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mutLBSgeneDB |
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| Gene summary for CSNK1G1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CSNK1G1 |
| Gene name | casein kinase 1, gamma 1 | |
| Synonyms | CK1gamma1 | |
| Cytomap | UCSC genome browser: 15q22.1-q22.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022048.3, | |
| Description | CKI-gamma 1casein kinase I isoform gamma-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606274 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169118 | ||
| Vega : OTTHUMG00000133019 | ||
| Protein | UniProt: Q9HCP0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CSNK1G1 | |
| BioGPS: 53944 | ||
| Pathway | NCI Pathway Interaction Database: CSNK1G1 | |
| KEGG: CSNK1G1 | ||
| REACTOME: CSNK1G1 | ||
| Pathway Commons: CSNK1G1 | ||
| Context | iHOP: CSNK1G1 | |
| ligand binding site mutation search in PubMed: CSNK1G1 | ||
| UCL Cancer Institute: CSNK1G1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CSNK1G1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L171 | F170V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CSNK1G1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L171 | F170V | -0.63373561 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CSNK1G1 from PDB |
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| Differential gene expression and gene-gene network for CSNK1G1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CSNK1G1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CSNK1G1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB08325 | 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CSNK1G1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | OLP | 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE | 2cmw | A | L171 |
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| Conservation information for LBS of CSNK1G1 |
| Multiple alignments for Q9HCP0 in multiple species |
| LBS | AA sequence | # species | Species | A71 | TNEYVAIKLEP | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | C110 | YYFGPCGKYNA | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | C110 | FYFGPCGKYNA | 1 | Danio rerio | E119 | NAMVLELLGPS | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | G122 | VLELLGPSLED | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | G47 | PNFRVGKKIGC | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | G51 | VGKKIGCGNFG | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | G61 | GELRLGKNLYT | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | G61 | GELKLGKNLYT | 1 | Danio rerio | I186 | HVIHIIDFGLA | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | I186 | HIIHIIDFGLA | 1 | Danio rerio | I50 | RVGKKIGCGNF | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | I72 | NEYVAIKLEPI | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | I72 | NEYVAIKLEPV | 1 | Danio rerio | K62 | ELRLGKNLYTN | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | K62 | ELKLGKNLYTN | 1 | Danio rerio | L118 | YNAMVLELLGP | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L120 | AMVLELLGPSL | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L121 | MVLELLGPSLE | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L171 | KPENFLIGRQG | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L58 | GNFGELRLGKN | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L58 | GNFGELKLGKN | 1 | Danio rerio | L64 | RLGKNLYTNEY | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | L64 | KLGKNLYTNEY | 1 | Danio rerio | N63 | LRLGKNLYTNE | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | N63 | LKLGKNLYTNE | 1 | Danio rerio | P334 | VGRPIPTPVGS | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | P334 | VGRQIPTPVGT | 1 | Danio rerio | P336 | RPIPTPVGSVH | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | P336 | RQIPTPVGTVH | 1 | Danio rerio | T335 | GRPIPTPVGSV | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | T335 | GRQIPTPVGTV | 1 | Danio rerio | V117 | KYNAMVLELLG | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | Y105 | GLPQVYYFGPC | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | Y105 | GLPQVFYFGPC | 1 | Danio rerio | Y106 | LPQVYYFGPCG | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus | Y106 | LPQVFYFGPCG | 1 | Danio rerio | Y65 | LGKNLYTNEYV | 6 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus, Mus musculus, Bos taurus |
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