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mutLBSgeneDB |
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| Gene summary for KCNK10 |
 Gene summary |
| Basic gene Info. | Gene symbol | KCNK10 |
| Gene name | potassium channel, subfamily K, member 10 | |
| Synonyms | K2p10.1|PPP1R97|TREK-2|TREK2 | |
| Cytomap | UCSC genome browser: 14q31.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021161.4, NM_138317.2,NM_138318.2, | |
| Description | 2P domain potassium channel TREK2TREK-2 K(+) channel subunitTWIK-related K+ channel 2outward rectifying potassium channel protein TREK-2potassium channel TREK-2potassium channel subfamily K member 10protein phosphatase 1, regulatory subunit 97 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605873 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100433 | ||
| HPRD : 12061 | ||
| Vega : OTTHUMG00000170743 | ||
| Protein | UniProt: P57789 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KCNK10 | |
| BioGPS: 54207 | ||
| Pathway | NCI Pathway Interaction Database: KCNK10 | |
| KEGG: KCNK10 | ||
| REACTOME: KCNK10 | ||
| Pathway Commons: KCNK10 | ||
| Context | iHOP: KCNK10 | |
| ligand binding site mutation search in PubMed: KCNK10 | ||
| UCL Cancer Institute: KCNK10 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for KCNK10 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T276 | T276M | COAD | 1 | T276 | T276M | KIRC | 1 | V271 | V272F | LUAD | 1 | L274 | L274V | LUSC | 1 | G171 | G171A | OV | 1 | V248 | V248M | PRAD | 1 | G280 | D281N | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for KCNK10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G171 | G171A | 0.083504513 | L274 | L274V | -1.1227835 | T276 | T276M | -0.87590741 | G280 | D281N | -0.77814444 | V248 | V248M | -0.62003065 | V271 | V272F | -0.23313671 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for KCNK10 from PDB |
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| Differential gene expression and gene-gene network for KCNK10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for KCNK10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for KCNK10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of KCNK10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of KCNK10 |
| Multiple alignments for P57789 in multiple species |
| LBS | AA sequence | # species | Species |
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