mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for POLA1
Gene summary
Basic gene Info.Gene symbolPOLA1
Gene namepolymerase (DNA directed), alpha 1, catalytic subunit
CytomapUCSC genome browser: Xp22.1-p21.3
Type of geneprotein-coding
DescriptionDNA polymerase alpha 1 catalytic subunitDNA polymerase alpha catalytic subunitDNA polymerase alpha catalytic subunit p180DNA polymerase alpha p180 subunitpolymerase (DNA-directed), alpha (70kD)
Modification date20141207
dbXrefs MIM : 312040
Ensembl : ENSG00000101868
HPRD : 02416
Vega : OTTHUMG00000021277
ProteinUniProt: P09884
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_POLA1
BioGPS: 5422
PathwayNCI Pathway Interaction Database: POLA1
Pathway Commons: POLA1
ContextiHOP: POLA1
ligand binding site mutation search in PubMed: POLA1
UCL Cancer Institute: POLA1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006269DNA replication, synthesis of RNA primer2175912
GO:0006270DNA replication initiation2175912
GO:0006272leading strand elongation2175912
GO:0006273lagging strand elongation2175912
GO:0006281DNA repair3335506
GO:0008283cell proliferation3359994

Ligand binding site mutations for POLA1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for POLA1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for POLA1 from PDB

Differential gene expression and gene-gene network for POLA1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of POLA1 and the right PPI network was created from samples without mutations in the LBS of POLA1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for POLA1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for POLA1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00242CladribineSmall molecule
Approved|investigationalDB00631ClofarabineSmall molecule
ApprovedDB01073FludarabineSmall molecule
Approved|investigationalDB01280NelarabineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of POLA1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4y97BC1283 C1310 C1315
ZNZINC(2+)4y97DC1283 C1310 C1315
ZNZINC(2+)4y97FC1283 C1310 C1315
ZNZINC(2+)4y97HC1283 C1310 C1315
NUCNucleic Acids4q5vES1189
NUCNucleic Acids4q5vAV844 S1189
NUCNucleic Acids4qclAV844 S1189

Conservation information for LBS of POLA1
Multiple alignments for P09884 in multiple species
LBSAA sequence# speciesSpecies
A1138FEINKALTKDP3Homo sapiens, Mus musculus, Rattus norvegicus
A1138YKINMKLSKDP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A1138FIIFNRLGKNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A1138YVITKTLTKPP1Arabidopsis thaliana
A1138FVITKQLTRTP1Drosophila melanogaster
A837KGRKKAAYAGG2Homo sapiens, Rattus norvegicus
A837---KKAKYQGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A837LGKKKDKYKGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A837KTKKGPAYAGG1Arabidopsis thaliana
A837QTKKKAAYAGG1Drosophila melanogaster
A837KGRKKATYAGG1Mus musculus
A838GRKKAAYAGGL2Homo sapiens, Rattus norvegicus
A838--KKAKYQGGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A838GKKKDKYKGGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A838TKKGPAYAGGL1Arabidopsis thaliana
A838TKKKAAYAGGL1Drosophila melanogaster
A838GRKKATYAGGL1Mus musculus
A840KKAAYAGGLVL3Homo sapiens, Drosophila melanogaster, Rattus norvegicus
A840KKAKYQGGLVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A840KKDKYKGGLVF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A840KGPAYAGGLVL1Arabidopsis thaliana
A840KKATYAGGLVL1Mus musculus
C1283KFKCLCPSCGT2Mus musculus, Rattus norvegicus
C1283RFKCPCPTCGT1Homo sapiens
C1283TLELSCPSCDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C1283PLLLKCPSCNA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C1283PLALTCPSCST1Arabidopsis thaliana
C1283PFRFQCVTCKT1Drosophila melanogaster
C1286CLCPSCGTE--2Mus musculus, Rattus norvegicus
C1286CPCPTCGTE--1Homo sapiens
C1286LSCPSCDKRFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C1286LKCPSCNAT--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C1286LTCPSCSTAFN1Arabidopsis thaliana
C1286FQCVTCKTE--1Drosophila melanogaster
C1310R----CSNID-2Homo sapiens, Rattus norvegicus
C1310-----CKHCE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C1310ANTVEC-DCG-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C1310E----TEESDS1Arabidopsis thaliana
C1310Q----CAKSE-1Drosophila melanogaster
C1310R----CSNVD-1Mus musculus
C1315-----CKASPL1Homo sapiens
C1315-----QLFTPL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C1315-----YEYSDF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C1315LHCPKCQQEDS1Arabidopsis thaliana
C1315-----CQTAPI1Drosophila melanogaster
C1315-----CKVSPL1Mus musculus
C1315-----CKASPA1Rattus norvegicus
C959NSMYGCLGFSY3Homo sapiens, Mus musculus, Rattus norvegicus
C959NSMYGCLGYVN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C959NSMYGCLGYTK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C959NSMYGCLGFSN1Arabidopsis thaliana
C959NSMYGCLGFAH1Drosophila melanogaster
D1002EVIYGDTDSIM4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
D1002LVVYGDTDSVM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D1002QVIYGDTDSVM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1002DVVYGDTDSLM1Drosophila melanogaster
D1004IYGDTDSIMIN3Homo sapiens, Mus musculus, Rattus norvegicus
D1004VYGDTDSVMID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D1004IYGDTDSVMLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1004IYGDTDSIMIH1Arabidopsis thaliana
D1004VYGDTDSLMIN1Drosophila melanogaster
D1083DIVRRDWCDLA3Homo sapiens, Mus musculus, Rattus norvegicus
D1083DMKRREFCPLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D1083DMKRREFCTLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1083DMVRRDWSLLS1Arabidopsis thaliana
D1083DIVRRDWSQLA1Drosophila melanogaster
D860FILLLDFNSLY3Homo sapiens, Mus musculus, Rattus norvegicus
D860YVLVMDFNSLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D860CILVMDFNSLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D860YVLLLDFNSLY1Arabidopsis thaliana
D860YVLLMDFNSLY1Drosophila melanogaster
E500GPCWLEVKNPQ2Mus musculus, Rattus norvegicus
E500GPCWLEVKSPQ1Homo sapiens
E500GPCWLDIKGAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E500GPCWLKIQQPN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E500GPCWLKISSFS1Arabidopsis thaliana
E500GPCWLQVTGFK1Drosophila melanogaster
F861ILLLDFNSLYP3Homo sapiens, Mus musculus, Rattus norvegicus
F861VLVMDFNSLYP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F861ILVMDFNSLYP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F861VLLLDFNSLYP1Arabidopsis thaliana
F861VLLMDFNSLYP1Drosophila melanogaster
F962YGCLGFSYSRF3Homo sapiens, Mus musculus, Rattus norvegicus
F962YGCLGYVNSRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F962YGCLGYTKSRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F962YGCLGFSNSRF1Arabidopsis thaliana
F962YGCLGFAHSRF1Drosophila melanogaster
G1076KQELKGLDIVR3Homo sapiens, Mus musculus, Rattus norvegicus
G1076VLEVKGLDMKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G1076--DVKGLDMKR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G1076DIERKGVDMVR1Arabidopsis thaliana
G1076EQEHKGLDIVR1Drosophila melanogaster
G783RTLMGGRSERN3Homo sapiens, Mus musculus, Rattus norvegicus
G783QTLGGTRAGRN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G783RTLTGTRAERN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G783KTLQGARAQRI1Arabidopsis thaliana
G783RTLQGGRSERN1Drosophila melanogaster
G841KAAYAGGLVLD2Homo sapiens, Rattus norvegicus
G841KAKYQGGLVFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G841KDKYKGGLVFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G841GPAYAGGLVLE1Arabidopsis thaliana
G841KAAYAGGLVLE1Drosophila melanogaster
G841KATYAGGLVLD1Mus musculus
G842AAYAGGLVLDP2Homo sapiens, Rattus norvegicus
G842AKYQGGLVFEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G842DKYKGGLVFEP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G842PAYAGGLVLEP1Arabidopsis thaliana
G842AAYAGGLVLEP1Drosophila melanogaster
G842ATYAGGLVLDP1Mus musculus
G958ANSMYGCLGFS4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
G958ANSMYGCLGYV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G958ANSMYGCLGYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G958ANSMYGCLGFA1Drosophila melanogaster
G961MYGCLGFSYSR3Homo sapiens, Mus musculus, Rattus norvegicus
G961MYGCLGYVNSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G961MYGCLGYTKSR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G961MYGCLGFSNSR1Arabidopsis thaliana
G961MYGCLGFAHSR1Drosophila melanogaster
H1154KKSLPHVHVAL2Homo sapiens, Rattus norvegicus
H1154GKNMPAVQVAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H1154GKTMPFVQVAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H1154SKSQPHVQVAL1Arabidopsis thaliana
H1154SASLPHVQVAL1Drosophila melanogaster
H1154RKSLPHVHVAL1Mus musculus
H342DEQVFQFYWLD2Mus musculus, Rattus norvegicus
H342EEQVFHFYWLD1Homo sapiens
H342ETDTFQMFWLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H342EDGSLFFFWMD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H342ADGSLRFFILD1Arabidopsis thaliana
H342SDQQLRFWYWE1Drosophila melanogaster
K1051SLLLLKKKKYA3Homo sapiens, Mus musculus, Rattus norvegicus
K1051KLLLHAKKKYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1051RMLLHAKKKYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1051RMLLLRKKKYA1Arabidopsis thaliana
K1051CLLLLKKKKYA1Drosophila melanogaster
K1052LLLLKKKKYAA4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
K1052LLLHAKKKYAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1052MLLHAKKKYAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1052MLLLRKKKYAA1Arabidopsis thaliana
K1053LLLKKKKYAAL3Homo sapiens, Mus musculus, Rattus norvegicus
K1053LLHAKKKYAAL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1053LLLRKKKYAAV1Arabidopsis thaliana
K1053LLLKKKKYAAI1Drosophila melanogaster
K1054LLKKKKYAALV3Homo sapiens, Mus musculus, Rattus norvegicus
K1054LHAKKKYAALT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1054LHAKKKYAALQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1054LLRKKKYAAVK1Arabidopsis thaliana
K1054LLKKKKYAAIK1Drosophila melanogaster
K1075TKQELKGLDIV3Homo sapiens, Mus musculus, Rattus norvegicus
K1075TVLEVKGLDMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1075---DVKGLDMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1075EDIERKGVDMV1Arabidopsis thaliana
K1075REQEHKGLDIV1Drosophila melanogaster
K1137QFEINKALTKD3Homo sapiens, Mus musculus, Rattus norvegicus
K1137KYKINMKLSKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1137KFIIFNRLGKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1137KYVITKTLTKP1Arabidopsis thaliana
K1137LFVITKQLTRT1Drosophila melanogaster
K1141NKALTKDPQDY3Homo sapiens, Mus musculus, Rattus norvegicus
K1141NMKLSKDPKAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K1141FNRLGKNPEDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1141TKTLTKPPAAY1Arabidopsis thaliana
K1141TKQLTRTPQEY1Drosophila melanogaster
K950RQKALKLTANS3Homo sapiens, Mus musculus, Rattus norvegicus
K950RQQALKLTANS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
K950QQQALKLTANS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K950RQMALKLTANS1Drosophila melanogaster
L1139EINKALTKDPQ3Homo sapiens, Mus musculus, Rattus norvegicus
L1139KINMKLSKDPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L1139IIFNRLGKNPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L1139VITKTLTKPPA1Arabidopsis thaliana
L1139VITKQLTRTPQ1Drosophila melanogaster
L1152PDKKSLPHVHV2Homo sapiens, Rattus norvegicus
L1152PGGKNMPAVQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L1152PNGKTMPFVQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L1152PDSKSQPHVQV1Arabidopsis thaliana
L1152ANSASLPHVQV1Drosophila melanogaster
L1152PDRKSLPHVHV1Mus musculus
L864LDFNSLYPSII4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
L864MDFNSLYPSII3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
L951QKALKLTANSM3Homo sapiens, Mus musculus, Rattus norvegicus
L951QQALKLTANSM3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana
L951QMALKLTANSM1Drosophila melanogaster
N862LLLDFNSLYPS4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
N862LVMDFNSLYPS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N862LLMDFNSLYPS1Drosophila melanogaster
N954LKLTANSMYGC7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus
R1081GLDIVRRDWCD3Homo sapiens, Mus musculus, Rattus norvegicus
R1081GLDMKRREFCP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R1081GLDMKRREFCT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R1081GVDMVRRDWSL1Arabidopsis thaliana
R1081GLDIVRRDWSQ1Drosophila melanogaster
R1082LDIVRRDWCDL3Homo sapiens, Mus musculus, Rattus norvegicus
R1082LDMKRREFCPL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R1082LDMKRREFCTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R1082VDMVRRDWSLL1Arabidopsis thaliana
R1082LDIVRRDWSQL1Drosophila melanogaster
R1222HPVVARICEPI3Homo sapiens, Mus musculus, Rattus norvegicus
R1222FAPVERLLERI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R1222LPPIERVIAPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R1222HPVVSRLCAEI1Arabidopsis thaliana
R1222HPVVTRMVEVL1Drosophila melanogaster
R702ELI--HCKSYH2Mus musculus, Rattus norvegicus
R702ELI--RCKSYH1Homo sapiens
R702QSLTPKCQSWD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R702SMI--KAQSWS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R702DLL--KEVSYS1Arabidopsis thaliana
R702ECI--RARSYD1Drosophila melanogaster
R784TLMGGRSERNE3Homo sapiens, Mus musculus, Rattus norvegicus
R784TLGGTRAGRNE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R784TLTGTRAERNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R784TLQGARAQRIE1Arabidopsis thaliana
R784TLQGGRSERNE1Drosophila melanogaster
R834KYKKGRKKAAY2Homo sapiens, Rattus norvegicus
R834S-----KKAKY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R834--SLGKKKDKY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R834KGSKTKKGPAY1Arabidopsis thaliana
R834ATMQTKKKAAY1Drosophila melanogaster
R834KYKKGRKKATY1Mus musculus
R922KLVERRKQVKQ3Homo sapiens, Mus musculus, Rattus norvegicus
R922NLVDRRREVKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R922NLVERRRQIKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R922HLVSIRKSVKL1Arabidopsis thaliana
R922RLVESRKEVKK1Drosophila melanogaster
S1151YPDKKSLPHVH2Homo sapiens, Rattus norvegicus
S1151YPGGKNMPAVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S1151YPNGKTMPFVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S1151YPDSKSQPHVQ1Arabidopsis thaliana
S1151YANSASLPHVQ1Drosophila melanogaster
S1151YPDRKSLPHVH1Mus musculus
S1189-----TQRAYA2Mus musculus, Rattus norvegicus
S1189-----SQRAYA1Homo sapiens
S1189PALSVAERAHA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S1189-----ADRAYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S1189SSAGIAERARH1Arabidopsis thaliana
S1189-----MQRAYH1Drosophila melanogaster
S785LMGGRSERNEF3Homo sapiens, Mus musculus, Rattus norvegicus
S785LGGTRAGRNEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S785LTGTRAERNEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S785LQGARAQRIEY1Arabidopsis thaliana
S785LQGGRSERNEF1Drosophila melanogaster
S863LLDFNSLYPSI4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
S863VMDFNSLYPSI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S863LMDFNSLYPSI1Drosophila melanogaster
S955KLTANSMYGCL7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus
T1140INKALTKDPQD3Homo sapiens, Mus musculus, Rattus norvegicus
T1140INMKLSKDPKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T1140IFNRLGKNPED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T1140ITKTLTKPPAA1Arabidopsis thaliana
T1140ITKQLTRTPQE1Drosophila melanogaster
T1187--SNLTA----2Homo sapiens, Mus musculus
T1187EIDNAADTPAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T1187--ADGHP----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T1187--GNASSASSA1Arabidopsis thaliana
T1187--TTNAA----1Drosophila melanogaster
T1187--SNLPA----1Rattus norvegicus
V1080KGLDIVRRDWC3Homo sapiens, Mus musculus, Rattus norvegicus
V1080KGLDMKRREFC2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V1080KGVDMVRRDWS1Arabidopsis thaliana
V1080KGLDIVRRDWS1Drosophila melanogaster
V844YAGGLVLDPKV3Homo sapiens, Mus musculus, Rattus norvegicus
V844YQGGLVFEPEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V844YKGGLVFEPQK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V844YAGGLVLEPKR1Arabidopsis thaliana
V844YAGGLVLEPMR1Drosophila melanogaster
W1084IVRRDWCDLAK3Homo sapiens, Mus musculus, Rattus norvegicus
W1084MKRREFCPLSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W1084MKRREFCTLAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W1084MVRRDWSLLSK1Arabidopsis thaliana
W1084IVRRDWSQLAV1Drosophila melanogaster
Y1146KDPQDYPDKKS2Homo sapiens, Rattus norvegicus
Y1146KDPKAYPGGKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y1146KNPEDYPNGKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y1146KPPAAYPDSKS1Arabidopsis thaliana
Y1146RTPQEYANSAS1Drosophila melanogaster
Y1146KDPQDYPDRKS1Mus musculus
Y839RKKAAYAGGLV2Homo sapiens, Rattus norvegicus
Y839-KKAKYQGGLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y839KKKDKYKGGLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y839KKGPAYAGGLV1Arabidopsis thaliana
Y839KKKAAYAGGLV1Drosophila melanogaster
Y839RKKATYAGGLV1Mus musculus
Y865DFNSLYPSIIQ7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus
Y957TANSMYGCLGF5Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus
Y957TANSMYGCLGY2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y964CLGFSYSRFYA3Homo sapiens, Mus musculus, Rattus norvegicus
Y964CLGYVNSRFYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y964CLGYTKSRFYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y964CLGFSNSRFYA1Arabidopsis thaliana
Y964CLGFAHSRFFA1Drosophila melanogaster

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