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mutLBSgeneDB |
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| Gene summary for TREM1 |
 Gene summary |
| Basic gene Info. | Gene symbol | TREM1 |
| Gene name | triggering receptor expressed on myeloid cells 1 | |
| Synonyms | CD354|TREM-1 | |
| Cytomap | UCSC genome browser: 6p21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001242589.1, NM_001242590.1,NM_018643.3, | |
| Description | triggering receptor expressed on monocytes 1triggering-receptor TREM1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 605085 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000124731 | ||
| HPRD : 05472 | ||
| Vega : OTTHUMG00000014674 | ||
| Protein | UniProt: Q9NP99 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TREM1 | |
| BioGPS: 54210 | ||
| Pathway | NCI Pathway Interaction Database: TREM1 | |
| KEGG: TREM1 | ||
| REACTOME: TREM1 | ||
| Pathway Commons: TREM1 | ||
| Context | iHOP: TREM1 | |
| ligand binding site mutation search in PubMed: TREM1 | ||
| UCL Cancer Institute: TREM1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for TREM1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y116 | I115M | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TREM1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y116 | I115M | -1.2451208 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TREM1 from PDB |
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| Differential gene expression and gene-gene network for TREM1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TREM1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023895 | Liver Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TREM1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01694 | D-tartaric acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TREM1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GSH | GLUTATHIONATE(1-) | 1q8m | A | Y116 |
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| Conservation information for LBS of TREM1 |
| Multiple alignments for Q9NP99 in multiple species |
| LBS | AA sequence | # species | Species | C69 | PKTLACTERPS | 1 | Homo sapiens | C69 | VQTLAITE--- | 1 | Bos taurus | C69 | PLTLVVTQRPF | 1 | Mus musculus | Q52 | KFASSQKAWQI | 1 | Homo sapiens | Q52 | IYSNSQKAWQR | 1 | Bos taurus | Q52 | KYANSQKAWQR | 1 | Mus musculus | T66 | GEMPKTLACTE | 1 | Homo sapiens | T66 | NGEVQTLAITE | 1 | Bos taurus | T66 | GKEPLTLVVTQ | 1 | Mus musculus | Y116 | YQCVIYQPPKE | 1 | Homo sapiens | Y116 | YRCVILG-PSD | 1 | Bos taurus | Y116 | YRCVIYHPPND | 1 | Mus musculus |
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