mutLBSgeneDB |
Gene summary for DCUN1D1 |
Gene summary |
Basic gene Info. | Gene symbol | DCUN1D1 |
Gene name | DCN1, defective in cullin neddylation 1, domain containing 1 | |
Synonyms | DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3 | |
Cytomap | UCSC genome browser: 3q26.3 | |
Type of gene | protein-coding | |
RefGenes | NM_020640.2, | |
Description | DCN1-like protein 1DCUN1 domain-containing protein 1RP42 homologdefective in cullin neddylation protein 1-like protein 1squamous cell carcinoma related oncogenesquamous cell carcinoma-related oncogene | |
Modification date | 20141207 | |
dbXrefs | MIM : 605905 | |
HGNC : HGNC | ||
HPRD : 12067 | ||
Protein | UniProt: Q96GG9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCUN1D1 | |
BioGPS: 54165 | ||
Pathway | NCI Pathway Interaction Database: DCUN1D1 | |
KEGG: DCUN1D1 | ||
REACTOME: DCUN1D1 | ||
Pathway Commons: DCUN1D1 | ||
Context | iHOP: DCUN1D1 | |
ligand binding site mutation search in PubMed: DCUN1D1 | ||
UCL Cancer Institute: DCUN1D1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for DCUN1D1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | P97,S99 | A98V | COAD | 1 | S99 | S99G | LUAD | 1 | V102 | S101R | OV | 1 | Q87 | F89L | STAD | 1 | N167 | N167H | STAD | 1 | F117 | F117V | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for DCUN1D1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S99 | S99G | -1.1113319 | F117 | F117V | -1.0353111 | P97 | A98V | -0.74771666 | S99 | A98V | -0.74771666 | Q87 | F89L | -0.65950244 | N167 | N167H | -0.61887905 | V102 | S101R | -0.41117801 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for DCUN1D1 from PDB |
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Differential gene expression and gene-gene network for DCUN1D1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for DCUN1D1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for DCUN1D1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of DCUN1D1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ACE,MET,ILE,LYS,LEU,LEU,SER,LEU,LYS,LEU,GLN,LYS) | 3tdz | A | Q87 P97 S99 V102 F117 N167 | III | Peptide ligand (ACE,MET,ILE,LYS,LEU,LEU,SER,LEU,LYS,LEU,GLN,LYS) | 3tdz | B | Q87 P97 S99 V102 F117 N167 |
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Conservation information for LBS of DCUN1D1 |
Multiple alignments for Q96GG9 in multiple species |
LBS | AA sequence | # species | Species | A180 | LEMAIAYWNLV | 3 | Homo sapiens, Gallus gallus, Mus musculus | A180 | LEMAIAYWCIV | 1 | Drosophila melanogaster | C115 | RAATQCEFSKQ | 2 | Homo sapiens, Mus musculus | C115 | HAEVQCEFSRD | 1 | Drosophila melanogaster | C115 | RAATQCEFSKL | 1 | Gallus gallus | D84 | NKIGIDGIQQF | 3 | Homo sapiens, Gallus gallus, Mus musculus | D84 | LKIGSQGVIHF | 1 | Drosophila melanogaster | F117 | ATQCEFSKQEF | 2 | Homo sapiens, Mus musculus | F117 | EVQCEFSRDEF | 1 | Drosophila melanogaster | F117 | ATQCEFSKLEF | 1 | Gallus gallus | F164 | QFTFNFAKNPG | 3 | Homo sapiens, Gallus gallus, Mus musculus | F164 | HFTFNYAKDPG | 1 | Drosophila melanogaster | I83 | ENKIGIDGIQQ | 3 | Homo sapiens, Gallus gallus, Mus musculus | I83 | PLKIGSQGVIH | 1 | Drosophila melanogaster | L103 | ASISVLIIAWK | 2 | Homo sapiens, Mus musculus | L103 | DSKLVLIIAWK | 1 | Drosophila melanogaster | L103 | ASITVLIIAWK | 1 | Gallus gallus | M177 | GLDLEMAIAYW | 3 | Homo sapiens, Gallus gallus, Mus musculus | M177 | GIDLEMAIAYW | 1 | Drosophila melanogaster | N167 | FNFAKNPGQKG | 3 | Homo sapiens, Gallus gallus, Mus musculus | N167 | FNYAKDPGQKG | 1 | Drosophila melanogaster | P97 | DLALDPASISV | 2 | Homo sapiens, Mus musculus | P97 | DLDLKPDSKLV | 1 | Drosophila melanogaster | P97 | DLALDPASITV | 1 | Gallus gallus | Q114 | FRAATQCEFSK | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q114 | FHAEVQCEFSR | 1 | Drosophila melanogaster | Q87 | GIDGIQQFCDD | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q87 | GSQGVIHFLED | 1 | Drosophila melanogaster | S99 | ALDPASISVLI | 2 | Homo sapiens, Mus musculus | S99 | DLKPDSKLVLI | 1 | Drosophila melanogaster | S99 | ALDPASITVLI | 1 | Gallus gallus | V102 | PASISVLIIAW | 2 | Homo sapiens, Mus musculus | V102 | PDSKLVLIIAW | 1 | Drosophila melanogaster | V102 | PASITVLIIAW | 1 | Gallus gallus | Y181 | EMAIAYWNLVL | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y181 | EMAIAYWCIVL | 1 | Drosophila melanogaster |
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