mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPARG
Gene summary
Basic gene Info.Gene symbolPPARG
Gene nameperoxisome proliferator-activated receptor gamma
SynonymsCIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma
CytomapUCSC genome browser: 3p25
Type of geneprotein-coding
RefGenesNM_005037.5,
NM_015869.4,NM_138711.3,NM_138712.3,
DescriptionPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1
Modification date20141222
dbXrefs MIM : 601487
HGNC : HGNC
Ensembl : ENSG00000132170
HPRD : 03288
Vega : OTTHUMG00000129764
ProteinUniProt: P37231
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPARG
BioGPS: 5468
PathwayNCI Pathway Interaction Database: PPARG
KEGG: PPARG
REACTOME: PPARG
Pathway Commons: PPARG
ContextiHOP: PPARG
ligand binding site mutation search in PubMed: PPARG
UCL Cancer Institute: PPARG
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PPARG.1. "Lüdtke A, Buettner J, Schmidt HH, Worman HJ. New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand. J Med Genet. 2007 Sep;44(9):e88." 17766367

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter12700342
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process18293083
GO:0007165signal transduction9568716
GO:0010745negative regulation of macrophage derived foam cell differentiation19114110
GO:0010871negative regulation of receptor biosynthetic process12700342
GO:0010887negative regulation of cholesterol storage19114110
GO:0010891negative regulation of sequestering of triglyceride12700342
GO:0030224monocyte differentiation9568716
GO:0032526response to retinoic acid16239304
GO:0042953lipoprotein transport9568716
GO:0045713low-density lipoprotein particle receptor biosynthetic process9568716
GO:0045944positive regulation of transcription from RNA polymerase II promoter12700342
GO:0048469cell maturation9568716
GO:0048662negative regulation of smooth muscle cell proliferation20622039
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity18293083
GO:0055098response to low-density lipoprotein particle9568716


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Ligand binding site mutations for PPARG
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E371G372SSKCM2
I290I290MBLCA1
H494H494YBLCA1
Y78E79KBRCA1
M213M213VCOAD1
V367D365GCOAD1
L493L493FCOAD1
R164R164QKIRC1
Y355,M357T356KLUAD1
I277I277NLUAD1
R187K185ELUAD1
R316R316CSKCM1
P214P214LSKCM1
L384R385QSKCM1
K395E397GSTAD1
H351,I353E352KUCEC1
L178L178IUCEC1
R308R308CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for PPARG from My Cancer Genome.
Polo-like kinase 1 (PLK1) is a gene that encodes a protein that functions as a serine/threonine protein kinase. The protein regulates several processes involved in the cell cycle, including centrosome maturation, spindle assembly, cohesion removal, the inactivation of anaphase-promoting complex/cyclosome inhibitors, and cytokinesis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.Modified: July 1, 2015

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Protein structure related information for PPARG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I290I290M-1.4781719
K395E397G-1.4590607
L384R385Q-1.439817
I277I277N-1.3882542
R164R164Q-1.2517389
Y78E79K-1.1525293
L178L178I-1.039698
E371G372S-0.9933239
L493L493F-0.96357223
R316R316C-0.91673472
R308R308C-0.82162904
V367D365G-0.6434606
H351E352K-0.55072849
I353E352K-0.55072849
M357T356K-0.53234178
Y355T356K-0.53234178
R187K185E-0.42712138
M213M213V-0.30295264
P214P214L-0.223211
H494H494Y-0.008642811
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPARG from PDB
PDB IDPDB titlePDB structure
1I7ICRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242

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Differential gene expression and gene-gene network for PPARG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPARG and the right PPI network was created from samples without mutations in the LBS of PPARG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPARG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0011860Diabetes Mellitus, Type 2267Biomarker, GeneticVariation, Therapeutic
umls:C0028754Obesity182Biomarker, GeneticVariation
umls:C0011849Diabetes Mellitus72Biomarker, GeneticVariation, Therapeutic
umls:C0699790Colon Carcinoma47Biomarker, GeneticVariation
umls:C0020538Hypertension44Biomarker, GeneticVariation, Therapeutic
umls:C0021655Insulin Resistance43GeneticVariation, Therapeutic
umls:C0004153Atherosclerosis37AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification, Therapeutic
umls:C0040136Thyroid Neoplasms17AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0001418Adenocarcinoma16AlteredExpression, Biomarker, GeneticVariation
umls:C0271694Lipodystrophy, Familial Partial15Biomarker, GeneticVariation
umls:C0021368Inflammation14Biomarker, GeneticVariation, Therapeutic
umls:C0009375Colonic Neoplasms14AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0242339Dyslipidemias13Biomarker, GeneticVariation, Therapeutic
umls:C2239176Carcinoma, Hepatocellular13Biomarker, Therapeutic
umls:C0025517Metabolic Diseases12Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms11AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0002395Alzheimer Disease10AlteredExpression, Biomarker, GeneticVariation
umls:C0028756Obesity, Morbid8Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms7AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0030297Pancreatic Neoplasms6AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0025202Melanoma6Biomarker, GeneticVariation
umls:C0029408Osteoarthritis6Biomarker
umls:C0010346Crohn Disease5Biomarker, GeneticVariation
umls:C2609414Acute Kidney Injury4Biomarker, Therapeutic
umls:C0011853Diabetes Mellitus, Experimental4Biomarker
umls:C0022116Ischemia4Biomarker, Therapeutic
umls:C0035126Reperfusion Injury4Biomarker, Therapeutic
umls:C0017638Glioma4Biomarker
umls:C0023903Liver Neoplasms4Biomarker
umls:C0033860Psoriasis3Biomarker, GeneticVariation, Therapeutic
umls:C1720861LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 32Biomarker, GeneticVariation
umls:C0242488Acute Lung Injury2Biomarker, Therapeutic
umls:C0282548Leukostasis2Biomarker, Therapeutic
umls:C0085413Polycystic Kidney, Autosomal Dominant2Biomarker
umls:C0004763Barrett Esophagus1Biomarker
umls:C0236811Chronobiology Disorders1Biomarker
umls:C0017658Glomerulonephritis1Therapeutic
umls:C0023794Lipidoses1Biomarker
umls:C0079772Lymphoma, T-Cell1Biomarker
umls:C0027746Nerve Degeneration1Therapeutic
umls:C0221406Pituitary ACTH Hypersecretion1Therapeutic
umls:C2931367Thyroid cancer, follicular1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPARG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00159IcosapentSmall molecule
WithdrawnDB00197TroglitazoneSmall molecule
ApprovedDB00244MesalazineSmall molecule
Approved|investigationalDB00328IndomethacinSmall molecule
Approved|investigationalDB00412RosiglitazoneSmall molecule
Approved|investigationalDB00731NateglinideSmall molecule
ApprovedDB00795SulfasalazineSmall molecule
Approved|investigationalDB00912RepaglinideSmall molecule
Approved|investigationalDB00966TelmisartanSmall molecule
Approved|investigationalDB01014BalsalazideSmall molecule
ApprovedDB01050IbuprofenSmall molecule
ApprovedDB01067GlipizideSmall molecule
Approved|investigationalDB01132PioglitazoneSmall molecule
Approved|investigationalDB01252MitiglinideSmall molecule
ApprovedDB01393BezafibrateSmall molecule
ExperimentalDB04270(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic AcidSmall molecule
ExperimentalDB046892-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDSmall molecule
InvestigationalDB04971ReglixaneSmall molecule
InvestigationalDB05187GFT505Small molecule
InvestigationalDB05490T131Small molecule
InvestigationalDB05854CLX-0921Small molecule
ExperimentalDB06908(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDSmall molecule
ExperimentalDB06926(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acidSmall molecule
ExperimentalDB070532-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDSmall molecule
ExperimentalDB07111(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acidSmall molecule
ExperimentalDB07172(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acidSmall molecule
ExperimentalDB07208(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acidSmall molecule
ExperimentalDB07209(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acidSmall molecule
ExperimentalDB07302(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acidSmall molecule
ExperimentalDB07509difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boronSmall molecule
ExperimentalDB07675(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACIDSmall molecule
ExperimentalDB077233-(5-methoxy-1H-indol-3-yl)propanoic acidSmall molecule
ExperimentalDB077243-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acidSmall molecule
ExperimentalDB07842(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acidSmall molecule
ExperimentalDB078632-chloro-5-nitro-N-phenylbenzamideSmall molecule
ExperimentalDB08121(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acidSmall molecule
ExperimentalDB083023-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acidSmall molecule
ExperimentalDB084022-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDSmall molecule
ExperimentalDB08435(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acidSmall molecule
ExperimentalDB085603-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDESmall molecule
ExperimentalDB08760(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acidSmall molecule
InvestigationalDB08915AleglitazarSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPARG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
3T0(5Z)-5-(5-BROMO-2-METHOXYBENZYLIDENE)-3-(4- METHYLBENZYL)-1,3-THIAZOLIDINE-2,4-DIONE3t03BR316 K395
3T0(5Z)-5-(5-BROMO-2-METHOXYBENZYLIDENE)-3-(4- METHYLBENZYL)-1,3-THIAZOLIDINE-2,4-DIONE3t03AR316 Y355
0W3IONOMYCIN(4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-DIHYDROXY- 22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-HYDROXYETHYL]-2,5'- DIMETHYLOCTAHYDRO-2,2'-BIFURAN-5-YL}-4,6,8,12,14,18, 20-HEPTAMETHYL-9,11-DIOXODOCOS-16-ENOIC ACID4fgyAR316 Y355 M357 V367


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Conservation information for LBS of PPARG
Multiple alignments for P37231 in multiple species
LBSAA sequence# speciesSpecies
A306QSKEVAIRIFQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
A306PSKEVAIRIFQ1Bos taurus
A320FRSVEAVQEIT6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C139LMAIECRVCGD6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C142IECRVCGDKAS6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C156YGVHACEGCKG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C159HACEGCKGFFR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C176LIYDRCDLNCR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C180RCDLNCRIHKK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C190KSRNKCQYCRF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C193NKCQYCRFQKC6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C313RIFQGCQFRSV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
D503QEIYKDLY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E157GVHACEGCKGF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E287SLMMGEDKIKF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E319QFRSVEAVQEI6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E323VEAVQEITEYA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E326VQEITEYAKSI3Homo sapiens, Canis lupus familiaris, Macaca mulatta
E326VQEITEYAKNI3Mus musculus, Rattus norvegicus, Bos taurus
E371GVLISEGQGFM6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
E499HPLLQEIYKDL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F149DKASGFHYGVH6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F162EGCKGFFRRTI6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F210HNAIRFGRMPQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F254SYIKSFPLTKA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F292EDKIKFKHITP5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
F292EDKIKFKHISP1Bos taurus
F310VAIRIFQGCQF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F315FQGCQFRSVEA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F334KSIPGFVNLDL3Homo sapiens, Canis lupus familiaris, Macaca mulatta
F334KNIPGFINLDL2Mus musculus, Rattus norvegicus
F334KNIPGFVNLDL1Bos taurus
F388SLRKPFGDFME5Homo sapiens, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
F388NLRKPFGDFME1Mus musculus
F391KPFGDFMEPKF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
G148GDKASGFHYGV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
G158VHACEGCKGFF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
G211NAIRFGRMPQA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
G312IRIFQGCQFRS6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H150KASGFHYGVHA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H205AVGMSHNAIRF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H245RALAKHLYDSY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H294KIKFKHITPLQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
H294KIKFKHISPLQ1Bos taurus
H351LKYGVHEIIYT6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H477QIVTEHVQLLQ4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
H477QIVTEHVQLLH2Mus musculus, Rattus norvegicus
H494TDMSLHPLLQE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I208MSHNAIRFGRM6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I277KSPFVIYDMNS6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I290MGEDKIKFKHI6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I295IKFKHITPLQE5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
I295IKFKHISPLQE1Bos taurus
I307SKEVAIRIFQG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I309EVAIRIFQGCQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I324EAVQEITEYAK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I353YGVHEIIYTML6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I354GVHEIIYTMLA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I369KDGVLISEGQG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
I484QLLQVIKKTET4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
I484QLLHVIKKTET2Mus musculus, Rattus norvegicus
I500PLLQEIYKDLY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K160ACEGCKGFFRR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K258SFPLTKAKARA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K289MMGEDKIKFKH6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K293DKIKFKHITPL5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
K293DKIKFKHISPL1Bos taurus
K329ITEYAKSIPGF3Homo sapiens, Canis lupus familiaris, Macaca mulatta
K329ITEYAKNIPGF3Mus musculus, Rattus norvegicus, Bos taurus
K347QVTLLKYGVHE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K395DFMEPKFEFAV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K502LQEIYKDLY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L178YDRCDLNCRIH6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L256IKSFPLTKAKA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L283YDMNSLMMGED6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L298KHITPLQEQSK5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
L298KHISPLQEPSK1Bos taurus
L339FVNLDLNDQVT4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
L339FINLDLNDQVT2Mus musculus, Rattus norvegicus
L346DQVTLLKYGVH6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L358IIYTMLASLMN6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L361TMLASLMNKDG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L368NKDGVLISEGQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L381MTREFLKSLRK5Homo sapiens, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L381MTREFLKNLRK1Mus musculus
L384EFLKSLRKPFG5Homo sapiens, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L384EFLKNLRKPFG1Mus musculus
L480TEHVQLLQVIK4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
L480TEHVQLLHVIK2Mus musculus, Rattus norvegicus
L481EHVQLLQVIKK4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
L481EHVQLLHVIKK2Mus musculus, Rattus norvegicus
L493ETDMSLHPLLQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L496MSLHPLLQEIY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L497SLHPLLQEIYK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M213IRFGRMPQAEK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M357EIIYTMLASLM6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M362MLASLMNKDGV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M376EGQGFMTREFL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M392PFGDFMEPKFE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
M491KTETDMSLHPL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
N188HKKSRNKCQYC6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
N340VNLDLNDQVTL4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
N340INLDLNDQVTL2Mus musculus, Rattus norvegicus
P214RFGRMPQAEKE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
P255YIKSFPLTKAK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
P297FKHITPLQEQS5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
P297FKHISPLQEPS1Bos taurus
P495DMSLHPLLQEI6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q191SRNKCQYCRFQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q311AIRIFQGCQFR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q314IFQGCQFRSVE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q322SVEAVQEITEY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q342LDLNDQVTLLK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Q498LHPLLQEIYKD6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R164CKGFFRRTIRL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R165KGFFRRTIRLK6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R168FRRTIRLKLIY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R187IHKKSRNKCQY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R194KCQYCRFQKCL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R209SHNAIRFGRMP6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R212AIRFGRMPQAE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R308KEVAIRIFQGC6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R316QGCQFRSVEAV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
S317GCQFRSVEAVQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
S360YTMLASLMNKD6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
S370DGVLISEGQGF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
S492TETDMSLHPLL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
T257KSFPLTKAKAR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
T296KFKHITPLQEQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
T296KFKHISPLQEP1Bos taurus
T325AVQEITEYAKS3Homo sapiens, Canis lupus familiaris, Macaca mulatta
T325AVQEITEYAKN3Mus musculus, Rattus norvegicus, Bos taurus
T344LNDQVTLLKYG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
V318CQFRSVEAVQE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
V321RSVEAVQEITE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
V335SIPGFVNLDLN3Homo sapiens, Canis lupus familiaris, Macaca mulatta
V335NIPGFINLDLN2Mus musculus, Rattus norvegicus
V335NIPGFVNLDLN1Bos taurus
V343DLNDQVTLLKY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
V367MNKDGVLISEG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y151ASGFHYGVHAC6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y250HLYDSYIKSFP6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y355VHEIIYTMLAS6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y501LLQEIYKDLY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y78ISTPHYEDIPF3Homo sapiens, Bos taurus, Canis lupus familiaris
Y78ISAPHYEDIPF3Mus musculus, Rattus norvegicus, Macaca mulatta
Y93PMVADYKYDLK5Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
Y93PVVADYKYDLK1Homo sapiens


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