mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PNMT

Gene summary

Basic gene Info.	Gene symbol	PNMT
	Gene name	phenylethanolamine N-methyltransferase
	Synonyms	PENT\|PNMTase
	Cytomap	UCSC genome browser: 17q12
	Type of gene	protein-coding
	RefGenes	NM_002686.4, NR_073461.1,
	Description	noradrenaline N-methyltransferasephenylethanolamine N-methylase
	Modification date	20141207
dbXrefs	MIM : 171190
	HGNC : HGNC
	HPRD : 07176
Protein	UniProt: P11086 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PNMT
	BioGPS: 5409
Pathway	NCI Pathway Interaction Database: PNMT
	KEGG: PNMT
	REACTOME: PNMT
	Pathway Commons: PNMT
Context	iHOP: PNMT
	ligand binding site mutation search in PubMed: PNMT
	UCL Cancer Institute: PNMT
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for PNMT

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R240	R240G	COAD	1
Y35	R33H	LUSC	1
Y40,R44	P42L	SKCM	1
A181	A181V	STAD	1
M258	A260T	STAD	1
E219	S220L	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PNMT

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R240	R240G	-0.7595608
Y40	P42L	-0.70222507
R44	P42L	-0.70222507
Y35	R33H	-0.44319886
A181	A181V	-0.44295824
E219	S220L	-0.40552855
M258	A260T	-0.39196853

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PNMT from PDB

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Differential gene expression and gene-gene network for PNMT

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PNMT and the right PPI network was created from samples without mutations in the LBS of PNMT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PNMT

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PNMT

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB01752	S-Adenosyl-L-Homocysteine	Small molecule
Experimental	DB03468	1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide	Small molecule
Experimental	DB03824	7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline	Small molecule
Experimental	DB04273	8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine	Small molecule
Experimental	DB07597	CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL	Small molecule
Experimental	DB07739	(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	Small molecule
Experimental	DB07747	(3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE	Small molecule
Experimental	DB07798	(3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE	Small molecule
Experimental	DB07906	[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL	Small molecule
Experimental	DB08128	(1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine	Small molecule
Experimental	DB08129	(1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol	Small molecule
Experimental	DB08550	7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE	Small molecule
Experimental	DB08631	N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE	Small molecule
Experimental	DB08654	TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PNMT go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
HNT		3(R)-HYDROXYMETHYL 7-NITRO 1,2,3,4-TETRAHYDROISOQUINOLINE	2g70	A	R240
PO4		PHOSPHATE ION	3kpj	B	R44
IMD		IMIDAZOLIUM CATION	4dm3	A	R44
OTR		(R)-OCTOPAMINE	3hca	A	R44 E219
OTR		(R)-OCTOPAMINE	3hca	B	R44 E219
OTR		(R)-OCTOPAMINE	3hce	B	R44 E219
FAN		FORMANILIDE	3kqv	B	R44 E219
IMD		IMIDAZOLIUM CATION	4dm3	B	R44 M258
RCO		RESORCINOL	4dm3	A	Y35 E219
OTR		(R)-OCTOPAMINE	3hce	A	Y35 R44 E219
ES5		6-QUINOLINAMINE	3kqp	A	Y35 R44 E219
CTL		CIS-(1R,2S)-2-AMINO-1-TETRALOL	2an3	A	Y35 R44 E219 M258
OTR		(R)-OCTOPAMINE	2an4	A	Y35 R44 E219 M258
OTR		(R)-OCTOPAMINE	2an4	B	Y35 R44 E219 M258
TTL		TRANS-(1S,2S)-2-AMINO-1-TETRALOL	2an5	B	Y35 R44 E219 M258
1SQ		1-AMINOISOQUINOLINE	3kpw	B	Y35 R44 E219 M258
ES5		6-QUINOLINAMINE	3kqp	B	Y35 R44 E219 M258
ES9		5-CHLORO-1H-BENZIMIDAZOLE	3kqw	A	Y35 R44 M258
ES9		5-CHLORO-1H-BENZIMIDAZOLE	3kqw	B	Y35 R44 M258
SAH		S-ADENOSYL-L-HOMOCYSTEINE	1hnn	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	1n7i	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	1n7j	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	1yz3	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	1yz3	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2an3	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2an4	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2an4	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2an5	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2an5	B	Y35 Y40 A181
SAM		S-ADENOSYL-L-METHIONINE	2g70	A	Y35 Y40 A181
SAM		S-ADENOSYL-L-METHIONINE	2g70	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2g71	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2g71	B	Y35 Y40 A181
SAM		S-ADENOSYL-L-METHIONINE	2g72	A	Y35 Y40 A181
SAM		S-ADENOSYL-L-METHIONINE	2g72	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2g8n	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2g8n	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2obf	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2ony	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2onz	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2opb	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	2opb	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hca	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hca	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcb	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcb	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcc	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcc	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcd	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcd	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hce	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hce	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcf	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3hcf	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpj	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpj	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpu	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpu	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpv	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpv	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpw	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpw	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpy	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kpy	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqm	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqm	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqo	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqo	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqp	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqp	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqq	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqq	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqs	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqs	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqt	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqt	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqv	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqv	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqw	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqw	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqy	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kqy	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr0	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr0	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr1	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr1	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr2	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	3kr2	B	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	4dm3	A	Y35 Y40 A181
SAH		S-ADENOSYL-L-HOMOCYSTEINE	4dm3	B	Y35 Y40 A181
TRS		HTRIS	4mik	A	Y35 Y40 A181
TRS		HTRIS	4mik	B	Y35 Y40 A181
LT2		(3S)-3-HYDROXY-2,3-DIHYDRO-1H-INDOLE-5,6-DIONE	3hcb	A	Y35 Y40 E219
LT2		(3S)-3-HYDROXY-2,3-DIHYDRO-1H-INDOLE-5,6-DIONE	3hcb	B	Y35 Y40 E219
ES2		6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE	3kpy	A	Y35 Y40 E219
ES2		6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE	3kpy	B	Y35 Y40 E219
FAN		FORMANILIDE	3kqv	A	Y35 Y40 E219
RCO		RESORCINOL	4dm3	B	Y35 Y40 E219
JIL		9-{5-S-[2-({[(3S)-7-NITRO-1,2,3,4- TETRAHYDROISOQUINOLIN-3-YL]METHYL}AMINO)ETHYL]-5-THIO- ALPHA-L-LYXOFURANOSYL}-9H-PURIN-6-AMINE	4mik	B	Y35 Y40 E219
SKA		7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE	1yz3	B	Y35 Y40 E219 M258
JIL		9-{5-S-[2-({[(3S)-7-NITRO-1,2,3,4- TETRAHYDROISOQUINOLIN-3-YL]METHYL}AMINO)ETHYL]-5-THIO- ALPHA-L-LYXOFURANOSYL}-9H-PURIN-6-AMINE	4mik	A	Y35 Y40 E219 M258
ES3		4-BROMO-1H-IMIDAZOLE	3kqm	B	Y35 Y40 M258
ES6		2-HYDROXYNICOTINIC ACID	3kqq	A	Y35 Y40 M258
AX7		2-AMINOBENZIMIDAZOLE	3kqs	A	Y35 Y40 R44
AX7		2-AMINOBENZIMIDAZOLE	3kqs	B	Y35 Y40 R44
ES7		1-METHYL-1H-BENZIMIDAZOL-2-AMINE	3kqt	A	Y35 Y40 R44
ES7		1-METHYL-1H-BENZIMIDAZOL-2-AMINE	3kqt	B	Y35 Y40 R44
FTS		3(R)-FLUOROMETHYL 7-TRIFLOUROPROPYLSULFONAMIDE 1,2,3,4-TETRAHYDROISOQUINOLINE	2g71	B	Y35 Y40 R44 E219
ADE		ADENINE	3kpv	A	Y35 Y40 R44 E219
ADE		ADENINE	3kpv	B	Y35 Y40 R44 E219
1SQ		1-AMINOISOQUINOLINE	3kpw	A	Y35 Y40 R44 E219
ES4		6-CHLORO-9H-PURINE	3kqo	A	Y35 Y40 R44 E219
2D5		5'-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3- YLCARBONYL]AMINO}PROPYL)-5'-THIOADENOSINE	4mq4	B	Y35 Y40 R44 E219
SKF		1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE	1hnn	A	Y35 Y40 R44 E219 M258
IDI		7-IODO-1,2,3,4-TETRAHYDROISOQUINOLINE	1n7j	A	Y35 Y40 R44 E219 M258
SKA		7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE	1yz3	A	Y35 Y40 R44 E219 M258
TTL		TRANS-(1S,2S)-2-AMINO-1-TETRALOL	2an5	A	Y35 Y40 R44 E219 M258
HNT		3(R)-HYDROXYMETHYL 7-NITRO 1,2,3,4-TETRAHYDROISOQUINOLINE	2g70	A	Y35 Y40 R44 E219 M258
HNT		3(R)-HYDROXYMETHYL 7-NITRO 1,2,3,4-TETRAHYDROISOQUINOLINE	2g70	B	Y35 Y40 R44 E219 M258
FTS		3(R)-FLUOROMETHYL 7-TRIFLOUROPROPYLSULFONAMIDE 1,2,3,4-TETRAHYDROISOQUINOLINE	2g71	A	Y35 Y40 R44 E219 M258
F21		(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2g72	A	Y35 Y40 R44 E219 M258
F21		(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2g72	B	Y35 Y40 R44 E219 M258
F83		3-HYDROXYMETHYL-7-(N-4-CHLOROPHENYLAMINOSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2g8n	A	Y35 Y40 R44 E219 M258
F83		3-HYDROXYMETHYL-7-(N-4-CHLOROPHENYLAMINOSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2g8n	B	Y35 Y40 R44 E219 M258
F83		3-HYDROXYMETHYL-7-(N-4-CHLOROPHENYLAMINOSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2obf	A	Y35 Y40 R44 E219 M258
TMJ		7-(N-4-CHLOROPHENYL-AMINSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2ony	A	Y35 Y40 R44 E219 M258
TMJ		7-(N-4-CHLOROPHENYL-AMINSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2onz	A	Y35 Y40 R44 E219 M258
F21		(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2opb	A	Y35 Y40 R44 E219 M258
F21		(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE	2opb	B	Y35 Y40 R44 E219 M258
LT3		(1S,4R,9S)-5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDRO-1,4-METHANONAPHTHALEN-9-AMINE	3hcc	A	Y35 Y40 R44 E219 M258
LT3		(1S,4R,9S)-5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDRO-1,4-METHANONAPHTHALEN-9-AMINE	3hcc	B	Y35 Y40 R44 E219 M258
LT5		3-TRIFLUOROMETHYL PHENYLETHANOLAMINE	3hcf	A	Y35 Y40 R44 E219 M258
LT5		3-TRIFLUOROMETHYL PHENYLETHANOLAMINE	3hcf	B	Y35 Y40 R44 E219 M258
ES4		6-CHLORO-9H-PURINE	3kqo	B	Y35 Y40 R44 E219 M258
VGD		6-CHLORO-1H-BENZIMIDAZOL-2-AMINE	3kr1	B	Y35 Y40 R44 E219 M258
2D5		5'-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3- YLCARBONYL]AMINO}PROPYL)-5'-THIOADENOSINE	4mq4	A	Y35 Y40 R44 E219 M258
LY1		8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE	1n7i	A	Y35 Y40 R44 M258
ES1		QUINOLIN-4-OL	3kpu	A	Y35 Y40 R44 M258
ES1		QUINOLIN-4-OL	3kpu	B	Y35 Y40 R44 M258
ES3		4-BROMO-1H-IMIDAZOLE	3kqm	A	Y35 Y40 R44 M258
ES6		2-HYDROXYNICOTINIC ACID	3kqq	B	Y35 Y40 R44 M258
ES0		2-AMINO-1H-BENZIMIDAZOL-7-OL	3kqy	A	Y35 Y40 R44 M258
ES0		2-AMINO-1H-BENZIMIDAZOL-7-OL	3kqy	B	Y35 Y40 R44 M258
172		2-AMINO-5-HYDROXY-BENZIMIDAZOLE	3kr0	A	Y35 Y40 R44 M258
172		2-AMINO-5-HYDROXY-BENZIMIDAZOLE	3kr0	B	Y35 Y40 R44 M258
VGD		6-CHLORO-1H-BENZIMIDAZOL-2-AMINE	3kr1	A	Y35 Y40 R44 M258
ET2		6-FLUORO-1H-BENZIMIDAZOL-2-AMINE	3kr2	A	Y35 Y40 R44 M258
ET2		6-FLUORO-1H-BENZIMIDAZOL-2-AMINE	3kr2	B	Y35 Y40 R44 M258
LNR		(R)-NORADRENALINE	3hcd	A	Y40 R44 E219
LNR		(R)-NORADRENALINE	3hcd	B	Y40 R44 E219 M258

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Conservation information for LBS of PNMT

Multiple alignments for P11086 in multiple species

LBS	AA sequence	# species	Species
A181	DALVSAFCLEA	3	Homo sapiens, Mus musculus, Rattus norvegicus
A186	AFCLEAVSPDL	3	Homo sapiens, Mus musculus, Rattus norvegicus
A216	LLLIGALEESW	2	Homo sapiens, Mus musculus
A216	LLFIGALEESW	1	Rattus norvegicus
C183	LVSAFCLEAVS	3	Homo sapiens, Mus musculus, Rattus norvegicus
D101	DITMTDFLEVN	3	Homo sapiens, Mus musculus, Rattus norvegicus
D158	RVLPIDVHKPQ	2	Mus musculus, Rattus norvegicus
D158	RVLPIDVHQPQ	1	Homo sapiens
D267	LQTGVDDVKGV	1	Homo sapiens
D267	LCTGVDDVKGI	1	Mus musculus
D267	LRTGVDDVKGI	1	Rattus norvegicus
E219	IGALEESWYLA	3	Homo sapiens, Mus musculus, Rattus norvegicus
F102	ITMTDFLEVNR	3	Homo sapiens, Mus musculus, Rattus norvegicus
F182	ALVSAFCLEAV	3	Homo sapiens, Mus musculus, Rattus norvegicus
F30	LAYQRFEPRAY	2	Mus musculus, Rattus norvegicus
F30	SAYQRFEPRAY	1	Homo sapiens
G54	NPDGVGPWKLR	2	Mus musculus, Rattus norvegicus
G54	NPNGVGPWKLR	1	Homo sapiens
G79	VLIDIGSGPTI	2	Mus musculus, Rattus norvegicus
G79	TLIDIGSGPTV	1	Homo sapiens
G81	IDIGSGPTIYQ	2	Mus musculus, Rattus norvegicus
G81	IDIGSGPTVYQ	1	Homo sapiens
H160	LPIDVHKPQPL	2	Mus musculus, Rattus norvegicus
H160	LPIDVHQPQPL	1	Homo sapiens
I157	KRVLPIDVHKP	2	Mus musculus, Rattus norvegicus
I157	KRVLPIDVHQP	1	Homo sapiens
K57	GVGPWKLRCMA	2	Mus musculus, Rattus norvegicus
K57	GVGPWKLRCLA	1	Homo sapiens
L103	TMTDFLEVNRQ	3	Homo sapiens, Mus musculus, Rattus norvegicus
L253	YKVRDLRTYIM	1	Homo sapiens
L253	YEVRELRTYIM	1	Mus musculus
L253	YEVRDLRTYIM	1	Rattus norvegicus
L47	PPRGDLSNPDG	2	Mus musculus, Rattus norvegicus
L47	PPRGDLCNPNG	1	Homo sapiens
L58	VGPWKLRCMAQ	2	Mus musculus, Rattus norvegicus
L58	VGPWKLRCLAQ	1	Homo sapiens
M258	LRTYIMPAHLQ	1	Homo sapiens
M258	LRTYIMPAHLC	1	Mus musculus
M258	LRTYIMPAHLR	1	Rattus norvegicus
N106	DFLEVNRQELG	3	Homo sapiens, Mus musculus, Rattus norvegicus
N39	AYLRNNYAPPR	3	Homo sapiens, Mus musculus, Rattus norvegicus
Q86	GPTIYQLLSAC	2	Mus musculus, Rattus norvegicus
Q86	GPTVYQLLSAC	1	Homo sapiens
R240	SEEEVREALVR	1	Homo sapiens
R240	SEEEVREALVL	1	Mus musculus
R240	SEEEVREALVC	1	Rattus norvegicus
R251	SGYKVRDLRTY	1	Homo sapiens
R251	GGYEVRELRTY	1	Mus musculus
R251	SGYEVRDLRTY	1	Rattus norvegicus
R44	NYAPPRGDLSN	2	Mus musculus, Rattus norvegicus
R44	NYAPPRGDLCN	1	Homo sapiens
S80	LIDIGSGPTIY	2	Mus musculus, Rattus norvegicus
S80	LIDIGSGPTVY	1	Homo sapiens
T83	IGSGPTIYQLL	2	Mus musculus, Rattus norvegicus
T83	IGSGPTVYQLL	1	Homo sapiens
V159	VLPIDVHKPQP	2	Mus musculus, Rattus norvegicus
V159	VLPIDVHQPQP	1	Homo sapiens
V187	FCLEAVSPDLA	1	Homo sapiens
V187	FCLEAVSPDLT	1	Mus musculus
V187	FCLEAVSPDLP	1	Rattus norvegicus
V250	RSGYKVRDLRT	1	Homo sapiens
V250	LGGYEVRELRT	1	Mus musculus
V250	CSGYEVRDLRT	1	Rattus norvegicus
V269	TGVDDVKGIFF	2	Mus musculus, Rattus norvegicus
V269	TGVDDVKGVFF	1	Homo sapiens
V272	DDVKGIFFAWA	2	Mus musculus, Rattus norvegicus
V272	DDVKGVFFAWA	1	Homo sapiens
V53	SNPDGVGPWKL	2	Mus musculus, Rattus norvegicus
V53	CNPNGVGPWKL	1	Homo sapiens
Y126	FNWSMYSQHAC	1	Homo sapiens
Y126	FDWSVYSQHAC	1	Mus musculus
Y126	FDWSVYSQHVC	1	Rattus norvegicus
Y222	LEESWYLAGEA	3	Homo sapiens, Mus musculus, Rattus norvegicus
Y27	AVASAYQRFEP	1	Homo sapiens
Y27	AVALAYQRFEP	1	Mus musculus
Y27	EVALAYQRFEP	1	Rattus norvegicus
Y35	FEPRAYLRNNY	3	Homo sapiens, Mus musculus, Rattus norvegicus
Y40	YLRNNYAPPRG	3	Homo sapiens, Mus musculus, Rattus norvegicus
Y85	SGPTIYQLLSA	2	Mus musculus, Rattus norvegicus
Y85	SGPTVYQLLSA	1	Homo sapiens