mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TREM1
Gene summary
Basic gene Info.Gene symbolTREM1
Gene nametriggering receptor expressed on myeloid cells 1
CytomapUCSC genome browser: 6p21.1
Type of geneprotein-coding
Descriptiontriggering receptor expressed on monocytes 1triggering-receptor TREM1
Modification date20141222
dbXrefs MIM : 605085
Ensembl : ENSG00000124731
HPRD : 05472
Vega : OTTHUMG00000014674
ProteinUniProt: Q9NP99
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TREM1
BioGPS: 54210
PathwayNCI Pathway Interaction Database: TREM1
Pathway Commons: TREM1
ContextiHOP: TREM1
ligand binding site mutation search in PubMed: TREM1
UCL Cancer Institute: TREM1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for TREM1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TREM1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TREM1 from PDB

Differential gene expression and gene-gene network for TREM1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TREM1 and the right PPI network was created from samples without mutations in the LBS of TREM1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TREM1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023895Liver Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TREM1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01694D-tartaric acidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TREM1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TREM1
Multiple alignments for Q9NP99 in multiple species
LBSAA sequence# speciesSpecies
C69PKTLACTERPS1Homo sapiens
C69VQTLAITE---1Bos taurus
C69PLTLVVTQRPF1Mus musculus
Q52KFASSQKAWQI1Homo sapiens
Q52KYANSQKAWQR1Mus musculus
T66GEMPKTLACTE1Homo sapiens
T66GKEPLTLVVTQ1Mus musculus
Y116YQCVIYQPPKE1Homo sapiens
Y116YRCVILG-PSD1Bos taurus
Y116YRCVIYHPPND1Mus musculus

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