
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| Differential gene expression and gene-gene network for PPIL3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PPIL3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PPIL3 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PPIL3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PPIL3 |
| Multiple alignments for Q9H2H8 in multiple species |
| LBS | AA sequence | # species | Species | A90 | GVVSMANNGPN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | A90 | GIVSMANKGPN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | A90 | GMLSMANSGPN | 1 | Arabidopsis thaliana | A90 | GCVSMANNGPD | 1 | Caenorhabditis elegans | F102 | NGSQFFITYGK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | F102 | NGSQFFILFDK | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | F102 | NGSQFFITYAK | 1 | Arabidopsis thaliana | F102 | NRSQFFITYAK | 1 | Caenorhabditis elegans | F49 | RNIKGFMVQTG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | F49 | RMIPSFMVQTG | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | F49 | RNIKGFMIQGG | 1 | Arabidopsis thaliana | F49 | RNIKDFMVQTG | 1 | Caenorhabditis elegans | G60 | DPTGTG----- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G60 | APANPSPPENP | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | G60 | DPKGTG----- | 1 | Arabidopsis thaliana | G60 | DPTHSG----- | 1 | Caenorhabditis elegans | G60 | DPLGTG----- | 1 | Gallus gallus | H110 | YGKQPHLDMKY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | H110 | FDKAPHLDGLN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | H110 | YAKQPHLNGLY | 1 | Arabidopsis thaliana | H110 | YAKQAHLDMKY | 1 | Caenorhabditis elegans | M50 | NIKGFMVQTGD | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | M50 | MIPSFMVQTGA | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | M50 | NIKGFMIQGGD | 1 | Arabidopsis thaliana | M50 | NIKDFMVQTGD | 1 | Caenorhabditis elegans | N91 | VVSMANNGPNT | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N91 | IVSMANKGPNT | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | N91 | MLSMANSGPNT | 1 | Arabidopsis thaliana | N91 | CVSMANNGPDS | 1 | Caenorhabditis elegans | N92 | VSMANNGPNTN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N92 | VSMANKGPNTN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | N92 | LSMANSGPNTN | 1 | Arabidopsis thaliana | N92 | VSMANNGPDSN | 1 | Caenorhabditis elegans | Q100 | NTNGSQFFITY | 5 | Homo sapiens, Arabidopsis thaliana, Gallus gallus, Mus musculus, Rattus norvegicus | Q100 | NTNGSQFFILF | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Q100 | DSNRSQFFITY | 1 | Caenorhabditis elegans | Q52 | KGFMVQTGDPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q52 | PSFMVQTGAPA | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Q52 | KGFMIQGGDPK | 1 | Arabidopsis thaliana | Q52 | KDFMVQTGDPT | 1 | Caenorhabditis elegans | Q52 | KGFMVQTGDPL | 1 | Gallus gallus | R44 | GCVFHRNIKGF | 3 | Gallus gallus, Mus musculus, Rattus norvegicus | R44 | GCIFHRNIKGF | 1 | Homo sapiens | R44 | ASPFHRMIPSF | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | R44 | GTIFHRNIKGF | 1 | Arabidopsis thaliana | R44 | GCIFHRNIKDF | 1 | Caenorhabditis elegans | R61 | -----KGGTSI | 2 | Arabidopsis thaliana, Gallus gallus | R61 | -----RGGSSI | 2 | Mus musculus, Rattus norvegicus | R61 | -----RGGNSI | 1 | Homo sapiens | R61 | PPENPKGGRSI | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | R61 | -----KGGESI | 1 | Caenorhabditis elegans | Y115 | HLDMKYTVFGK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y115 | HLDGLNTVFGK | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Y115 | HLNGLYTIFGK | 1 | Arabidopsis thaliana | Y115 | HLDMKYTLFGK | 1 | Caenorhabditis elegans |
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