mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for POR
Gene summary
Basic gene Info.Gene symbolPOR
Gene nameP450 (cytochrome) oxidoreductase
SynonymsCPR|CYPOR|P450R
CytomapUCSC genome browser: 7q11.2
Type of geneprotein-coding
RefGenesNM_000941.2,
DescriptionNADPH--cytochrome P450 reductaseNADPH-dependent cytochrome P450 reductase
Modification date20141219
dbXrefs MIM : 124015
HGNC : HGNC
Ensembl : ENSG00000127948
HPRD : 00485
Vega : OTTHUMG00000130413
ProteinUniProt: P16435
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_POR
BioGPS: 5447
PathwayNCI Pathway Interaction Database: POR
KEGG: POR
REACTOME: POR
Pathway Commons: POR
ContextiHOP: POR
ligand binding site mutation search in PubMed: POR
UCL Cancer Institute: POR
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0032770positive regulation of monooxygenase activity19448135
GO:0055114oxidation-reduction process19448135
GO:0090346cellular organofluorine metabolic process19448135


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Ligand binding site mutations for POR

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G488G486SLUSC1
G534V534AUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for POR
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for POR from PDB

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Differential gene expression and gene-gene network for POR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of POR and the right PPI network was created from samples without mutations in the LBS of POR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for POR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0001627Adrenal Hyperplasia, Congenital7Biomarker, GeneticVariation
umls:C2350233Antley-Bixler Syndrome Phenotype4Biomarker, GeneticVariation
umls:C1860042DISORDERED STEROIDOGENESIS DUE TO CYTOCHROME P450 OXIDOREDUCTASE DEFICIENCY2Biomarker, GeneticVariation
umls:C0005695Urinary Bladder Neoplasms2Biomarker, GeneticVariation
umls:C0002453Amenorrhea1Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0206726Gliosarcoma1Therapeutic
umls:C0023186Learning Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for POR
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB03147Flavin adenine dinucleotideSmall molecule
ExperimentalDB03247Riboflavin MonophosphateSmall molecule
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of POR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of POR
Multiple alignments for P16435 in multiple species
LBSAA sequence# speciesSpecies
A473SVHICAVAVEY3Mus musculus, Rattus norvegicus, Bos taurus
A473SVHICAVVVEY1Homo sapiens
A473TVHVTSIVENF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A473KVHVTAVVDKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A473RIHVTCALV-Y1Arabidopsis thaliana
A473DVHVTAVLVEY1Drosophila melanogaster
A490VNKGVATSWL-2Mus musculus, Rattus norvegicus
A490INKGVATNWL-1Homo sapiens
A490PVVGVTTNLL-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A490IFYGLTTNYLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A490IHKGVCSTWM-1Arabidopsis thaliana
A490INKGVATTYL-1Drosophila melanogaster
A490INKGVATSWL-1Bos taurus
A538PGTGVAPFIGF2Homo sapiens, Bos taurus
A538PGTGVAPFRGF2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A538PGTGLAPFRGF2Arabidopsis thaliana, Drosophila melanogaster
A538PGTGVAPFMGF1Mus musculus
A538PGTGIAPFMGF1Rattus norvegicus
C472NSVHICAVAVE3Mus musculus, Rattus norvegicus, Bos taurus
C472NSVHICAVVVE1Homo sapiens
C472QTVHVTSIVEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C472DKVHVTAVVDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C472TRIHVTCALV-1Arabidopsis thaliana
C472TDVHVTAVLVE1Drosophila melanogaster
C566LLYYGCRRSDE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C566ILFYGSRNTD-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C566LLFYGCQYSDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C566VLFFGCRNRRM1Arabidopsis thaliana
C566ILYFGCRKRSE1Drosophila melanogaster
D612HLLKQDREHLW1Homo sapiens
D612DKLKDYEDQVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D612HRLLEHSDTIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D612HKMMDKASDIW1Arabidopsis thaliana
D612HLLEQDADLIW1Drosophila melanogaster
D612HLLKRDKEHLW1Mus musculus
D612HLLKRDREHLW1Rattus norvegicus
D612HLLKKDKEHLW1Bos taurus
D638RNMARDVQNTF2Homo sapiens, Bos taurus
D638RNMAKDVQNTF2Mus musculus, Rattus norvegicus
D638KGMAKGVSTAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D638DHMAKDVVNAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D638KGMARDVHRSL1Arabidopsis thaliana
D638KNMAVDVRNIL1Drosophila melanogaster
G488GRVNKGVATSW2Mus musculus, Rattus norvegicus
G488GRINKGVATNW1Homo sapiens
G488APPVVGVTTNL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G488NHIFYGLTTNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G488GRIHKGVCSTW1Arabidopsis thaliana
G488GRINKGVATTY1Drosophila melanogaster
G488GRINKGVATSW1Bos taurus
G534IMVGPGTGVAP4Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Bos taurus
G534IMIGPGTGVAP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G534IMIGPGTGLAP1Arabidopsis thaliana
G534IMVGPGTGLAP1Drosophila melanogaster
G534IMVGPGTGIAP1Rattus norvegicus
H319YESGDHVAVYP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H319YSTGDHLAVWP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H319YQTGDYASICP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H319YETGDHVGVLC1Arabidopsis thaliana
H319YDAGDHVAMFP1Drosophila melanogaster
K602-EQAHKVYVQH2Mus musculus, Rattus norvegicus
K602-EQSHKVYVQH1Homo sapiens
K602LPNTKKVYVQD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K602-EQDHKIYVQH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K602-EGPTKEYVQH1Arabidopsis thaliana
K602-DQGKKVYVQH1Drosophila melanogaster
K602-EQPQKVYVQH1Bos taurus
M635GDARNMARDVQ2Homo sapiens, Bos taurus
M635GDARNMAKDVQ2Mus musculus, Rattus norvegicus
M635GDAKGMAKGVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M635GDADHMAKDVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M635GDAKGMARDVH1Arabidopsis thaliana
M635GDAKNMAVDVR1Drosophila melanogaster
N592ALTQLNVAFSR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N592SF-EMVVAHSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N592SF-ELITAFSR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N592ALAELSVAFSR1Arabidopsis thaliana
N592TL-NLKAAFSR1Drosophila melanogaster
N634CGDARNMARDV2Homo sapiens, Bos taurus
N634CGDARNMAKDV2Mus musculus, Rattus norvegicus
N634CGDAKGMAKGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N634CGDADHMAKDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N634CGDAKGMARDV1Arabidopsis thaliana
N634CGDAKNMAVDV1Drosophila melanogaster
P533VIMVGPGTGVA3Homo sapiens, Mus musculus, Bos taurus
P533VIMIGPGTGVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P533IIMVGPGTGVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P533IIMIGPGTGLA1Arabidopsis thaliana
P533IIMVGPGTGLA1Drosophila melanogaster
P533VIMVGPGTGIA1Rattus norvegicus
Q606HKVYVQHLLKR2Mus musculus, Rattus norvegicus
Q606HKVYVQHLLKQ1Homo sapiens
Q606KKVYVQDKLKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q606HKIYVQHRLLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q606TKEYVQHKMMD1Arabidopsis thaliana
Q606KKVYVQHLLEQ1Drosophila melanogaster
Q606QKVYVQHLLKK1Bos taurus
R298Q-GTERHLMHL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R298S-SNDRNCIHS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R298K-SGSRNCLHL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R298TPESDRSCIHL1Arabidopsis thaliana
R298K-GGGRSCMHI1Drosophila melanogaster
R424WVVEARRHILA3Homo sapiens, Mus musculus, Rattus norvegicus
R424EITSKYFNIAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R424NVVDLHLNLAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R424WVVESQRSLLE1Arabidopsis thaliana
R424WIQDACRNIVH1Drosophila melanogaster
R424WVLEARRHILA1Bos taurus
R454PRLQARYYSIA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R454PQMTPRYYSIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R454AHMKPRYYSIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R454PRLQPRFYSIS1Arabidopsis thaliana
R454PRLQPRYYSIS1Drosophila melanogaster
R514-PMFVRKSQFR3Homo sapiens, Mus musculus, Rattus norvegicus
R514LPVHVRRSNFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R514-PMFVKKSTFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R514-PIFVRQSNFK1Arabidopsis thaliana
R514-PVFIRKSQFR1Drosophila melanogaster
R514-PMYVRKSQFR1Bos taurus
R567LYYGCRRSDED4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R567LFYGSRNTD-D1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R567LFYGCQYSDKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R567LFFGCRNRRMD1Arabidopsis thaliana
R567LYFGCRKRSED1Drosophila melanogaster
R597NVAFSR-EQAH2Mus musculus, Rattus norvegicus
R597NVAFSR-EQSH1Homo sapiens
R597VVAHSRLPNTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R597ITAFSR-EQDH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R597SVAFSR-EGPT1Arabidopsis thaliana
R597KAAFSR-DQGK1Drosophila melanogaster
R597NVAFSR-EQPQ1Bos taurus
S457QARYYSIASSS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S457TPRYYSISSSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S457KPRYYSISSSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S457QPRFYSISSSP1Arabidopsis thaliana
S457QPRYYSISSSA1Drosophila melanogaster
S596LNVAFSR-EQA2Mus musculus, Rattus norvegicus
S596LNVAFSR-EQS1Homo sapiens
S596MVVAHSRLPNT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S596LITAFSR-EQD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S596LSVAFSR-EGP1Arabidopsis thaliana
S596LKAAFSR-DQG1Drosophila melanogaster
S596LNVAFSR-EQP1Bos taurus
T491NKGVATSWL--3Mus musculus, Rattus norvegicus, Bos taurus
T491NKGVATNWL--1Homo sapiens
T491VVGVTTNLL--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T491FYGLTTNYLLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T491HKGVCSTWM--1Arabidopsis thaliana
T491NKGVATTYL--1Drosophila melanogaster
T535MVGPGTGVAPF4Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Bos taurus
T535MIGPGTGVAPF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T535MIGPGTGLAPF1Arabidopsis thaliana
T535MVGPGTGLAPF1Drosophila melanogaster
T535MVGPGTGIAPF1Rattus norvegicus
V474VHICAVAVEY-3Mus musculus, Rattus norvegicus, Bos taurus
V474VHICAVVVEY-1Homo sapiens
V474VHVTSIVENFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V474VHVTAVVDKK-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V474IHVTCALV-Y-1Arabidopsis thaliana
V474VHVTAVLVEY-1Drosophila melanogaster
V476ICAVAVEY---3Mus musculus, Rattus norvegicus, Bos taurus
V476ICAVVVEY---1Homo sapiens
V476VTSIVENFPNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V476VTAVVDKK---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V476VTCALV-Y---1Arabidopsis thaliana
V476VTAVLVEY---1Drosophila melanogaster
V489RVNKGVATSWL2Mus musculus, Rattus norvegicus
V489RINKGVATNWL1Homo sapiens
V489PPVVGVTTNLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V489HIFYGLTTNYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V489RIHKGVCSTWM1Arabidopsis thaliana
V489RINKGVATTYL1Drosophila melanogaster
V489RINKGVATSWL1Bos taurus
W676YSLDVWS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W676YQEDVW-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W676FFEDTW-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W676YLRDVW-1Arabidopsis thaliana
W676YSADVWS1Drosophila melanogaster
Y455RLQARYYSIAS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y455QMTPRYYSISS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y455HMKPRYYSISS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y455RLQPRFYSISS1Arabidopsis thaliana
Y455RLQPRYYSISS1Drosophila melanogaster
Y456LQARYYSIASS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y456MTPRYYSISSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y456MKPRYYSISSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y456LQPRFYSISSS1Arabidopsis thaliana
Y456LQPRYYSISSS1Drosophila melanogaster
Y478AVAVEY---E-3Mus musculus, Rattus norvegicus, Bos taurus
Y478AVVVEY---E-1Homo sapiens
Y478SIVENFPNPE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y478AVVDKK---EW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y478CALV-Y---EK1Arabidopsis thaliana
Y478AVLVEY---K-1Drosophila melanogaster
Y604QAHKVYVQHLL2Mus musculus, Rattus norvegicus
Y604QSHKVYVQHLL1Homo sapiens
Y604NTKKVYVQDKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y604QDHKIYVQHRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y604GPTKEYVQHKM1Arabidopsis thaliana
Y604QGKKVYVQHLL1Drosophila melanogaster
Y604QPQKVYVQHLL1Bos taurus


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