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mutLBSgeneDB |
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| Gene summary for PNLIPRP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | PNLIPRP1 |
| Gene name | pancreatic lipase-related protein 1 | |
| Synonyms | PLRP1 | |
| Cytomap | UCSC genome browser: 10q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001303135.1, NM_006229.3, | |
| Description | inactive pancreatic lipase-related protein 1 | |
| Modification date | 20141220 | |
| dbXrefs | MIM : 604422 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000187021 | ||
| HPRD : 05109 | ||
| Vega : OTTHUMG00000019109 | ||
| Protein | UniProt: P54315 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PNLIPRP1 | |
| BioGPS: 5407 | ||
| Pathway | NCI Pathway Interaction Database: PNLIPRP1 | |
| KEGG: PNLIPRP1 | ||
| REACTOME: PNLIPRP1 | ||
| Pathway Commons: PNLIPRP1 | ||
| Context | iHOP: PNLIPRP1 | |
| ligand binding site mutation search in PubMed: PNLIPRP1 | ||
| UCL Cancer Institute: PNLIPRP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PNLIPRP1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E458 | T460M | BRCA | 1 | E458 | D459N | LUAD | 1 | E205 | E205K | LUAD | 1 | D213 | D215N | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PNLIPRP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D213 | D215N | -1.6451458 | E205 | E205K | -0.78642381 | E458 | D459N | -0.58451431 | E458 | T460M | -0.28932121 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PNLIPRP1 from PDB |
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| Differential gene expression and gene-gene network for PNLIPRP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PNLIPRP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PNLIPRP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PNLIPRP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2ppl | A | E205 D213 | CA | CALCIUM(2+) | 2ppl | A | E458 | CA | CALCIUM(2+) | 2ppl | A | E458 |
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| Conservation information for LBS of PNLIPRP1 |
| Multiple alignments for P54315 in multiple species |
| LBS | AA sequence | # species | Species | D210 | EEVRLDPSDAD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D210 | EEVRLDPTDAD | 1 | Canis lupus familiaris | D213 | RLDPSDADFVD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D213 | RLDPTDADFVD | 1 | Canis lupus familiaris | E205 | FEGTPEEVRLD | 2 | Mus musculus, Rattus norvegicus | E205 | FESTPEEVRLD | 1 | Homo sapiens | E205 | FQGTPEEVRLD | 1 | Canis lupus familiaris | E458 | EDTVREDTLLT | 1 | Homo sapiens | E458 | EETVREDILLT | 1 | Mus musculus | E458 | EETVREDTLLT | 1 | Rattus norvegicus | E458 | ESTVREDVLLT | 1 | Canis lupus familiaris | N421 | VKFLWNNNVIN | 1 | Homo sapiens | N421 | VKFLWNNHVVN | 1 | Mus musculus | N421 | VKFLWNNQVIN | 1 | Rattus norvegicus | N421 | VKFLWNNNVVN | 1 | Canis lupus familiaris | N422 | KFLWNNNVINP | 1 | Homo sapiens | N422 | KFLWNNHVVNP | 1 | Mus musculus | N422 | KFLWNNQVINP | 1 | Rattus norvegicus | N422 | KFLWNNNVVNP | 1 | Canis lupus familiaris | N426 | NNNVINPTLPK | 1 | Homo sapiens | N426 | NNHVVNPSFPK | 1 | Mus musculus | N426 | NNQVINPSFPK | 1 | Rattus norvegicus | N426 | NNNVVNPTFPK | 1 | Canis lupus familiaris | R208 | TPEEVRLDPSD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R208 | TPEEVRLDPTD | 1 | Canis lupus familiaris | V424 | LWNNNVINPTL | 1 | Homo sapiens | V424 | LWNNHVVNPSF | 1 | Mus musculus | V424 | LWNNQVINPSF | 1 | Rattus norvegicus | V424 | LWNNNVVNPTF | 1 | Canis lupus familiaris |
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