mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPARA
Gene summary
Basic gene Info.Gene symbolPPARA
Gene nameperoxisome proliferator-activated receptor alpha
SynonymsNR1C1|PPAR|PPARalpha|hPPAR
CytomapUCSC genome browser: 22q13.31
Type of geneprotein-coding
RefGenesNM_001001928.2,
NM_005036.4,NM_001001929.2,NM_001001930.2,NM_032644.3,
DescriptionPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3
Modification date20141222
dbXrefs MIM : 170998
HGNC : HGNC
Ensembl : ENSG00000186951
HPRD : 01369
Vega : OTTHUMG00000150443
ProteinUniProt: Q07869
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPARA
BioGPS: 5465
PathwayNCI Pathway Interaction Database: PPARA
KEGG: PPARA
REACTOME: PPARA
Pathway Commons: PPARA
ContextiHOP: PPARA
ligand binding site mutation search in PubMed: PPARA
UCL Cancer Institute: PPARA
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PPARA.1. "Sapone A, Peters JM, Sakai S, Tomita S, Papiha SS, Dai R, Friedman FK, Gonzalez FJ. The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants. Pharmacogenetics. 2000 Jun;10(4):321-33." 10862523

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter12700342
GO:0010745negative regulation of macrophage derived foam cell differentiation19114110
GO:0010871negative regulation of receptor biosynthetic process12700342
GO:0010887negative regulation of cholesterol storage19114110
GO:0010891negative regulation of sequestering of triglyceride12700342
GO:0030522intracellular receptor signaling pathway12955147
GO:0045893positive regulation of transcription, DNA-templated12955147
GO:0045944positive regulation of transcription from RNA polymerase II promoter19955185
GO:0072363regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter19955185
GO:0072366regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter19955185
GO:0072369regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter19955185


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Ligand binding site mutations for PPARA
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M330M330IBRCA1
K358K358RCOAD1
K358K358ECOAD1
L258A260VLUAD1
F359D360HSKCM1
L321M320VTHCA1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPARA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M330M330I-1.1249864
L258A260V-1.0003466
F359D360H-0.95721133
L321M320V-0.71570579
K358K358R-0.16556383
K358K358E-0.10101482
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPARA from PDB

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Differential gene expression and gene-gene network for PPARA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPARA and the right PPI network was created from samples without mutations in the LBS of PPARA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPARA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0011860Diabetes Mellitus, Type 245Biomarker, GeneticVariation
umls:C0028754Obesity36Biomarker, GeneticVariation
umls:C0242339Dyslipidemias29AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0015695Fatty Liver14Biomarker, GeneticVariation, Therapeutic
umls:C0400966Non-alcoholic Fatty Liver Disease12Biomarker, GeneticVariation
umls:C0020473Hyperlipidemias11Biomarker, GeneticVariation, Therapeutic
umls:C0020538Hypertension10Biomarker, GeneticVariation, Therapeutic
umls:C0023903Liver Neoplasms6Biomarker
umls:C0011615Dermatitis, Atopic5AlteredExpression, Biomarker
umls:C0021655Insulin Resistance4GeneticVariation, Therapeutic
umls:C0007097Carcinoma4AlteredExpression, Biomarker
umls:C0021368Inflammation3Biomarker, GeneticVariation, Therapeutic
umls:C0014072Encephalomyelitis, Autoimmune, Experimental3Biomarker
umls:C0019209Hepatomegaly3Biomarker
umls:C0011853Diabetes Mellitus, Experimental3Biomarker
umls:C0035126Reperfusion Injury2Biomarker, Therapeutic
umls:C0018800Cardiomegaly2AlteredExpression, Therapeutic
umls:C0022661Kidney Failure, Chronic2AlteredExpression, Biomarker
umls:C0027651Neoplasms2Biomarker
umls:C0033578Prostatic Neoplasms2Biomarker
umls:C0020557Hypertriglyceridemia2Biomarker, GeneticVariation
umls:C0015696Fatty Liver, Alcoholic2Biomarker
umls:C0022658Kidney Diseases2Biomarker
umls:C0022672Kidney Tubular Necrosis, Acute2Biomarker
umls:C0026848Muscular Diseases1Biomarker
umls:C2930930Abdominal obesity metabolic syndrome1Biomarker
umls:C0010346Crohn Disease1Biomarker
umls:C0860207Drug-Induced Liver Injury1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0020476Hyperlipoproteinemias1Biomarker
umls:C0020615Hypoglycemia1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0027055Myocardial Reperfusion Injury1Therapeutic
umls:C0033687Proteinuria1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPARA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00328IndomethacinSmall molecule
ApprovedDB00636ClofibrateSmall molecule
ApprovedDB01039FenofibrateSmall molecule
ApprovedDB01241GemfibrozilSmall molecule
ApprovedDB01393BezafibrateSmall molecule
NutraceuticalDB01708DehydroepiandrosteroneSmall molecule
ExperimentalDB01890N,N-bis(3-(D-gluconamido)propyl)deoxycholamideSmall molecule
InvestigationalDB04971ReglixaneSmall molecule
InvestigationalDB05187GFT505Small molecule
ExperimentalDB072152-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACIDSmall molecule
ExperimentalDB077243-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acidSmall molecule
InvestigationalDB08915AleglitazarSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPARA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
WY12-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO] PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID4bcrAL258
5442-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID1k7lAL321 M330
5442-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID1k7lCL321 M330
5442-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID1k7lEL321 M330
5442-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID1k7lGL321 M330
MMB(R,E)-2-(4-((5-METHYL-2-PHENYLOXAZOL-4-YL)METHOXY)BENZYL)-3-(PROPOXYIMINO)BUTANOIC ACID2npaAL321 M330
MMB(R,E)-2-(4-((5-METHYL-2-PHENYLOXAZOL-4-YL)METHOXY)BENZYL)-3-(PROPOXYIMINO)BUTANOIC ACID2npaCL321 M330
7352-METHYL-2-PHENOXYPROPANOIC ACID2p54AL321 M330
REW4-[2-(3-{[(2S,3S)-2-CARBOXY-1-(4-METHOXYPHENYL)-4-OXOAZETIDIN-3-YL]METHYL}PHENOXY)ETHYL]-5-METHYL-2-PHENYL-1,3-OXAZOL-3-IUM2rewAL321 M330
7HAN-(3-{[2-(4-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHOXY}BENZYL)-N-(METHOXYCARBONYL)GLYCINE3kdtAL321 M330
7HAN-(3-{[2-(4-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHOXY}BENZYL)-N-(METHOXYCARBONYL)GLYCINE3kdtBL321 M330
NKSN-(3-{[2-(4-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHOXY}BENZYL)-N-[(4-METHYLPHENOXY)CARBONYL]GLYCINE3kduAL321 M330
NKSN-(3-{[2-(4-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHOXY}BENZYL)-N-[(4-METHYLPHENOXY)CARBONYL]GLYCINE3kduBL321 M330
13M(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL) AMINO]METHYL}BENZYL)BUTANOIC ACID3vi8AL321 M330
Y1N2-METHYL-2-[4-[2-[4-[(E)-PHENYLDIAZENYL] PHENOXY]ETHYL]PHENOXY]PROPANOIC ACID4ci4AL321 M330
RO7(2S)-2-METHOXY-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]-1-BENZOTHIOPHEN-7-YL}PROPANOIC ACID3g8iAL321 M330 K358
WY12-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO] PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID4bcrAL321 M330 K358
WY12-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO] PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID4bcrBL321 M330 K358
S44(S)-2-{3-[(4-ADAMANTAN-1-YLBENZOYLAMINO)METHYL]-4-PROPOXYBENZYL} BUTYRIC ACID2znnAL321 M330 K358 F359
AZ2AZ 2421i7gAM330
471N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE1kkqBM330
471N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE1kkqCM330
471N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE1kkqDM330
CTM3-{4-[2-(4-CHLORO-PHENYL)-THIAZOL-4-YLMETHOXY]-2-METHYL-PHENYL}-2-(S)-ETHOXY-PROPIONIC ACID3feiAM330


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Conservation information for LBS of PPARA
Multiple alignments for Q07869 in multiple species
LBSAA sequence# speciesSpecies
A207DLKSLAKRIYE2Homo sapiens, Canis lupus familiaris
A207DLKSLGKRIHE1Mus musculus
A207DLKSLAKRIHE1Rattus norvegicus
A250ETLCMAEKTLV4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
A333DGMLVAYGNGF2Homo sapiens, Canis lupus familiaris
A333DGMLIAYGNGF2Mus musculus, Rattus norvegicus
A454KTESDAALHPL4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
C275VRIFHCCQCTS2Homo sapiens, Canis lupus familiaris
C275VRFFHCCQCMS2Mus musculus, Rattus norvegicus
C276RIFHCCQCTSV2Homo sapiens, Canis lupus familiaris
C276RFFHCCQCMSV2Mus musculus, Rattus norvegicus
C278FHCCQCTSVET2Homo sapiens, Canis lupus familiaris
C278FHCCQCMSVET2Mus musculus, Rattus norvegicus
D466QEIYRDMY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
E251TLCMAEKTLVA4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
E269QNKEAEVRIFH2Homo sapiens, Canis lupus familiaris
E269EDKEAEVRFFH1Mus musculus
E269ENKEAEVRFFH1Rattus norvegicus
E289VTELTEFAKAI3Homo sapiens, Mus musculus, Rattus norvegicus
E289VTELTEFAKSI1Canis lupus familiaris
E462HPLLQEIYRDM4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
F273AEVRIFHCCQC2Homo sapiens, Canis lupus familiaris
F273AEVRFFHCCQC2Mus musculus, Rattus norvegicus
F297KAIPGFANLDL3Homo sapiens, Mus musculus, Rattus norvegicus
F297KSIPGFANLDL1Canis lupus familiaris
F318VYEAIFAMLSS2Homo sapiens, Canis lupus familiaris
F318VYEAIFTMLSS2Mus musculus, Rattus norvegicus
F351SLRKPFCDIME2Homo sapiens, Canis lupus familiaris
F351NLRKPFCDIME2Mus musculus, Rattus norvegicus
F359IMEPKFDFAMK4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
H274EVRIFHCCQCT2Homo sapiens, Canis lupus familiaris
H274EVRFFHCCQCM2Mus musculus, Rattus norvegicus
H411HVLKLHLQSNH2Mus musculus, Rattus norvegicus
H411HVLRLHLQSNH1Homo sapiens
H411HVLKLHLQTNH1Canis lupus familiaris
H440QLVTEHAQLVQ4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
I241NPPFVIHDMET4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
I263LVANGIQNKEA2Homo sapiens, Canis lupus familiaris
I263MVANGVEDKEA1Mus musculus
I263MVANGVENKEA1Rattus norvegicus
I272EAEVRIFHCCQ2Homo sapiens, Canis lupus familiaris
I272EAEVRFFHCCQ2Mus musculus, Rattus norvegicus
I317GVYEAIFAMLS2Homo sapiens, Canis lupus familiaris
I317GVYEAIFTMLS2Mus musculus, Rattus norvegicus
I339YGNGFITREFL4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
I354KPFCDIMEPKF4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
I447QLVQVIKKTES3Mus musculus, Rattus norvegicus, Canis lupus familiaris
I447QLVQIIKKTES1Homo sapiens
I463PLLQEIYRDMY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
K204ETADLKSLAKR3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
K204ETADLKSLGKR1Mus musculus
K208LKSLAKRIYEA2Homo sapiens, Canis lupus familiaris
K208LKSLGKRIHEA1Mus musculus
K208LKSLAKRIHEA1Rattus norvegicus
K266NGIQNKEAEVR2Homo sapiens, Canis lupus familiaris
K266NGVEDKEAEVR1Mus musculus
K266NGVENKEAEVR1Rattus norvegicus
K292LTEFAKAIPGF3Homo sapiens, Mus musculus, Rattus norvegicus
K292LTEFAKSIPGF1Canis lupus familiaris
K310QVTLLKYGVYE4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
K358DIMEPKFDFAM4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L247HDMETLCMAEK4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L254MAEKTLVAKLV2Homo sapiens, Canis lupus familiaris
L254MAEKTLVAKMV2Mus musculus, Rattus norvegicus
L258TLVAKLVANGI2Homo sapiens, Canis lupus familiaris
L258TLVAKMVANGV2Mus musculus, Rattus norvegicus
L302FANLDLNDQVT4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L309DQVTLLKYGVY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L321AIFAMLSSVMN2Homo sapiens, Canis lupus familiaris
L321AIFTMLSSLMN2Mus musculus, Rattus norvegicus
L344ITREFLKSLRK2Homo sapiens, Canis lupus familiaris
L344ITREFLKNLRK2Mus musculus, Rattus norvegicus
L347EFLKSLRKPFC2Homo sapiens, Canis lupus familiaris
L347EFLKNLRKPFC2Mus musculus, Rattus norvegicus
L410VHVLKLHLQSN2Mus musculus, Rattus norvegicus
L410VHVLRLHLQSN1Homo sapiens
L410VHVLKLHLQTN1Canis lupus familiaris
L456ESDAALHPLLQ4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L459AALHPLLQEIY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
L460ALHPLLQEIYR4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
M330MNKDGMLVAYG2Homo sapiens, Canis lupus familiaris
M330MNKDGMLIAYG2Mus musculus, Rattus norvegicus
M355PFCDIMEPKFD4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
N303ANLDLNDQVTL4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
P458DAALHPLLQEI4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
Q277IFHCCQCTSVE2Homo sapiens, Canis lupus familiaris
Q277FFHCCQCMSVE2Mus musculus, Rattus norvegicus
Q305LDLNDQVTLLK4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
R271KEAEVRIFHCC2Homo sapiens, Canis lupus familiaris
R271KEAEVRFFHCC2Mus musculus, Rattus norvegicus
R465LQEIYRDMY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
S280CCQCTSVETVT2Homo sapiens, Canis lupus familiaris
S280CCQCMSVETVT2Mus musculus, Rattus norvegicus
S373LELDDSDISLF4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
T279HCCQCTSVETV2Homo sapiens, Canis lupus familiaris
T279HCCQCMSVETV2Mus musculus, Rattus norvegicus
T283CTSVETVTELT2Homo sapiens, Canis lupus familiaris
T283CMSVETVTELT2Mus musculus, Rattus norvegicus
T285SVETVTELTEF4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
T288TVTELTEFAKA3Homo sapiens, Mus musculus, Rattus norvegicus
T288TVTELTEFAKS1Canis lupus familiaris
T307LNDQVTLLKYG4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
V255AEKTLVAKLVA2Homo sapiens, Canis lupus familiaris
V255AEKTLVAKMVA2Mus musculus, Rattus norvegicus
V281CQCTSVETVTE2Homo sapiens, Canis lupus familiaris
V281CQCMSVETVTE2Mus musculus, Rattus norvegicus
V284TSVETVTELTE2Homo sapiens, Canis lupus familiaris
V284MSVETVTELTE2Mus musculus, Rattus norvegicus
V306DLNDQVTLLKY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
V332KDGMLVAYGNG2Homo sapiens, Canis lupus familiaris
V332KDGMLIAYGNG2Mus musculus, Rattus norvegicus
V444EHAQLVQVIKK3Mus musculus, Rattus norvegicus, Canis lupus familiaris
V444EHAQLVQIIKK1Homo sapiens
Y314LKYGVYEAIFA2Homo sapiens, Canis lupus familiaris
Y314LKYGVYEAIFT2Mus musculus, Rattus norvegicus
Y464LLQEIYRDMY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris


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