mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DCUN1D1
Gene summary
Basic gene Info.Gene symbolDCUN1D1
Gene nameDCN1, defective in cullin neddylation 1, domain containing 1
SynonymsDCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3
CytomapUCSC genome browser: 3q26.3
Type of geneprotein-coding
RefGenesNM_020640.2,
DescriptionDCN1-like protein 1DCUN1 domain-containing protein 1RP42 homologdefective in cullin neddylation protein 1-like protein 1squamous cell carcinoma related oncogenesquamous cell carcinoma-related oncogene
Modification date20141207
dbXrefs MIM : 605905
HGNC : HGNC
HPRD : 12067
ProteinUniProt: Q96GG9
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DCUN1D1
BioGPS: 54165
PathwayNCI Pathway Interaction Database: DCUN1D1
KEGG: DCUN1D1
REACTOME: DCUN1D1
Pathway Commons: DCUN1D1
ContextiHOP: DCUN1D1
ligand binding site mutation search in PubMed: DCUN1D1
UCL Cancer Institute: DCUN1D1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for DCUN1D1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P97,S99A98VCOAD1
S99S99GLUAD1
V102S101ROV1
Q87F89LSTAD1
N167N167HSTAD1
F117F117VSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DCUN1D1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S99S99G-1.1113319
F117F117V-1.0353111
P97A98V-0.74771666
S99A98V-0.74771666
Q87F89L-0.65950244
N167N167H-0.61887905
V102S101R-0.41117801
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DCUN1D1 from PDB

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Differential gene expression and gene-gene network for DCUN1D1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DCUN1D1 and the right PPI network was created from samples without mutations in the LBS of DCUN1D1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DCUN1D1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DCUN1D1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DCUN1D1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ACE,MET,ILE,LYS,LEU,LEU,SER,LEU,LYS,LEU,GLN,LYS)3tdzAQ87 P97 S99 V102 F117 N167
IIIPeptide ligand (ACE,MET,ILE,LYS,LEU,LEU,SER,LEU,LYS,LEU,GLN,LYS)3tdzBQ87 P97 S99 V102 F117 N167


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Conservation information for LBS of DCUN1D1
Multiple alignments for Q96GG9 in multiple species
LBSAA sequence# speciesSpecies
A180LEMAIAYWNLV3Homo sapiens, Gallus gallus, Mus musculus
A180LEMAIAYWCIV1Drosophila melanogaster
C115RAATQCEFSKQ2Homo sapiens, Mus musculus
C115HAEVQCEFSRD1Drosophila melanogaster
C115RAATQCEFSKL1Gallus gallus
D84NKIGIDGIQQF3Homo sapiens, Gallus gallus, Mus musculus
D84LKIGSQGVIHF1Drosophila melanogaster
F117ATQCEFSKQEF2Homo sapiens, Mus musculus
F117EVQCEFSRDEF1Drosophila melanogaster
F117ATQCEFSKLEF1Gallus gallus
F164QFTFNFAKNPG3Homo sapiens, Gallus gallus, Mus musculus
F164HFTFNYAKDPG1Drosophila melanogaster
I83ENKIGIDGIQQ3Homo sapiens, Gallus gallus, Mus musculus
I83PLKIGSQGVIH1Drosophila melanogaster
L103ASISVLIIAWK2Homo sapiens, Mus musculus
L103DSKLVLIIAWK1Drosophila melanogaster
L103ASITVLIIAWK1Gallus gallus
M177GLDLEMAIAYW3Homo sapiens, Gallus gallus, Mus musculus
M177GIDLEMAIAYW1Drosophila melanogaster
N167FNFAKNPGQKG3Homo sapiens, Gallus gallus, Mus musculus
N167FNYAKDPGQKG1Drosophila melanogaster
P97DLALDPASISV2Homo sapiens, Mus musculus
P97DLDLKPDSKLV1Drosophila melanogaster
P97DLALDPASITV1Gallus gallus
Q114FRAATQCEFSK3Homo sapiens, Gallus gallus, Mus musculus
Q114FHAEVQCEFSR1Drosophila melanogaster
Q87GIDGIQQFCDD3Homo sapiens, Gallus gallus, Mus musculus
Q87GSQGVIHFLED1Drosophila melanogaster
S99ALDPASISVLI2Homo sapiens, Mus musculus
S99DLKPDSKLVLI1Drosophila melanogaster
S99ALDPASITVLI1Gallus gallus
V102PASISVLIIAW2Homo sapiens, Mus musculus
V102PDSKLVLIIAW1Drosophila melanogaster
V102PASITVLIIAW1Gallus gallus
Y181EMAIAYWNLVL3Homo sapiens, Gallus gallus, Mus musculus
Y181EMAIAYWCIVL1Drosophila melanogaster


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